{ "assessed_biomarker_entity": "Ovarian cancer AGPAT1, B2M, BASP2, IER3, IL1B RNA signature panel", "assessed_entity_type": "RNA", "components": { "protein": [ { "accession": "P01584-1", "name": "Interleukin-1 beta", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "22095100", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22095100" } ] }, { "accession": "Q99943-1", "name": "1-acyl-sn-glycerol-3-phosphate acyltransferase alpha", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "22095100", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22095100" } ] }, { "accession": "P61769-1", "name": "Beta-2-microglobulin", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "22095100", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22095100" } ] }, { "accession": "P17677-1", "name": "Neuromodulin", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "22095100", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22095100" } ] }, { "accession": "P46695-1", "name": "Radiation-inducible immediate-early gene IEX-1", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "22095100", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22095100" } ] } ], "glycan": [] }, "instances": [ { "best_biomarker_type": "diagnostic", "status": "decreased IL1B, AGPAT1, B2M, BASP2, IER3 level", "notes": "A0445|Interleukin-1 beta protein|IL1B|Catabolin|IL1F2|A0320||1-Acyl-sn-glycerol-3-phosphate acyltransferase alpha|AGPAT1|1-acylglycerol-3-phosphate O-acyltransferase 1|1-AGP acyltransferase 1|1-AGPAT 1|Lysophosphatidic acid acyltransferase alpha 1|LPAAT-alpha|Protein G15|A0321|Beta-2-microglobulin|B2M|A0322|Growth associated protein 43|BASP2|Neuromodulin|Axonal membrane protein GAP-43|Growth-associated protein 43|GAP43|Neural phosphoprotein B-50|pp46|A0323|Radiation-inducible immediate-early gene IEX-1|IER3|Differentiation-dependent gene 2 protein|Protein DIF-2|Immediate early protein GLY96|Immediate early response 3 protein|PACAP-responsive gene 1 protein|Protein PRG1|UPKB:P01584|UPKB:Q99943|UPKB:P61769|UPKB:P17677|UPKB:P46695", "literature_evidence": "The logistic regression model revealed the combination of five validated biomarkers (AGPAT1, B2M, BASP2, IER3, and IL1B) can significantly discriminate ovarian cancer patients (n = 21) from the healthy controls (n = 35), yielding a receiver operating characteristic plot, area under the curve value of 0.909 with 85.7% sensitivity and 91.4% specificity. In summary, we have demonstrated that the RNA signatures in saliva could serve as biomarkers for detection of ovarian cancer with high sensitivity and specificity. [PMID:22095100]", "loinc_code": "", "tissue": { "name": "saliva", "namespace": "UBERON", "id": "0001836", "url": "http://purl.obolibrary.org/obo/UBERON_0001836" }, "disease": { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ] }, "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "22095100", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22095100" } ] } ], "publication": [ { "title": "Salivary transcriptomic biomarkers for detection of ovarian cancer: for serous papillary adenocarcinoma.", "journal": "Journal of molecular medicine (Berlin, Germany)", "authors": "Lee Yu-Hsiang, Kim Jae Hoon, Zhou Hui, Kim Bo Wook, Wong David T", "date": "2012-04", "reference": [ { "type": "PubMed", "id": "22095100", "url": "https://glygen.org/publication/PubMed/22095100" } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "22095100", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22095100" } ], "biomarker_id": "A0466", "aclist": [ "P46695-1", "P17677-1", "Q99943-1", "P01584-1", "P61769-1" ], "crossref": [], "section_stats": [ { "table_id": "instances", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "best_biomarker_type", "status", "notes", "literature_evidence", "loinc_code", "tissue.name", "tissue.namespace", "tissue.id", "tissue.url", "disease.disease_id" ] }, { "table_id": "components", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "authors", "date" ] } ] }