{
    "assessed_biomarker_entity": "Transgelin (TAGLN)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "Q01995-1",
                "name": "Transgelin",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "23174934",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/23174934"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "increased TAGLN level",
            "notes": "immunohistochemical detection of TAGLN|expression of TAGLN|22 kDa actin-binding protein|Protein WS3-10|Smooth muscle protein 22-alpha|SM22-alpha",
            "literature_evidence": "For the diagnosis of leiomyosarcomas versus all other sarcomas including GIST, transgelin emerged as the best diagnostic marker with 83% Se, 82% Sp, a PPV of 67%, a NPV of 92% and an accuracy rate of 83%. [PMID:23174934]",
            "loinc_code": "",
            "tissue": {
                "name": "smooth muscle tissue",
                "namespace": "UBERON",
                "id": "0001135",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001135"
            },
            "disease": {
                "disease_id": "DOID:363",
                "recommended_name": {
                    "id": "DOID:363",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:363",
                    "name": "uterine cancer",
                    "description": "A female reproductive organ cancer that is located_in the uterus."
                },
                "synonyms": [
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "CA - cancer of uterus",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "Tumour of uterus",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "malignant neoplasm of uterus",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "malignant uterine tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "neoplasm of uterus",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "uterine tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "uterus neoplasm",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "23174934",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/23174934"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Transgelin is a novel marker of smooth muscle differentiation that improves diagnostic accuracy of leiomyosarcomas: a comparative immunohistochemical reappraisal of myogenic markers in 900 soft tissue tumors.",
            "journal": "Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc",
            "authors": "Robin Yves-Marie, Penel Nicolas, P\u00e9rot Ga\u00eblle, Neuville Agnes, V\u00e9lasco Val\u00e9rie, Ranch\u00e8re-Vince Dominique, Terrier Philippe, Coindre Jean-Michel",
            "date": "2013-04",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23174934",
                    "url": "https://glygen.org/publication/PubMed/23174934"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "23174934",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/23174934"
        }
    ],
    "biomarker_id": "A0356",
    "aclist": [
        "Q01995-1"
    ],
    "crossref": [],
    "section_stats": [
        {
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}