{
    "assessed_biomarker_entity": "Differentiation antagonizing non-protein coding RNA (DANCR)",
    "assessed_entity_type": "RNA",
    "components": {
        "protein": [
            {
                "accession": "Q6P1J9-1",
                "name": "Parafibromin",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
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                        "url": "https://glygen.org/publication/PubMed/30910839"
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                ]
            }
        ],
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    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "decreased DANCR level",
            "notes": "Down-regulation of DANCR",
            "literature_evidence": "These results demonstrated that the expression of DANCR was notably decreased in tumor tissues in comparison with adjacent normal tissues. The present study demonstrated that DANCR was associated with PTC aggressive clinical features and may serve as a diagnostic biomarker for detecting PTC patients. [PMID:30910839]",
            "loinc_code": "",
            "tissue": {
                "name": "thyroid gland",
                "namespace": "UBERON",
                "id": "0002046",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046"
            },
            "disease": {
                "disease_id": "DOID:1781",
                "recommended_name": {
                    "id": "DOID:1781",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1781",
                    "name": "thyroid cancer",
                    "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                },
                "synonyms": [
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "thyroid gland cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "Thyroid gland neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "malignant neoplasm of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "malignant tumour of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "neoplasm of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "thyroid neoplasm",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "30910839",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30910839"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Down-regulation of DANCR acts as a potential biomarker for papillary thyroid cancer diagnosis.",
            "journal": "Bioscience reports",
            "authors": "Zhang Ke, Lv Jing, Peng Xiaowei, Liu Jianqiu, Li Cuilin, Li Jing, Yin Ningwei, Li Hui, Li Zhi",
            "date": "2019-04-30",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30910839",
                    "url": "https://glygen.org/publication/PubMed/30910839"
                }
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                }
            ]
        }
    ],
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        {
            "id": "30910839",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/30910839"
        }
    ],
    "biomarker_id": "A0303",
    "aclist": [
        "Q6P1J9-1"
    ],
    "crossref": [],
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