{
    "assessed_biomarker_entity": "Glycosyltransferase 8 domain containing 1 (GLT8D1)",
    "assessed_entity_type": "gene",
    "components": {
        "protein": [
            {
                "accession": "Q68CQ7-1",
                "name": "Glycosyltransferase 8 domain-containing protein 1",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "31305325",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/31305325"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased GLT8D1 level",
            "notes": "Specific specimen type: cutaneous melanoma and mucosal melanoma|Upregulation of GLT8D1 mRNA expression",
            "literature_evidence": "The GEO data analysis exhibited that the GLT8D1 mRNA expression was upregulated in the melanoma samples compared with the benign nevus samples. Furthermore, the GLT8D1 protein expression in cutaneous melanoma was higher than that in mucosal melanoma (P = 0.001). The high GLT8D1 protein expression was remarkably correlated with Clark level (P = 0.027), AJCC stage (P = 0.003), ulceration status (P = 0.041) Ki-67 expression (P = 0.030) and especially with histopathological type (P = 0.001). The results of the Kaplan-Meier survival and Cox regression analyses revealed that cutaneous melanoma patients with high GLT8D1 expression (P = 0.036), Clark level (P = 0.018) and advanced AJCC stage (P = 0.003) encountered poor overall survival. Overall survival (P = 0.040) and progression free survival (P = 0.019) were worse for the patients with high GLT8D1 expression than for the patients with low expression. These data implied that GLT8D1 could be an independent prognostic factor for an unfavorable prognosis in cutaneous malignant melanoma patients and that GLT8D1 overexpression might serve as a novel prognostic biomarker. [PMID:31305325]",
            "loinc_code": "",
            "tissue": {
                "name": "skin epidermis",
                "namespace": "UBERON",
                "id": "0001003",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001003"
            },
            "disease": {
                "disease_id": "DOID:4159",
                "recommended_name": {
                    "id": "DOID:4159",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4159",
                    "name": "skin cancer",
                    "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
                },
                "synonyms": [
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "CA - skin cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "malignant neoplasm of skin",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "melanoma and Non-melanoma skin cancer",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "31305325",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31305325"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "GLT8D1 overexpression as a novel prognostic biomarker in human cutaneous melanoma.",
            "journal": "Melanoma research",
            "authors": "Hu H, Li Z, Zhou Y, Zhang Y, Zhao L, Zhao W, Huang Y, Song X",
            "date": "2019",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31305325",
                    "url": "https://glygen.org/publication/PubMed/31305325"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "31305325",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31305325"
        }
    ],
    "biomarker_id": "A0182",
    "aclist": [
        "Q68CQ7-1"
    ],
    "crossref": [],
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