{
    "assessed_biomarker_entity": "Glypican 6 (GPC6)",
    "assessed_entity_type": "gene",
    "components": {
        "protein": [
            {
                "accession": "Q9Y625-1",
                "name": "Glypican-6",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "31199813",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/31199813"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased GPC6 level",
            "notes": "Upregulation of GPC6",
            "literature_evidence": "GPC6 expression was up-regulated in a melanoma cell line compared to normal melanocytes and in metastatic melanoma compared to primary melanoma. Together, our findings identified GPC6 as an early biomarker for melanoma metastatic progression, one that can be regulated by miR-509-3p. [PMID:31199813]",
            "loinc_code": "",
            "tissue": {
                "name": "skin epidermis",
                "namespace": "UBERON",
                "id": "0001003",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001003"
            },
            "disease": {
                "disease_id": "DOID:4159",
                "recommended_name": {
                    "id": "DOID:4159",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4159",
                    "name": "skin cancer",
                    "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
                },
                "synonyms": [
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "CA - skin cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "malignant neoplasm of skin",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "melanoma and Non-melanoma skin cancer",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "31199813",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31199813"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Glypican 6 is a putative biomarker for metastatic progression of cutaneous melanoma.",
            "journal": "PloS one",
            "authors": "Li Y, Li M, Shats I, Krahn JM, Flake GP, Umbach DM, Li X, Li L",
            "date": "2019",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31199813",
                    "url": "https://glygen.org/publication/PubMed/31199813"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "31199813",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31199813"
        }
    ],
    "biomarker_id": "A0179",
    "aclist": [
        "Q9Y625-1"
    ],
    "crossref": [],
    "section_stats": [
        {
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            ],
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}