{
    "assessed_biomarker_entity": "Prolyl 4-hydroxylase subunit alpha 1 (P4HA1)",
    "assessed_entity_type": "gene",
    "components": {
        "protein": [
            {
                "accession": "P13674-1",
                "name": "Prolyl 4-hydroxylase subunit alpha-1",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
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                        "id": "32053263",
                        "database": "PubMed",
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                    }
                ]
            }
        ],
        "glycan": []
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        {
            "best_biomarker_type": "prognostic",
            "status": "decreased P4HA1 level",
            "notes": "Depletion of P4HA1",
            "literature_evidence": "We studied further the significance of one of the genes, prolyl 4-hydroxylase subunit alpha 1 (P4HA1), in melanoma progression. P4HA1 depletion in melanoma cells reduced cell adhesion, invasion, and viability in vitro. Taken together, P4HA1 is an interesting potential prognostic marker and therapeutic target in primary melanomas, influencing many aspects of melanoma tumor progression. [PMID:32053263]",
            "loinc_code": "",
            "tissue": {
                "name": "skin epidermis",
                "namespace": "UBERON",
                "id": "0001003",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001003"
            },
            "disease": {
                "disease_id": "DOID:4159",
                "recommended_name": {
                    "id": "DOID:4159",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4159",
                    "name": "skin cancer",
                    "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
                },
                "synonyms": [
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "CA - skin cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "malignant neoplasm of skin",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "melanoma and Non-melanoma skin cancer",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "32053263",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32053263"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls.",
            "journal": "Molecular oncology",
            "authors": "Eriksson J, Le Joncour V, Jahkola T, Juteau S, Laakkonen P, Saksela O, Holtta E",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32053263",
                    "url": "https://glygen.org/publication/PubMed/32053263"
                }
            ],
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                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
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        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
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        {
            "id": "32053263",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32053263"
        }
    ],
    "biomarker_id": "A0176",
    "aclist": [
        "P13674-1"
    ],
    "crossref": [],
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