{
    "assessed_biomarker_entity": "Kinesin-like protein KIF1A gene promoter methylation (KIF1A)",
    "assessed_entity_type": "gene",
    "components": {
        "protein": [
            {
                "accession": "Q12756-1",
                "name": "Kinesin-like protein KIF1A",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "21558411",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/21558411"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "presence of",
            "notes": "EDRN biomarker|Axonal transporter of synaptic vesicles|Microtubule-based motor KIF1A|Unc-104- and KIF1A-related protein|hUnc-104",
            "literature_evidence": "EDNRB, HOXA9, GATA4, NID2, KIF1A, DCC show differential methylation between cases and controls. Promoter methylation of KIF1A, NID2, and EDNRB had a moderate to substantial agreement with clinical diagnosis. [PMID:21558411]",
            "loinc_code": "",
            "tissue": {
                "name": "oral cavity",
                "namespace": "UBERON",
                "id": "0000167",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000167"
            },
            "disease": {
                "disease_id": "DOID:11934",
                "recommended_name": {
                    "id": "DOID:11934",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11934",
                    "name": "head and neck cancer",
                    "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
                },
                "synonyms": [
                    {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck tumours",
                        "description": ""
                    },
                    {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head/neck neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "tumor of head and neck",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "21558411",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/21558411"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva.",
            "journal": "Cancer prevention research (Philadelphia, Pa.)",
            "authors": "Guerrero-Preston R, Soudry E, Acero J, Orera M, Moreno-L\u00f3pez L, Mac\u00eda-Col\u00f3n G, Jaffe A, Berdasco M, Ili-Gangas C, Brebi-Mieville P, Fu Y, Engstrom C, Irizarry R A, Esteller M, Westra W, Koch W, Califano J, Sidransky D",
            "date": "2011-07",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21558411",
                    "url": "https://glygen.org/publication/PubMed/21558411"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "21558411",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/21558411"
        }
    ],
    "biomarker_id": "A0160",
    "aclist": [
        "Q12756-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
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                "status",
                "notes",
                "literature_evidence",
                "loinc_code",
                "tissue.name",
                "tissue.namespace",
                "tissue.id",
                "tissue.url",
                "disease.disease_id"
            ]
        },
        {
            "table_id": "components",
            "table_stats": [
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                    "count": 2
                }
            ],
            "sort_fields": []
        },
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        }
    ]
}