{
    "assessed_biomarker_entity": "Breast cancer metastasis suppressor 1 (BRMS1)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "Q9HCU9-1",
                "name": "Breast cancer metastasis-suppressor 1",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "20935672",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/20935672"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "decreased BRMS1 level",
            "notes": "Specimen type also unspecified metastatic tissues|Also associated with several metastases|Breast tissue (UN:0000310)|ovary tissue (UN:0000992)|Decreased BRMS1 expression",
            "literature_evidence": "BRMS1 expression was significantly correlated with disease-specific 5-year survival of melanoma patients (P=0.007, log-rank test). Multivariate Cox regression analysis revealed that BRMS1 staining was an independent prognostic factor for melanoma patients (relative risk=0.51; confidence interval=0.29-0.91; P=0.022). BRMS1 expression was significantly decreased in metastatic melanoma compared with primary melanoma or dysplastic nevi (P=0.021 and 0.001, respectively, chi(2) test). BRMS1 may serve an important prognostic marker and therapeutic target for melanoma patients. [PMID:20935672]",
            "loinc_code": "",
            "tissue": {
                "name": "skin epidermis",
                "namespace": "UBERON",
                "id": "0001003",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001003"
            },
            "disease": {
                "disease_id": "DOID:4159",
                "recommended_name": {
                    "id": "DOID:4159",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4159",
                    "name": "skin cancer",
                    "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
                },
                "synonyms": [
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "CA - skin cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "malignant neoplasm of skin",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "melanoma and Non-melanoma skin cancer",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "20935672",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/20935672"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Prognostic significance of BRMS1 expression in human melanoma and its role in tumor angiogenesis.",
            "journal": "Oncogene",
            "authors": "Li J, Cheng Y, Tai D, Martinka M, Welch DR, Li G",
            "date": "2011",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20935672",
                    "url": "https://glygen.org/publication/PubMed/20935672"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "20935672",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/20935672"
        }
    ],
    "biomarker_id": "A0155",
    "aclist": [
        "Q9HCU9-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "best_biomarker_type",
                "status",
                "notes",
                "literature_evidence",
                "loinc_code",
                "tissue.name",
                "tissue.namespace",
                "tissue.id",
                "tissue.url",
                "disease.disease_id"
            ]
        },
        {
            "table_id": "components",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}