{
    "assessed_biomarker_entity": "Epidermal growth factor receptor gene mutation L858R (EGFR)",
    "assessed_entity_type": "gene",
    "components": {
        "protein": [
            {
                "accession": "P00533-1",
                "name": "Epidermal growth factor receptor",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "23599147",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/23599147"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "presence of",
            "notes": "EDRN biomarker|FDA approved for lung cancer|Alternate LOINC ID:14050-9|Epidermal growth factor receptor [Moles/mass] in tissue|UPKB:P00533",
            "literature_evidence": "EGFR mutation-specific (E746-A750del and L858R) antibodies could be an additional tool distinguishing primary versus metastatic carcinomas in the lung. EGFR mutation-specific antibodies are negative in other tumors that overexpress wild-type EGFR protein. [PMID:23599147]",
            "loinc_code": "13659-8",
            "tissue": {
                "name": "lung",
                "namespace": "UBERON",
                "id": "0002048",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002048"
            },
            "disease": {
                "disease_id": "DOID:1324",
                "recommended_name": {
                    "id": "DOID:1324",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1324",
                    "name": "lung cancer",
                    "description": "A respiratory system cancer that is located_in the lung."
                },
                "synonyms": [
                    {
                        "id": "MONDO:0012159",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                        "name": "lung cancer susceptibility 1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012159",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                        "name": "LNCR1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012159",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                        "name": "lung cancer susceptibility",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012159",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                        "name": "lung cancer susceptibility 1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012942",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                        "name": "lung cancer susceptibility 3",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012942",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                        "name": "LNCR3",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012942",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                        "name": "lung cancer susceptibility 3",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012942",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                        "name": "adenocarcinoma of lung, susceptibility to",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012955",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                        "name": "lung cancer susceptibility 4",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012955",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                        "name": "LNCR4",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012955",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                        "name": "lung cancer susceptibility 4",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0013631",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                        "name": "lung cancer susceptibility 5",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0013631",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                        "name": "LNCR5",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0013631",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                        "name": "lung cancer susceptibility 5",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer",
                        "description": "A malignant neoplasm involving the lung."
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "adenocarcinoma of lung, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "cancer of lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, protection against, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant lung neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant lung tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant lung tumour",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant neoplasm of lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant neoplasm of the lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant tumor of lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant tumor of the lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant tumour of lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant tumour of the lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "nonsmall cell lung cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "Nonsmall cell lung cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "alveolar cell carcinoma",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, protection against",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MIM:211980",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/211980",
                        "name": "Lung cancer",
                        "description": "Lung cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "23599147",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/23599147"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Immunohistochemical staining with EGFR mutation-specific antibodies: high specificity as a diagnostic marker for lung adenocarcinoma.",
            "journal": "Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc",
            "authors": "Wen YH, Brogi E, Hasanovic A, Ladanyi M, Soslow RA, Chitale D, Shia J, Moreira AL",
            "date": "2013",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23599147",
                    "url": "https://glygen.org/publication/PubMed/23599147"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "23599147",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/23599147"
        }
    ],
    "biomarker_id": "A0152",
    "aclist": [
        "P00533-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "best_biomarker_type",
                "status",
                "notes",
                "literature_evidence",
                "loinc_code",
                "tissue.name",
                "tissue.namespace",
                "tissue.id",
                "tissue.url",
                "disease.disease_id"
            ]
        },
        {
            "table_id": "components",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}
