{
    "assessed_biomarker_entity": "De Ritis ratio (GOT1 to GPT)",
    "assessed_entity_type": "protein",
    "components": {
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            {
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                "name": "Aspartate aminotransferase, cytoplasmic",
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                        "url": "https://data.glygen.org/GLY_000625"
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                ]
            },
            {
                "accession": "P24298-1",
                "name": "Alanine aminotransferase 1",
                "evidence": [
                    {
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                        "url": "https://data.glygen.org/GLY_000625"
                    },
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        ],
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    },
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        {
            "best_biomarker_type": "prognostic",
            "status": "increased GOT1 to GPT ratio",
            "notes": "UPKB:P17174|UPKB:P24298",
            "literature_evidence": "De Ritis ratio on admission was significantly associated with in-hospital mortality in COVID-19 patients. [PMID:33043447]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:0080600",
                "recommended_name": {
                    "id": "DOID:0080600",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080600",
                    "name": "COVID-19",
                    "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2."
                },
                "synonyms": [
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019 Novel Coronavirus (2019-nCoV)",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
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                    },
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                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan seafood market pneumonia virus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "COVID19",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "SARS-CoV-2 infection",
                        "description": ""
                    }
                ]
            },
            "evidence": [
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                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
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                    "id": "33043447",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/33043447"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "The De Ritis ratio as prognostic biomarker of in-hospital mortality in COVID-19 patients.",
            "journal": "European journal of clinical investigation",
            "authors": "Zinellu Angelo, Arru Francesco, De Vito Andrea, Sassu Alessandro, Valdes Giovanni, Scano Valentina, Zinellu Elisabetta, Perra Roberto, Madeddu Giordano, Carru Ciriaco, Pirina Pietro, Mangoni Arduino A, Babudieri Sergio, Fois Alessandro G",
            "date": "2021-01",
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    ],
    "biomarker_id": "A0146",
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        "P17174-1",
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    ],
    "crossref": [],
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