{ "assessed_biomarker_entity": "Protein S100A9 (S100A9)", "assessed_entity_type": "protein", "components": { "protein": [ { "accession": "P06702-1", "name": "Protein S100-A9", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "32989935", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32989935" }, { "id": "25673070", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25673070" }, { "id": "31262951", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31262951" } ] } ], "glycan": [] }, "instances": [ { "best_biomarker_type": "prognostic", "status": "increased S100A9 level", "notes": "", "literature_evidence": "Among the most highly increased inflammatory mediators in severe/critically ill patients, S100A9, an alarmin and TLR4 ligand, was found as a noteworthy biomarker, because it inversely correlated with the serum albumin levels. [PMID:32989935]", "loinc_code": "", "tissue": { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178" }, "disease": { "disease_id": "DOID:0080600", "recommended_name": { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2." }, "synonyms": [ { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "2019 Novel Coronavirus (2019-nCoV)", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "2019-nCoV infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "Wuhan coronavirus infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "Wuhan seafood market pneumonia virus infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "COVID19", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "SARS-CoV-2 infection", "description": "" } ] }, "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "32989935", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32989935" } ] }, { "best_biomarker_type": "predictive", "status": "increased S100A9 level", "notes": "Measured in serum (UN:0001977) as well|renal cell carcinoma (DOID:4450)", "literature_evidence": "Serum and mRNA expression levels of S100A8 and S100A9 were found to be upregulated in patients with RCC. The overexpression of S100A8 and S100A9 in cancer cells was also confirmed by immunohistochemistry. [PMID:25673070]", "loinc_code": "", "tissue": { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178" }, "disease": { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] }, "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "25673070", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25673070" } ] }, { "best_biomarker_type": "monitoring", "status": "Increased S100A9 level", "notes": "Increased S100A9 expression|Measured in serum (UN: 0001977) as well.", "literature_evidence": "S100A9 and Galectin-3 are overexpressed in PCDM tumors and mediate insulin resistance. Galectin-3 and S100A9 distinguish PCDM from type 2 diabetes in subjects with new-onset diabetes. [PMID:31262951]", "loinc_code": "", "tissue": { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178" }, "disease": { "disease_id": "DOID:9351", "recommended_name": { "id": "DOID:9351", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9351", "name": "diabetes mellitus", "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both." }, "synonyms": [ { "id": "DOID:9351", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9351", "name": "diabetes", "description": "" } ] }, "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "31262951", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31262951" } ] } ], "publication": [ { "title": "Proteins S100A8 and S100A9 are potential biomarkers for renal cell carcinoma in the early stages: results from a proteomic study integrated with bioinformatics analysis.", "journal": "Molecular medicine reports", "authors": "Zhang L, Jiang H, Xu G, Wen H, Gu B, Liu J, Mao S, Na R, Jing Y, Ding Q, Zhang Y", "date": "2015", "reference": [ { "type": "PubMed", "id": "25673070", "url": "https://glygen.org/publication/PubMed/25673070" } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] }, { "title": "COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis.", "journal": "Journal of Korean medical science", "authors": "Sohn KM, Lee SG, Kim HJ, Cheon S, Jeong H, Lee J, Kim IS, Silwal P, Kim YJ, Paik S, Chung C, Park C, Kim YS, Jo EK", "date": "2020", "reference": [ { "type": "PubMed", "id": "32989935", "url": "https://glygen.org/publication/PubMed/32989935" } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] }, { "title": "Galectin-3 and S100A9: Novel Diabetogenic Factors Mediating Pancreatic Cancer-Associated Diabetes.", "journal": "Diabetes care", "authors": "Liao WC, Huang BS, Yu YH, Yang HH, Chen PR, Huang CC, Huang HY, Wu MS, Chow LP", "date": "2019", "reference": [ { "type": "PubMed", "id": "31262951", "url": "https://glygen.org/publication/PubMed/31262951" } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "32989935", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32989935" }, { "id": "25673070", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25673070" }, { "id": "31262951", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31262951" } ], "biomarker_id": "A0134", "aclist": [ "P06702-1" ], "crossref": [], "section_stats": [ { "table_id": "instances", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "best_biomarker_type", "status", "notes", "literature_evidence", "loinc_code", "tissue.name", "tissue.namespace", "tissue.id", "tissue.url", "disease.disease_id" ] }, { "table_id": "components", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "authors", "date" ] } ] }