{
    "assessed_biomarker_entity": "Interleukin-10 (IL10)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P22301-1",
                "name": "Interleukin-10",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "30304975",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/30304975"
                    },
                    {
                        "id": "31986264",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/31986264"
                    },
                    {
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                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32222466"
                    },
                    {
                        "id": "28420440",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/28420440"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased IL10 level",
            "notes": "Measured in serum (UN:0001977) as well",
            "literature_evidence": "IL-6, IL-8, and IL-10 showed significant positive correlations with each other. Moreover, high levels of serum IL-6, IL-8, and IL-10 were independently strongly associated with poor survival of patients with pancreatic cancer. Patients with high IL-6, IL-8, or IL-10 expression (greater than median expression levels) exhibited a significantly shorter survival time, compared with patients with low expression (less than median expression levels) (p<0.001 for IL-6, p<0.01 for IL-8, and p<0.05 for IL-10)  Univariate Cox analysis revealed that a high expression level of either IL-6, IL-8, or IL-10 was associated with poor survival (IL-6: HR = 0.204, 95% CI: 0.107-0.410, p<0.001; IL-8: HR = 0.303, 95% CI: 0.135-0.683, p<0.01; IL-10: HR = 0.336, 95% CI: 0.125-0.900, p<0.05). [PMID:30304975]",
            "loinc_code": "26848-2",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:1793",
                "recommended_name": {
                    "id": "DOID:1793",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1793",
                    "name": "pancreatic cancer",
                    "description": "An endocrine gland cancer located_in the pancreas."
                },
                "synonyms": [
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca body of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca head of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca tail of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of body of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of head of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of tail of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreas neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreatic neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreatic tumor",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "30304975",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30304975"
                }
            ]
        },
        {
            "best_biomarker_type": "monitoring",
            "status": "increased IL10 level",
            "notes": "Measured in plasma (UN:0001969) as well.",
            "literature_evidence": "Comparison between ICU and non-ICU patients showed that plasma concentrations of IL2, IL7, IL10, GCSF, IP10, MCP1, MIP1A, and TNF alpha were higher in ICU patients than non-ICU patients. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNF alpha. [PMID:31986264] IL-2, IL-7, IL-10, G-CSF, IP10, MCP1, MIP1A, TNF alpha were higher in severe patients. [PMID:32222466]",
            "loinc_code": "26848-2",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:0080600",
                "recommended_name": {
                    "id": "DOID:0080600",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080600",
                    "name": "COVID-19",
                    "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2."
                },
                "synonyms": [
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019 Novel Coronavirus (2019-nCoV)",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019-nCoV infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan coronavirus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan seafood market pneumonia virus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "COVID19",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "SARS-CoV-2 infection",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "31986264",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31986264"
                },
                {
                    "id": "32222466",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32222466"
                }
            ]
        },
        {
            "best_biomarker_type": "predictive",
            "status": "decreased IL10 level",
            "notes": "",
            "literature_evidence": "A reduction of plasma interleukin-10 levels significantly correlated with an increase in the mean number of metabolic risk factors such as increased waist circumference, BMI, dyslipidaemia, high blood pressure and glucose intolerance. [PMID:28420440]",
            "loinc_code": "26848-2",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:9351",
                "recommended_name": {
                    "id": "DOID:9351",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9351",
                    "name": "diabetes mellitus",
                    "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both."
                },
                "synonyms": [
                    {
                        "id": "DOID:9351",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:9351",
                        "name": "diabetes",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "28420440",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/28420440"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Serum levels of IL-6, IL-8, and IL-10 are indicators of prognosis in pancreatic cancer.",
            "journal": "The Journal of international medical research",
            "authors": "Feng L, Qi Q, Wang P, Chen H, Chen Z, Meng Z, Liu L",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30304975",
                    "url": "https://glygen.org/publication/PubMed/30304975"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.",
            "journal": "Lancet (London, England)",
            "authors": "Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31986264",
                    "url": "https://glygen.org/publication/PubMed/31986264"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus.",
            "journal": "Stem cell research & therapy",
            "authors": "Ye L, Li L, Wan B, Yang M, Hong J, Gu W, Wang W, Ning G",
            "date": "2017",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28420440",
                    "url": "https://glygen.org/publication/PubMed/28420440"
                }
            ],
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                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.",
            "journal": "Clinical immunology (Orlando, Fla.)",
            "authors": "Zhang W, Zhao Y, Zhang F, Wang Q, Li T, Liu Z, Wang J, Qin Y, Zhang X, Yan X, Zeng X, Zhang S",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
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                    "url": "https://glygen.org/publication/PubMed/32222466"
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            "id": "28420440",
            "database": "PubMed",
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    "biomarker_id": "A0046",
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