{
    "assessed_biomarker_entity": "Macrophage inflammatory protein 1-alpha (CCL3)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P10147-1",
                "name": "C-C motif chemokine 3",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "31986264",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/31986264"
                    },
                    {
                        "id": "32222466",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32222466"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "monitoring",
            "status": "increased CCL3 level",
            "notes": "Measured in plasma (UN:0001969) as well.",
            "literature_evidence": "Comparison between ICU and non-ICU patients showed that plasma concentrations of IL2, IL7, IL10, GCSF, IP10, MCP1, MIP1A, and TNF alpha were higher in ICU patients than non-ICU patients. [PMID:31986264] IL-2, IL-7, IL-10, G-CSF, IP10, MCP1, MIP1A, TNF alpha were higher in severe patients. [PMID:32222466]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:0080600",
                "recommended_name": {
                    "id": "DOID:0080600",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080600",
                    "name": "COVID-19",
                    "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2."
                },
                "synonyms": [
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019 Novel Coronavirus (2019-nCoV)",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019-nCoV infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan coronavirus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan seafood market pneumonia virus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "COVID19",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "SARS-CoV-2 infection",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "31986264",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31986264"
                },
                {
                    "id": "32222466",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32222466"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.",
            "journal": "Lancet (London, England)",
            "authors": "Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31986264",
                    "url": "https://glygen.org/publication/PubMed/31986264"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.",
            "journal": "Clinical immunology (Orlando, Fla.)",
            "authors": "Zhang W, Zhao Y, Zhang F, Wang Q, Li T, Liu Z, Wang J, Qin Y, Zhang X, Yan X, Zeng X, Zhang S",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32222466",
                    "url": "https://glygen.org/publication/PubMed/32222466"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
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        {
            "id": "31986264",
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        {
            "id": "32222466",
            "database": "PubMed",
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        }
    ],
    "biomarker_id": "A0044",
    "aclist": [
        "P10147-1"
    ],
    "crossref": [],
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