{ "uniprot_canonical_ac": "A0A8I5ZUI5-1", "uniprot_ac": "A0A8I5ZUI5", "uniprot_id": "A0A8I5ZUI5_RAT", "mass": { "chemical_mass": 50011.0, "monoisotopic_mass": 50011.0 }, "refseq": { "ac": "NP_001107219", "name": "SET domain-containing protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107219" }, "gene_names": [ { "name": "Setd4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5", "id": "A0A8I5ZUI5" }, { "name": "Rda279", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107219", "id": "NP_001107219" }, { "name": "Setd4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107219", "id": "NP_001107219" } ], "protein_names": [ { "name": "SET domain containing 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A8I5ZUI5" }, { "name": "SET domain-containing protein 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107219", "id": "NP_001107219" }, { "name": "hypothetical protein RDA279", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107219", "id": "NP_001107219" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "common_name": "Rat" } ], "gene": [ { "name": "Setd4", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5", "locus": { "chromosome": "11", "start_pos": 32838063, "end_pos": 32858243, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000001699", "url": "https://www.ensembl.org/id/ENSRNOG00000001699" } ] } } ], "crossref": [ { "id": "ENSRNOG00000001699", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000001699", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19177", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19177", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "245975", "url": "https://www.ncbi.nlm.nih.gov/gene/245975", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015353", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015353", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016852", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016852", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044429", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044429", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:245975", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:245975", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NTRSFYW", "url": "https://omabrowser.org/oma/group/NTRSFYW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "11215at2759", "url": "http://www.orthodb.org/?query=11215at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13271", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13271", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13271:SF151", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13271:SF151", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00856", "url": "http://pfam.xfam.org/family/PF00856", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF09273", "url": "http://pfam.xfam.org/family/PF09273", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "619899", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=619899", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZUI5-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B0BN36", "url": "https://www.uniprot.org/uniprot/B0BN36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B0BN36-1", "url": "https://www.uniprot.org/uniprot/B0BN36-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYLRVHFQISPEPRRITRKHKISVSLNESCRSEFIELRKWLKERKFEDTGLLVPACFPGTGRGLMSKASLQEGQVIISLPESCLLTTDTVIRSSVGPYIKKWKPPVSPLLALCTFLVSERHAGSHSLWKSYLDILPKSYTCPVCLEPEVVDLLPGPLRAKAEEQRARVQDLFASSRDFFSTLQPLFAESVDSIFSYHAFLWAWCTVNTRAVYLKSRRQECLSSEPDTCALAPFLDLLNHSPHVQVKAAFNEKTRCYEIRTASRCRKHQEAFICYGPHDNQRLLLEYGFVAFGNPHACVPVSGEMLLKYLPPADKQVHKKLSILEDHGFTGNLTFGWDGPSWRLLTALKLLCLEAERFTSWKKVLIGDVISDRNEKASLGVAQKICSDFIAEIHSELRKVSDMKERKGSLISQLCLVEALRMEELRILQASAEILSSSLAPLS", "length": 442, "header": "tr|A0A8I5ZUI5-1|A0A8I5ZUI5_RAT Isoform 1 of SET domain containing 4 OS=Rattus norvegicus OX=10116 GN=Setd4 PE=4 SV=1 CANONICAL=A0A8I5ZUI5-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZUI5-1", "url": "", "sequence": { "sequence": "MYLRVHFQISPEPRRITRKHKISVSLNESCRSEFIELRKWLKERKFEDTGLLVPACFPGTGRGLMSKASLQEGQVIISLPESCLLTTDTVIRSSVGPYIKKWKPPVSPLLALCTFLVSERHAGSHSLWKSYLDILPKSYTCPVCLEPEVVDLLPGPLRAKAEEQRARVQDLFASSRDFFSTLQPLFAESVDSIFSYHAFLWAWCTVNTRAVYLKSRRQECLSSEPDTCALAPFLDLLNHSPHVQVKAAFNEKTRCYEIRTASRCRKHQEAFICYGPHDNQRLLLEYGFVAFGNPHACVPVSGEMLLKYLPPADKQVHKKLSILEDHGFTGNLTFGWDGPSWRLLTALKLLCLEAERFTSWKKVLIGDVISDRNEKASLGVAQKICSDFIAEIHSELRKVSDMKERKGSLISQLCLVEALRMEELRILQASAEILSSSLAPLS", "length": 442, "header": "tr|A0A8I5ZUI5-1|A0A8I5ZUI5_RAT Isoform 1 of SET domain containing 4 OS=Rattus norvegicus OX=10116 GN=Setd4 PE=4 SV=1 CANONICAL=A0A8I5ZUI5-1" }, "locus": { "chromosome": "11", "start_pos": 32854510, "end_pos": 32838151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000104229.1", "url": "https://www.ensembl.org/id/ENSRNOT00000104229.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000082204.1", "url": "https://www.ensembl.org/id/ENSRNOP00000082204.1" } ] } }, { "isoform_ac": "B0BN36-1", "url": "", "sequence": { "sequence": "MQRRRGRTERVRRRRRSSGSRGVNESCRSEFIELRKWLKERKFEDTGLLVPACFPGTGRGLMSKASLQEGQVIISLPESCLLTTDTVIRSSVGPYIKKWKPPVSPLLALCTFLVSERHAGSHSLWKSYLDILPKSYTCPVCLEPEVVDLLPGPLRAKAEEQRARVQDLFASSRDFFSTLQPLFAESVDSIFSYHAFLWAWCTVNTRAVYLKSRRQECLSSEPDTCALAPFLDLLNHSPHVQVKAAFNEKTRCYEIRTASRCRKHQEAFICYGPHDNQRLLLEYGFVAFGNPHACVPVSGEMLLKYLPPADKQVHKKLSILEDHGFTGNLTFGWDGPSWRLLTALKLLCLEAERFTSWKKVLIGDVISDRNEKASLGVAQKICSDFIAEIHSELRKVSDMKERKGSLISQLCLVEALRMEELRILQASAEILSSSLAPLS", "length": 439, "header": "tr|B0BN36-1|B0BN36_RAT Computationally mapped isoform of Setd4 protein OS=Rattus norvegicus OX=10116 GN=Setd4 PE=2 SV=1 CANONICAL=A0A8I5ZUI5-1" }, "locus": { "chromosome": "11", "start_pos": 32855957, "end_pos": 32838151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000002308.6", "url": "https://www.ensembl.org/id/ENSRNOT00000002308.6" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000002308.5", "url": "https://www.ensembl.org/id/ENSRNOP00000002308.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:245975", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:245975", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P58467-1", "protein_name": "SET domain-containing protein 4", "gene_name": "Setd4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQRRRGRTERARKRRRRSSGSRAVNESYRSEFIELRKWLKERKFEDTDLVPASFPGTGRGLMSKASLQEGQVMISLPESCLLTTDTVIRSSLGPYIKKWKPPVSPLLALCTFLVSEKHAGCRSLWKSYLDILPKSYTCPVCLEPEVVDLLPSPLKAKAEEQRARVQDLFTSARGFFSTLQPLFAEPVDSVFSYRAFLWAWCTVNTRAVYLRSRRQECLSAEPDTCALAPFLDLLNHSPHVQVKAAFNEKTRCYEIRTASRCRKHQEVFICYGPHDNQRLLLEYGFVSVRNPHACVPVSADMLVKFLPAADKQLHRKITILKDHGFTGNLTFGWDGPSWRLLTALKLLCLEAERFTSWKKVLLGEVISDTNEKTSLGVAQKICSDVIEETHAVLRKVSDMKEGTVSLRSQLSLVEALRMEELRILQASAEILSGLLAPFS", "length": 439 }, "evidence": [ { "id": "45233853", "url": "http://www.informatics.jax.org/homology/45233853", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NVD3-1", "protein_name": "SET domain-containing protein 4", "gene_name": "SETD4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQKGKGRTSRIRRRKLCGSSESRGVNESHKSEFIELRKWLKARKFQDSNLAPACFPGTGRGLMSQTSLQEGQMIISLPESCLLTTDTVIRSYLGAYITKWKPPPSPLLALCTFLVSEKHAGHRSLWKPYLEILPKAYTCPVCLEPEVVNLLPKSLKAKAEEQRAHVQEFFASSRDFFSSLQPLFAEAVDSIFSYSALLWAWCTVNTRAVYLRPRQRECLSAEPDTCALAPYLDLLNHSPHVQVKAAFNEETHSYEIRTTSRWRKHEEVFICYGPHDNQRLFLEYGFVSVHNPHACVYVSREILVKYLPSTDKQMDKKISILKDHGYIENLTFGWDGPSWRLLTALKLLCLEAEKFTCWKKVLLGEVISDTNEKTSLDIAQKICYYFIEETNAVLQKVSHMKDEKEALINQLTLVESLWTEELKILRASAETLHSLQTAFT", "length": 440 }, "evidence": [ { "id": "45233853", "url": "http://www.informatics.jax.org/homology/45233853", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" }, { "name": "histone H3K4 methyltransferase activity", "id": "GO:0042800", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042800", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" }, { "name": "histone H3K36 methyltransferase activity", "id": "GO:0046975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046975", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" }, { "name": "histone H4K20 methyltransferase activity", "id": "GO:0042799", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042799", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" }, { "name": "positive regulation of interleukin-6 production", "id": "GO:0032755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" }, { "name": "positive regulation of inflammatory response", "id": "GO:0050729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050729", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" }, { "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" }, { "name": "peptidyl-lysine monomethylation", "id": "GO:0018026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018026", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" }, { "name": "peptidyl-lysine trimethylation", "id": "GO:0018023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018023", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" }, { "name": "peptidyl-lysine dimethylation", "id": "GO:0018027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018027", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" }, { "name": "histone H3-K4 dimethylation", "id": "GO:0044648", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044648", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" }, { "name": "histone H3-K4 monomethylation", "id": "GO:0097692", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097692", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" }, { "name": "regulation of cell proliferation in bone marrow", "id": "GO:0071863", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071863", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZUI5", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUI5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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