{ "uniprot_canonical_ac": "A0A8I5ZTL7-1", "uniprot_ac": "A0A8I5ZTL7", "uniprot_id": "A0A8I5ZTL7_RAT", "mass": { "chemical_mass": 130400.0, "monoisotopic_mass": 130400.0 }, "refseq": { "ac": "NP_001100794", "name": "phospholipid-transporting ATPase IH isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100794" }, "gene_names": [ { "name": "Atp11a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7", "id": "A0A8I5ZTL7" }, { "name": "Atp11a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100794", "id": "NP_001100794" }, { "name": "Ua20", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100794", "id": "NP_001100794" } ], "protein_names": [ { "name": "Phospholipid-transporting ATPase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A8I5ZTL7" }, { "name": "7.6.2.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A8I5ZTL7" }, { "name": "phospholipid-transporting ATPase IH isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100794", "id": "NP_001100794" }, { "name": "probable phospholipid-transporting ATPase IH; ATPase, class VI, type 11A; UA20 protein-like", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100794", "id": "NP_001100794" } ], "function": [], "disease": [ { "disease_id": "DOID:0050564", "recommended_name": { "id": "DOID:0050564", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050564", "name": "autosomal dominant nonsyndromic deafness", "description": "A nonsyndromic deafness characterized by an autosomal dominant inheritance mode." }, "synonyms": [ { "id": "DOID:0050564", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050564", "name": "autosomal dominant deafness", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "autosomal dominant nonsyndromic hearing loss 1", "description": "Any autosomal dominant nonsyndromic deafness in which the cause of the disease is a mutation in the DIAPH1 gene." }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "Konigsmark syndrome", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "LFHL1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "hereditary low frequency hearing loss 1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "DFNA1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "DIAPH1 autosomal dominant nonsyndromic deafness", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "autosomal dominant deafness 1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "autosomal dominant nonsyndromic deafness 1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "autosomal dominant nonsyndromic deafness caused by mutation in DIAPH1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "autosomal dominant nonsyndromic deafness type 1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "deafness, autosomal dominant 1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "deafness, autosomal dominant 1, with or without thrombocytopenia", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "deafness, autosomal dominant type 1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "deafness, progressive Low tone", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "hereditary Low frequency hearing loss", "description": "" }, { "id": "MIM:124900", "resource": "MIM", "url": "https://www.omim.org/entry/124900", "name": "Deafness, autosomal dominant 1, with or without thrombocytopenia", "description": "Deafness, autosomal dominant 1, with or without thrombocytopenia" } ], "evidence": [ { "id": "0050564", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050564" } ] }, { "disease_id": "DOID:0070406", "recommended_name": { "id": "DOID:0070406", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070406", "name": "hypomyelinating leukodystrophy 24", "description": "A hypomyelinating leukodystrophy characterized by global developmental delay and neurologic deterioration that has_material_basis_in heterozygous mutation in the ATP11A gene on chromosome 13q34." }, "synonyms": [ { "id": "DOID:0070406", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070406", "name": "HLD24", "description": "" }, { "id": "MONDO:0859242", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0859242", "name": "leukodystrophy, hypomyelinating, 24", "description": "" }, { "id": "MIM:619851", "resource": "MIM", "url": "https://www.omim.org/entry/619851", "name": "Leukodystrophy, hypomyelinating, 24", "description": "Leukodystrophy, hypomyelinating, 24" } ], "evidence": [ { "id": "0070406", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070406" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "common_name": "Rat" } ], "gene": [ { "name": "Atp11a", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7", "locus": { "chromosome": "16", "start_pos": 76657752, "end_pos": 76767640, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000017154", "url": "https://www.ensembl.org/id/ENSRNOG00000017154" } ] } } ], "crossref": [ { "id": "ENSRNOG00000017154", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017154", 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"https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:306600", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:306600", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DAQITEY", "url": "https://omabrowser.org/oma/group/DAQITEY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "275833at2759", "url": "http://www.orthodb.org/?query=275833at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24092", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24092:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00122", "url": "http://pfam.xfam.org/family/PF00122", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13246", "url": "http://pfam.xfam.org/family/PF13246", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16209", "url": "http://pfam.xfam.org/family/PF16209", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16212", "url": "http://pfam.xfam.org/family/PF16212", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-936837", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-936837", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1308688", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308688", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K8V1", "url": "https://www.uniprot.org/uniprot/A0A0G2K8V1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K8V1-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K8V1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZTL7-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4A7K5", "url": "https://www.uniprot.org/uniprot/D4A7K5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4A7K5-1", "url": "https://www.uniprot.org/uniprot/D4A7K5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDCSLLRTLVRRYCAGEENWVDSRTIYVGHKEPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLIIFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADSAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNRADGTCHVTTASLDGESSHKTHYAVQDTKGFHTEADVDSLHATIECEQPQPDLYKFVGRINVYNDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNTFLIVYLCILVSKALINTVLKYVWQSEPFRDEPWYNQKTESERQRNLFLRAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEEMGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMAFKECCIEGHVYVPHVICNGQVLPDSSGIDMIDSSPGVSGREREELFFRAICLCHTVQVKDDHCGDDVDGPQKSPDAKSCVYISSSPDEVALVEGMQRLGFTYLRLKDNYMEILNRENDIERFELLEVLTFDSVRRRMSVIVKSTTGEIYLFCKGADSSIFPRVIEGKVDQVRSRVERNAVEGLRTLCVAYKRLEPEQYEDACRLLQDAKVALQDREKKLAEAYEQIEKDLILLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETASATCYACKLFRRSTQLLELTTKKLEEQSLHDVLFELSKTVLRCSGSLTRDSFSGLSTDMHDYGLIIDGAALSLIMKPREDGSSSGNYRELFLEICRNCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPSLYRDIAKNALLRWRLFIYWTFLGVFDALVFFFGAYFMFENTTVTINGQMFGNWTFGTLVFTVMVFTVTLKLALDTHYWTWINHFVIWGSLLFYIVFSLLWGGIIWPFLSYQRMYYVFIYMLSSGPAWLGIILLVTVGLLPDVLKKVLCRQLWPTATERTQLTAAPRVHHGGQGLQHYLAQVAQPLST", "length": 1139, "header": "tr|A0A8I5ZTL7-1|A0A8I5ZTL7_RAT Isoform 1 of Phospholipid-transporting ATPase OS=Rattus norvegicus OX=10116 GN=Atp11a PE=3 SV=1 CANONICAL=A0A8I5ZTL7-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K8V1-1", "url": "", "sequence": { "sequence": "MDCSLLRTLVRRYCAGEENWVDSRTIYVGHKEPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLIIFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADSAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNRADGTCHVTTASLDGESSHKTHYAVQDTKGFHTEADVDSLHATIECEQPQPDLYKFVGRINVYNDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNTFLIVYLCILVSKALINTVLKYVWQSEPFRDEPWYNQKTESERQRNLFLRAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEEMGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMAFKECCIEGHVYVPHVICNGQVLPDSSGIDMIDSSPGVSGREREELFFRAICLCHTVQVKDDHCGDDVDGPQKSPDAKSCVYISSSPDEVALVEGMQRLGFTYLRLKDNYMEILNRENDIERFELLEVLTFDSVRRRMSVIVKSTTGEIYLFCKGADSSIFPRVIEGKVDQVRSRVERNAVEGLRTLCVAYKRLEPEQYEDACRLLQDAKVALQDREKKLAEAYEQIEKDLILLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETASATCYACKLFRRSTQLLELTTKKLEEQSLHDVLFELSKTVLRCSGSLTRDSFSGLSTDMHDYGLIIDGAALSLIMKPREDGSSSGNYRELFLEICRNCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPSLYRDIAKNALLRWRLFIYWTFLGVFDALVFFFGAYFMFENTTVTINGQMFGNWTFGTLVFTVMVFTVTLKLALDTHYWTWINHFVIWGSLLFYIVFSLLWGGIIWPFLSYQRMYYVFIYMLSSGPAWLGIILLVTVGLLPDVLKKVLCRQLWPTATERTQARNKCLSVEQPTVFMLSQTASGLSF", "length": 1137, "header": "tr|A0A0G2K8V1-1|A0A0G2K8V1_RAT Computationally mapped isoform of Phospholipid-transporting ATPase OS=Rattus norvegicus OX=10116 GN=Atp11a PE=1 SV=2 CANONICAL=A0A8I5ZTL7-1" }, "locus": { "chromosome": "16", "start_pos": 76767337, "end_pos": 76664871, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000089447.2", "url": "https://www.ensembl.org/id/ENSRNOT00000089447.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074747.2", "url": "https://www.ensembl.org/id/ENSRNOP00000074747.2" } ] } }, { "isoform_ac": "A0A8I5ZTL7-1", "url": "", "sequence": { "sequence": "MDCSLLRTLVRRYCAGEENWVDSRTIYVGHKEPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLIIFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADSAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNRADGTCHVTTASLDGESSHKTHYAVQDTKGFHTEADVDSLHATIECEQPQPDLYKFVGRINVYNDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNTFLIVYLCILVSKALINTVLKYVWQSEPFRDEPWYNQKTESERQRNLFLRAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEEMGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMAFKECCIEGHVYVPHVICNGQVLPDSSGIDMIDSSPGVSGREREELFFRAICLCHTVQVKDDHCGDDVDGPQKSPDAKSCVYISSSPDEVALVEGMQRLGFTYLRLKDNYMEILNRENDIERFELLEVLTFDSVRRRMSVIVKSTTGEIYLFCKGADSSIFPRVIEGKVDQVRSRVERNAVEGLRTLCVAYKRLEPEQYEDACRLLQDAKVALQDREKKLAEAYEQIEKDLILLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETASATCYACKLFRRSTQLLELTTKKLEEQSLHDVLFELSKTVLRCSGSLTRDSFSGLSTDMHDYGLIIDGAALSLIMKPREDGSSSGNYRELFLEICRNCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPSLYRDIAKNALLRWRLFIYWTFLGVFDALVFFFGAYFMFENTTVTINGQMFGNWTFGTLVFTVMVFTVTLKLALDTHYWTWINHFVIWGSLLFYIVFSLLWGGIIWPFLSYQRMYYVFIYMLSSGPAWLGIILLVTVGLLPDVLKKVLCRQLWPTATERTQLTAAPRVHHGGQGLQHYLAQVAQPLST", "length": 1139, "header": "tr|A0A8I5ZTL7-1|A0A8I5ZTL7_RAT Isoform 1 of Phospholipid-transporting ATPase OS=Rattus norvegicus OX=10116 GN=Atp11a PE=3 SV=1 CANONICAL=A0A8I5ZTL7-1" }, "locus": { "chromosome": "16", "start_pos": 76767337, "end_pos": 76664616, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000117454.1", "url": "https://www.ensembl.org/id/ENSRNOT00000117454.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000081780.1", "url": "https://www.ensembl.org/id/ENSRNOP00000081780.1" } ] } }, { "isoform_ac": "D4A7K5-1", "url": "", "sequence": { "sequence": "MDCSLLRTLVRRYCAGEENWVDSRTIYVGHKEPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLIIFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADSAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNRADGTCHVTTASLDGESSHKTHYAVQDTKGFHTEADVDSLHATIECEQPQPDLYKFVGRINVYNDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNTFLIVYLCILVSKALINTVLKYVWQSEPFRDEPWYNQKTESERQRNLFLRAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEEMGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMAFKECCIEGHVYVPHVICNGQVLPDSSGIDMIDSSPGVSGREREELFFRAICLCHTVQVKDDHCGDDVDGPQKSPDAKSCVYISSSPDEVALVEGMQRLGFTYLRLKDNYMEILNRENDIERFELLEVLTFDSVRRRMSVIVKSTTGEIYLFCKGADSSIFPRVIEGKVDQVRSRVERNAVEGLRTLCVAYKRLEPEQYEDACRLLQDAKVALQDREKKLAEAYEQIEKDLILLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETASATCYACKLFRRSTQLLELTTKKLEEQSLHDVLFELSKTVLRCSGSLTRDSFSGLSTDMHDYGLIIDGAALSLIMKPREDGSSSGNYRELFLEICRNCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPSLYRDIAKNALLRWRLFIYWTFLGVFDALVFFFGAYFMFENTTVTINGQMFGNWTFGTLVFTVMVFTVTLKLALDTHYWTWINHFVIWGSLLFYIVFSLLWGGIIWPFLSYQRMYYVFIYMLSSGPAWLGIILLVTVGLLPDVLKKVLCRQLWPTATERTQTVQLRDSISEFTPLASLQSRGAQGTRLLAAQCSSPSGRVVCSRWESEEYPVLPTHPGLLHKARYGCCRSSLETPT", "length": 1187, "header": "tr|D4A7K5-1|D4A7K5_RAT Computationally mapped isoform of Phospholipid-transporting ATPase OS=Rattus norvegicus OX=10116 GN=Atp11a PE=1 SV=1 CANONICAL=A0A8I5ZTL7-1" }, "locus": { "chromosome": "16", "start_pos": 76767337, "end_pos": 76661347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000023163.7", "url": "https://www.ensembl.org/id/ENSRNOT00000023163.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000023163.5", "url": "https://www.ensembl.org/id/ENSRNOP00000023163.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "rno:306600", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:306600", "resource": "KEGG Pathway" }, { "id": "R-RNO-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-RNO-936837", "name": "Ion transport by P-type ATPases", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-936837", "resource": "Reactome", "description": "Ion transport by P-type ATPases" } ], "orthologs": [ { "uniprot_canonical_ac": "P98196-1", "protein_name": "Phospholipid-transporting ATPase IH", "gene_name": "ATP11A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLIIFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPHVICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLKDNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQEEYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQLLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVFFFGAYFVFENTTVTSNGQIFGNWTFGTLVFTVMVFTVTLKLALDTHYWTWINHFVIWGSLLFYVVFSLLWGGVIWPFLNYQRMYYVFIQMLSSGPAWLAIVLLVTISLLPDVLKKVLCRQLWPTATERVQTKSQCLSVEQSTIFMLSQTSSSLSF", "length": 1134 }, "evidence": [ { "id": "45234797", "url": "http://www.informatics.jax.org/homology/45234797", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P98197-1", "protein_name": "Phospholipid-transporting ATPase IH", "gene_name": "Atp11a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDCSLLRTLVRRYCAGEENWVDSRTIYVGHKEPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLIIFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNRADGTCHVTTASLDGESSHKTHYAVQDTKGFHTEADVDSLHATIECEQPQPDLYKFVGRINVYNDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNTFLIVYLCILVSKALINTVLKYVWQSEPFRDEPWYNEKTESERQRNLFLRAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEEMGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMAFKECCIEGHVYVPHVICNGQVLPDSSGIDMIDSSPGVCGREREELFFRAICLCHTVQVKDDHCGDDVDGPQKSPDAKSCVYISSSPDEVALVEGVQRLGFTYLRLKDNYMEILNRENDIERFELLEVLTFDSVRRRMSVIVKSTTGEIYLFCKGADSSIFPRVIEGKVDQVRSRVERNAVEGLRTLCVAYKRLEPEQYEDACRLLQSAKVALQDREKKLAEAYEQIEKDLVLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETASATCYACKLFRRSTQLLELTTKKLEEQSLHDVLFDLSKTVLRCSGSMTRDSFSGLSTDMHDYGLIIDGAALSLIMKPREDGSSSGNYRELFLEICRNCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDIAKNALLRWRVFIYWTFLGVFDALVFFFGAYFIFENTTVTINGQMFGNWTFGTLVFTVMVLTVTLKLALDTHYWTWINHFVIWGSLLFYIAFSLLWGGVIWPFLSYQRMYYVFISMLSSGPAWLGIILLVTVGLLPDVLKKVLCRQLWPTATERTQNIQHQDSISEFTPLASLPSWGAQGSRLLAAQCSSPSGRVVCSRWESEECPVLPLHPGLPHKARYGCCRSSLEMPT", "length": 1187 }, "evidence": [ { "id": "45234797", "url": "http://www.informatics.jax.org/homology/45234797", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of myotube differentiation", "id": "GO:0010831", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010831", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" }, { "name": "in utero embryonic development", "id": "GO:0001701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" }, { "name": "phospholipid translocation", "id": "GO:0045332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045332", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" }, { "name": "regulation of membrane lipid distribution", "id": "GO:0097035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097035", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" }, { "name": "phosphatidylethanolamine flippase activity", "id": "GO:0090555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090555", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" }, { "name": "ATPase-coupled intramembrane lipid transporter activity", "id": "GO:0140326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140326", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" }, { "name": "phosphatidylserine flippase activity", "id": "GO:0140346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140346", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" }, { "name": "phospholipid-translocating ATPase complex", "id": "GO:1990531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990531", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZTL7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1004, "end_pos": 1006, "annotation": "n_glycosylation_sequon" }, { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" }, { "start_pos": 793, "end_pos": 795, "annotation": "n_glycosylation_sequon" }, { "start_pos": 924, "end_pos": 926, "annotation": "n_glycosylation_sequon" }, { "start_pos": 992, "end_pos": 994, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-RNO-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane, tertiary granule membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P62483-1", "P70496-1", "Q2TL32-1", "A0A8I5ZTL7-1", "Q10743-1", "Q04970-1", "P29598-1", "P61227-1", "Q6P7A9-1", "A0A8I5ZV35-1" ], "evidence": [ { "id": "R-RNO-6798747", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798747" } ] }, { "id": "R-RNO-6799350", "name": "Exocytosis of specific granule membrane proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane, specific granule membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P62483-1", "P70496-1", "Q2TL32-1", "E9PTG8-1", "A0A8I5ZTL7-1", "Q10743-1", "Q5XIF5-1", "P23711-1", "A0A8I6GK94-1", "A0A8I5ZXX6-1", "D4AC45-1", "Q5XI42-1", "Q63072-1", "P97524-1", "P29598-1", "P61227-1", "P62836-1", "Q9ERM3-1", "A0A8I5ZV35-1" ], "evidence": [ { "id": "R-RNO-6799350", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6799350" } ] }, { "id": "R-RNO-939763", "name": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZE62-1", "D4A4W5-1", "A0A8I5ZTL7-1", "A0A8I6A3Z6-1", "D4AA47-1", "A0A8I5ZXX6-1", "D3ZN41-1", "D4ABB8-1", "A0A0G2JWQ8-1", "A0A8I6A6I4-1", "A0A8I5ZV31-1", "A0A8I6GJC6-1", "A0A8I6GI47-1" ], "evidence": [ { "id": "R-RNO-939763", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-939763" } ] }, { "id": "R-RNO-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZE62-1", "D4A4W5-1", "A0A8I5ZTL7-1", "A0A8I6A3Z6-1", "D4AA47-1", "A0A8I5ZXX6-1", "D3ZN41-1", "D4ABB8-1", "A0A0G2JWQ8-1", "A0A8I6A6I4-1", "A0A8I5ZV31-1", "A0A8I6GJC6-1", "A0A8I6GI47-1" ], "evidence": [ { "id": "R-RNO-947591", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-947591" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JWQ8", "gene_name": "Atp10a", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A0G2JWQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JWQ8" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A0G2JWQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JWQ8" } ] } ] }, { "uniprot_ac": "A0A8I5ZTL7", "gene_name": "Atp11a", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A8I5ZTL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A8I5ZTL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTL7" } ] } ] }, { "uniprot_ac": "A0A8I5ZV31", "gene_name": "Atp11c", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A8I5ZV31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZV31" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A8I5ZV31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZV31" } ] } ] }, { "uniprot_ac": "A0A8I5ZV35", "gene_name": "Ptprb", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I5ZV35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZV35" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8I5ZV35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZV35" } ] } ] }, { "uniprot_ac": "A0A8I5ZXX6", "gene_name": "Atp8a1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A8I5ZXX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZXX6" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A8I5ZXX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZXX6" } ] } ] }, { "uniprot_ac": "A0A8I6A3Z6", "gene_name": "Atp8a2", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A8I6A3Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A3Z6" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A8I6A3Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A3Z6" } ] } ] }, { "uniprot_ac": "A0A8I6A6I4", "gene_name": "Atp11b", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A8I6A6I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A6I4" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A8I6A6I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A6I4" } ] } ] }, { "uniprot_ac": "A0A8I6GI47", "gene_name": "Atp9a", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A8I6GI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GI47" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A8I6GI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GI47" } ] } ] }, { "uniprot_ac": "A0A8I6GJC6", "gene_name": "Atp8b2", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A8I6GJC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJC6" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A8I6GJC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJC6" } ] } ] }, { "uniprot_ac": "A0A8I6GK94", "gene_name": "Ptprj", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I6GK94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GK94" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8I6GK94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GK94" } ] } ] }, { "uniprot_ac": "D3ZE62", "gene_name": "Atp8b3", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "D3ZE62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZE62" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "D3ZE62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZE62" } ] } ] }, { "uniprot_ac": "D3ZN41", "gene_name": "Atp10d", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "D3ZN41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZN41" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "D3ZN41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZN41" } ] } ] }, { "uniprot_ac": "D4A4W5", "gene_name": "Atp10b", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "D4A4W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A4W5" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "D4A4W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A4W5" } ] } ] }, { "uniprot_ac": "D4AA47", "gene_name": "Atp8b1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "D4AA47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AA47" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "D4AA47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AA47" } ] } ] }, { "uniprot_ac": "D4ABB8", "gene_name": "Atp9b", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "D4ABB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ABB8" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "D4ABB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ABB8" } ] } ] }, { "uniprot_ac": "D4AC45", "gene_name": "Agpat2", "activity": [ { "ec_number": "2.3.1.51", "activity": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA.", "evidence": [ { "id": "D4AC45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AC45" } ] }, { "ec_number": "2.3.1.51", "activity": "", "evidence": [ { "id": "D4AC45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AC45" } ] } ] }, { "uniprot_ac": "E9PTG8", "gene_name": "Stk10", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "E9PTG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PTG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E9PTG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PTG8" } ] } ] }, { "uniprot_ac": "P23711", "gene_name": "Hmox2", "activity": [ { "ec_number": "1.14.14.18", "activity": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P23711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23711" } ] }, { "ec_number": "1.14.14.18", "activity": "", "evidence": [ { "id": "P23711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23711" } ] } ] }, { "uniprot_ac": "P29598", "gene_name": "Plau", "activity": [ { "ec_number": "3.4.21.73", "activity": "Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.", "evidence": [ { "id": "P29598", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29598" } ] }, { "ec_number": "3.4.21.73", "activity": "", "evidence": [ { "id": "P29598", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29598" } ] } ] }, { "uniprot_ac": "P61227", "gene_name": "Rap2b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61227" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61227" } ] } ] }, { "uniprot_ac": "P62483", "gene_name": "Kcnab2", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "P62483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62483" } ] } ] }, { "uniprot_ac": "P62836", "gene_name": "Rap1a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62836", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62836" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62836", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62836" } ] } ] }, { "uniprot_ac": "P70496", "gene_name": "Pld1", "activity": [ { "ec_number": "3.1.4.4", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphate + choline + H(+).", "evidence": [ { "id": "P70496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70496" } ] }, { "ec_number": "3.1.4.4", "activity": "", "evidence": [ { "id": "P70496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70496" } ] } ] }, { "uniprot_ac": "P97524", "gene_name": "Slc27a2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] } ] }, { "uniprot_ac": "Q04970", "gene_name": "Nras", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "Q04970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04970" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q04970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04970" } ] } ] }, { "uniprot_ac": "Q10743", "gene_name": "Adam10", "activity": [ { "ec_number": "3.4.24.81", "activity": "Endopeptidase of broad specificity.", "evidence": [ { "id": "Q10743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q10743" } ] }, { "ec_number": "3.4.24.81", "activity": "", "evidence": [ { "id": "Q10743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q10743" } ] } ] }, { "uniprot_ac": "Q2TL32", "gene_name": "Ubr4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TL32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TL32" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q2TL32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TL32" } ] } ] }, { "uniprot_ac": "Q5XI42", "gene_name": "Aldh3b1", "activity": [ { "ec_number": "1.2.1.5", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.28", "activity": "benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH.", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.7", "activity": "benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH.", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.7", "activity": "", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.5", "activity": "", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.28", "activity": "", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] } ] }, { "uniprot_ac": "Q5XIF5", "gene_name": "Degs1", "activity": [ { "ec_number": "1.14.19.17", "activity": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O.", "evidence": [ { "id": "Q5XIF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIF5" } ] }, { "ec_number": "5.2.1.-", "activity": "", "evidence": [ { "id": "Q5XIF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIF5" } ] }, { "ec_number": "1.14.19.17", "activity": "", "evidence": [ { "id": "Q5XIF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIF5" } ] } ] }, { "uniprot_ac": "Q63072", "gene_name": "Bst1", "activity": [ { "ec_number": "3.2.2.6", "activity": "H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide.", "evidence": [ { "id": "Q63072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63072" } ] }, { "ec_number": "3.2.2.6", "activity": "", "evidence": [ { "id": "Q63072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63072" } ] } ] }, { "uniprot_ac": "Q6P7A9", "gene_name": "Gaa", "activity": [ { "ec_number": "3.2.1.20", "activity": "Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.", "evidence": [ { "id": "Q6P7A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A9" } ] }, { "ec_number": "3.2.1.20", "activity": "", "evidence": [ { "id": "Q6P7A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A9" } ] } ] }, { "uniprot_ac": "Q9ERM3", "gene_name": "Dgat1", "activity": [ { "ec_number": "2.3.1.20", "activity": "a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA.", "evidence": [ { "id": "Q9ERM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERM3" } ] }, { "ec_number": "2.3.1.76", "activity": "all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA.", "evidence": [ { "id": "Q9ERM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERM3" } ] }, { "ec_number": "2.3.1.20", "activity": "", "evidence": [ { "id": "Q9ERM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERM3" 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