{
    "uniprot_canonical_ac": "A0A8I5ZNF3-1",
    "uniprot_ac": "A0A8I5ZNF3",
    "uniprot_id": "A0A8I5ZNF3_RAT",
    "mass": {
        "chemical_mass": 38732.0,
        "monoisotopic_mass": 38732.0
    },
    "refseq": {
        "ac": "NP_001120776",
        "name": "neutrophil cytosol factor 4",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120776"
    },
    "gene_names": [
        {
            "name": "Ncf4",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZNF3",
            "id": "A0A8I5ZNF3"
        },
        {
            "name": "Ncf4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120776",
            "id": "NP_001120776"
        }
    ],
    "protein_names": [
        {
            "name": "Neutrophil cytosolic factor 4",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A8I5ZNF3"
        },
        {
            "name": "neutrophil cytosol factor 4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120776",
            "id": "NP_001120776"
        }
    ],
    "function": [
        {
            "annotation": "The levels of cytosolic p67Phox, p47Phox, and p40Phox were increased in membrane fractions following traumatic brain injury.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001120776",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120776"
                },
                {
                    "database": "PubMed",
                    "id": "25224032",
                    "url": "https://glygen.org/publication/PubMed/25224032"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0070194",
            "recommended_name": {
                "id": "DOID:0070194",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0070194",
                "name": "autosomal recessive chronic granulomatous disease 3",
                "description": "A chronic granulomatous disease characterized by that autosomal recessive inheritance has_material_basis_in mutation in the NCF4 gene on chromosome 22q12."
            },
            "synonyms": [
                {
                    "id": "DOID:0070194",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070194",
                    "name": "autosomal recessive chronic granulomatous disease cytochrome b-positive type III",
                    "description": ""
                },
                {
                    "id": "DOID:0070194",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070194",
                    "name": "autosomal recessive cytochrome b-positive CGD type III",
                    "description": ""
                },
                {
                    "id": "DOID:0070194",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070194",
                    "name": "CDG3",
                    "description": ""
                },
                {
                    "id": "DOID:0070194",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070194",
                    "name": "chronic granulomatous disease due to NCF4 deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0013507",
                    "resource": "MONDO",
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                    "name": "granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0013507",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013507",
                    "name": "chronic granulomatous disease 3, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0013507",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013507",
                    "name": "granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0013507",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013507",
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                },
                {
                    "id": "MONDO:0013507",
                    "resource": "MONDO",
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                    "name": "CGD, autosomal recessive cytochrome B-positive, type 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0013507",
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                    "description": ""
                },
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                    "name": "granulomatous disease, chronic, due to Ncf4 deficiency",
                    "description": ""
                },
                {
                    "id": "MIM:613960",
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                    "url": "https://www.omim.org/entry/613960",
                    "name": "Granulomatous disease, chronic, autosomal recessive, 3",
                    "description": "Granulomatous disease, chronic, autosomal recessive, 3"
                }
            ],
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                {
                    "id": "0070194",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070194"
                }
            ]
        },
        {
            "disease_id": "DOID:7148",
            "recommended_name": {
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                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:7148",
                "name": "rheumatoid arthritis",
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            },
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                    "url": "http://disease-ontology.org/term/DOID:7148",
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                    "description": ""
                },
                {
                    "id": "DOID:7148",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:7148",
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                    "description": ""
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                {
                    "id": "MONDO:0008383",
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                    "description": "A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor."
                },
                {
                    "id": "MONDO:0008383",
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                {
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                    "resource": "MONDO",
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                    "description": ""
                },
                {
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                    "resource": "MONDO",
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                    "name": "arthritis, rheumatoid",
                    "description": ""
                },
                {
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                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008383",
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                {
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                    "description": ""
                },
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        }
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    "expression_disease": [],
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            "name": "Rattus norvegicus",
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            "id": "R-RNO-4420097",
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        {
            "id": "R-RNO-5668599",
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            "id": "R-RNO-9013149",
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            "id": "R-RNO-9013404",
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            "id": "R-RNO-9013423",
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            ]
        },
        {
            "id": "A0A8I5ZNF3",
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            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZNF3-1",
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            "categories": [
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            ]
        },
        {
            "id": "B2RZ98",
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            ]
        },
        {
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            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
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        "sequence": "CCLAQANLDRLDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFYALQSKLEERFGPESKNSPFTCSLPTLPAKVYMGVKQEIAETRIPALNAYMKNLLSLPVCVLMDPDVRIFFYQSAYDAEQVPQALRRLRPRTRKIKGVTPQGPSMDRMEAPRAEALFDFTGNSKLELSFKAGDVIFLLSKINKDWLEGTTQGATGIFPGSFVKILKDFPEDEDTTNWLRCYFYEDTGKTIKDIAVEEDLSSTPLFKDLLALMRREFQREDIALNYQDAEGDLVRLLSDEDVGLMVKQAQGLPSQKRLFPWKLHVTQKDNYGVYNTVP",
        "length": 339,
        "header": "tr|A0A8I5ZNF3-1|A0A8I5ZNF3_RAT Isoform 1 of Neutrophil cytosolic factor 4  OS=Rattus norvegicus OX=10116 GN=Ncf4 PE=1 SV=1 CANONICAL=A0A8I5ZNF3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I5ZNF3-1",
            "url": "",
            "sequence": {
                "sequence": "CCLAQANLDRLDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFYALQSKLEERFGPESKNSPFTCSLPTLPAKVYMGVKQEIAETRIPALNAYMKNLLSLPVCVLMDPDVRIFFYQSAYDAEQVPQALRRLRPRTRKIKGVTPQGPSMDRMEAPRAEALFDFTGNSKLELSFKAGDVIFLLSKINKDWLEGTTQGATGIFPGSFVKILKDFPEDEDTTNWLRCYFYEDTGKTIKDIAVEEDLSSTPLFKDLLALMRREFQREDIALNYQDAEGDLVRLLSDEDVGLMVKQAQGLPSQKRLFPWKLHVTQKDNYGVYNTVP",
                "length": 339,
                "header": "tr|A0A8I5ZNF3-1|A0A8I5ZNF3_RAT Isoform 1 of Neutrophil cytosolic factor 4  OS=Rattus norvegicus OX=10116 GN=Ncf4 PE=1 SV=1 CANONICAL=A0A8I5ZNF3-1"
            },
            "locus": {
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                "start_pos": 109843143,
                "end_pos": 109830304,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000101098.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000101098.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000079654.1",
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                ]
            }
        },
        {
            "isoform_ac": "B2RZ98-1",
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                "sequence": "MALAQQLRSESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFYALQSKLEERFGPESKNSPFTCSLPTLPAKVYMGVKQEIAETRIPALNAYMKNLLSLPVCVLMDPDVRIFFYQSAYDAEQVPQALRRLRPRTRKIKGVTPQGPSMDRMEAPRAEALFDFTGNSKLELSFKAGDVIFLLSKINKDWLEGTTQGATGIFPGSFVKILKDFPEDEDTTNWLRCYFYEDTGKTIKDIAVEEDLSSTPLFKDLLALMRREFQREDIALNYQDAEGDLVRLLSDEDVGLMVKQAQGLPSQKRLFPWKLHVTQKDNYGVYNTVP",
                "length": 339,
                "header": "tr|B2RZ98-1|B2RZ98_RAT Computationally mapped isoform of Neutrophil cytosolic factor 4  OS=Rattus norvegicus OX=10116 GN=Ncf4 PE=4 SV=1 CANONICAL=A0A8I5ZNF3-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 109843143,
                "end_pos": 109826253,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000009544.7",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000009544.7"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000009544.6",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000009544.6"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "A time course of NADPH-oxidase up-regulation and endothelial nitric oxide synthase activation in the hippocampus following neurotrauma.",
            "journal": "Free radical biology & medicine",
            "date": "2014",
            "authors": "Ansari MA, Roberts KN, Scheff SW",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001120776",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120776"
                }
            ],
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                    "type": "PubMed",
                    "id": "25224032",
                    "url": "https://glygen.org/publication/PubMed/25224032"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:500904",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:500904",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-1222556",
            "name": "ROS and RNS production in phagocytes",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1222556",
            "resource": "Reactome",
            "description": "ROS and RNS production in phagocytes"
        },
        {
            "id": "R-RNO-1236973",
            "name": "Cross-presentation of particulate exogenous antigens (phagosomes)",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1236973",
            "resource": "Reactome",
            "description": "Cross-presentation of particulate exogenous antigens (phagosomes)"
        },
        {
            "id": "R-RNO-3299685",
            "name": "Detoxification of Reactive Oxygen Species",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3299685",
            "resource": "Reactome",
            "description": "Detoxification of Reactive Oxygen Species"
        },
        {
            "id": "R-RNO-4420097",
            "name": "VEGFA-VEGFR2 Pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4420097",
            "resource": "Reactome",
            "description": "VEGFA-VEGFR2 Pathway"
        },
        {
            "id": "R-RNO-5668599",
            "name": "RHO GTPases Activate NADPH Oxidases",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5668599",
            "resource": "Reactome",
            "description": "RHO GTPases Activate NADPH Oxidases"
        },
        {
            "id": "R-RNO-9013149",
            "name": "RAC1 GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013149",
            "resource": "Reactome",
            "description": "RAC1 GTPase cycle"
        },
        {
            "id": "R-RNO-9013404",
            "name": "RAC2 GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013404",
            "resource": "Reactome",
            "description": "RAC2 GTPase cycle"
        },
        {
            "id": "R-RNO-9013423",
            "name": "RAC3 GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013423",
            "resource": "Reactome",
            "description": "RAC3 GTPase cycle"
        }
    ],
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        {
            "uniprot_canonical_ac": "P97369-1",
            "protein_name": "Neutrophil cytosol factor 4",
            "gene_name": "Ncf4",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MALAQQLRSESDFEQLPDDVAVSANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFYALQSKLEERFGPESKNSPFTCSLPTLPAKVYMGAKQEIAETRIPALNAYMKNLLSLPVCVLMDPDVRIFFYQSAYDAEQVPQALRRLRPRTRKIKGVSPQGAIMDRMEAPRAEALFDFTGNSKLELSFKAGDVIFLLSKINKDWLEGTSQGATGIFPGSFVKILKDFPEDEDTTNWLRCYFYEDTGKTIKDIAVEEDLSSTPLFKDLLALMRREFQREDIALSYQDAEGDLVRLLSDEDVGLMVKQARGLPSQKRLFPWKLHVTQKDNYSVYNTVP",
                "length": 339
            },
            "evidence": [
                {
                    "id": "45226816",
                    "url": "http://www.informatics.jax.org/homology/45226816",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q15080-1",
            "protein_name": "Neutrophil cytosol factor 4",
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            "tax_id": 9606,
            "organism": "Homo sapiens",
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                {
                    "id": "45226816",
                    "url": "http://www.informatics.jax.org/homology/45226816",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
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                "name": "Cellular Component",
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                "go_terms": [
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                        "name": "NADPH oxidase complex",
                        "id": "GO:0043020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043020",
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                                "database": "UniProtKB",
                                "id": "A0A8I5ZNF3",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZNF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
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                                "id": "A0A8I5ZNF3",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZNF3"
                            }
                        ],
                        "pmid": ""
                    },
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                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
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                            }
                        ],
                        "pmid": ""
                    },
                    {
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                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZNF3",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZNF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endosome membrane",
                        "id": "GO:0010008",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZNF3",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZNF3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "phagocytosis",
                        "id": "GO:0006909",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZNF3",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZNF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "respiratory burst",
                        "id": "GO:0045730",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045730",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZNF3",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZNF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "superoxide anion generation",
                        "id": "GO:0042554",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042554",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZNF3",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZNF3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "phosphatidylinositol-3-phosphate binding",
                        "id": "GO:0032266",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZNF3",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZNF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "superoxide-generating NADPH oxidase activator activity",
                        "id": "GO:0016176",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016176",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZNF3",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZNF3"
                            }
                        ],
                        "pmid": ""
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                ]
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    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
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        {
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        {
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