{ "uniprot_canonical_ac": "A0A8I5ZMX2-1", "uniprot_ac": "A0A8I5ZMX2", "uniprot_id": "A0A8I5ZMX2_RAT", "mass": { "chemical_mass": 135079.0, "monoisotopic_mass": 135079.0 }, "refseq": {}, "gene_names": [ { "name": "Adamts3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2", "id": "A0A8I5ZMX2" } ], "protein_names": [ { "name": "ADAM metallopeptidase with thrombospondin type 1, motif 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A8I5ZMX2" } ], "function": [], "disease": [ { "disease_id": "DOID:0060366", "recommended_name": { "id": "DOID:0060366", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060366", "name": "Hennekam syndrome", "description": "A lymphatic system disease characterized by he presence of intestinal lymphangiectasia, mental retardation, and characteristic facial anomalies. It is inherited in an autosomal recessive pattern. Most individuals with Hennekam syndrome have characteristic facial abnormalities, such as a flat face with accompanying puffy eyelids and hypertelorism; the nasal bridge is typically flat and the ears are typically small. Congenital extremity and genital lymphedema is present in most patients." }, "synonyms": [ { "id": "DOID:0060366", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060366", "name": "Hennekam lymphangiectasia-lymphedema syndrome", "description": "" }, { "id": "DOID:0060366", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060366", "name": "lymphedem-lymphangiectasia-intellectual disability syndrome", "description": "" }, { "id": "MONDO:0014454", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014454", "name": "Hennekam lymphangiectasia-lymphedema syndrome 2", "description": "Any Hennekam syndrome in which the cause of the disease is a mutation in the FAT4 gene." }, { "id": "MONDO:0014454", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014454", "name": "FAT4 Hennekam syndrome", "description": "" }, { "id": "MONDO:0014454", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014454", "name": "Hennekam lymphangiectasia-lymphedema syndrome 2", "description": "" }, { "id": "MONDO:0014454", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014454", "name": "Hennekam lymphangiectasia-lymphedema syndrome type 2", "description": "" }, { "id": "MONDO:0014454", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014454", "name": "Hennekam syndrome caused by mutation in FAT4", "description": "" }, { "id": "MONDO:0014454", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014454", "name": "HKLLS2", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "Hennekam lymphangiectasia-lymphedema syndrome 1", "description": "Any Hennekam syndrome in which the cause of the disease is a mutation in the CCBE1 gene." }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "CCBE1 Hennekam syndrome", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "Hennekam lymphangiectasia-lymphedema syndrome 1", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "Hennekam lymphangiectasia-lymphedema syndrome type 1", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "Hennekam syndrome caused by mutation in CCBE1", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "HKLLS1", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "Hennekam lymphangiectasia-lymphedema syndrome", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "lymphatic dysplasia, generalised", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "lymphatic dysplasia, generalized", "description": "" }, { "id": "MIM:616006", "resource": "MIM", "url": "https://www.omim.org/entry/616006", "name": "Hennekam lymphangiectasia-lymphedema syndrome 2", "description": "Hennekam lymphangiectasia-lymphedema syndrome 2" }, { "id": "MIM:235510", "resource": "MIM", "url": "https://www.omim.org/entry/235510", "name": "Hennekam lymphangiectasia-lymphedema syndrome 1", "description": "Hennekam lymphangiectasia-lymphedema syndrome 1" } ], "evidence": [ { "id": "0060366", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060366" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2" } ], "common_name": "Rat" } ], "gene": [ { "name": "Adamts3", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2", "locus": { "chromosome": "14", "start_pos": 18435556, "end_pos": 18231165, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000027463", "url": "https://www.ensembl.org/id/ENSRNOG00000027463" } ] } } ], "crossref": [ { "id": "ENSRNOG00000027463", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000027463", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04273", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04273", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "305253", "url": "https://www.ncbi.nlm.nih.gov/gene/305253", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:305253", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:305253", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GYCDANK", "url": "https://omabrowser.org/oma/group/GYCDANK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2910701at2759", "url": "http://www.orthodb.org/?query=2910701at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13723", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13723:SF158", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723:SF158", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00090", "url": "http://pfam.xfam.org/family/PF00090", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01421", "url": "http://pfam.xfam.org/family/PF01421", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01562", "url": "http://pfam.xfam.org/family/PF01562", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05986", "url": "http://pfam.xfam.org/family/PF05986", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17771", "url": "http://pfam.xfam.org/family/PF17771", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19030", "url": "http://pfam.xfam.org/family/PF19030", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19236", "url": "http://pfam.xfam.org/family/PF19236", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-1650814", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1650814", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5173214", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5173214", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_006250836", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006250836", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1310750", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310750", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZMX2-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AA07", "url": "https://www.uniprot.org/uniprot/A0A8I6AA07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AA07-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AA07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4AD55", "url": "https://www.uniprot.org/uniprot/D4AD55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4AD55-1", "url": "https://www.uniprot.org/uniprot/D4AD55-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVFLSLWLIAASLVEVRTSADGQAGAEEMVQIDLPTKRYREYELVTPVSTNLKGHYLSHILSANHKKRSPRDVSSNSEQLFFNVTAFGRDFHLRLRPNTHFIAPGAVVEWHETAPRPGNTTDPRNSRPHRSSSEGGWRSEPLQTSCAYVGDIMDVPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMDEENGRIHIVYKRSAMERAPRDVSEDVYYKESNLEGLDDLGTVYSNIGQQLNETTRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWACQQQKSDPNHAEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFEHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGKTRGAFVLPKGARNISLAETRETKNVLAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIETLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPIRRMCNIQECTHPLWAAEAWEHCSRSCGSSGYQLRTVRCLQPLQDGTNRSVHSRYCLGERPESRRPCNRIPCPAQWKTGPWNECSVTCGEGTEVRQVLCRTGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYSELCCESCSKRSGTLPPPYLQEAAEIHSDAIFGPSDLPRSLVMPTPFLPYYSGSRADKKSLSSVSSVANPSAYAAFRSSSRASVSFPRKKAQEGGTKTPVSMPPSSSIKTDHLHSSSPGAAAPSPAITDSIGASPQTRTPKKDGKTISRRHPIRSTASER", "length": 1203, "header": "tr|A0A8I5ZMX2-1|A0A8I5ZMX2_RAT Isoform 1 of ADAM metallopeptidase with thrombospondin type 1, motif 3 OS=Rattus norvegicus OX=10116 GN=Adamts3 PE=4 SV=1 CANONICAL=A0A8I5ZMX2-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZMX2-1", "url": "", "sequence": { "sequence": "MVFLSLWLIAASLVEVRTSADGQAGAEEMVQIDLPTKRYREYELVTPVSTNLKGHYLSHILSANHKKRSPRDVSSNSEQLFFNVTAFGRDFHLRLRPNTHFIAPGAVVEWHETAPRPGNTTDPRNSRPHRSSSEGGWRSEPLQTSCAYVGDIMDVPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMDEENGRIHIVYKRSAMERAPRDVSEDVYYKESNLEGLDDLGTVYSNIGQQLNETTRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWACQQQKSDPNHAEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFEHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGKTRGAFVLPKGARNISLAETRETKNVLAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIETLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPIRRMCNIQECTHPLWAAEAWEHCSRSCGSSGYQLRTVRCLQPLQDGTNRSVHSRYCLGERPESRRPCNRIPCPAQWKTGPWNECSVTCGEGTEVRQVLCRTGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYSELCCESCSKRSGTLPPPYLQEAAEIHSDAIFGPSDLPRSLVMPTPFLPYYSGSRADKKSLSSVSSVANPSAYAAFRSSSRASVSFPRKKAQEGGTKTPVSMPPSSSIKTDHLHSSSPGAAAPSPAITDSIGASPQTRTPKKDGKTISRRHPIRSTASER", "length": 1203, "header": "tr|A0A8I5ZMX2-1|A0A8I5ZMX2_RAT Isoform 1 of ADAM metallopeptidase with thrombospondin type 1, motif 3 OS=Rattus norvegicus OX=10116 GN=Adamts3 PE=4 SV=1 CANONICAL=A0A8I5ZMX2-1" }, "locus": { "chromosome": "14", "start_pos": 18435200, "end_pos": 18231615, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000117104.1", "url": "https://www.ensembl.org/id/ENSRNOT00000117104.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000079355.1", "url": "https://www.ensembl.org/id/ENSRNOP00000079355.1" } ] } }, { "isoform_ac": "A0A8I6AA07-1", "url": "", "sequence": { "sequence": "MVFLSLWLIAASLVEVRTSADGQAGAEEMVQIDLPTKRYREYELVTPVSTNLKGHYLSHILSANHKKRSPRDVSSNSEQLFFNVTAFGRDFHLRLRPNTHFIAPGAVVEWHETAPRPGNTTDPRNSRPHRSSSEGGWRSEPLQTSCAYVGDIMDVPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMDEENGRIHIVYKRSAMERAPRDVSEDVYYKESNLEGLDDLGTVYSNIGQQLNETTRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWACQQQKSDPNHAEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFEHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHVLAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIETLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPIRRMCNIQECTHPLWAAEAWEHCSRSCGSSGYQLRTVRCLQPLQDGTNRSVHSRYCLGERPESRRPCNRIPCPAQWKTGPWNECSVTCGEGTEVRQVLCRTGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYSELCCESCSKRSGTLPPPYLQEAAEIHSDAIFGPSDLPRSLVMPTPFLPYYSGSRADKKSLSSVSSVANPSAYAAFRSSSRASVSFPRKKAQEGGTKTPVSMPPSSSIKTDHLHSSSPGAAAPSPAITDSIGASPQTRTPKKDGKTISRRHPIRSTASER", "length": 1202, "header": "tr|A0A8I6AA07-1|A0A8I6AA07_RAT Computationally mapped isoform of ADAM metallopeptidase with thrombospondin type 1, motif 3 OS=Rattus norvegicus OX=10116 GN=Adamts3 PE=4 SV=1 CANONICAL=A0A8I5ZMX2-1" }, "locus": { "chromosome": "14", "start_pos": 18435200, "end_pos": 18231615, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000115233.1", "url": "https://www.ensembl.org/id/ENSRNOT00000115233.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000088066.1", "url": "https://www.ensembl.org/id/ENSRNOP00000088066.1" } ] } }, { "isoform_ac": "D4AD55-1", "url": "", "sequence": { "sequence": "MVFLSLWLIAASLVEVRTSADGQAGAEEMVQIDLPTKRYREYELVTPVSTNLKGHYLSHILSANHKKRSPRDVSSNSEQLFFNVTAFGRDFHLRLRPNTHFIAPGAVVEWHETAPRPGNTTDPRNSRPHRSSSEGGWRSEPLQTSCAYVGDIMDVPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMDEENGRIHIVYKRSAMERAPRDVSEDVYYKESNLEGLDDLGTVYSNIGQQLNETTRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWACQQQKSDPNHAEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFEHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHVLAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIETLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPIRRMCNIQECTHPLVR", "length": 910, "header": "tr|D4AD55-1|A0A8I5ZMX2_RAT Computationally mapped isoform of ADAM metallopeptidase with thrombospondin type 1, motif 3 OS=Rattus norvegicus OX=10116 GN=Adamts3 PE=4 SV=2 CANONICAL=A0A8I5ZMX2-1" }, "locus": { "chromosome": "14", "start_pos": 18430464, "end_pos": 18231615, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000060465.4", "url": "https://www.ensembl.org/id/ENSRNOT00000060465.4" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000057209.3", "url": "https://www.ensembl.org/id/ENSRNOP00000057209.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:305253", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:305253", "resource": "KEGG Pathway" }, { "id": "R-RNO-1650814", "name": "Collagen biosynthesis and modifying enzymes", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1650814", "resource": "Reactome", "description": "Collagen biosynthesis and modifying enzymes" }, { "id": "R-RNO-5173214", "name": "O-glycosylation of TSR domain-containing proteins", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5173214", "resource": "Reactome", "description": "O-glycosylation of TSR domain-containing proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "E9Q287-1", "protein_name": "A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3", "gene_name": "Adamts3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVFLSLWLIAASLVEVRTSADGQAGTDEMVQIDLPTKRYREYELVTPVSTNLKGHYLSHILSANHKKRSPRDVSSNSEHLFFNVTAFGRDFHLRLKPNTHFIAPGAVVEWHETAPRPGNTTDPRNSHLHGSASEGSWRSEPLQTSCAYVGDIMDIPGTSVAISNCDGLAGMIKSDDEEYFIEPLERGKQMDEENGRIHVVYKRSAVEQPPRDVSEDVYHRESDLEGLDDLGTVYSNIGQQLNKTMRRRRHTGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWACQQQKTDPNHAEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFEHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYKDPYSICVRGECVKVGCDREIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGKTRGAFVLPKGARNISLAETRETKNVLAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIETLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSEPCGGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPIRRMCNIQECTHPVWAADEWEHCSRSCGSSGNQLRTVRCLQPLQDGTNRSVHSKYCLGDRPESRRPCNRVPCPAQWKTGSWNECSVTCGEGTEVRQVLCRTGDHCDGEKPESVRPCQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSGTLPPPYLQEAAEIHSDAIFGPSDLPRSLVMPTPFLPSSSGTRAEKKSLSSFSSMANPNADAAFRASSRASADFPRKRAHQAGRKTLESVPSSSSIKTDHLRPASPVAAAPSPAISDSIGASPQTRTPKKDDAKSVSRRHPTRSTASER", "length": 1204 }, "evidence": [ { "id": "45230714", "url": "http://www.informatics.jax.org/homology/45230714", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "O15072-1", "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 3", "gene_name": "ADAMTS3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRRTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRSSTLER", "length": 1205 }, "evidence": [ { "id": "45230714", "url": "http://www.informatics.jax.org/homology/45230714", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "in utero embryonic development", "id": "GO:0001701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2" } ], "pmid": "" }, { "name": "protein processing", "id": "GO:0016485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016485", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2" } ], "pmid": "" }, { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2" } ], "pmid": "" }, { "name": "vascular endothelial growth factor production", "id": "GO:0010573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010573", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2" } ], "pmid": "" }, { "name": "collagen biosynthetic process", "id": "GO:0032964", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032964", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2" } ], "pmid": "" }, { "name": "positive regulation of vascular endothelial growth factor signaling pathway", "id": "GO:1900748", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900748", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "endopeptidase activity", "id": "GO:0004175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004175", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2" } ], "pmid": "" }, { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2" } ], "pmid": "" }, { "name": "peptidase activity", "id": "GO:0008233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008233", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMX2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMX2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 242, "end_pos": 244, "annotation": "n_glycosylation_sequon" }, { "start_pos": 475, "end_pos": 477, "annotation": "n_glycosylation_sequon" }, { "start_pos": 741, "end_pos": 743, "annotation": "n_glycosylation_sequon" }, { "start_pos": 815, "end_pos": 817, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" }, { "start_pos": 943, "end_pos": 945, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", 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