{ "uniprot_canonical_ac": "A0A8I5ZMU2-1", "uniprot_ac": "A0A8I5ZMU2", "uniprot_id": "A0A8I5ZMU2_RAT", "mass": { "chemical_mass": 34139.0, "monoisotopic_mass": 34139.0 }, "refseq": { "ac": "NP_001162121", "name": "transcription factor SOX-12", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162121" }, "gene_names": [ { "name": "Sox12", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2", "id": "A0A8I5ZMU2" }, { "name": "Sox12", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162121", "id": "NP_001162121" } ], "protein_names": [ { "name": "Transcription factor SOX", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A8I5ZMU2" }, { "name": "SRY-box containing gene 12; SRY (sex determining region Y)-box 12; SRY box 12", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162121", "id": "NP_001162121" }, { "name": "transcription factor SOX-12", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162121", "id": "NP_001162121" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "common_name": "Rat" } ], "gene": [ { "name": "Sox12", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2", "locus": { "chromosome": "3", "start_pos": 140856579, "end_pos": 140860975, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000065264", "url": "https://www.ensembl.org/id/ENSRNOG00000065264" } ] } } ], "crossref": [ { "id": "689988", "url": "https://www.ncbi.nlm.nih.gov/gene/689988", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017386", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017386", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:689988", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:689988", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GEPAWCK", "url": "https://omabrowser.org/oma/group/GEPAWCK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10270", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10270", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10270:SF221", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10270:SF221", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00505", "url": "http://pfam.xfam.org/family/PF00505", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001162121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162121", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1586313", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1586313", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZMU2-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVQQRGARAKRDGGPPPPGPGPAAEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGGGGGSRLKPGPQLPGRGGRRATGGPLGGGAAAPEDDDEDEEEELLEVRLLETPGRELWRMVPAGRAARGPAERAQGPSSEGAAASAASPTLSEDEEPEEEEEEAATAEEGEEETVASGEEPLGFLSRMPPGPTGLDCSALDRDPDLLPPSGTSHFEFPDYCTPEVTEMIAGDWRPSSIADLVFTY", "length": 314, "header": "tr|A0A8I5ZMU2-1|A0A8I5ZMU2_RAT Isoform 1 of Transcription factor SOX OS=Rattus norvegicus OX=10116 GN=Sox12 PE=4 SV=1 CANONICAL=A0A8I5ZMU2-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZMU2-1", "url": "", "sequence": { "sequence": "MVQQRGARAKRDGGPPPPGPGPAAEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGGGGGSRLKPGPQLPGRGGRRATGGPLGGGAAAPEDDDEDEEEELLEVRLLETPGRELWRMVPAGRAARGPAERAQGPSSEGAAASAASPTLSEDEEPEEEEEEAATAEEGEEETVASGEEPLGFLSRMPPGPTGLDCSALDRDPDLLPPSGTSHFEFPDYCTPEVTEMIAGDWRPSSIADLVFTY", "length": 314, "header": "tr|A0A8I5ZMU2-1|A0A8I5ZMU2_RAT Isoform 1 of Transcription factor SOX OS=Rattus norvegicus OX=10116 GN=Sox12 PE=4 SV=1 CANONICAL=A0A8I5ZMU2-1" }, "locus": { "chromosome": "3", "start_pos": 140860518, "end_pos": 140859577, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000094453.1", "url": "https://www.ensembl.org/id/ENSRNOT00000094453.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000079143.1", "url": "https://www.ensembl.org/id/ENSRNOP00000079143.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:689988", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:689988", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O15370-1", "protein_name": "Transcription factor SOX-12", "gene_name": "SOX12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVQQRGARAKRDGGPPPPGPGPAEEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGSGGGSRLKPGPQLPGRGGRRAAGGPLGGGAAAPEDDDEDDDEELLEVRLVETPGRELWRMVPAGRAARGQAERAQGPSGEGAAAAAAASPTPSEDEEPEEEEEEAAAAEEGEEETVASGEESLGFLSRLPPGPAGLDCSALDRDPDLQPPSGTSHFEFPDYCTPEVTEMIAGDWRPSSIADLVFTY", "length": 315 }, "evidence": [ { "id": "45226725", "url": "http://www.informatics.jax.org/homology/45226725", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q04890-1", "protein_name": "Transcription factor SOX-12", "gene_name": "Sox12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVQQRGARAKRDGGPPPPGPGPAAEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGGGGGSRLKPGPQLPGRGGRRASGGPLGGGAAAPEDDDEDEEEELLEVRLLETPGRELWRMVPAGRAARGPAERAQGPSGEGAAASAASPTLSEDEEPEEEEEEAATAEEGEEETVVSGEEPLGFLSRMPPGPAGLDCSALDRDPDLLPPSGTSHFEFPDYCTPEVTEMIAGDWRSSSIADLVFTY", "length": 314 }, "evidence": [ { "id": "45226725", "url": "http://www.informatics.jax.org/homology/45226725", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" }, { "name": "spinal cord development", "id": "GO:0021510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021510", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" }, { "name": "anatomical structure morphogenesis", "id": "GO:0009653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009653", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" }, { "name": "positive regulation of regulatory T cell differentiation", "id": "GO:0045591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045591", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" }, { "name": "protein-DNA complex", "id": "GO:0032993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032993", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZMU2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMU2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }