{
    "uniprot_canonical_ac": "A0A8I5ZMT2-1",
    "uniprot_ac": "A0A8I5ZMT2",
    "uniprot_id": "A0A8I5ZMT2_RAT",
    "mass": {
        "chemical_mass": 50661.0,
        "monoisotopic_mass": 50661.0
    },
    "refseq": {
        "ac": "NP_001185518",
        "name": "transcriptional enhancer factor TEF-1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185518"
    },
    "gene_names": [
        {
            "name": "Tead1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2",
            "id": "A0A8I5ZMT2"
        },
        {
            "name": "TEF-1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185518",
            "id": "NP_001185518"
        },
        {
            "name": "Tead1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185518",
            "id": "NP_001185518"
        }
    ],
    "protein_names": [
        {
            "name": "TEA domain family member 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185518",
            "id": "NP_001185518"
        },
        {
            "name": "TEA domain transcription factor 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A8I5ZMT2"
        },
        {
            "name": "transcriptional enhancer factor TEF-1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185518",
            "id": "NP_001185518"
        }
    ],
    "function": [
        {
            "annotation": "Transcription enhancer factor 1 (Tef-1)binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001185518",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185518"
                },
                {
                    "database": "PubMed",
                    "id": "12861002",
                    "url": "https://glygen.org/publication/PubMed/12861002"
                }
            ]
        },
        {
            "annotation": "Yap1 post-translational modifications favoring its ubiquitination and apoptosis characterize hepatocellular carcinoma (HCC) with better prognosis, whereas conditions favoring the formation of YAP1-TEAD complexes are associated with aggressiveness and acquisition of stemness features by HCC cells",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001185518",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185518"
                },
                {
                    "database": "PubMed",
                    "id": "27359056",
                    "url": "https://glygen.org/publication/PubMed/27359056"
                }
            ]
        },
        {
            "annotation": "[CRISPR/Cas9-mediated TEAD1 knockout induces phenotypic modulation of corpus cavernosum smooth muscle cells in diabetic rats with erectile dysfunction].",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001185518",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185518"
                },
                {
                    "database": "PubMed",
                    "id": "33963717",
                    "url": "https://glygen.org/publication/PubMed/33963717"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0111228",
            "recommended_name": {
                "id": "DOID:0111228",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111228",
                "name": "Sveinsson chorioretinal atrophy",
                "description": "An eye disease characterized by presence in the fundus of progressive bilateral retinal and choroidal atrophy leading to central vision loss that has_material_basis_in heterozygous mutation in TEAD1 on 11p15.3."
            },
            "synonyms": [
                {
                    "id": "DOID:0111228",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111228",
                    "name": "HPCD",
                    "description": ""
                },
                {
                    "id": "DOID:0111228",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111228",
                    "name": "SCRA",
                    "description": ""
                },
                {
                    "id": "DOID:0111228",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111228",
                    "name": "atrophia areata",
                    "description": ""
                },
                {
                    "id": "DOID:0111228",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111228",
                    "name": "helicoid peripapillary chorioretinal degeneration",
                    "description": ""
                },
                {
                    "id": "DOID:0111228",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111228",
                    "name": "peripapillary chorioretinal degeneration, Icelandic type",
                    "description": ""
                },
                {
                    "id": "MONDO:0007176",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007176",
                    "name": "helicoid peripapillary chorioretinal degeneration",
                    "description": "Helicoid peripapillary chorioretinal degeneration is a rare autosomal dominantly inherited chorioretinal degeneration disease, presenting at birth or infancy, characterized by progressive bilateral retinal and choroidal atrophy, appearing as lesions on the optic nerve and peripheral ocular fundus and leading to central vision loss. Congenital anterior polar cataracts are sometimes associated with this disease."
                },
                {
                    "id": "MONDO:0007176",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007176",
                    "name": "SCRA",
                    "description": ""
                },
                {
                    "id": "MONDO:0007176",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007176",
                    "name": "Sveinsson chorioretinal atrophy",
                    "description": ""
                },
                {
                    "id": "MONDO:0007176",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007176",
                    "name": "atrophia areata",
                    "description": ""
                },
                {
                    "id": "MONDO:0007176",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007176",
                    "name": "SVEINSSON chorioretinal atrophy",
                    "description": ""
                },
                {
                    "id": "MONDO:0007176",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007176",
                    "name": "helicoidal peripapillary chorioretinal Degeneration",
                    "description": ""
                },
                {
                    "id": "MONDO:0007176",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007176",
                    "name": "peripapillary chorioretinal Degeneration, Icelandic type",
                    "description": ""
                },
                {
                    "id": "MIM:108985",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/108985",
                    "name": "Sveinsson chorioretinal atrophy",
                    "description": "Sveinsson chorioretinal atrophy"
                }
            ],
            "evidence": [
                {
                    "id": "0111228",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111228"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A8I5ZMT2",
                    "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2"
                }
            ],
            "common_name": "Rat"
        }
    ],
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        {
            "name": "Tead1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2",
            "locus": {
                "chromosome": "1",
                "start_pos": 167003369,
                "end_pos": 166792628,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000015488",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000015488"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000015488",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015488",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "361630",
            "url": "https://www.ncbi.nlm.nih.gov/gene/361630",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000818",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000818",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR016361",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016361",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR038096",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038096",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR041086",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041086",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:361630",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:361630",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "CAFVEYP",
            "url": "https://omabrowser.org/oma/group/CAFVEYP/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1408493at2759",
            "url": "http://www.orthodb.org/?query=1408493at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11834",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11834",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11834:SF4",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11834:SF4",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01285",
            "url": "http://pfam.xfam.org/family/PF01285",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF17725",
            "url": "http://pfam.xfam.org/family/PF17725",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-2032785",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2032785",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-8951671",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951671",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1549742",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1549742",
            "database": "RGD",
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            ]
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        {
            "id": "A0A0G2K2N3",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K2N3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2K2N3-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K2N3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5Y7H2",
            "url": "https://www.uniprot.org/uniprot/A0A8I5Y7H2",
            "database": "UniProtKB",
            "categories": [
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            ]
        },
        {
            "id": "A0A8I5Y7H2-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5Y7H2-1",
            "database": "UniProtKB",
            "categories": [
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            ]
        },
        {
            "id": "A0A8I5Y8C5",
            "url": "https://www.uniprot.org/uniprot/A0A8I5Y8C5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5Y8C5-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5Y8C5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZKU4",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZKU4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZKU4-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZKU4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZM31",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZM31",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZM31-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZM31-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZMT2",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZMT2-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZVQ4",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZVQ4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZVQ4-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZVQ4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6A1B4",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A1B4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6A1B4-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A1B4-1",
            "database": "UniProtKB",
            "categories": [
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            ]
        },
        {
            "id": "F1M7P3",
            "url": "https://www.uniprot.org/uniprot/F1M7P3",
            "database": "UniProtKB",
            "categories": [
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            ]
        },
        {
            "id": "F1M7P3-1",
            "url": "https://www.uniprot.org/uniprot/F1M7P3-1",
            "database": "UniProtKB",
            "categories": [
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            ]
        },
        {
            "id": "Q6QQT9",
            "url": "https://www.uniprot.org/uniprot/Q6QQT9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6QQT9-1",
            "url": "https://www.uniprot.org/uniprot/Q6QQT9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
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        "sequence": "IEPSSWSGSESPADNMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREIQAAIKVSSHIQVLARRKSRDFHSKLKVTSMDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD",
        "length": 451,
        "header": "tr|A0A8I5ZMT2-1|A0A8I5ZMT2_RAT Isoform 1 of TEA domain transcription factor 1  OS=Rattus norvegicus OX=10116 GN=Tead1 PE=4 SV=1 CANONICAL=A0A8I5ZMT2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2K2N3-1",
            "url": "",
            "sequence": {
                "sequence": "MERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREIQAAIKVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD",
                "length": 432,
                "header": "tr|A0A0G2K2N3-1|A0A0G2K2N3_RAT Computationally mapped isoform of TEA domain transcription factor 1  OS=Rattus norvegicus OX=10116 GN=Tead1 PE=4 SV=2 CANONICAL=A0A8I5ZMT2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 167002655,
                "end_pos": 166865921,
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                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000090042.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000090042.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000072311.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000072311.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I5Y7H2-1",
            "url": "",
            "sequence": {
                "sequence": "MERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKVTSMDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD",
                "length": 357,
                "header": "tr|A0A8I5Y7H2-1|A0A8I5Y7H2_RAT Computationally mapped isoform of TEA domain transcription factor 1  OS=Rattus norvegicus OX=10116 GN=Tead1 PE=4 SV=1 CANONICAL=A0A8I5ZMT2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 167002655,
                "end_pos": 166865921,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000099524.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000099524.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000077383.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000077383.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I5Y8C5-1",
            "url": "",
            "sequence": {
                "sequence": "MERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREIQAAIKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD",
                "length": 411,
                "header": "tr|A0A8I5Y8C5-1|A0A8I5Y8C5_RAT Computationally mapped isoform of TEA domain transcription factor 1  OS=Rattus norvegicus OX=10116 GN=Tead1 PE=4 SV=1 CANONICAL=A0A8I5ZMT2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 167002655,
                "end_pos": 166865921,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000104208.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000104208.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000077946.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000077946.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I5ZKU4-1",
            "url": "",
            "sequence": {
                "sequence": "MERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREIQAAIKVTSMDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD",
                "length": 415,
                "header": "tr|A0A8I5ZKU4-1|A0A8I5ZMT2_RAT Computationally mapped isoform of TEA domain transcription factor 1  OS=Rattus norvegicus OX=10116 GN=Tead1 PE=4 SV=1 CANONICAL=A0A8I5ZMT2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 167002655,
                "end_pos": 166865921,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000096192.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000096192.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000078399.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000078399.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I5ZM31-1",
            "url": "",
            "sequence": {
                "sequence": "MERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVTSMDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD",
                "length": 394,
                "header": "tr|A0A8I5ZM31-1|A0A8I5ZM31_RAT Computationally mapped isoform of TEA domain transcription factor 1  OS=Rattus norvegicus OX=10116 GN=Tead1 PE=4 SV=1 CANONICAL=A0A8I5ZMT2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 167002655,
                "end_pos": 166865921,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000111991.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000111991.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000079105.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000079105.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I5ZMT2-1",
            "url": "",
            "sequence": {
                "sequence": "IEPSSWSGSESPADNMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREIQAAIKVSSHIQVLARRKSRDFHSKLKVTSMDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD",
                "length": 451,
                "header": "tr|A0A8I5ZMT2-1|A0A8I5ZMT2_RAT Isoform 1 of TEA domain transcription factor 1  OS=Rattus norvegicus OX=10116 GN=Tead1 PE=4 SV=1 CANONICAL=A0A8I5ZMT2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 167002655,
                "end_pos": 166865876,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000100503.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000100503.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000079346.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000079346.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I5ZVQ4-1",
            "url": "",
            "sequence": {
                "sequence": "MENWETRGASHDWWRLLEACWVWEWGQDCRLLSGIARTYECGPWPWRPGRGASGLSALCGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREIQAAIKVSSHIQVLARRKSRDFHSKLKVTSMDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD",
                "length": 443,
                "header": "tr|A0A8I5ZVQ4-1|A0A8I5ZMT2_RAT Computationally mapped isoform of TEA domain transcription factor 1  OS=Rattus norvegicus OX=10116 GN=Tead1 PE=4 SV=1 CANONICAL=A0A8I5ZMT2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 167002655,
                "end_pos": 166875660,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000096896.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000096896.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000082861.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000082861.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6A1B4-1",
            "url": "",
            "sequence": {
                "sequence": "MRTGFWIPSAGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREIQAAIKVSSHIQVLARRKSRDFHSKLKVTSMDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD",
                "length": 394,
                "header": "tr|A0A8I6A1B4-1|A0A8I6A1B4_RAT Computationally mapped isoform of TEA domain transcription factor 1  OS=Rattus norvegicus OX=10116 GN=Tead1 PE=4 SV=1 CANONICAL=A0A8I5ZMT2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 167002655,
                "end_pos": 166925161,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000101620.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000101620.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000085279.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000085279.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F1M7P3-1",
            "url": "",
            "sequence": {
                "sequence": "IEPSSWSGSESPADNMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKVTSMDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD",
                "length": 430,
                "header": "tr|F1M7P3-1|F1M7P3_RAT Computationally mapped isoform of TEA domain transcription factor 1  OS=Rattus norvegicus OX=10116 GN=Tead1 PE=2 SV=3 CANONICAL=A0A8I5ZMT2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 167002655,
                "end_pos": 166865876,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000021020.5",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000021020.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000021020.4",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000021020.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q6QQT9-1",
            "url": "",
            "sequence": {
                "sequence": "IEPSSWSGSESPADNMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD",
                "length": 405,
                "header": "tr|Q6QQT9-1|Q6QQT9_RAT Computationally mapped isoform of TEA domain transcription factor 1  OS=Rattus norvegicus OX=10116 GN=Tead1 PE=2 SV=1 CANONICAL=A0A8I5ZMT2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 167002655,
                "end_pos": 166865876,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000105758.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000105758.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000092848.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000092848.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Tumor cell splice variants of the transcription factor TEF-1 induced by SV40 T-antigen transformation.",
            "journal": "Biochim. Biophys. Acta",
            "date": "2000",
            "authors": "Zuzarte P C, Farrance I K, Simpson P C, Wildeman A G",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6QQT9",
                    "url": "https://www.uniprot.org/uniprot/Q6QQT9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11118619",
                    "url": "https://glygen.org/publication/PubMed/11118619"
                }
            ]
        },
        {
            "title": "Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions.",
            "journal": "Molecular and cellular biology",
            "date": "2003",
            "authors": "Karasseva N, Tsika G, Ji J, Zhang A, Mao X, Tsika R",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001185518",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185518"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12861002",
                    "url": "https://glygen.org/publication/PubMed/12861002"
                }
            ]
        },
        {
            "title": "Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease.",
            "journal": "Oncotarget",
            "date": "2016",
            "authors": "Simile MM, Latte G, Demartis MI, Brozzetti S, Calvisi DF, Porcu A, Feo CF, Seddaiu MA, Daino L, Berasain C, Tomasi ML, Avila MA, Feo F, Pascale RM",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001185518",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185518"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27359056",
                    "url": "https://glygen.org/publication/PubMed/27359056"
                }
            ]
        },
        {
            "title": "[CRISPR/Cas9-mediated TEAD1 knockout induces phenotypic modulation of corpus cavernosum smooth muscle cells in diabetic rats with erectile dysfunction].",
            "journal": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
            "date": "2021",
            "authors": "Zhang T, Li W, Qiu X, Liu B, Li G, Feng C, Liao J, Lin K",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001185518",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185518"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33963717",
                    "url": "https://glygen.org/publication/PubMed/33963717"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:361630",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:361630",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-2032785",
            "name": "YAP1- and WWTR1 (TAZ)-stimulated gene expression",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2032785",
            "resource": "Reactome",
            "description": "YAP1- and WWTR1 (TAZ)-stimulated gene expression"
        },
        {
            "id": "R-RNO-8951671",
            "name": "RUNX3 regulates YAP1-mediated transcription",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951671",
            "resource": "Reactome",
            "description": "RUNX3 regulates YAP1-mediated transcription"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P28347-1",
            "protein_name": "Transcriptional enhancer factor TEF-1",
            "gene_name": "TEAD1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD",
                "length": 426
            },
            "evidence": [
                {
                    "id": "45232381",
                    "url": "http://www.informatics.jax.org/homology/45232381",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P30051-1",
            "protein_name": "Transcriptional enhancer factor TEF-1",
            "gene_name": "Tead1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPTSAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD",
                "length": 426
            },
            "evidence": [
                {
                    "id": "45232381",
                    "url": "http://www.informatics.jax.org/homology/45232381",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 20,
                "go_terms": [
                    {
                        "name": "positive regulation of stem cell population maintenance",
                        "id": "GO:1902459",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902459",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZMT2",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZMT2",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "heart development",
                        "id": "GO:0007507",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZMT2",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of cell growth",
                        "id": "GO:0030307",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030307",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZMT2",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of cell population proliferation",
                        "id": "GO:0042127",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZMT2",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZMT2",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to retinoic acid",
                        "id": "GO:0071300",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZMT2",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of DNA-templated transcription",
                        "id": "GO:0006355",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZMT2",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "hippo signaling",
                        "id": "GO:0035329",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035329",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZMT2",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of DNA-templated transcription",
                        "id": "GO:0045893",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZMT2",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of protein serine/threonine kinase activity",
                        "id": "GO:0071902",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071902",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZMT2",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5ZMT2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transition between fast and slow fiber",
                        "id": "GO:0014883",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014883",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5ZMT2",
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                    {
                        "name": "embryonic heart tube morphogenesis",
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