{ "uniprot_canonical_ac": "A0A8I5XWT0-1", "uniprot_ac": "A0A8I5XWT0", "uniprot_id": "A0A8I5XWT0_RAT", "mass": { "chemical_mass": 82663.0, "monoisotopic_mass": 82663.0 }, "refseq": { "ac": "NP_071605", "name": "complement decay-accelerating factor precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071605" }, "gene_names": [ { "name": "Cd55", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0", "id": "A0A8I5XWT0" }, { "name": "Cd55", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017454412", "id": "XP_017454412" }, { "name": "Daf1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0", "id": "A0A8I5XWT0" }, { "name": "Daf; Daf1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017454412", "id": "XP_017454412" } ], "protein_names": [ { "name": "CD55 molecule (Cromer blood group)", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A8I5XWT0" }, { "name": "complement decay-accelerating factor isoform X2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017454412", "id": "XP_017454412" }, { "name": "complement decay-accelerating factor precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071605", "id": "NP_071605" }, { "name": "decay accelerating factor GPI-form; glycosylphophatidylinositol-anchored form; decay accelerating factor 1; CD55 molecule, decay accelerating factor for complement; complement decay-accelerating factor; CD55 antigen; decay accelarating factor 1; decay-accelarating factor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071605", "id": "NP_071605" } ], "function": [ { "annotation": "Generation of a novel decay accelerating factor (DAF) knock-out rat model using clustered regularly-interspaced short palindromic repeats, (CRISPR)/associated protein 9 (Cas9), genome editing.", "evidence": [ { "database": "RefSeq", "id": "NP_071605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071605" }, { "database": "PubMed", "id": "33387103", "url": "https://glygen.org/publication/PubMed/33387103" } ] }, { "annotation": "HO-1 is a physiologic regulator of glomerular decay accelerating factor (DAF) and identify hemin analogues as inducers of functional glomerular DAF able to minimize complement component C3 fragment b (C3b) deposition.", "evidence": [ { "database": "RefSeq", "id": "NP_071605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071605" }, { "database": "PubMed", "id": "27662796", "url": "https://glygen.org/publication/PubMed/27662796" } ] } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ], "evidence": [ { "id": "10283", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:10611", "recommended_name": { "id": "DOID:10611", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10611", "name": "protein-losing enteropathy", "description": "" }, "synonyms": [ { "id": "DOID:10611", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10611", "name": "Enteropathy, exudative", "description": "" }, { "id": "DOID:10611", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10611", "name": "Exudative enteropathy", "description": "" }, { "id": "MONDO:0009174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009174", "name": "protein-losing enteropathy", "description": "Pathological conditions in the intestines that are characterized by the gastrointestinal loss of serum proteins, including serum albumin; immunoglobulins; and at times lymphocytes. Severe condition can result in hypogammaglobulinemia or lymphopenia. Protein-losing enteropathies are associated with a number of diseases including intestinal lymphangiectasis; whipple'S disease; and neoplasms of the small intestine." }, { "id": "MONDO:0009174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009174", "name": "enteropathy, exudative", "description": "" }, { "id": "MONDO:0009174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009174", "name": "exudative enteropathy", "description": "" }, { "id": "MONDO:0009174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009174", "name": "protein-losing enteropathy", "description": "" }, { "id": "MONDO:0009174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009174", "name": "protein-losing enteropathy (disease)", "description": "" }, { "id": "MONDO:0009174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009174", "name": "CHAPLE", "description": "" }, { "id": "MONDO:0009174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009174", "name": "complement hyperactivation, ANGIOPATHIC thrombosis, and PROTEIN-losing enteropathy", "description": "" }, { "id": "MONDO:0009174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009174", "name": "complement hyperactivation, Angiopathic thrombosis, and Protein-losing enteropathy", "description": "" }, { "id": "MONDO:0009174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009174", "name": "enteropathy, PROTEIN-losing", "description": "" }, { "id": "MIM:226300", "resource": "MIM", "url": "https://www.omim.org/entry/226300", "name": "Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy", "description": "Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy" } ], "evidence": [ { "id": "10611", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10611" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": 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"MIRTRAPGTRAPPPPPLLLSLSLLLLLLSPTVSGDCGPPPDIPNATPNSGKHTKFAHQSQVTYSCNKGFKQIPDKPNTVVCLENDQWSNYETFCNKTCSAPLRLNYASLKKEYRNMNFFPIGTTVEFECRPGFQKVTSRTGKSTCLEELVWSPVVEFCKKRACPNPRELKNGHINIPTDILFGSEIIFSCDKGYKLVGVTSTFCSITGNAVDWDDVFPVCTTIFCPDPPKINNGRIREESDSYAYRQSVTYSCDQGFILVGNSSVHCTLNGEVGEWSSAPPKCIERHKVPTKTPPEVDIPSTMPHESTLINFPSTRAPLSHKPTTVKVPGTRVKPTSHKPTEVKVPGTRVPPTSQKHTTVNVPSTRVPATSQKPSMVHVSDTRVSPKPQKPTKANNPSTEIPPTPQKANTADVPSTESPPTPQKANTAVVPATEIPPAPQKTNTAVAPATEIPPTPQKTNTADVPSTESPPTPQKANTADVPATEIPPALQKANTAVVPATETLPTPQKANTAIVPATETPPAPQKTNTAVAPSTEIPPTPQKANTADVPATEIPPTPQNANTADVPSTEIPPTPQKSNTADVPATEIPPTPQKANTADVPATEIPPTPQNANTADVPSTEIPPTPQKTNTAKVSAIKPATAQMSLISTTVFAQTPPITQHPTTVNSSAVQTAQTTRGFATAKPSLTQNPPATQRPTISHFSMTKGLHTVTQIFTSAHITATQHVPVSKTTVRHPTRTSKDRGESNSGGDHFIYGHTCLITMTILHVMLLLTG", "length": 773, "header": "tr|A0A8I5XWT0-1|A0A8I5XWT0_RAT Isoform 1 of CD55 molecule (Cromer blood group) OS=Rattus norvegicus OX=10116 GN=Cd55 PE=1 SV=1 CANONICAL=A0A8I5XWT0-1" }, "isoforms": [ { "isoform_ac": "A0A8I5XWT0-1", "url": "", "sequence": { "sequence": "MIRTRAPGTRAPPPPPLLLSLSLLLLLLSPTVSGDCGPPPDIPNATPNSGKHTKFAHQSQVTYSCNKGFKQIPDKPNTVVCLENDQWSNYETFCNKTCSAPLRLNYASLKKEYRNMNFFPIGTTVEFECRPGFQKVTSRTGKSTCLEELVWSPVVEFCKKRACPNPRELKNGHINIPTDILFGSEIIFSCDKGYKLVGVTSTFCSITGNAVDWDDVFPVCTTIFCPDPPKINNGRIREESDSYAYRQSVTYSCDQGFILVGNSSVHCTLNGEVGEWSSAPPKCIERHKVPTKTPPEVDIPSTMPHESTLINFPSTRAPLSHKPTTVKVPGTRVKPTSHKPTEVKVPGTRVPPTSQKHTTVNVPSTRVPATSQKPSMVHVSDTRVSPKPQKPTKANNPSTEIPPTPQKANTADVPSTESPPTPQKANTAVVPATEIPPAPQKTNTAVAPATEIPPTPQKTNTADVPSTESPPTPQKANTADVPATEIPPALQKANTAVVPATETLPTPQKANTAIVPATETPPAPQKTNTAVAPSTEIPPTPQKANTADVPATEIPPTPQNANTADVPSTEIPPTPQKSNTADVPATEIPPTPQKANTADVPATEIPPTPQNANTADVPSTEIPPTPQKTNTAKVSAIKPATAQMSLISTTVFAQTPPITQHPTTVNSSAVQTAQTTRGFATAKPSLTQNPPATQRPTISHFSMTKGLHTVTQIFTSAHITATQHVPVSKTTVRHPTRTSKDRGESNSGGDHFIYGHTCLITMTILHVMLLLTG", "length": 773, "header": "tr|A0A8I5XWT0-1|A0A8I5XWT0_RAT Isoform 1 of CD55 molecule (Cromer blood group) OS=Rattus norvegicus OX=10116 GN=Cd55 PE=1 SV=1 CANONICAL=A0A8I5XWT0-1" }, "locus": { "chromosome": "13", "start_pos": 41885772, "end_pos": 41860166, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000101971.1", "url": "https://www.ensembl.org/id/ENSRNOT00000101971.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000078089.1", "url": "https://www.ensembl.org/id/ENSRNOP00000078089.1" } ] } }, { "isoform_ac": "A0A8I5ZMB7-1", "url": "", "sequence": { "sequence": "MIRTRAPGTRAPPPPPLLLSLSLLLLLLSPTVSGDCGPPPDIPNATPNSGKHTKFAHQSQVTYSCNKGFKQIPDKPNTVVCLENDQWSNYETFCNKTCSAPLRLNYASLKKEYRNMNFFPIGTTVEFECRPGFQKVTSRTGKSTCLEELVWSPVVEFCKKRACPNPRELKNGHINIPTDILFGSEIIFSCDKGYKLVGVTSTFCSITGNAVDWDDVFPVCTTIFCPDPPKINNGRIREESDSYAYRQSVTYSCDQGFILVGNSSVHCTLNGEVGEWSSAPPKCIERHKVPTKTPPEVDIPSTMPHESTLINFPSTRAPLSHKPTTVKVPGTRVKPTSHKPTEVKVPATQHVPVSKTTVRHPTRTSKDRGESNSGGDHFIYGFVAVIVTIDSIILIKTLWWTILSSNRSSDLQGKKKRENVPE", "length": 422, "header": "tr|A0A8I5ZMB7-1|A0A8I5XWT0_RAT Computationally mapped isoform of CD55 molecule (Cromer blood group) OS=Rattus norvegicus OX=10116 GN=Cd55 PE=1 SV=1 CANONICAL=A0A8I5XWT0-1" }, "locus": { "chromosome": "13", "start_pos": 41885772, "end_pos": 41857470, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000097302.1", "url": "https://www.ensembl.org/id/ENSRNOT00000097302.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000079102.1", "url": "https://www.ensembl.org/id/ENSRNOP00000079102.1" } ] } }, { "isoform_ac": "Q9Z0M0-1", "url": "", "sequence": { "sequence": "MIRTRAPGTRAPPPPPLLLSLSLLLLLLSPTVSGDCGPPPDIPNATPNSGKHTKFAHQSQVTYSCNKGFKQIPDKPNTVVCLENDQWSNYETFCNKTCSAPLRLNYASLKKEYRNMNFFPIGTTVEFECRPGFQKVTSRTGKSTCLEELVWSPVVEFCKKRACPNPRELKNGHINIPTDILFGSEIIFSCDKGYKLVGVTSTFCSITGNAVDWDDVFPVCTTIFCPDPPKINNGRIREESDSYAYRQSVTYSCDQGFILVGNSSVHCTLNGEVGEWSSAPPKCIERHKVPTKTPPEVDIPSTMPHESTLINFPSTRAPLSHKPTTVKVPGTRVKPTSHKPTEVKVPATQHVPVSKTTVRHPTRTSKDRGESNSGGDHFIYGHTCLITMTILHVMLLLTG", "length": 399, "header": "tr|Q9Z0M0-1|A0A8I5XWT0_RAT Computationally mapped isoform of CD55 molecule (Cromer blood group) OS=Rattus norvegicus OX=10116 GN=Cd55 PE=1 SV=1 CANONICAL=A0A8I5XWT0-1" }, "locus": { "chromosome": "13", "start_pos": 41885772, "end_pos": 41860166, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000005284.7", "url": "https://www.ensembl.org/id/ENSRNOT00000005284.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000005284.7", "url": "https://www.ensembl.org/id/ENSRNOP00000005284.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Heme Oxygenase 1 Up-Regulates Glomerular Decay Accelerating Factor Expression and Minimizes Complement Deposition and Injury.", "journal": "The American journal of pathology", "date": "2016", "authors": "Detsika MG, Duann P, Atsaves V, Papalois A, Lianos EA", "evidence": [ { "database": "RefSeq", "id": "NP_071605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071605" } ], "reference": [ { "type": "PubMed", "id": "27662796", "url": "https://glygen.org/publication/PubMed/27662796" } ] }, { "title": "Generation of a novel decay accelerating factor (DAF) knock-out rat model using clustered regularly-interspaced short palindromic repeats, (CRISPR)/associated protein 9 (Cas9), genome editing.", "journal": "Transgenic research", "date": "2021", "authors": "Detsika MG, Goudevenou K, Geurts AM, Gakiopoulou H, Grapsa E, Lianos EA", "evidence": [ { "database": "RefSeq", "id": "NP_071605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071605" } ], "reference": [ { "type": "PubMed", "id": "33387103", "url": "https://glygen.org/publication/PubMed/33387103" } ] } ], "pathway": [ { "id": "rno:64036", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:64036", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P08174-1", "protein_name": "Complement decay-accelerating factor", "gene_name": "CD55", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLSGHTCFTLTGLLGTLVTMGLLT", "length": 381 }, "evidence": [ { "id": "45240752", "url": "http://www.informatics.jax.org/homology/45240752", "database": "MGI" }, { "id": "45238965", "url": "http://www.informatics.jax.org/homology/45238965", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q61475-1", "protein_name": "Complement decay-accelerating factor, GPI-anchored", "gene_name": "Cd55", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIRGRAPRTRPSPPPPLLPLLSLSLLLLSPTVRGDCGPPPDIPNARPILGRHSKFAEQSKVAYSCNNGFKQVPDKSNIVVCLENGQWSSHETFCEKSCVAPERLSFASLKKEYLNMNFFPVGTIVEYECRPGFRKQPPLPGKATCLEDLVWSPVAQFCKKKSCPNPKDLDNGHINIPTGILFGSEINFSCNPGYRLVGVSSTFCSVTGNTVDWDDEFPVCTEIHCPEPPKINNGIMRGESDSYTYSQVVTYSCDKGFILVGNASIYCTVSKSDVGQWSSPPPRCIEKSKVPTKKPTINVPSTGTPSTPQKPTTESVPNPGDQPTPQKPSTVKVSATQHVPVTKTTVRHPIRTSTDKGEPNTGGDRYIYGHTCLITLTVLHVMLSLIGYLT", "length": 390 }, "evidence": [ { "id": "45238965", "url": "http://www.informatics.jax.org/homology/45238965", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q61476-1", "protein_name": "Complement decay-accelerating factor transmembrane isoform", "gene_name": "Cd55b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVSSTWGYDPRAGAGDLVITTTAAGAVTIAVLLFQTVCGDCGPPPDIPNARPILGRHSKFAEQSKVAYSCNNGFKQVPDKSNIVVCLENGQWSSHETFCEKSCDTPERLSFASLKKEYFNMNFFPVGTIVEYECRPGFRKQPSLSGKSTCLEDLVWSPVAQFCKKKSCPNPKDLDNGHINIPTGILFGSEINFSCNPGYRLVGITSILCTIIGNTVDWDDEFPVCTEIFCPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSKSDVGQWSSPPPQCIEESKVPIKKPVVNVPSTGIPSTPQKPTTESVPNPGDQPTPQKPSTVKVPATQHEPDTTTRTSTDKGESNSGGDRYIYGFVAVIAMIDSLIIVKTLWTILSPNRRSDFQGKERKDVSK", "length": 407 }, "evidence": [ { "id": "45240752", "url": "http://www.informatics.jax.org/homology/45240752", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "enzyme inhibitor activity", "id": "GO:0004857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004857", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "virus receptor activity", "id": "GO:0001618", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001618", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "positive regulation of cytosolic calcium ion concentration", "id": "GO:0007204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007204", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "positive regulation of T cell cytokine production", "id": "GO:0002726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002726", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "response to peptide hormone", "id": "GO:0043434", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043434", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "negative regulation of complement activation", "id": "GO:0045916", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045916", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "regulation of complement activation", "id": "GO:0030449", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030449", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "maternal process involved in parturition", "id": "GO:0060137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060137", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "regulation of complement activation, classical pathway", "id": "GO:0030450", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030450", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "positive regulation of CD4-positive, alpha-beta T cell activation", "id": "GO:2000516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000516", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "positive regulation of CD4-positive, alpha-beta T cell proliferation", "id": "GO:2000563", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000563", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "regulation of lipopolysaccharide-mediated signaling pathway", "id": "GO:0031664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031664", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" }, { "name": "regulation of complement-dependent cytotoxicity", "id": "GO:1903659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903659", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5XWT0", "url": "https://www.uniprot.org/uniprot/A0A8I5XWT0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 262, "end_pos": 264, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 666, "end_pos": 668, "annotation": "n_glycosylation_sequon" }, { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { 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