{ "uniprot_canonical_ac": "A0A5K7RLP0-1", "uniprot_ac": "A0A5K7RLP0", "uniprot_id": "MEIOS_MOUSE", "mass": { "chemical_mass": 65090.0, "monoisotopic_mass": 65090.0 }, "refseq": { "ac": "XP_011249055", "name": "meiosis initiator protein isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011249055" }, "gene_names": [ { "name": "Meiosin", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0", "id": "A0A5K7RLP0" }, { "name": "9330180I18; Bhmg1; EG243866; Gm4969", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011249055", "id": "XP_011249055" }, { "name": "Bhmg1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0", "id": "A0A5K7RLP0" }, { "name": "Gm4969", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0", "id": "A0A5K7RLP0" }, { "name": "Meiosin", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011249055", "id": "XP_011249055" } ], "protein_names": [ { "name": "Meiosis initiator protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A5K7RLP0" }, { "name": "meiosis initiator protein isoform X3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011249055", "id": "XP_011249055" } ], "function": [ { "annotation": "Gatekeeper of meiotic initiation in both male and female germ cells (PubMed:32032549). In complex with STRA8, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. Temporal expression of MEIOSIN is required for meiotic entry decision (PubMed:32032549).", "evidence": [ { "database": "UniProtKB", "id": "A0A5K7RLP0", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0#function" }, { "database": "PubMed", "id": "32032549", "url": "https://glygen.org/publication/PubMed/32032549" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A5K7RLP0", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Meiosin", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0", "locus": { "chromosome": "7", "start_pos": 18832971, "end_pos": 18852293, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000085601", "url": "https://www.ensembl.org/id/ENSMUSG00000085601" } ] } } ], "crossref": [ { "id": "ENSMUSG00000085601", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000085601", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21977", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21977", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "243866", "url": "https://www.ncbi.nlm.nih.gov/gene/243866", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "3647482", "url": "http://www.informatics.jax.org/marker/MGI:3647482", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "RRPYCIK", "url": "https://omabrowser.org/oma/group/RRPYCIK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2970715at2759", "url": "http://www.orthodb.org/?query=2970715at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47658", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47658", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47658:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47658:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00505", "url": "http://pfam.xfam.org/family/PF00505", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A5K7RLP0", "url": "http://purl.obolibrary.org/obo/PR_A0A5K7RLP0", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_011249055", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011249055", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A5K7RLP0", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5K7RLP0-1", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5K7RLP0-2", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RG70", "url": "https://www.uniprot.org/uniprot/D6RG70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RG70-1", "url": "https://www.uniprot.org/uniprot/D6RG70-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGSDKFSCFSDQHRARSPSPTDRKDKKNHTNKLRELALLIPVTMKTRDKKYTKKEILLRVLHYIQYLQRNIDMTKALLKLHSSNGKGRFVGPGLNPSAGQTQQQHSTPSSSQKPSLWSTSSKPRKKKFTRVSEHPSWPYNPRRSLALDQAENPNTIHPGLKEENEECATYPGVLSPSTYPTTEPSVSEGDGQGAQLVFLDMAQNIFAYDILSDHAVEVQGGEPNADIKVQRSFFLTRAQPCVSSCRQKLFLCTSSEADKEAPDSDPWLPVWTSEDSPNGSPLALGSSQINTWHVADYLNEILGVSSSLFSSPSKILPDHVLEDGTYFLTEGLLESSPATCEVESPQEKEVSSEGPTGPPNFQSSVSLDHCYLSLSENVKVLSNCGSSSESTDTESLWGQEEVRGVATYPRRTGVFSLAQPSVLQQANPEGLQTSSDEDRDYTWTPTGQSSGLPVASKKIKKVQASQGPVKPKDSRKACPGQVKKKCVNGFIMFCRMNRKQYIRACPGTASTAATKDLAQLWRGMTLEEKKPYCTKARRFSRQNNRIVKQENSSSEDDDGETPKPFYQLLAEKAQVSLGLTSLPTPNCQ", "length": 589, "header": "sp|A0A5K7RLP0-1|MEIOS_MOUSE Isoform 1 of Meiosis initiator protein OS=Mus musculus OX=10090 GN=Meiosin PE=1 SV=1 CANONICAL=A0A5K7RLP0-1" }, "isoforms": [ { "isoform_ac": "A0A5K7RLP0-1", "url": "", "sequence": { "sequence": "MLGSDKFSCFSDQHRARSPSPTDRKDKKNHTNKLRELALLIPVTMKTRDKKYTKKEILLRVLHYIQYLQRNIDMTKALLKLHSSNGKGRFVGPGLNPSAGQTQQQHSTPSSSQKPSLWSTSSKPRKKKFTRVSEHPSWPYNPRRSLALDQAENPNTIHPGLKEENEECATYPGVLSPSTYPTTEPSVSEGDGQGAQLVFLDMAQNIFAYDILSDHAVEVQGGEPNADIKVQRSFFLTRAQPCVSSCRQKLFLCTSSEADKEAPDSDPWLPVWTSEDSPNGSPLALGSSQINTWHVADYLNEILGVSSSLFSSPSKILPDHVLEDGTYFLTEGLLESSPATCEVESPQEKEVSSEGPTGPPNFQSSVSLDHCYLSLSENVKVLSNCGSSSESTDTESLWGQEEVRGVATYPRRTGVFSLAQPSVLQQANPEGLQTSSDEDRDYTWTPTGQSSGLPVASKKIKKVQASQGPVKPKDSRKACPGQVKKKCVNGFIMFCRMNRKQYIRACPGTASTAATKDLAQLWRGMTLEEKKPYCTKARRFSRQNNRIVKQENSSSEDDDGETPKPFYQLLAEKAQVSLGLTSLPTPNCQ", "length": 589, "header": "sp|A0A5K7RLP0-1|MEIOS_MOUSE Isoform 1 of Meiosis initiator protein OS=Mus musculus OX=10090 GN=Meiosin PE=1 SV=1 CANONICAL=A0A5K7RLP0-1" }, "locus": {} }, { "isoform_ac": "A0A5K7RLP0-2", "url": "", "sequence": { "sequence": "MLGSDKFSCFSDQHRARSPSPTDRKDKKNHTNKLRELALLIPVTMKTRDKKYTKKEILLRVLHYIQYLQRNIDMTKALLKLHSSNGKGRFVGPGLNPSAGQTQQQHSTPSSSQKPSLWSTSSKPRKKKFTRVSEHPSWPYNPRRSLALDQAENPNTIHPGLKEENEECATYPGVLSPSTYPTTEPSVSEGDGQGAQLVFLDMAQNIFAYDILSDHAVEVQGGEPNADIKVQRSFFLTRAQPCVSSCRQKLFLCTSSEADKEAPDSDPWLPVWTSEDSPNGSPLALGSSQINTWHVADYLNEILGVSSSLFSSPSKILPDHVLEDGTYFLTEGLLESSPATCEVESPQEKEVSSEGPTGPPNFQSSVSLDHCYLSLSENVKVLSNCGSSSESTDTESLWGQEEQANPEGLQTSSDEDRDYTWTPTGQSSGLPVASKKIKKVQASQGPVKPKDSRKACPGQVKKKCVNGFIMFCRMNRKQYIRACPGTASTAATKDLAQLWRGMTLEEKKPYCTKARRFSRQNNRIVKQENSSSEDDDGETPKPFYQLLAEKAQVSLGLTSLPTPNCQ", "length": 566, "header": "sp|A0A5K7RLP0-2|MEIOS_MOUSE Isoform 2 of Meiosis initiator protein OS=Mus musculus OX=10090 GN=Meiosin PE=1 SV=1 CANONICAL=A0A5K7RLP0-1" }, "locus": { "chromosome": "7", "start_pos": 18848406, "end_pos": 18832974, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000141380", "url": "https://www.ensembl.org/id/ENSMUST00000141380" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000115575", "url": "https://www.ensembl.org/id/ENSMUSP00000115575" } ] } }, { "isoform_ac": "D6RG70-1", "url": "", "sequence": { "sequence": "MLGSDKFSCFSDQHRARSPSPTDRKDKKNHTNKLRELALLIPVTMKTRDKKYTKGQV", "length": 57, "header": "tr|D6RG70-1|MEIOS_MOUSE Computationally mapped isoform of Meiosis initiator protein OS=Mus musculus OX=10090 GN=Meiosin PE=1 SV=1 CANONICAL=A0A5K7RLP0-1" }, "locus": { "chromosome": "7", "start_pos": 18848406, "end_pos": 18839763, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000127433.7", "url": "https://www.ensembl.org/id/ENSMUST00000127433.7" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000115597.2", "url": "https://www.ensembl.org/id/ENSMUSP00000115597.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "C9JSJ3-1", "protein_name": "Meiosis initiator protein", "gene_name": "MEIOSIN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFGSSRYLGSSEQPRANSLGPSDRTLVLCSLVEGEDKVNPSEPHGLRMEEKWLLKGKLRNQRNQNKLLSPNKKQRKNHTSKLQELALLLPIALKTGTKKLTKKEILVHVLQYIQYLQRNIDAAKALFKCHITTGEGGLAGLGQKPAWGPARRRRHSTPSSSPSSQKSCLQGACQKPRKKKLTQASESQTRTPKPRRSLALNKPEKLVAPSPDQKGSGTGGTTTPPRCPDSCGHPRPASSSPPGDRKGGQSQLTLLDLAEDTIHCDISSCWCQGSVQDDAPFPALLAQEDVARIHFLNKTQPHPRQKLVFYDSSEDVDKGSLDADPWLPAWTPENSPQGSPLFLGPPQIDVWSGTGHPSEILGLSPSLFSSPGKLLPDEILEDDMEYLTQAAFFEEVCLDLESSPSAYTQEAPQEKDTASKAPKDPPESHSLHRSSVSLDHCYLSLSGNSKAPSSSSSSSSSSSSSEDSDSEPLWKQREDMQANPVGTPGSSEEDEDTTWTPTRLASPLLAAEKKATKGQVARAPVKPKEKKKGPCPPQMKKKCVNGFIMFCRMNRKQYIRSCPGTASTAATKELAQLWRVMTQQERRPYCTKARRFSRQHNRIVKQDGSSSEAEDWETPKPFYQLLAEKALPLPPHLQ", "length": 638 }, "evidence": [ { "id": "45242040", "url": "http://www.informatics.jax.org/homology/45242040", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A5K7RLP0", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0A5K7RLP0", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A5K7RLP0", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A5K7RLP0", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0A5K7RLP0", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0" } ], "pmid": "" }, { "name": "cellular response to retinoic acid", "id": "GO:0071300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300", "evidence": [ { "database": "UniProtKB", "id": "A0A5K7RLP0", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0" } ], "pmid": "" }, { "name": "oogenesis", "id": "GO:0048477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048477", "evidence": [ { "database": "UniProtKB", "id": "A0A5K7RLP0", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0" } ], "pmid": "" }, { "name": "meiotic cell cycle", "id": "GO:0051321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "database": "UniProtKB", "id": "A0A5K7RLP0", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0" } ], "pmid": "" }, { "name": "activation of meiosis", "id": "GO:0090427", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090427", "evidence": [ { "database": "UniProtKB", "id": "A0A5K7RLP0", "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 279, "end_pos": 281, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 552, "end_pos": 554, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }