{
    "uniprot_canonical_ac": "A0A5F8MPI9-1",
    "uniprot_ac": "A0A5F8MPI9",
    "uniprot_id": "A0A5F8MPI9_MOUSE",
    "mass": {
        "chemical_mass": 122268.0,
        "monoisotopic_mass": 122268.0
    },
    "refseq": {
        "ac": "NP_001034175",
        "name": "rap guanine nucleotide exchange factor 1 isoform 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034175"
    },
    "gene_names": [
        {
            "name": "Rapgef1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A5F8MPI9",
            "id": "A0A5F8MPI9"
        },
        {
            "name": "4932418O06Rik; C3G; Grf2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473391",
            "id": "NP_473391"
        },
        {
            "name": "Grf2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A5F8MPI9",
            "id": "A0A5F8MPI9"
        },
        {
            "name": "Rapgef1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473391",
            "id": "NP_473391"
        }
    ],
    "protein_names": [
        {
            "name": "Rap guanine nucleotide exchange factor (GEF) 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A5F8MPI9"
        },
        {
            "name": "guanine nucleotide releasing factor 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034176",
            "id": "NP_001034176"
        },
        {
            "name": "rap guanine nucleotide exchange factor 1 isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034176",
            "id": "NP_001034176"
        },
        {
            "name": "rap guanine nucleotide exchange factor 1 isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034175",
            "id": "NP_001034175"
        },
        {
            "name": "rap guanine nucleotide exchange factor 1 isoform 3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473391",
            "id": "NP_473391"
        },
        {
            "name": "rap guanine nucleotide exchange factor 1 isoform X20",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006497655",
            "id": "XP_006497655"
        }
    ],
    "function": [
        {
            "annotation": "Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001034175",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034175"
                },
                {
                    "database": "PubMed",
                    "id": "33951626",
                    "url": "https://glygen.org/publication/PubMed/33951626"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_473391",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473391"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001034176",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034176"
                }
            ]
        },
        {
            "annotation": "C3G Regulates STAT3, ERK, Adhesion Signaling, and Is Essential for Differentiation of Embryonic Stem Cells.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001034175",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034175"
                },
                {
                    "database": "PubMed",
                    "id": "33624208",
                    "url": "https://glygen.org/publication/PubMed/33624208"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_473391",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473391"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001034176",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034176"
                }
            ]
        },
        {
            "annotation": "C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001034175",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034175"
                },
                {
                    "database": "PubMed",
                    "id": "32371504",
                    "url": "https://glygen.org/publication/PubMed/32371504"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_473391",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473391"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001034176",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034176"
                }
            ]
        },
        {
            "annotation": "Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001034175",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034175"
                },
                {
                    "database": "PubMed",
                    "id": "11909944",
                    "url": "https://glygen.org/publication/PubMed/11909944"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_473391",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473391"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001034176",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034176"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:4780",
            "recommended_name": {
                "id": "DOID:4780",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:4780",
                "name": "anti-basement membrane glomerulonephritis",
                "description": "A Goodpasture syndrome that is characterized by damage to only kidney capillaries."
            },
            "synonyms": [
                {
                    "id": "DOID:4780",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4780",
                    "name": "anti-GBM glomerulonephritis",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "4780",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:4780"
                }
            ]
        },
        {
            "disease_id": "DOID:4783",
            "recommended_name": {
                "id": "DOID:4783",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:4783",
                "name": "mesangial proliferative glomerulonephritis",
                "description": ""
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "4783",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:4783"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A5F8MPI9",
                    "url": "https://www.uniprot.org/uniprot/A0A5F8MPI9"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Rapgef1",
            "url": "https://www.uniprot.org/uniprot/A0A5F8MPI9",
            "locus": {
                "chromosome": "2",
                "start_pos": 29630990,
                "end_pos": 29509732,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000039844",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000039844"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000039844",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000039844",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00155",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00155",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd06224",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06224",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "107746",
            "url": "https://www.ncbi.nlm.nih.gov/gene/107746",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000651",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000651",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001895",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001895",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR008937",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008937",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019804",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019804",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR023578",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023578",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036964",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036964",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:107746",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:107746",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "104580",
            "url": "http://www.informatics.jax.org/marker/MGI:104580",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "INRQEDF",
            "url": "https://omabrowser.org/oma/group/INRQEDF/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "68574at2759",
            "url": "http://www.orthodb.org/?query=68574at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23113",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23113:SF224",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113:SF224",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00617",
            "url": "http://pfam.xfam.org/family/PF00617",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00618",
            "url": "http://pfam.xfam.org/family/PF00618",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q3UHC1",
            "url": "http://purl.obolibrary.org/obo/PR_Q3UHC1",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-170968",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-170968",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-186763",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-186763",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-8875555",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8875555",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-9013423",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013423",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-9027284",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9027284",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-912631",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-912631",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_006497655",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006497655",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A5F8MPI9",
            "url": "https://www.uniprot.org/uniprot/A0A5F8MPI9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A5F8MPI9-1",
            "url": "https://www.uniprot.org/uniprot/A0A5F8MPI9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A1L338",
            "url": "https://www.uniprot.org/uniprot/A1L338",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A1L338-1",
            "url": "https://www.uniprot.org/uniprot/A1L338-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6ZDE5",
            "url": "https://www.uniprot.org/uniprot/F6ZDE5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6ZDE5-1",
            "url": "https://www.uniprot.org/uniprot/F6ZDE5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q3UGX8",
            "url": "https://www.uniprot.org/uniprot/Q3UGX8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q3UGX8-1",
            "url": "https://www.uniprot.org/uniprot/Q3UGX8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q3UHC1",
            "url": "https://www.uniprot.org/uniprot/Q3UHC1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q3UHC1-1",
            "url": "https://www.uniprot.org/uniprot/Q3UHC1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q91ZZ2",
            "url": "https://www.uniprot.org/uniprot/Q91ZZ2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q91ZZ2-1",
            "url": "https://www.uniprot.org/uniprot/Q91ZZ2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MGNAVEKQKPLRQSHLCPWKQDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSKIPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVASRSQRQKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTDREMEILNKTTSVSPSAELLPDSTSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPPQAACNLSPLPESLGESGPPFLGHPFQLPLGSCLQQEGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEGDLQNPVPVQPVPYPPFAAVLPFQQGASSASAEFVGDFSVPELAGDTEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSESFCGSDSTQELAPPPALPPKQRQLEPPSGKDGHPRDPSVSSASGKDSRENGERSPKSLDGLESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT",
        "length": 1087,
        "header": "tr|A0A5F8MPI9-1|A0A5F8MPI9_MOUSE Isoform 1 of Rap guanine nucleotide exchange factor (GEF) 1  OS=Mus musculus OX=10090 GN=Rapgef1 PE=1 SV=1 CANONICAL=A0A5F8MPI9-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A5F8MPI9-1",
            "url": "",
            "sequence": {
                "sequence": "MGNAVEKQKPLRQSHLCPWKQDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSKIPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVASRSQRQKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTDREMEILNKTTSVSPSAELLPDSTSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPPQAACNLSPLPESLGESGPPFLGHPFQLPLGSCLQQEGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEGDLQNPVPVQPVPYPPFAAVLPFQQGASSASAEFVGDFSVPELAGDTEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSESFCGSDSTQELAPPPALPPKQRQLEPPSGKDGHPRDPSVSSASGKDSRENGERSPKSLDGLESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT",
                "length": 1087,
                "header": "tr|A0A5F8MPI9-1|A0A5F8MPI9_MOUSE Isoform 1 of Rap guanine nucleotide exchange factor (GEF) 1  OS=Mus musculus OX=10090 GN=Rapgef1 PE=1 SV=1 CANONICAL=A0A5F8MPI9-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 29628079,
                "end_pos": 29533863,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000238899.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000238899.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000158995.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000158995.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A1L338-1",
            "url": "",
            "sequence": {
                "sequence": "MSSGLGLRRSPEMSGKIEKADSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSKIPEKPVSKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTDREMEILNKTTSVSPSAELLPDSTSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPPQAACNLSPLPESLGESGPPFLGHPFQLPLGSCLQQEGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEGDLQNPVPVQPVPYPPFAAVLPFQQGASSASAEFVGDFSVPELAGDTEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSESFCGSDSTQELAPPPALPPKQRQLASYAASSFSVSYCVQQTKVAFTPEDGSAAQGLSVSVSNSFLNRHGSLPVPSYKSVFRSYSQDFMPHHQASVQPFLPPTSSSSPHFPPVHTSQSSDLAVPTVSSPPPSTVDGPLSSSQDSSFHGNPVRLPSETSFTDSEPPSGKDGHPRDPSVSSASGKDSRENGERSPKSLDGLESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT",
                "length": 1185,
                "header": "tr|A1L338-1|A1L338_MOUSE Computationally mapped isoform of Rap guanine nucleotide exchange factor (GEF) 1  OS=Mus musculus OX=10090 GN=Rapgef1 PE=1 SV=1 CANONICAL=A0A5F8MPI9-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 29628079,
                "end_pos": 29510015,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000147755.10",
                        "url": "https://www.ensembl.org/id/ENSMUST00000147755.10"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000121615.4",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000121615.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F6ZDE5-1",
            "url": "",
            "sequence": {
                "sequence": "XDNISEGDLQNPVPVQPVPYPPFAAVLPFQQGASSASAEFVGDFSVPELAGDTEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSESFCGSDSTQELAPPPALPPKQRQLASYAASSFSVSYCVQQTKVAFTPEDGSAAQGLSVSVSNSFLNRHGSLPVPSEPPSGKDGHPRDPSVSSASGKDSRENGERSPKSLDGLESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT",
                "length": 643,
                "header": "tr|F6ZDE5-1|A0A5F8MPI9_MOUSE Computationally mapped isoform of Rap guanine nucleotide exchange factor (GEF) 1  OS=Mus musculus OX=10090 GN=Rapgef1 PE=1 SV=1 CANONICAL=A0A5F8MPI9-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 29628081,
                "end_pos": 29592494,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000147488.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000147488.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000117631.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000117631.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q3UGX8-1",
            "url": "",
            "sequence": {
                "sequence": "MSSGLGLRRSPEMSGKIEKADSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSKIPEKPVSKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTDREMEILNKTTSVSPSAELLPDSTSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPPQAACNLSPLPESLGESGPPFLGHPFQLPLGSCLQQEGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEGDLQNPVPVQPVPYPPFAAVLPFQQGASSASAEFVGDFSVPELAGDTEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSESFCGSDSTQELAPPPALPPKQRQLQASYAASSFSVSYCVQQTKVAFTPEDGSAAQGLSVSVSNSFLNRHGSLPVPSYKSVFRSYSQDFMPHHQASVQPFLPPTSSSSPHFPPVHTSQSSDLAVPTVSSPPPSTVDGPLSSSQDSSFHGNPVRLPSETSFTDSSEKASSEEAGGDEYVSLYSSGQTSEELAPCRGEPPSGKDGHPRDPSVSSASGKDSRENGERSPKSLDGLESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT",
                "length": 1218,
                "header": "tr|Q3UGX8-1|A0A5F8MPI9_MOUSE Computationally mapped isoform of Rap guanine nucleotide exchange factor (GEF) 1  OS=Mus musculus OX=10090 GN=Rapgef1 PE=1 SV=1 CANONICAL=A0A5F8MPI9-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 29628079,
                "end_pos": 29510015,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000091146.12",
                        "url": "https://www.ensembl.org/id/ENSMUST00000091146.12"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000088680.6",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000088680.6"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q3UHC1-1",
            "url": "",
            "sequence": {
                "sequence": "MSSGLGLRRSPEMSGKIEKADSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSKIPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVASRSQRQKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTDREMEILNKTTSVSPSAELLPDSTSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPPQAACNLSPLPESLGESGPPFLGHPFQLPLGSCLQQEGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEGDLQNPVPVQPVPYPPFAAVLPFQQGASSASAEFVGDFSVPELAGDTEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSESFCGSDSTQELAPPPALPPKQRQLQASYAASSFSVSYCVQQTKVAFTPEDGSAAQGLSVSVSNSFLNRHGSLPVPSYKSVFRSYSQDFMPHHQASVQPFLPPTSSSSPHFPPVHTSQSSDLAVPTVSSPPPSTVDGPLSSSQDSSFHGNPVRLPSETSFTDSEPPSGKDGHPRDPSVSSASGKDSRENGERSPKSLDGLESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT",
                "length": 1224,
                "header": "tr|Q3UHC1-1|Q3UHC1_MOUSE Computationally mapped isoform of Rap guanine nucleotide exchange factor (GEF) 1  OS=Mus musculus OX=10090 GN=Rapgef1 PE=1 SV=1 CANONICAL=A0A5F8MPI9-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 29628079,
                "end_pos": 29510015,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000095087.11",
                        "url": "https://www.ensembl.org/id/ENSMUST00000095087.11"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000092703.5",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000092703.5"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q91ZZ2-1",
            "url": "",
            "sequence": {
                "sequence": "MSSGLGLRRSPEMSGKIEKADSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSKIPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVASRSQRQKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTDREMEILNKTTSVSPSAELLPDSTSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPPQAACNLSPLPESLGESGPPFLGHPFQLPLGSCLQQEGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEGDLQNPVPVQPVPYPPFAAVLPFQQGASSASAEFVGDFSVPELAGDTEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSESFCGSDSTQELAPPPALPPKQRQLEPPSGKDGHPRDPSVSSASGKDSRENGERSPKSLDGLESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT",
                "length": 1086,
                "header": "tr|Q91ZZ2-1|Q91ZZ2_MOUSE Computationally mapped isoform of Rap guanine nucleotide exchange factor (GEF) 1  OS=Mus musculus OX=10090 GN=Rapgef1 PE=1 SV=1 CANONICAL=A0A5F8MPI9-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 29628079,
                "end_pos": 29510015,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000102872.11",
                        "url": "https://www.ensembl.org/id/ENSMUST00000102872.11"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000099936.5",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000099936.5"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "C3G, a guanine nucleotide exchange factor bound to adapter molecule c-Crk, has two alternative splicing forms.",
            "journal": "Biochem. Biophys. Res. Commun.",
            "date": "2001",
            "authors": "Zhai B, Huo H, Liao K",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q91ZZ2",
                    "url": "https://www.uniprot.org/uniprot/Q91ZZ2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11485308",
                    "url": "https://glygen.org/publication/PubMed/11485308"
                }
            ]
        },
        {
            "title": "Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.",
            "journal": "Molecular and cellular biology",
            "date": "2002",
            "authors": "Fernandez-Medarde A, Esteban LM, Nunez A, Porteros A, Tessarollo L, Santos E",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001034176",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034176"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001034175",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034175"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_473391",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473391"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11909944",
                    "url": "https://glygen.org/publication/PubMed/11909944"
                }
            ]
        },
        {
            "title": "C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length.",
            "journal": "Journal of cell science",
            "date": "2020",
            "authors": "Nayak SC, Radha V",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_473391",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473391"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001034176",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034176"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001034175",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034175"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32371504",
                    "url": "https://glygen.org/publication/PubMed/32371504"
                }
            ]
        },
        {
            "title": "C3G Regulates STAT3, ERK, Adhesion Signaling, and Is Essential for Differentiation of Embryonic Stem Cells.",
            "journal": "Stem cell reviews and reports",
            "date": "2021",
            "authors": "Vishnu VV, Muralikrishna B, Verma A, Nayak SC, Sowpati DT, Radha V, Shekar PC",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001034176",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034176"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_473391",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473391"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001034175",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034175"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33624208",
                    "url": "https://glygen.org/publication/PubMed/33624208"
                }
            ]
        },
        {
            "title": "Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells.",
            "journal": "Journal of vascular research",
            "date": "2021",
            "authors": "Chavkin NW, Leaf EM, Brooks KE, Wallingford MC, Lund SM, Giachelli CM",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001034175",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034175"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001034176",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034176"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_473391",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473391"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33951626",
                    "url": "https://glygen.org/publication/PubMed/33951626"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:107746",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:107746",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-170968",
            "name": "Frs2-mediated activation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-170968",
            "resource": "Reactome",
            "description": "Frs2-mediated activation"
        },
        {
            "id": "R-MMU-186763",
            "name": "Downstream signal transduction",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-186763",
            "resource": "Reactome",
            "description": "Downstream signal transduction"
        },
        {
            "id": "R-MMU-8875555",
            "name": "MET activates RAP1 and RAC1",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8875555",
            "resource": "Reactome",
            "description": "MET activates RAP1 and RAC1"
        },
        {
            "id": "R-MMU-9013423",
            "name": "RAC3 GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013423",
            "resource": "Reactome",
            "description": "RAC3 GTPase cycle"
        },
        {
            "id": "R-MMU-9027284",
            "name": "Erythropoietin activates RAS",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9027284",
            "resource": "Reactome",
            "description": "Erythropoietin activates RAS"
        },
        {
            "id": "R-MMU-912631",
            "name": "Regulation of signaling by CBL",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-912631",
            "resource": "Reactome",
            "description": "Regulation of signaling by CBL"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q13905-1",
            "protein_name": "Rap guanine nucleotide exchange factor 1",
            "gene_name": "RAPGEF1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MDTDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVEFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT",
                "length": 1077
            },
            "evidence": [
                {
                    "id": "45232028",
                    "url": "http://www.informatics.jax.org/homology/45232028",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 25,
                "go_terms": [
                    {
                        "name": "negative regulation of Ras protein signal transduction",
                        "id": "GO:0046580",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046580",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5F8MPI9",
                                "url": "https://www.uniprot.org/uniprot/A0A5F8MPI9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "establishment of endothelial barrier",
                        "id": "GO:0061028",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061028",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5F8MPI9",
                                "url": "https://www.uniprot.org/uniprot/A0A5F8MPI9"
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                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Rap protein signal transduction",
                        "id": "GO:0032486",
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                    {
                        "name": "positive regulation of neuron projection development",
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                                "database": "UniProtKB",
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                                "database": "UniProtKB",
                                "id": "A0A5F8MPI9",
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                        ],
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                    {
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                    {
                        "name": "cellular response to cAMP",
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                    {
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                        "name": "ERK1 and ERK2 cascade",
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                                "id": "A0A5F8MPI9",
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                    {
                        "name": "activation of GTPase activity",
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                                "id": "A0A5F8MPI9",
                                "url": "https://www.uniprot.org/uniprot/A0A5F8MPI9"
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                        "name": "protein kinase B signaling",
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                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043491",
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                                "id": "A0A5F8MPI9",
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                                "url": "https://www.uniprot.org/uniprot/A0A5F8MPI9"
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                    {
                        "name": "platelet-derived growth factor receptor signaling pathway",
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                        "name": "neural precursor cell proliferation",
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