{ "uniprot_canonical_ac": "A0A571BF69-1", "uniprot_ac": "A0A571BF69", "uniprot_id": "A0A571BF69_MOUSE", "mass": { "chemical_mass": 413021.0, "monoisotopic_mass": 413021.0 }, "refseq": { "ac": "XP_006506105", "name": "maltase-glucoamylase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006506105" }, "gene_names": [ { "name": "Mgam", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A571BF69", "id": "A0A571BF69" }, { "name": "6030407P20Rik; MGA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006506105", "id": "XP_006506105" }, { "name": "Mgam", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006506105", "id": "XP_006506105" } ], "protein_names": [ { "name": "Maltase-glucoamylase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A571BF69" }, { "name": "maltase-glucoamylase isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164474", "id": "NP_001164474" }, { "name": "maltase-glucoamylase isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006506105", "id": "XP_006506105" } ], "function": [ { "annotation": "Investigation of dietary control of Mgam expression in jejunum: high starch diet induces Mgam through mechanism involving increased acetylation of histones and increased binding of CREBBP, CDX2, and HNF1 to Mgam gene", "evidence": [ { "database": "RefSeq", "id": "NP_001164474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164474" }, { "database": "PubMed", "id": "20425755", "url": "https://glygen.org/publication/PubMed/20425755" } ] }, { "annotation": "Mucosal alpha-glucogenic activity of Mgam plays a crucial role in the regulation of prandial glucose homeostasis", "evidence": [ { "database": "RefSeq", "id": "NP_001164474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164474" }, { "database": "PubMed", "id": "19193815", "url": "https://glygen.org/publication/PubMed/19193815" } ] }, { "annotation": "The alpha-glucogenic activities of the jejunal mucosa with and without added recombinant pancreatic alpha-amylase, using a range of food starch substrates are reported.", "evidence": [ { "database": "RefSeq", "id": "NP_001164474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164474" }, { "database": "PubMed", "id": "17585022", "url": "https://glygen.org/publication/PubMed/17585022" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A571BF69", "url": "https://www.uniprot.org/uniprot/A0A571BF69" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Mgam", "url": "https://www.uniprot.org/uniprot/A0A571BF69", "locus": { "chromosome": "6", "start_pos": 40746057, "end_pos": 40605765, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000068587", "url": "https://www.ensembl.org/id/ENSMUSG00000068587" } ] } } ], "crossref": [ { "id": "ENSMUSG00000068587", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000068587", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.2.1.20", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.20&UniProtAcc=A0A571BF69", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "GH31", "url": "http://www.cazy.org/GH31.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "cd00111", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00111", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06602", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06602", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14752", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14752", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "232714", "url": "https://www.ncbi.nlm.nih.gov/gene/232714", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0001331", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0001331", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0001334", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0001334", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0001985", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0001985", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR000322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011013", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011013", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025887", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025887", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030458", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030458", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030459", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030459", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031727", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031727", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:232714", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:232714", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1203495", "url": "http://www.informatics.jax.org/marker/MGI:1203495", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "YYTARNI", "url": "https://omabrowser.org/oma/group/YYTARNI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5480935at2759", "url": "http://www.orthodb.org/?query=5480935at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22762", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22762", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22762:SF155", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22762:SF155", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22762:SF63", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22762:SF63", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00088", "url": "http://pfam.xfam.org/family/PF00088", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01055", "url": "http://pfam.xfam.org/family/PF01055", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13802", "url": "http://pfam.xfam.org/family/PF13802", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16863", "url": "http://pfam.xfam.org/family/PF16863", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-189085", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-189085", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_006506105", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006506105", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0J9YVE6", "url": "https://www.uniprot.org/uniprot/A0A0J9YVE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0J9YVE6-1", "url": "https://www.uniprot.org/uniprot/A0A0J9YVE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0J9YVJ0", "url": "https://www.uniprot.org/uniprot/A0A0J9YVJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0J9YVJ0-1", "url": "https://www.uniprot.org/uniprot/A0A0J9YVJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BF69", "url": "https://www.uniprot.org/uniprot/A0A571BF69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BF69-1", "url": "https://www.uniprot.org/uniprot/A0A571BF69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B5THE2", "url": "https://www.uniprot.org/uniprot/B5THE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B5THE2-1", "url": "https://www.uniprot.org/uniprot/B5THE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6XK23", "url": "https://www.uniprot.org/uniprot/Q6XK23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6XK23-1", "url": "https://www.uniprot.org/uniprot/Q6XK23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGRRFKKFSKLELVLIVLLLVLFIIAVVLIVLLANSTPENAIGAETTGTPDTTVTRTTLNSPNCPVLSELERINCIPDQSSNKGTCDERGCCWDPQGSISVPCYYSRNHGYKMESDVVNTNAGFTATLKNLPSAPVFGNSIENILLTAEYQTSNRFHFKLTDQTKKRYEVPHEHVQPFSGNAPSSLNYKVEVSKEPFSIKVTRKSNNRVLFDSSIGPLLFSDQFLQFSTHLPSANVYGLGEHVHQQYRHNMNWKTWPMFSRDTTPNEDGTNLYGVQTFFLCLEDNSGLSFGVFLMNSNAMEVTLQPTPAITYRTTGGILDFYVFLGNTPEQVVQEYLELIGRPALPSYWTLGFQLSRYDYKSLDNMKAVVERNRAAQLPYDVQHADIDYMDQKKDFTYDPVNFKGFPEFVKELHNNGQKLVIILDPAISNNSFSSNPYGPYDRGSAMKIWVNSSDGISPVIGKVWPGTTVFPDYTSPNCAVWWTKEFELFHKEVEFDGIWIDMNEVSNFIDGSFSGCSQNNLNYPPFTPKVLDGYLFSKTLCMDAVQHWGKQYDVHNLYGYSMAIATAKAVKDVFPDKRSFIITRSTFAGSGKFAAHWLGDNTATWKDLQWSIPGMLEFNLFGIPMVGADICGFAQDTYEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFGNNSLLLNSSRHYLNIRYTLLPYLYTLFYRAHSRGDTVARPLLHEFYDDNNTWGIDRQFLWGPGLLITPVLDQGAEKVKAYVPNATWYDYETGEELGWRKQSIEMQLPGDKIGLHLRGGYIFPTQQPATTTEASRKNPLGLIVALDENKEARGELFWDDGESKDTVAQNIYLFSEFSVTQNHLDVTISSPNYKDPNNLEFQEIKIFGTREFRNVRVKQNGNLLQMSPQVTYNPNLKVATITNIHLRLGEAYTVEWDFFTREEERIDCYPDEHGASEANCSARGCIWEASNTTRGPPCYFAHELYSVSNVQYDSHGATADISLKASTYSNAFPSTPVNKLKLQVTYHKNEMLQFKIYDPNHSRYEVPVPLNIPSAPLSTPEGRLYDVLIKENPFGIQIRRKTTGTVIWDSQLLGFTFNDMFIRISTRLPSTYIYGFGETEHTTFKIDMNWHTWGMFSRDEPPGYKKNSYGVHPYYMGLEEDGNAHGVLLMNSNAMDVTFQPMPALTYRTIGGILDFYVFLGPTPEIVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDTEIANLYDEMVAKQIPYDVQYSDIDYMERQLDFKLSPKFSGFPALINRMKANGMRVILILDPAISGNETQPYPAFTQGVENDVFIRYPNNGGIVWGKVWPDYPNITVDSSLDWDIQVERYRAYVAFPDFFRDSTALWWKKEIKELHSNSQDQAKSLKFDGLWIDMNEPSSFVNGAVPSGCSDATLNHPPYMPHVEGRDRGLSSKTLCMESEHILPDGSRVRHYDVHSLYGWSQTRPTYEAMQEVTGERGIVITRSTFPSSGRWGGHWLGDNTAAWDQLGKSIIGMMDFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTKRQDPVSWDKTFEDISRSVLETRYTLLPYLYTLMYKAHKEGSTVVRPLLHEFLADRETWNIDKQFLLGPAFLVSPVLEPNARNVTAYFPKAQWYDYYTGADINSTGWTTLPAPLEHINLHVRGGYILPWQQPALNTNLSRKKPLGLLIALDEKKEARGELFWDDGQSKDTVAKNIYLFSEFSVTQNHLDVTISSPNYKDPNNLEFQEIKIFGTQEFSNVRVKQNGNLLQMSPQVTYNPNLKVATITNIHLRLGEAYTVEWGFFTREEERIDCYPDEHGASEANCSARGCIWEESNTIGVPTCYFAHELYSVSNVQYDSHGATADISLKASTYSNAFPSTPVNKLKLQVTYHKNEMLQFKIYDPNNSRYEVPVPLNIPSAPSSTNEGRLYDVLIKENPFGIQVRRKSTGTVIWDSQLLGFTFNDMFIRISTRLPSTYIYGFGETEHTTFKIDMNWHTWGMFSRDEPPGYKKNSYGVHPYYMGLEEDGNAHGVLLMNSNAMDVTFQPMPALTYRTTGGILDFYVLLGPTPEIVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDSEIASLYDEMVDKQIPYDVQYSDIDYMERQLDFKLSPKFSGFPALINRMKANGMRVILILDPAISGNETQPYPAFTRGVENDVFIRYPNNGSIVWGKVWPDYPNITVDPSLGWDHQVEQYRAYVAFPDFFRNSTATWWKKEIEELYTNTEEPEKSLKFDGLWIDMNEPSSFVNGAVPSGCSDATLNHPPYMPHVEGRDRGLSSKTLCMESEHILPDGSRVQHYDVHSLYGWSQTRPTYEAVQEVTGERGIVITRSTFPSSGRWGGHWLGDNTAAWDQLGKSIIGMMDFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTKRQDPVSWNKTFEDISRSVLETRYTLLPYLYTLMYKAHMEGSTVVRPLLHEFVSDRKTWNIDKQFLLGPAFLVSPVLEPNARNISAYFPTALWYDYYTGANINSTGEWKTLPAPLEHINLHVRGGYILPWQRPALNTHLSRKNPLGLLIALDENKEARGELFWDDGQSKDLTTNNILCKFSVTQNRLDVSTLQSTYMNPDNLAFQEIKIFGTRPLYNVTVKHNGMVNQMAPQVSYDPSMKVAVITGLQLLLNESYTVEWDDSIRDEEKIDCYPDQHGASETSCTARGCVWEESNSDVVPFCYFVNELYSVSNVQYGSHGATANISLKASPYSGAFPSTPVKELQLQVTYHKNEMLQFKIYDPNHSRYEVPVPLNIPSAPSSTPESRLYDVLIKENPFGIEIRRKGTGTVVWDSQLLGFTFSDMFIRISTRLPSTYIYGFGETEHTTFKIDMNWNKWGMFSRDEPPGYRKNSYGVHPYYMGLEEDGNAHGVLLMNSNAMDVTFQPMPALTYRTTGGILDFYVFLGPTPEFVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDSEIASLYDEMVDKKIPYDVQYSDIDYMERQLDFKLSPKFSGFPALINRMKANGMRVILILDPAISGNETEPYPAFTRGVENDVFIRYPNNGSIVWGKVWPDYPNITVDPSLGWDHQVEQYRAYVAFPDFFRNSTATWWKKEIKELHSNTQDPAKSLKFDGLWIDMNEPSSFVNGAVPSGCSDATLNHPPYMPYLEARDRGLSSKTLCMESEQILPDGSRVRHYDVHNLYGWSQTRPTYEAVQEVTGERGIVITRSTFPSSGRWGGHWLGDNTAAWDQLGKSIIGMMDFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWNKTFEDISRSVLETRYTLLPYLYTLMYKAHTEGSTVVRPLLHEFVSDRETWNIDKQFLLGPAFLVSPVLEPNARKVEAYFPRARWYDYYKGVDINATGEWKTLEAPLEYINLHIRGGYILPWQEPAMNTHLSRQKFMGLRAALNAEGRAEGWLFWDDGKRINTDQYYLARFSVNQTTLLTHEKFNNYLTGTAPLYLGYIDIWGLSSSSITNVSISWNTNNEEVFANYNSTTKILSVNMTDKKISLHTFNSLTWSSS", "length": 3616, "header": "tr|A0A571BF69-1|A0A571BF69_MOUSE Isoform 1 of Maltase-glucoamylase OS=Mus musculus OX=10090 GN=Mgam PE=1 SV=1 CANONICAL=A0A571BF69-1" }, "isoforms": [ { "isoform_ac": "A0A0J9YVE6-1", "url": "", "sequence": { "sequence": "MLFQTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTKRQDPVSWNKTFEDISRSVLETRYTLLPYLYTLMYKAHMEGSTVVRPLLHEFVSDRKTWNIDKQFLLGPAFLVSPVLEPNARNISAYFPTALWYDYYTGANINSTGEWKTLPAPLEHINLHVRGGYILPWQRPALNTHLSRKNPLGLLIALDENKEARGELFWDDGQSKDLTTNNILCKFSVTQNRLDVSTLQSTYMNPDNLAFQEIKIFGTRPLYNVTVKHNGMVNQMAPQVSYDPSMKVAVITGLQLLLNESYTVEWDDSIRDEEKIDCYPDQHGASETSCTARGCVWEESNSDVVPFCYFVNELYSVSNVQYGSHGATANISLKASPYSGAFPSTPVKELQLQVTYHKNEMLQFKIYDPNHSRYEVPVPLNIPSAPSSTPESRLYDVLIKENPFGIEIRRKGTGTVVWDSQLLGFTFSDMFIRISTRLPSTYIYGFGETEHTTFKIDMNWNKWGMFSRDEPPGYRKNSYGVHPYYMGLEEDGNAHGVLLMNSNAMDVTFQPMPALTYRTTGGILDFYVFLGPTPEFVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDSEIASLYDEMVDKKIPYDVQYSDIDYMERQLDFKLSPKFSGFPALINRMKANGMRVILILDPAISGNETEPYPAFTRGVENDVFIRYPNNGSIVWGKVWPDYPNITVDPSLGWDHQVEQYRAYVAFPDFFRNSTATWWKKEIKELHSNTQDPAKSLKFDGLWIDMNEPSSFVNGAVPSGCSDATLNHPPYMPYLEARDRGLSSKTLCMESEQILPDGSRVRHYDVHNLYGWSQTRPTYEAVQEVTGERGIVITRSTFPSSGRWGGHWLGDNTAAWDQLGKSIIGMMDFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWNKTFEDISRSVLETRYTLLPYLYTLMYKAHTEGSTVVRPLLHEFVSDRETWNIDKQFLLGPAFLVSPVLEPNARKVEAYFPRARWYDYYKGVDINATGEWKTLEAPLEYINLHIRGGYILPWQEPAMNTHLSRQKFMGLRAALNAEGRAEGWLFWDDGKRINTDQYYLARFSVNQTTLLTHEKFNNYLTGTAPLYLGYIDIWGLSSSSITNVSISWNTNNEEVFANYNSTTKILSVNMTDKKISLHTFNSLTWSSS", "length": 1200, "header": "tr|A0A0J9YVE6-1|A0A0J9YVE6_MOUSE Computationally mapped isoform of Maltase-glucoamylase OS=Mus musculus OX=10090 GN=Mgam PE=1 SV=1 CANONICAL=A0A571BF69-1" }, "locus": { "chromosome": "6", "start_pos": 40745215, "end_pos": 40705933, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000202779.3", "url": "https://www.ensembl.org/id/ENSMUST00000202779.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000144627.2", "url": "https://www.ensembl.org/id/ENSMUSP00000144627.2" } ] } }, { "isoform_ac": "A0A0J9YVJ0-1", "url": "", "sequence": { "sequence": "GAEKVKAYVPNATWYDYETGEELGWRKQSIEMQLPGDKIGLHLRGGYIFPTQQPATTTEASRKNPLGLIVALDENKEARGELFWDDGESKDTVAQNIYLFSEFSVTQNRLDVSTLQSTYMNPDNLAFQEIKIFGTRPLYNVTVKHNGMVNQMAPQVSYDPSMKVAVITGLQLLLNESYTVEWDDSIRDEEKIDCYPDQHGASETSCTARGCVWEESNSDVVPFCYFVNELYSVSNVQYGSHGATANISLKASPYSGAFPSTPVKELQLQVTYHKNEMLQFKIYDPNHSRYEVPVPLNIPSAPSSTPESRLYDVLIKENPFGIEIRRKGTGTVVWDSQLLGFTFSDMFIRISTRLPSTYIYGFGETEHTTFKIDMNWNKWGMFSRDEPPGYRKNSYGVHPYYMGLEEDGNAHGVLLMNSNAMDVTFQPMPALTYRTTGGILDFYVFLGPTPEFVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDSEIASLYDEMVDKKIPYDVQYSDIDYMERQLDFKLSPKFSGFPALINRMKANGMRVILILDPAISGNETEPYPAFTRGVENDVFIRYPNNGSIVWGKVWPDYPNITVDPSLGWDHQVEQYRAYVAFPDFFRNSTATWWKKEIKELHSNTQDPAKSLKFDGLWIDMNEPSSFVNGAVPSGCSDATLNHPPYMPYLEARDRGLSSKTLCMESEQILPDGSRVRHYDVHNLYGWSQTRPTYEAVQEVTGERGIVITRSTFPSSGRWGGHWLGDNTAAWDQLGKSIIGMMDFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWNKTFEDISRSVLETRYTLLPYLYTLMYKAHTEGSTVVRPLLHEFVSDRETWNIDKQFLLGPAFLVSPVLEPNARKVEAYFPRARWYDYYKGVDINATGEWKTLEAPLEYINLHIRGGYILPWQEPAMNTHLSRQKFMGLRAALNAEGRAEGWLFWDDGKRI", "length": 986, "header": "tr|A0A0J9YVJ0-1|A0A0J9YVJ0_MOUSE Computationally mapped isoform of Maltase-glucoamylase OS=Mus musculus OX=10090 GN=Mgam PE=1 SV=1 CANONICAL=A0A571BF69-1" }, "locus": { "chromosome": "6", "start_pos": 40741202, "end_pos": 40648828, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000202966.4", "url": "https://www.ensembl.org/id/ENSMUST00000202966.4" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000144680.2", "url": "https://www.ensembl.org/id/ENSMUSP00000144680.2" } ] } }, { "isoform_ac": "A0A571BF69-1", "url": "", "sequence": { "sequence": "MAGRRFKKFSKLELVLIVLLLVLFIIAVVLIVLLANSTPENAIGAETTGTPDTTVTRTTLNSPNCPVLSELERINCIPDQSSNKGTCDERGCCWDPQGSISVPCYYSRNHGYKMESDVVNTNAGFTATLKNLPSAPVFGNSIENILLTAEYQTSNRFHFKLTDQTKKRYEVPHEHVQPFSGNAPSSLNYKVEVSKEPFSIKVTRKSNNRVLFDSSIGPLLFSDQFLQFSTHLPSANVYGLGEHVHQQYRHNMNWKTWPMFSRDTTPNEDGTNLYGVQTFFLCLEDNSGLSFGVFLMNSNAMEVTLQPTPAITYRTTGGILDFYVFLGNTPEQVVQEYLELIGRPALPSYWTLGFQLSRYDYKSLDNMKAVVERNRAAQLPYDVQHADIDYMDQKKDFTYDPVNFKGFPEFVKELHNNGQKLVIILDPAISNNSFSSNPYGPYDRGSAMKIWVNSSDGISPVIGKVWPGTTVFPDYTSPNCAVWWTKEFELFHKEVEFDGIWIDMNEVSNFIDGSFSGCSQNNLNYPPFTPKVLDGYLFSKTLCMDAVQHWGKQYDVHNLYGYSMAIATAKAVKDVFPDKRSFIITRSTFAGSGKFAAHWLGDNTATWKDLQWSIPGMLEFNLFGIPMVGADICGFAQDTYEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFGNNSLLLNSSRHYLNIRYTLLPYLYTLFYRAHSRGDTVARPLLHEFYDDNNTWGIDRQFLWGPGLLITPVLDQGAEKVKAYVPNATWYDYETGEELGWRKQSIEMQLPGDKIGLHLRGGYIFPTQQPATTTEASRKNPLGLIVALDENKEARGELFWDDGESKDTVAQNIYLFSEFSVTQNHLDVTISSPNYKDPNNLEFQEIKIFGTREFRNVRVKQNGNLLQMSPQVTYNPNLKVATITNIHLRLGEAYTVEWDFFTREEERIDCYPDEHGASEANCSARGCIWEASNTTRGPPCYFAHELYSVSNVQYDSHGATADISLKASTYSNAFPSTPVNKLKLQVTYHKNEMLQFKIYDPNHSRYEVPVPLNIPSAPLSTPEGRLYDVLIKENPFGIQIRRKTTGTVIWDSQLLGFTFNDMFIRISTRLPSTYIYGFGETEHTTFKIDMNWHTWGMFSRDEPPGYKKNSYGVHPYYMGLEEDGNAHGVLLMNSNAMDVTFQPMPALTYRTIGGILDFYVFLGPTPEIVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDTEIANLYDEMVAKQIPYDVQYSDIDYMERQLDFKLSPKFSGFPALINRMKANGMRVILILDPAISGNETQPYPAFTQGVENDVFIRYPNNGGIVWGKVWPDYPNITVDSSLDWDIQVERYRAYVAFPDFFRDSTALWWKKEIKELHSNSQDQAKSLKFDGLWIDMNEPSSFVNGAVPSGCSDATLNHPPYMPHVEGRDRGLSSKTLCMESEHILPDGSRVRHYDVHSLYGWSQTRPTYEAMQEVTGERGIVITRSTFPSSGRWGGHWLGDNTAAWDQLGKSIIGMMDFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTKRQDPVSWDKTFEDISRSVLETRYTLLPYLYTLMYKAHKEGSTVVRPLLHEFLADRETWNIDKQFLLGPAFLVSPVLEPNARNVTAYFPKAQWYDYYTGADINSTGWTTLPAPLEHINLHVRGGYILPWQQPALNTNLSRKKPLGLLIALDEKKEARGELFWDDGQSKDTVAKNIYLFSEFSVTQNHLDVTISSPNYKDPNNLEFQEIKIFGTQEFSNVRVKQNGNLLQMSPQVTYNPNLKVATITNIHLRLGEAYTVEWGFFTREEERIDCYPDEHGASEANCSARGCIWEESNTIGVPTCYFAHELYSVSNVQYDSHGATADISLKASTYSNAFPSTPVNKLKLQVTYHKNEMLQFKIYDPNNSRYEVPVPLNIPSAPSSTNEGRLYDVLIKENPFGIQVRRKSTGTVIWDSQLLGFTFNDMFIRISTRLPSTYIYGFGETEHTTFKIDMNWHTWGMFSRDEPPGYKKNSYGVHPYYMGLEEDGNAHGVLLMNSNAMDVTFQPMPALTYRTTGGILDFYVLLGPTPEIVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDSEIASLYDEMVDKQIPYDVQYSDIDYMERQLDFKLSPKFSGFPALINRMKANGMRVILILDPAISGNETQPYPAFTRGVENDVFIRYPNNGSIVWGKVWPDYPNITVDPSLGWDHQVEQYRAYVAFPDFFRNSTATWWKKEIEELYTNTEEPEKSLKFDGLWIDMNEPSSFVNGAVPSGCSDATLNHPPYMPHVEGRDRGLSSKTLCMESEHILPDGSRVQHYDVHSLYGWSQTRPTYEAVQEVTGERGIVITRSTFPSSGRWGGHWLGDNTAAWDQLGKSIIGMMDFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTKRQDPVSWNKTFEDISRSVLETRYTLLPYLYTLMYKAHMEGSTVVRPLLHEFVSDRKTWNIDKQFLLGPAFLVSPVLEPNARNISAYFPTALWYDYYTGANINSTGEWKTLPAPLEHINLHVRGGYILPWQRPALNTHLSRKNPLGLLIALDENKEARGELFWDDGQSKDLTTNNILCKFSVTQNRLDVSTLQSTYMNPDNLAFQEIKIFGTRPLYNVTVKHNGMVNQMAPQVSYDPSMKVAVITGLQLLLNESYTVEWDDSIRDEEKIDCYPDQHGASETSCTARGCVWEESNSDVVPFCYFVNELYSVSNVQYGSHGATANISLKASPYSGAFPSTPVKELQLQVTYHKNEMLQFKIYDPNHSRYEVPVPLNIPSAPSSTPESRLYDVLIKENPFGIEIRRKGTGTVVWDSQLLGFTFSDMFIRISTRLPSTYIYGFGETEHTTFKIDMNWNKWGMFSRDEPPGYRKNSYGVHPYYMGLEEDGNAHGVLLMNSNAMDVTFQPMPALTYRTTGGILDFYVFLGPTPEFVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDSEIASLYDEMVDKKIPYDVQYSDIDYMERQLDFKLSPKFSGFPALINRMKANGMRVILILDPAISGNETEPYPAFTRGVENDVFIRYPNNGSIVWGKVWPDYPNITVDPSLGWDHQVEQYRAYVAFPDFFRNSTATWWKKEIKELHSNTQDPAKSLKFDGLWIDMNEPSSFVNGAVPSGCSDATLNHPPYMPYLEARDRGLSSKTLCMESEQILPDGSRVRHYDVHNLYGWSQTRPTYEAVQEVTGERGIVITRSTFPSSGRWGGHWLGDNTAAWDQLGKSIIGMMDFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWNKTFEDISRSVLETRYTLLPYLYTLMYKAHTEGSTVVRPLLHEFVSDRETWNIDKQFLLGPAFLVSPVLEPNARKVEAYFPRARWYDYYKGVDINATGEWKTLEAPLEYINLHIRGGYILPWQEPAMNTHLSRQKFMGLRAALNAEGRAEGWLFWDDGKRINTDQYYLARFSVNQTTLLTHEKFNNYLTGTAPLYLGYIDIWGLSSSSITNVSISWNTNNEEVFANYNSTTKILSVNMTDKKISLHTFNSLTWSSS", "length": 3616, "header": "tr|A0A571BF69-1|A0A571BF69_MOUSE Isoform 1 of Maltase-glucoamylase OS=Mus musculus OX=10090 GN=Mgam PE=1 SV=1 CANONICAL=A0A571BF69-1" }, "locus": { "chromosome": "6", "start_pos": 40745215, "end_pos": 40619913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238599.2", "url": "https://www.ensembl.org/id/ENSMUST00000238599.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158794.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158794.2" } ] } }, { "isoform_ac": "B5THE2-1", "url": "", "sequence": { "sequence": "MAGRRFKKFSKLELVLIVLLLVLFIIAVVLIVLLANSTPENAIGAETTGTPDTTVTRTTLNSPNCPVLSELERINCIPDQSSNKGTCDERGCCWDPQGSISVPCYYSRNHGYKMESDVVNTNAGFTATLKNLPSAPVFGNSIENILLTAEYQTSNRFHFKLTDQTKKRYEVPHEHVQPFSGNAPSSLNYKVEVSKEPFSIKVTRKSNNRVLFDSSIGPLLFSDQFLQFSTHLPSANVYGLGEHVHQQYRHNMNWKTWPMFSRDTTPNEDGTNLYGVQTFFLCLEDNSGLSFGVFLMNSNAMEVTLQPTPAITYRTTGGILDFYVFLGNTPEQVVQEYLELIGRPALPSYWTLGFQLSRYDYKSLDNMKAVVERNRAAQLPYDVQHADIDYMDQKKDFTYDPVNFKGFPEFVKELHNNGQKLVIILDPAISNNSFSSNPYGPYDRGSAMKIWVNSSDGISPVIGKVWPGTTVFPDYTSPNCAVWWTKEFELFHKEVEFDGIWIDMNEVSNFIDGSFSGCSQNNLNYPPFTPKVLDGYLFSKTLCMDAVQHWGKQYDVHNLYGYSMAIATAKAVKDVFPDKRSFIITRSTFAGSGKFAAHWLGDNTATWKDLQWSIPGMLEFNLFGIPMVGADICGFAQDTYEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFGNNSLLLNSSRHYLNIRYTLLPYLYTLFYRAHSRGDTVARPLLHEFYDDNNTWGIDRQFLWGPGLLITPVLDQGAEKVKAYVPNATWYDYETGEELGWRKQSIEMQLPGDKIGLHLRGGYIFPTQQPATTTEASRKNPLGLIVALDENKEARGELFWDDGESKDTVAQNIYLFSEFSVTQNHLDVTISSPNYKDPNNLEFQEIKIFGTREFRNVRVKQNGNLLQMSPQVTYNPNLKVATITNIHLRLGEAYTVEWDFFTREEERIDCYPDEHGASEANCSARGCIWEASNTTRGPPCYFAHELYSVSNVQYDSHGATADISLKASTYSNAFPSTPVNKLKLQVTYHKNEMLQFKIYDPNHSRYEVPVPLNIPSAPLSTPEGRLYDVLIKENPFGIQIRRKTTGTVIWDSQLLGFTFNDMFIRISTRLPSTYIYGFGETEHTTFKIDMNWHTWGMFSRDEPPGYKKNSYGVHPYYMGLEEDGNAHGVLLMNSNAMDVTFQPMPALTYRTIGGILDFYVFLGPTPEIVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDTEIANLYDEMVAKQIPYDVQYSDIDYMERQLDFKLSPKFSGFPALINRMKANGMRVILILDPAISGNETEPYPAFTRGVENDVFIRYPNNGSIVWGKVWPDYPNITVDPSLGWDHQVEQYRAYVAFPDFFRNSTATWWKKEIKELHSNTQDPAKSLKFDGLWIDMNEPSSFVNGAVPSGCSDATLNHPPYMPYLEARDRGLSSKTLCMESEQILPDGSRVRHYDVHNLYGWSQTRPTYEAVQEVTGERGIVITRSTFPSSGRWGGHWLGDNTAAWDQLGKSIIGMMDFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWNKTFEDISRSVLETRYTLLPYLYTLMYKAHTEGSTVVRPLLHEFVSDRETWNIDKQFLLGPAFLVSPVLEPNARKVEAYFPRARWYDYYKGVDINATGEWKTLEAPLEYINLHIRGGYILPWQEPAMNTHLSRQKFMGLRAALNAEGRAEGWLFWDDGKRINTDQYYLARFSVNQTTLLTHEKFNNYLTGTAPLYLGYIDIWGLSSSSITNVSISWNTNNEEVFANYNSTTKILSVNMTDKKISLHTFNSLTWSSS", "length": 1827, "header": "tr|B5THE2-1|B5THE2_MOUSE Computationally mapped isoform of Maltase-glucoamylase OS=Mus musculus OX=10090 GN=Mgam PE=1 SV=1 CANONICAL=A0A571BF69-1" }, "locus": { "chromosome": "6", "start_pos": 40745215, "end_pos": 40619913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000201148.4", "url": "https://www.ensembl.org/id/ENSMUST00000201148.4" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000143946.2", "url": "https://www.ensembl.org/id/ENSMUSP00000143946.2" } ] } }, { "isoform_ac": "Q6XK23-1", "url": "", "sequence": { "sequence": "MRNKAIGAETTGTPDTTVTRTTLNSPNCPVLSELERINCIPDQSSNKGTCDERGCCWDPQGSISVPCYYSRNHGYKMESDVVNTNAGFTATLKNLPSAPVFGNSIENILLTAEYQTSNRFHFKLTDQTKKRYEVPHEHVQPFSGNAPSSLNYKVEVSKEPFSIKVTRKSNNRVLFDSSIGPLLFSDQFLQFSTHLPSANVYGLGEHVHQQYRHNMNWKTWPMFSRDTTPNEDGTNLYGVQTFFLCLEDNSGLSFGVFLMNSNAMEVTLQPTPAITYRTTGGILDFYVFLGNTPEQVVQEYLELIGRPALPSYWTLG", "length": 316, "header": "tr|Q6XK23-1|Q6XK23_MOUSE Computationally mapped isoform of Soluble maltase-glucoamylase OS=Mus musculus OX=10090 GN=Mgam PE=1 SV=1 CANONICAL=A0A571BF69-1" }, "locus": { "chromosome": "6", "start_pos": 40635905, "end_pos": 40605917, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000202636.4", "url": "https://www.ensembl.org/id/ENSMUST00000202636.4" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000144652.2", "url": "https://www.ensembl.org/id/ENSMUSP00000144652.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Contribution of mucosal maltase-glucoamylase activities to mouse small intestinal starch alpha-glucogenesis.", "journal": "The Journal of nutrition", "date": "2007", "authors": "Quezada-Calvillo R, Robayo-Torres CC, Opekun AR, Sen P, Ao Z, Hamaker BR, Quaroni A, Brayer GD, Wattler S, Nehls MC, Sterchi EE, Nichols BL", "evidence": [ { "database": "RefSeq", "id": "NP_001164474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164474" } ], "reference": [ { "type": "PubMed", "id": "17585022", "url": "https://glygen.org/publication/PubMed/17585022" } ] }, { "title": "Mucosal maltase-glucoamylase plays a crucial role in starch digestion and prandial glucose homeostasis of mice.", "journal": "The Journal of nutrition", "date": "2009", "authors": "Nichols BL, Quezada-Calvillo R, Robayo-Torres CC, Ao Z, Hamaker BR, Butte NF, Marini J, Jahoor F, Sterchi EE", "evidence": [ { "database": "RefSeq", "id": "NP_001164474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164474" } ], "reference": [ { "type": "PubMed", "id": "19193815", "url": "https://glygen.org/publication/PubMed/19193815" } ] }, { "title": "The regulation of jejunal induction of the maltase-glucoamylase gene by a high-starch/low-fat diet in mice.", "journal": "Molecular nutrition & food research", "date": "2010", "authors": "Mochizuki K, Honma K, Shimada M, Goda T", "evidence": [ { "database": "RefSeq", "id": "NP_001164474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164474" } ], "reference": [ { "type": "PubMed", "id": "20425755", "url": "https://glygen.org/publication/PubMed/20425755" } ] } ], "pathway": [ { "id": "mmu:232714", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:232714", "resource": "KEGG Pathway" }, { "id": "R-MMU-189085", "name": "Digestion of dietary carbohydrate", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-189085", "resource": "Reactome", "description": "Digestion of dietary carbohydrate" }, { "id": "R-MMU-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "O43451-2", "protein_name": "Maltase-glucoamylase", "gene_name": "MGAM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARKKLKKFTTLEIVLSVLLLVLFIISIVLIVLLAKESLKSTAPDPGTTGTPDPGTTGTPDPGTTGTTHARTTGPPDPGTTGTTPVSAECPVVNELERINCIPDQPPTKATCDQRGCCWNPQGAVSVPWCYYSKNHSYHVEGNLVNTNAGFTARLKNLPSSPVFGSNVDNVLLTAEYQTSNRFHFKLTDQTNNRFEVPHEHVQSFSGNAAASLTYQVEISRQPFSIKVTRRSNNRVLFDSSIGPLLFADQFLQLSTRLPSTNVYGLGEHVHQQYRHDMNWKTWPIFNRDTTPNGNGTNLYGAQTFFLCLEDASGLSFGVFLMNSNAMEVVLQPAPAITYRTIGGILDFYVFLGNTPEQVVQEYLELIGRPALPSYWALGFHLSRYEYGTLDNMREVVERNRAAQLPYDVQHADIDYMDERRDFTYDSVDFKGFPEFVNELHNNGQKLVIIVDPAISNNSSSSKPYGPYDRGSDMKIWVNSSDGVTPLIGEVWPGQTVFPDYTNPNCAVWWTKEFELFHNQVEFDGIWIDMNEVSNFVDGSVSGCSTNNLNNPPFTPRILDGYLFCKTLCMDAVQHWGKQYDIHNLYGYSMAVATAEAAKTVFPNKRSFILTRSTFAGSGKFAAHWLGDNTATWDDLRWSIPGVLEFNLFGIPMVGPDICGFALDTPEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFGADSLLLNSSRHYLNIRYTLLPYLYTLFFRAHSRGDTVARPLLHEFYEDNSTWDVHQQFLWGPGLLITPVLDEGAEKVMAYVPDAVWYDYETGSQVRWRKQKVEMELPGDKIGLHLRGGYIFPTQQPNTTTLASRKNPLGLIIALDENKEAKGELFWDNGETKDTVANKVYLLCEFSVTQNRLEVNISQSTYKDPNNLAFNEIKILGTEEPSNVTVKHNGVPSQTSPTVTYDSNLKVAIITDIDLLLGEAYTVEWSIKIRDEEKIDCYPDENGASAENCTARGCIWEASNSSGVPFCYFVNDLYSVSDVQYNSHGATADISLKSSVYANAFPSTPVNPLRLDVTYHKNEMLQFKIYDPNKNRYEVPVPLNIPSMPSSTPEGQLYDVLIKKNPFGIEIRRKSTGTIIWDSQLLGFTFSDMFIRISTRLPSKYLYGFGETEHRSYRRDLEWHTWGMFSRDQPPGYKKNSYGVHPYYMGLEEDGSAHGVLLLNSNAMDVTFQPLPALTYRTTGGVLDFYVFLGPTPELVTQQYTELIGRPVMVPYWSLGFQLCRYGYQNDSEIASLYDEMVAAQIPYDVQYSDIDYMERQLDFTLSPKFAGFPALINRMKADGMRVILILDPAISGNETQPYPAFTRGVEDDVFIKYPNDGDIVWGKVWPDFPDVVVNGSLDWDSQVELYRAYVAFPDFFRNSTAKWWKREIEELYNNPQNPERSLKFDGMWIDMNEPSSFVNGAVSPGCRDASLNHPPYMPHLESRDRGLSSKTLCMESQQILPDGSLVQHYNVHNLYGWSQTRPTYEAVQEVTGQRGVVITRSTFPSSGRWAGHWLGDNTAAWDQLKKSIIGMMEFSLFGISYTGADICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWDAAFVNISRNVLQTRYTLLPYLYTLMQKAHTEGVTVVRPLLHEFVSDQVTWDIDSQFLLGPAFLVSPVLERNARNVTAYFPRARWYDYYTGVDINARGEWKTLPAPLDHINLHVRGGYILPWQEPALNTHLSRKNPLGLIIALDENKEAKGELFWDDGQTKDTVAKKVYLLCEFSVTQNHLEVTISQSTYKDPNNLAFNEIKILGMEEPSNVTVKHNGVPSQTSPTVTYDSNLKVAIITDINLFLGEAYTVEWSIKIRDEEKIDCYPDENGDSAENCTARGCIWEASNSSGVPFCYFVNDLYSVSDVQYNSHGATADISLKSSVHANAFPSTPVNPLRLDVTYHKNEMLQFKIYDPNNNRYEVPVPLNIPSVPSSTPEGQLYDVLIKKNPFGIEIRRKSTGTIIWDSQLLGFTFNDMFIRISTRLPSKYLYGFGETEHTSYRRDLEWHTWGMFSRDQPPGYKKNSYGVHPYYMGLEEDGSAHGVLLLNSNAMDVTFQPLPALTYRTTGGVLDFYVFLGPTPELVTQQYTELIGRPVMVPYWSLGFQLCRYGYQNDSEISSLYDEMVAAQIPYDVQYSDIDYMERQLDFTLSPKFAGFPALINRMKADGMRVILILDPAISGNETQPYPAFTRGVEDDVFIKYPNDGDIVWGKVWPDFPDVVVNGSLDWDSQVELYRAYVAFPDFFRNSTAKWWKREIEELYNNPQNPERSLKFDGMWIDMNEPSSFVNGAVSPGCRDASLNHPPYMPYLESRDRGLSSKTLCMESQQILPDGSPVQHYNVHNLYGWSQTRPTYEAVQEVTGQRGVVITRSTFPSSGRWAGHWLGDNTAAWDQLKKSIIGMMEFSLFGISYTGADICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWDVAFVNISRTVLQTRYTLLPYLYTLMHKAHTEGVTVVRPLLHEFVSDQVTWDIDSQFLLGPAFLVSPVLERNARNVTAYFPRARWYDYYTGVDINARGEWKTLPAPLDHINLHVRGGYILPWQEPALNTHLSRQKFMGFKIALDDEGTAGGWLFWDDGQSIDTYGKGLYYLASFSASQNTMQSHIIFNNYITGTNPLKLGYIEIWGVGSVPVTSVSISVSGMVITPSFNNDPTTQVLSIDVTDRNISLHNFTSLTWISTL", 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