{ "uniprot_canonical_ac": "A0A494BAW1-1", "uniprot_ac": "A0A494BAW1", "uniprot_id": "A0A494BAW1_MOUSE", "mass": { "chemical_mass": 174547.0, "monoisotopic_mass": 174547.0 }, "refseq": { "ac": "XP_006499173", "name": "dual oxidase 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006499173" }, "gene_names": [ { "name": "Duox2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A494BAW1", "id": "A0A494BAW1" } ], "protein_names": [ { "name": "NAD(P)H oxidase (H2O2-forming)", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A494BAW1" }, { "name": "1.6.3.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A494BAW1" }, { "name": "dual oxidase 2 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006499173", "id": "XP_006499173" } ], "function": [ { "annotation": "Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1#function" }, { "database": "UniProtKB", "id": "ARBA00003796", "url": "https://www.uniprot.org/uniprot/ARBA00003796#function" }, { "database": "UniProtKB", "id": "A2AQ99", "url": "https://www.uniprot.org/uniprot/A2AQ99#function" } ] } ], "disease": [ { "disease_id": "DOID:0050328", "recommended_name": { "id": "DOID:0050328", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050328", "name": "congenital hypothyroidism", "description": "A hypothyroidism that is present at birth." }, "synonyms": [ { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "hypothyroidism due to TSH receptor mutations", "description": "Hypothyroidism due to thyroid-stimulating hormone (TSH) receptor mutations is a type of primary congenital hypothyroidism, a permanent thyroid hormone deficiency that is present from birth due to thyroid resistance to TSH." }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "CHNG1", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "TSH resistance", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "hypothyroidism, congenital, nongoitrous, type 1", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "congenital nongoitrous hypothryoidism 1", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "congenital nongoitrous hypothyroidism 1", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "hypothyroidism due to unresponsiveness to thyrotropin", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "hypothyroidism, Nonautoimmune", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "hypothyroidism, congenital, due to TSH resistance", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "hypothyroidism, congenital, nongoitrous, 1", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "thyroid-stimulating hormone, resistance to", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "thyrotropin resistance", "description": "" }, { "id": "MIM:275200", "resource": "MIM", "url": "https://www.omim.org/entry/275200", "name": "Hypothyroidism, congenital, non-goitrous, 1", "description": "Hypothyroidism, congenital, non-goitrous, 1" } ], "evidence": [ { "id": "0050328", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050328" } ] }, { "disease_id": "DOID:0050338", "recommended_name": { "id": "DOID:0050338", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050338", "name": "primary bacterial infectious disease", "description": "A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread." }, "synonyms": [], "evidence": [ { "id": "0050338", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050338" } ] }, { "disease_id": "DOID:0112189", "recommended_name": { "id": "DOID:0112189", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112189", "name": "thyroid dyshormonogenesis 6", "description": "A familial thyroid dyshormonogenesis that has_material_basis_in homozygous or compound heterozygous mutation in DUOX2 on chromosome 15q21.1." }, "synonyms": [ { "id": "DOID:0112189", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112189", "name": "TDH6", "description": "" }, { "id": "DOID:0112189", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112189", "name": "genetic defect in thyroid hormonogenesis 6", "description": "" }, { "id": "MONDO:0011792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011792", "name": "thyroid dyshormonogenesis 6", "description": "Any familial thyroid dyshormonogenesis in which the cause of the disease is a mutation in the DUOX2 gene." }, { "id": "MONDO:0011792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011792", "name": "DUOX2 familial thyroid dyshormonogenesis", "description": "" }, { "id": "MONDO:0011792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011792", "name": "familial thyroid dyshormonogenesis caused by mutation in DUOX2", "description": "" }, { "id": "MONDO:0011792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011792", "name": "thyroid dyshormonogenesis 6", "description": "" }, { "id": "MONDO:0011792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011792", "name": "thyroid dyshormonogenesis type 6", "description": "" }, { "id": "MONDO:0011792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011792", "name": "TDH6", "description": "" }, { "id": "MONDO:0011792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011792", "name": "hypothyroidism, congenital, due to dyshormonogenesis, 6", "description": "" }, { "id": "MONDO:0011792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011792", "name": "thyroid hormonogenesis, genetic defect in, 6", "description": "" }, { "id": "MIM:607200", "resource": "MIM", "url": "https://www.omim.org/entry/607200", "name": "Thyroid dyshormonogenesis 6", "description": "Thyroid dyshormonogenesis 6" } ], "evidence": [ { "id": "0112189", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0112189" } ] }, { "disease_id": "DOID:1459", "recommended_name": { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "hypothyroidism", "description": "A thyroid gland disease which involves an underproduction of thyroid hormone." }, "synonyms": [ { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "Thyroid deficiency", "description": "" }, { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "Thyroid insufficiency", "description": "" } ], "evidence": [ { "id": "1459", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1459" } ] }, { "disease_id": "DOID:1498", "recommended_name": { "id": "DOID:1498", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1498", "name": "cholera", "description": "A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock." }, "synonyms": [ { "id": "DOID:1498", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1498", "name": "Cholera - Vibrio cholerae", "description": "" }, { "id": "DOID:1498", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1498", "name": "Cholera due to Vibrio cholerae", "description": "" }, { "id": "DOID:1498", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1498", "name": "Vibrio cholerae", "description": "" } ], "evidence": [ { "id": "1498", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1498" } ] }, { "disease_id": "DOID:8577", "recommended_name": { "id": "DOID:8577", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8577", "name": "ulcerative colitis", "description": "A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores." }, "synonyms": [ { "id": "DOID:8577", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8577", "name": "Left-sided ulcerative colitis", "description": "" } ], "evidence": [ { "id": "8577", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:8577" } ] }, { "disease_id": "DOID:8778", "recommended_name": { "id": "DOID:8778", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8778", "name": "Crohn's disease", "description": "An intestinal disease that involves inflammation located_in intestine." }, "synonyms": [ { "id": "DOID:8778", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8778", "name": "Crohn disease", "description": "" }, { "id": "DOID:8778", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8778", "name": "Crohn's disease of colon", "description": "" }, { "id": "DOID:8778", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8778", "name": "Crohn's disease of large bowel", "description": "" }, { "id": "DOID:8778", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8778", "name": "Granulomatous Colitis", "description": "" }, { "id": "DOID:8778", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8778", "name": "Pediatric Crohn's disease", "description": "" } ], "evidence": [ { "id": "8778", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:8778" } ] }, { "disease_id": "DOID:9281", "recommended_name": { "id": "DOID:9281", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9281", "name": "phenylketonuria", "description": "An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional." }, "synonyms": [ { "id": "DOID:9281", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9281", "name": "Folling's disease", "description": "" }, { "id": "DOID:9281", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9281", "name": "PKU", "description": "" }, { "id": "DOID:9281", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9281", "name": "maternal phenylketonuria", "description": "" }, { "id": "DOID:9281", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9281", "name": "phenylalaninemia", "description": "" }, { "id": "MONDO:0009861", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009861", "name": "phenylketonuria", "description": "Phenylketonuria (PKU) is the most common inborn error of amino acid metabolism and is characterized by mild to severe mental disability in untreated patients." }, { "id": "MONDO:0009861", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009861", "name": "PAH deficiency", "description": "" }, { "id": "MONDO:0009861", "resource": 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"https://www.reactome.org/PathwayBrowser/#R-MMU-209968", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_006499173", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006499173", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11260", "url": "https://www.rhea-db.org/rhea/11260", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "11264", "url": "https://www.rhea-db.org/rhea/11264", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BAW1-1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AQ99", "url": "https://www.uniprot.org/uniprot/A2AQ99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AQ99-1", "url": "https://www.uniprot.org/uniprot/A2AQ99-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPTSPKTLVLLGALLTGPLGPAGGQDAPSLPWEVQRYDGWFNNLKYHQRGAAGSRLRRLIPANYADGVYQALEEPLLPNPRRLSDAVAKGKAGLPSVHNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLPFQRSRWDHNTGQSPSNPRDQSNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPRNSQSSLLMWMAPDPSTGRGGPQGVYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELFQHARKRVIATYQNIALYQWLPSFLQKTPPEYSGYRPFMDPSISPEFVVASEQFLSTMVPPGVYMRNSSCHFRKFPKEGSDSSPALRVCNSYWIRENPNLKTAQDVDQLLLGMASQISELEDRIVIEDLRDYWPGPERFSRTDYVASSIQRGRDMGLPSYSQALLALGLEPPKNWSALNPQVEPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSNIILDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTTLRDVLVAVSNVDPSALQPNVFFWQEGAPCPQPRQLTTDGLPQCAPVTVIDYFEGSGAGYGVTLVAVCCFPLVSLIVAGVVAHFRNREHKMLLKKGKESLKKQPASDGVPAMEWPGPKEKSYPVTLQLLPDRSLQVLDKRFTVLRTIQLQSPQQVNLILSSNSGRRTLLLKIPKEYDLVLMFNSEEDRGAFVRLLQDLCICCTPGLHIAEVDEKELLRKAVTKQQRAGILEIFFRQLFAQVLDINQADAGTLPLDSSQQVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYISFREFLDILVVFMKGSSEDKSRLMFTMYDLDGNGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGGAGGTKDIFKQSSACRVSFINRTPGNSSCPPETALSDMETPELGSTGLKKRFGKKVMGPSPRLYTEALQEKKQSGFLAQKFKQYKRFVENYRRHIVCVTIFSAICIGLFADRAYYYGFASPPTDIEETTYVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRWIAMAAVVLAVLHSAGHAVNVYIFSVSPLSLMACVFPNVFVNDGSKFPPKYYWWFFETVPGMTGVLLLLVLAIMYVFASHHFRRHSFRGFWLTHHLYVVLYVLIIIHGSYALIQLPSFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPKTFEYKSGQWVRIACLDLGTNEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSPPVGGTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSMGSQMLCKKIYFIWVTRTQRQFEWLADIIREVEENDCQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKALNRSLFTGLRSITHFGRPPFELFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRAHFVHHYENF", "length": 1545, "header": "tr|A0A494BAW1-1|A0A494BAW1_MOUSE Isoform 1 of NAD(P)H oxidase (H2O2-forming) OS=Mus musculus OX=10090 GN=Duox2 PE=1 SV=1 CANONICAL=A0A494BAW1-1" }, "isoforms": [ { "isoform_ac": "A0A494BAW1-1", "url": "", "sequence": { "sequence": "MLPTSPKTLVLLGALLTGPLGPAGGQDAPSLPWEVQRYDGWFNNLKYHQRGAAGSRLRRLIPANYADGVYQALEEPLLPNPRRLSDAVAKGKAGLPSVHNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLPFQRSRWDHNTGQSPSNPRDQSNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPRNSQSSLLMWMAPDPSTGRGGPQGVYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELFQHARKRVIATYQNIALYQWLPSFLQKTPPEYSGYRPFMDPSISPEFVVASEQFLSTMVPPGVYMRNSSCHFRKFPKEGSDSSPALRVCNSYWIRENPNLKTAQDVDQLLLGMASQISELEDRIVIEDLRDYWPGPERFSRTDYVASSIQRGRDMGLPSYSQALLALGLEPPKNWSALNPQVEPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSNIILDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTTLRDVLVAVSNVDPSALQPNVFFWQEGAPCPQPRQLTTDGLPQCAPVTVIDYFEGSGAGYGVTLVAVCCFPLVSLIVAGVVAHFRNREHKMLLKKGKESLKKQPASDGVPAMEWPGPKEKSYPVTLQLLPDRSLQVLDKRFTVLRTIQLQSPQQVNLILSSNSGRRTLLLKIPKEYDLVLMFNSEEDRGAFVRLLQDLCICCTPGLHIAEVDEKELLRKAVTKQQRAGILEIFFRQLFAQVLDINQADAGTLPLDSSQQVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYISFREFLDILVVFMKGSSEDKSRLMFTMYDLDGNGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGGAGGTKDIFKQSSACRVSFINRTPGNSSCPPETALSDMETPELGSTGLKKRFGKKVMGPSPRLYTEALQEKKQSGFLAQKFKQYKRFVENYRRHIVCVTIFSAICIGLFADRAYYYGFASPPTDIEETTYVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRWIAMAAVVLAVLHSAGHAVNVYIFSVSPLSLMACVFPNVFVNDGSKFPPKYYWWFFETVPGMTGVLLLLVLAIMYVFASHHFRRHSFRGFWLTHHLYVVLYVLIIIHGSYALIQLPSFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPKTFEYKSGQWVRIACLDLGTNEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSPPVGGTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSMGSQMLCKKIYFIWVTRTQRQFEWLADIIREVEENDCQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKALNRSLFTGLRSITHFGRPPFELFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRAHFVHHYENF", "length": 1545, "header": "tr|A0A494BAW1-1|A0A494BAW1_MOUSE Isoform 1 of NAD(P)H oxidase (H2O2-forming) OS=Mus musculus OX=10090 GN=Duox2 PE=1 SV=1 CANONICAL=A0A494BAW1-1" }, "locus": { "chromosome": "2", "start_pos": 122128646, "end_pos": 122110921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000237546.2", "url": "https://www.ensembl.org/id/ENSMUST00000237546.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158204.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158204.2" } ] } }, { "isoform_ac": "A2AQ99-1", "url": "", "sequence": { "sequence": "MLPTSPKTLVLLGALLTGPLGPAGGQDAPSLPWEVQRYDGWFNNLKYHQRGAAGSRLRRLIPANYADGVYQALEEPLLPNPRRLSDAVAKGKAGLPSVHNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLPFQRSRWDHNTGQSPSNPRDQSNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPRNSQSSLLMWMAPDPSTGRGGPQGVYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELFQHARKRVIATYQNIALYQWLPSFLQKTPPEYSGYRPFMDPSISPEFVVASEQFLSTMVPPGVYMRNSSCHFRKFPKEGSDSSPALRVCNSYWIRENPNLKTAQDVDQLLLGMASQISELEDRIVIEDLRDYWPGPERFSRTDYVASSIQRGRDMGLPSYSQALLALGLEPPKNWSALNPQVEPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSNIILDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTTLRDVLVAVSNVDPSALQPNVFFWQEGAPCPQPRQLTTDGLPQCAPVTVIDYFEGSGAGYGVTLVAVCCFPLVSLIVAGVVAHFRNREHKMLLKKGKESLKKQPASDGVPAMEWPGPKEKSYPVTLQLLPDRSLQVLDKRFTVLRTIQLQSPQQVNLILSSNSGRRTLLLKIPKEYDLVLMFNSEEDRGAFVRLLQDLCICCTPGLHIAEVDEKELLRKAVTKQQRAGILEIFFRQLFAQVLDINQADAGTLPLDSSQQVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYISFREFLDILVVFMKGSSEDKSRLMFTMYDLDGNGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGGAGGTKDIFKQSSACRVSFINRTPGNRVMGPSPRLYTEALQEKKQSGFLAQKFKQYKRFVENYRRHIVCVTIFSAICIGLFADRAYYYGFASPPTDIEETTYVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRWIAMAAVVLAVLHSAGHAVNVYIFSVSPLSLMACVFPNVFVNDGSKFPPKYYWWFFETVPGMTGVLLLLVLAIMYVFASHHFRRHSFRGFWLTHHLYVVLYVLIIIHGSYALIQLPSFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPKTFEYKSGQWVRIACLDLGTNEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSPPVGGTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSMGSQMLCKKIYFIWVTRTQRQFEWLADIIREVEENDCQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKALNRSLFTGLRSITHFGRPPFELFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRAHFVHHYENF", "length": 1517, "header": "tr|A2AQ99-1|A0A494BAW1_MOUSE Computationally mapped isoform of NAD(P)H oxidase (H2O2-forming) OS=Mus musculus OX=10090 GN=Duox2 PE=1 SV=1 CANONICAL=A0A494BAW1-1" }, "locus": { "chromosome": "2", "start_pos": 122128646, "end_pos": 122110921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000053734.6", "url": "https://www.ensembl.org/id/ENSMUST00000053734.6" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000050314.6", "url": "https://www.ensembl.org/id/ENSMUSP00000050314.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-MMU-209968", "name": "Thyroxine biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-209968", "resource": "Reactome", "description": "Thyroxine biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9ES45-1", "protein_name": "Dual oxidase 2", "gene_name": "Duox2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLPTSLKTLVLLGALLTGPLGPAGGQDAPSLPREVQRYDGWFNNLKYHQRGAAGSQLRRLVPANYADGVYQALQEPLLPNARLLSDAVSKGKAGLPSAHNRTVLGLFFGYHVLSDLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLPFQRSRWDRSTGQSPSNPRDLTNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPRNSQNSLLMWMAPDPATGQGGPQGLYAFGAQRGNREPFLQALGLLWFRYHNLCAKRLAQEHPHWGDEELFQHARKRVIATYQNIALYQWLPSFLQKTPPEYSGYRPFMDPSISPEFVAASEQFLSTMVPPGVYMRNSSCHFREFPKEGSSSSPALRVCNNYWIRENPSLKTAQDVDQLLLGMASQISELEDRIVIEDLRDYWPGPDRYSRTDYVASSIQSGRDMGLPSYSQALQALGLEPPKNWSALNPKVDPQVLEATAALYNQDLSRLELFLGGLLESHGDPGPLFSNIILDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTTLRDVLVAVSNVDPSALQPNVFFWQEGAPCPQPQQLTTEGLPQCVPVTVIDYFEGSGAGYGVTLLAVCCFPVVSLIIAWVVARFRNRERKMLLKKGKESLKKQTASDGVPAMEWPGPKESSYPVTVQLLPDRSLKVLDKRLTVLRTIQLQPTQQVNLILSSSHGRRTLLLKIPKEYDLVLMFNSEEDRDAFVQLLQDLCVCSTPGLRIAEMDEKELLRKAVTKQQRAGILEIFFRQLFAQVLDINQADAGTLPLDSSQQVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYISFREFLDILVVFMKGSPQDKSRLMFTMYDLDGNGFLSKEEFFTMMRSFIEISNNCLSKDQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGGAGGTGDIFKQSNACRVSFLTRTPGNRVMAPSPRLYTEALQEKMQRGFLAQKLKQFKRFVENYRRHIVCVTIFSAICAGLFADRAYYYGFASPPTDIEETTYVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRWIAMAAVVLAVVHSLGHAVNVYIFSVSPLSLMTCVFPSVFVNDGSKLPPKYYWWFFETVPGMTGVLLLLVLAIMYVFASHHFRRHSFRGFWLTHHLYVVLYALIIIHGSYALIQLPSFHIYFLVPAIIYVGDKLVSLSRKKVEISVVKVELLPSGVTYLQFQRPKTFEYKSGQWVRIACLSLGTNEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSPPVGGTSARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSMGTQMLCKKIYFIWVTRTQRQFEWLADIIREVEENGSRDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSVTHFGRPPFELFLDSLQEVHPQVHKIGVFSCGPPGMTKNVEKACQLINRQDRAHFVHHYENF", "length": 1517 }, "evidence": [ { "id": "45230205", "url": "http://www.informatics.jax.org/homology/45230205", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NRD8-1", "protein_name": "Dual oxidase 2", "gene_name": "DUOX2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF", "length": 1548 }, "evidence": [ { "id": "45230205", "url": "http://www.informatics.jax.org/homology/45230205", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 20, "go_terms": [ { "name": "thyroid gland development", "id": "GO:0030878", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030878", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "adenohypophysis morphogenesis", "id": "GO:0048855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048855", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "defense response", "id": "GO:0006952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006952", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "fertilization", "id": "GO:0009566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "multicellular organism growth", "id": "GO:0035264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035264", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "response to virus", "id": "GO:0009615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009615", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "positive regulation of wound healing", "id": "GO:0090303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090303", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "hormone biosynthetic process", "id": "GO:0042446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042446", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "hydrogen peroxide biosynthetic process", "id": "GO:0050665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050665", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "hormone metabolic process", "id": "GO:0042445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042445", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "hydrogen peroxide catabolic process", "id": "GO:0042744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042744", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "response to cAMP", "id": "GO:0051591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051591", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "positive regulation of cell motility", "id": "GO:2000147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000147", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "inner ear development", "id": "GO:0048839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048839", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "bone mineralization", "id": "GO:0030282", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030282", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "thyroid hormone generation", "id": "GO:0006590", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006590", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "thyroid hormone metabolic process", "id": "GO:0042403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042403", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "superoxide anion generation", "id": "GO:0042554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042554", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "NADPH oxidase complex", "id": "GO:0043020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043020", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "cell leading edge", "id": "GO:0031252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031252", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "apical part of cell", "id": "GO:0045177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "NAD(P)H oxidase H2O2-forming activity", "id": "GO:0016174", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016174", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "peroxidase activity", "id": "GO:0004601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004601", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" }, { "name": "superoxide-generating NAD(P)H oxidase activity", "id": "GO:0016175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016175", "evidence": [ { "database": "UniProtKB", "id": "A0A494BAW1", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1474, "end_pos": 1476, "annotation": "n_glycosylation_sequon" }, { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 455, "end_pos": 457, "annotation": "n_glycosylation_sequon" }, { "start_pos": 537, "end_pos": 539, "annotation": "n_glycosylation_sequon" }, { "start_pos": 965, "end_pos": 967, "annotation": "n_glycosylation_sequon" }, { "start_pos": 970, "end_pos": 972, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11260", "name": "", "equation": "H(+) + NADPH + O2 = H2O2 + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CIY2-1", "Q9ES45-1", "Q8K4C0-1", "D3ZD07-1", "D3ZBP4-1", "Q9NRD8-1", "Q9NRD9-1", "P49326-1", "Q8TDZ2-1", "P97872-1", "A2AQ92-1", "A0A494BAW1-1", "Q8C116-1", "B2RWH8-1", "Q8VDP3-1", "Q9VQH2-1" ], "evidence": [ { "id": "11260", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11260" } ] }, { "id": "11264", "name": "", "equation": "H(+) + NADH + O2 = H2O2 + NAD(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CIY2-1", "Q9ES45-1", "Q9NRD8-1", "Q9NRD9-1", "A2AQ92-1", "A0A494BAW1-1", "Q9VQH2-1" ], "evidence": [ { "id": "11264", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11264" } ] }, { "id": "R-MMU-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [ "R-ALL-351627" ], "output_participant_list": [], "enzyme_list": [ "A2AQ92-1", "A0A494BAW1-1" ], "evidence": [ { "id": "R-MMU-5693681", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5693681" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-351627", "participant_name": "NADPH [extracellular region]", "crossref": [ { "id": "3041", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "000008215411", "database": "ZINC", "url": "" }, { "id": "16474", "database": "ChEBI", "url": "" }, { "id": "C00005", "database": "COMPOUND", "url": "" }, { "id": "8145663", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000221", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0000221", "database": "HMDB Metabolite", "url": "" }, { "id": "8145663", "database": "PubChem Substance", "url": "" }, { "id": "C00005", "database": "COMPOUND", "url": "" }, { "id": "000008215411", "database": "ZINC", "url": "" }, { "id": "3041", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "16474", "database": "ChEBI", "url": "" }, { "id": "3041", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "16474", "database": "ChEBI", "url": "" }, { "id": "000008215411", "database": "ZINC", "url": "" }, { "id": "C00005", "database": "COMPOUND", "url": "" }, { "id": "8145663", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000221", "database": "HMDB Metabolite", "url": "" }, { "id": "C00005", "database": "COMPOUND", "url": "" }, { "id": "16474", "database": "ChEBI", "url": "" }, { "id": "HMDB0000221", "database": "HMDB Metabolite", "url": "" }, { "id": "3041", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8145663", "database": "PubChem Substance", "url": "" }, { "id": "000008215411", "database": "ZINC", "url": "" }, { "id": "HMDB0000221", "database": "HMDB Metabolite", "url": "" }, { "id": "8145663", "database": "PubChem Substance", "url": "" }, { "id": "C00005", "database": "COMPOUND", "url": "" }, { "id": "3041", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "000008215411", "database": "ZINC", "url": "" }, { "id": "16474", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A494BAW1", "gene_name": "Duox2", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "A0A494BAW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "A0A494BAW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ] } ] }, { "uniprot_ac": "A2AQ92", "gene_name": "Duox1", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "A2AQ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "A2AQ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ] } ] }, { "uniprot_ac": "B2RWH8", "gene_name": "Gm4846", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "B2RWH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RWH8" } ] } ] }, { "uniprot_ac": "D3ZBP4", "gene_name": "Mical1", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "D3ZBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBP4" } ] }, { "ec_number": "1.14.13.225", "activity": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+).", "evidence": [ { "id": "D3ZBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBP4" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "D3ZBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBP4" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "D3ZBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBP4" } ] } ] }, { "uniprot_ac": "D3ZD07", "gene_name": "Fmo9", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "D3ZD07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD07" } ] } ] }, { "uniprot_ac": "P49326", "gene_name": "FMO5", "activity": [ { "ec_number": "1.14.13.-", "activity": "", "evidence": [ { "id": "P49326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49326" } ] }, { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "P49326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49326" } ] }, { "ec_number": "1.14.13.8", "activity": "H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+).", "evidence": [ { "id": "P49326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49326" } ] }, { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "P49326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49326" } ] } ] }, { "uniprot_ac": "P97872", "gene_name": "Fmo5", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "P97872", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97872" } ] }, { "ec_number": "1.14.13.8", "activity": "H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+).", "evidence": [ { "id": "P97872", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97872" } ] } ] }, { "uniprot_ac": "Q8C116", "gene_name": "Fmo9", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "Q8C116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C116" } ] } ] }, { "uniprot_ac": "Q8CIY2", "gene_name": "Duox1", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "Q8CIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIY2" } ] }, { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "Q8CIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIY2" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "Q8CIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIY2" } ] } ] }, { "uniprot_ac": "Q8K4C0", "gene_name": "Fmo5", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "Q8K4C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4C0" } ] }, { "ec_number": "1.14.13.8", "activity": "H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+).", "evidence": [ { "id": "Q8K4C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4C0" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "Q8K4C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4C0" } ] }, { "ec_number": "1.14.13.8", "activity": "", "evidence": [ { "id": "Q8K4C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4C0" } ] } ] }, { "uniprot_ac": "Q8TDZ2", "gene_name": "MICAL1", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "Q8TDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDZ2" } ] }, { "ec_number": "1.14.13.225", "activity": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+).", "evidence": [ { "id": "Q8TDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDZ2" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "Q8TDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDZ2" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "Q8TDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDZ2" } ] } ] }, { "uniprot_ac": "Q8VDP3", "gene_name": "Mical1", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "Q8VDP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ] }, { "ec_number": "1.14.13.225", "activity": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+).", "evidence": [ { "id": "Q8VDP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "Q8VDP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "Q8VDP3", "database": 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