{
    "uniprot_canonical_ac": "A0A3B3IU63-1",
    "uniprot_ac": "A0A3B3IU63",
    "uniprot_id": "H2AL3_HUMAN",
    "mass": {
        "chemical_mass": 17661.0,
        "monoisotopic_mass": 17661.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "H2AL3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A3B3IU63",
            "id": "A0A3B3IU63"
        },
        {
            "name": "H2AL1RP",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A3B3IU63",
            "id": "A0A3B3IU63"
        }
    ],
    "protein_names": [
        {
            "name": "Histone H2A-like 3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A0A3B3IU63"
        },
        {
            "name": "H2A.L.3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A3B3IU63"
        }
    ],
    "function": [
        {
            "annotation": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A3B3IU63",
                    "url": "https://www.uniprot.org/uniprot/A0A3B3IU63#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A3B3IU63",
                    "url": "https://www.uniprot.org/uniprot/A0A3B3IU63"
                }
            ],
            "common_name": "Human"
        }
    ],
    "gene": [
        {
            "name": "H2AL3",
            "url": "https://www.uniprot.org/uniprot/A0A3B3IU63",
            "locus": {
                "chromosome": "X",
                "start_pos": 37994904,
                "end_pos": 37994272,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSG00000229674",
                        "url": "https://www.ensembl.org/id/ENSG00000229674"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSG00000229674",
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000229674",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "H2AL3",
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=H2AL3",
            "database": "GeneCards",
            "categories": [
                "Organism-specific",
                "Gene Annotation"
            ]
        },
        {
            "id": "53960",
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=53960",
            "database": "HGNC",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "IPR002119",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002119",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR009072",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "HHKMRIT",
            "url": "https://omabrowser.org/oma/group/HHKMRIT/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5211369at2759",
            "url": "http://www.orthodb.org/?query=5211369at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23430",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23430",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23430:SF11",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23430:SF11",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_A0A3B3IU63",
            "url": "http://purl.obolibrary.org/obo/PR_A0A3B3IU63",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A3B3IU63",
            "url": "https://www.uniprot.org/uniprot/A0A3B3IU63",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A3B3IU63-1",
            "url": "https://www.uniprot.org/uniprot/A0A3B3IU63-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAGNKMFCRPRRQRLSHSRRAELQFPVSHLERCLRESQHARHLSSTTPVFLAGVLEYLTANILEKVGKEVKNSCRLCITPEHVKRALQKDEQLRWILELEDDTHSQVEEMPQSEEEEEEEEEKEEEMVVLVVMGGRRRRRRRRRRKDS",
        "length": 148,
        "header": "sp|A0A3B3IU63-1|H2AL3_HUMAN Isoform 1 of Histone H2A-like 3  OS=Homo sapiens OX=9606 GN=H2AL3 PE=3 SV=1 CANONICAL=A0A3B3IU63-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A3B3IU63-1",
            "url": "",
            "sequence": {
                "sequence": "MAGNKMFCRPRRQRLSHSRRAELQFPVSHLERCLRESQHARHLSSTTPVFLAGVLEYLTANILEKVGKEVKNSCRLCITPEHVKRALQKDEQLRWILELEDDTHSQVEEMPQSEEEEEEEEEKEEEMVVLVVMGGRRRRRRRRRRKDS",
                "length": 148,
                "header": "sp|A0A3B3IU63-1|H2AL3_HUMAN Isoform 1 of Histone H2A-like 3  OS=Homo sapiens OX=9606 GN=H2AL3 PE=3 SV=1 CANONICAL=A0A3B3IU63-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 37994787,
                "end_pos": 37994344,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENST00000448797.3",
                        "url": "https://www.ensembl.org/id/ENST00000448797.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSP00000498087.1",
                        "url": "https://www.ensembl.org/id/ENSP00000498087.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
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                                "id": "A0A3B3IU63",
                                "url": "https://www.uniprot.org/uniprot/A0A3B3IU63"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein heterodimerization activity",
                        "id": "GO:0046982",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A3B3IU63",
                                "url": "https://www.uniprot.org/uniprot/A0A3B3IU63"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "structural constituent of chromatin",
                        "id": "GO:0030527",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030527",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A3B3IU63",
                                "url": "https://www.uniprot.org/uniprot/A0A3B3IU63"
                            }
                        ],
                        "pmid": ""
                    }
                ]
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            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A3B3IU63",
                                "url": "https://www.uniprot.org/uniprot/A0A3B3IU63"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleosome",
                        "id": "GO:0000786",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000786",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A3B3IU63",
                                "url": "https://www.uniprot.org/uniprot/A0A3B3IU63"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
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    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [],
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