{ "uniprot_canonical_ac": "A0A338P791-1", "uniprot_ac": "A0A338P791", "uniprot_id": "A0A338P791_MOUSE", "mass": { "chemical_mass": 44863.0, "monoisotopic_mass": 44863.0 }, "refseq": { "ac": "NP_001155304", "name": "brachyury 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304" }, "gene_names": [ { "name": "T2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A338P791", "id": "A0A338P791" }, { "name": "T2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304", "id": "NP_001155304" }, { "name": "brachyury2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304", "id": "NP_001155304" } ], "protein_names": [ { "name": "Brachyury 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A338P791" }, { "name": "brachyury 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304", "id": "NP_001155304" }, { "name": "brachyury the second", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304", "id": "NP_001155304" } ], "function": [ { "annotation": "Tint interacts with brachyury 2 but not with brachyury T1; T2 may be part of the T1 regulatory region through direct or indirect participation of tint GeneRIF: An unlinked modifier of Brachyury (T) called tint, interacts with T2 but not with T1. Highly conserved genomic sequences between mice and humans map to the distal end of T2. T2 may embed the long sought mammalian notochord enhancer of Brachyury.", "evidence": [ { "database": "RefSeq", "id": "NP_001155304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304" }, { "database": "PubMed", "id": "17954925", "url": "https://glygen.org/publication/PubMed/17954925" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A338P791", "url": "https://www.uniprot.org/uniprot/A0A338P791" } ], "common_name": "Mouse" } ], "gene": [ { "name": "T2", "url": "https://www.uniprot.org/uniprot/A0A338P791", "locus": { "chromosome": "17", "start_pos": 8642345, "end_pos": 8574824, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000058159", "url": "https://www.ensembl.org/id/ENSMUSG00000058159" } ] } } ], "crossref": [ { "id": "ENSMUSG00000058159", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000058159", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "21331", "url": "https://www.ncbi.nlm.nih.gov/gene/21331", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "mmu:21331", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:21331", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "104658", "url": "http://www.informatics.jax.org/marker/MGI:104658", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "HTHRNHT", "url": "https://omabrowser.org/oma/group/HTHRNHT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5349480at2759", "url": "http://www.orthodb.org/?query=5349480at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "NP_001155304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A338P791", "url": "https://www.uniprot.org/uniprot/A0A338P791", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A338P791-1", "url": "https://www.uniprot.org/uniprot/A0A338P791-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q4EGG8", "url": "https://www.uniprot.org/uniprot/A0A3Q4EGG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q4EGG8-1", "url": "https://www.uniprot.org/uniprot/A0A3Q4EGG8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQILRDHFKTPKKHRGCHTQVEDKEKAAQQTLPEQSQPEAWSASPPKASTRFPSRSNAYLIIGLQNELTKCGILKNMSDDEDFWKLVQEEALGVGTKEKLQKIKLKLMNPRPWPPAASRRRETEMLVSSDQDSGARQGTQDHPGREQEVVEDGPEKERIKQGPHQPGLDPPKHRGDTASLLARLTEWRKRCQQHGAAQRLHRGPEESKTMCKTRTDSQSKMYLSRLYRMYSTSLANMEFSRKLLERDGRFADMDAEHRARSLLDYMVPRERTQADVPPRERTQADVPPRELEEEDSPTPEQQPQAGPALRFLKCQSPESPQRRPHLKTGRHQVTLCGTSKLSEHERGTLAPARRTTDPRPTAPLTLAHVIQTHPVVEAKTASRYWVNNVDEE", "length": 393, "header": "tr|A0A338P791-1|A0A338P791_MOUSE Isoform 1 of Brachyury 2 OS=Mus musculus OX=10090 GN=T2 PE=4 SV=1 CANONICAL=A0A338P791-1" }, "isoforms": [ { "isoform_ac": "A0A338P791-1", "url": "", "sequence": { "sequence": "MAQILRDHFKTPKKHRGCHTQVEDKEKAAQQTLPEQSQPEAWSASPPKASTRFPSRSNAYLIIGLQNELTKCGILKNMSDDEDFWKLVQEEALGVGTKEKLQKIKLKLMNPRPWPPAASRRRETEMLVSSDQDSGARQGTQDHPGREQEVVEDGPEKERIKQGPHQPGLDPPKHRGDTASLLARLTEWRKRCQQHGAAQRLHRGPEESKTMCKTRTDSQSKMYLSRLYRMYSTSLANMEFSRKLLERDGRFADMDAEHRARSLLDYMVPRERTQADVPPRERTQADVPPRELEEEDSPTPEQQPQAGPALRFLKCQSPESPQRRPHLKTGRHQVTLCGTSKLSEHERGTLAPARRTTDPRPTAPLTLAHVIQTHPVVEAKTASRYWVNNVDEE", "length": 393, "header": "tr|A0A338P791-1|A0A338P791_MOUSE Isoform 1 of Brachyury 2 OS=Mus musculus OX=10090 GN=T2 PE=4 SV=1 CANONICAL=A0A338P791-1" }, "locus": { "chromosome": "17", "start_pos": 8640984, "end_pos": 8591228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000163578.8", "url": "https://www.ensembl.org/id/ENSMUST00000163578.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000156321.2", "url": "https://www.ensembl.org/id/ENSMUSP00000156321.2" } ] } }, { "isoform_ac": "A0A3Q4EGG8-1", "url": "", "sequence": { "sequence": "MAQILRDHFKTPKKHRGCHTQVEDKEKAAQQTLPEQSQPEAWSASPPKASTRFPSRSNAYLIIGLQNELTKCGILKNMSDDEDFWKLVQEEALGVGTKEKLQKIKLKLMNPRPWPPAASRRRETEMLVSSDQDSGARQGTQDHPGREQEVVEDGPEKERIKQGPHQPGLDPPKHRGDTASLLARLTEWRKRCQQHGAAQRLHRGPEESKTMCKTRTDSQSKMYLSRLYRMYSTSLANMEFSRKSKLSEHERGTLAPARRTTDPRPTAPLTLAHVIQTHPVVEAKTASRYWVNNVDEE", "length": 297, "header": "tr|A0A3Q4EGG8-1|A0A338P791_MOUSE Computationally mapped isoform of Brachyury 2 OS=Mus musculus OX=10090 GN=T2 PE=4 SV=1 CANONICAL=A0A338P791-1" }, "locus": { "chromosome": "17", "start_pos": 8640984, "end_pos": 8591228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000234809.2", "url": "https://www.ensembl.org/id/ENSMUST00000234809.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157191.2", "url": "https://www.ensembl.org/id/ENSMUSP00000157191.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury.", "journal": "Genetics", "date": "2007", "authors": "Wu JI, Centilli MA, Vasquez G, Young S, Scolnick J, Durfee LA, Spearow JL, Schwantz SD, Rennebeck G, Artzt K", "evidence": [ { "database": "RefSeq", "id": "NP_001155304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304" } ], "reference": [ { "type": "PubMed", "id": "17954925", "url": "https://glygen.org/publication/PubMed/17954925" } ] } ], "pathway": [ { "id": "mmu:21331", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:21331", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "notochord formation", "id": "GO:0014028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014028", "evidence": [ { "database": "UniProtKB", "id": "A0A338P791", "url": "https://www.uniprot.org/uniprot/A0A338P791" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { 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