{ "uniprot_canonical_ac": "A0A286YEC0-1", "uniprot_ac": "A0A286YEC0", "uniprot_id": "CIROP_MOUSE", "mass": { "chemical_mass": 76711.0, "monoisotopic_mass": 76711.0 }, "refseq": {}, "gene_names": [ { "name": "Cirop", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A286YEC0", "id": "A0A286YEC0" }, { "name": "Gm29776", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A286YEC0", "id": "A0A286YEC0" } ], "protein_names": [ { "name": "Ciliated left-right organizer metallopeptidase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A286YEC0" }, { "name": "3.4.24.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A286YEC0" }, { "name": "Leishmanolysin-like peptidase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A286YEC0" } ], "function": [ { "annotation": "Putative metalloproteinase that plays a role in left-right patterning process.", "evidence": [ { "database": "UniProtKB", "id": "A0A286YEC0", "url": "https://www.uniprot.org/uniprot/A0A286YEC0#function" }, { "database": "UniProtKB", "id": "A0A1D5NSK0", "url": "https://www.uniprot.org/uniprot/A0A1D5NSK0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A286YEC0", "url": "https://www.uniprot.org/uniprot/A0A286YEC0" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Cirop", "url": "https://www.uniprot.org/uniprot/A0A286YEC0", "locus": { "chromosome": "14", "start_pos": 54930055, "end_pos": 54936290, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000114865", "url": "https://www.ensembl.org/id/ENSMUSG00000114865" } ] } } ], "crossref": [ { "id": "ENSMUSG00000114865", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000114865", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "5588935", "url": "http://www.informatics.jax.org/marker/MGI:5588935", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "TGRCYLH", "url": "https://omabrowser.org/oma/group/TGRCYLH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10942", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10942", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10942:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10942:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01457", "url": "http://pfam.xfam.org/family/PF01457", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A286YEC0", "url": "http://purl.obolibrary.org/obo/PR_A0A286YEC0", "database": "PRO", "categories": [ "Protein" ] }, { "id": "A0A286YEC0", "url": "https://www.uniprot.org/uniprot/A0A286YEC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A286YEC0-1", "url": "https://www.uniprot.org/uniprot/A0A286YEC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2I3BPF0", "url": "https://www.uniprot.org/uniprot/A0A2I3BPF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2I3BPF0-1", "url": "https://www.uniprot.org/uniprot/A0A2I3BPF0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKMWRLLLLGVATGRCLHEETQKSVRLLRPPFSQMPTHFRSSILPLPGSHEPRPLRIQTYYSRAPVPGEAWDPEGETRALAAVTETTRRIQGILAVLPVQGPLLLSRDPAQYCHAVWGDPDTPNYQRCSILNPGYKGESCLGAKIPDAHLRGYSLWPEHGLPQLIQPDGPGVQNADFLLYVQVAHTSKCHKEPSVIAYAACCQLDSEDRPLAGTIVYCGQHLRSPTLSHDDIVMATLHELLHALGFSGQLFKMWRDCPSGLSARENCSTRKQVTRRDERGQLLLTTPAVSHSLAKHLGVPGTLQGAPLEEKQGSLSSHWESRLLQGSIMTATFHGAQHTRLDPVTLAAFEDSGWYQVNHSAAEELLWGQGSGPDFGLVSTCRTGSSDFFCTGSGLGCHYLHLDKGSCDSDSTLEGCRIYKPLAKGSECWKEENGLHTRAENPHGEIYHRHSRCFLANLTSQVLSKHTSQPSTAPDLEDPTGCCYLHQCTHKGAYEVQVEGSPWIPCLPGKAVQIPGYDGLLYCPQGRLCLRDEGARAATSQPMSFTTQDLLSQLSLRLTGTPGHSLGKGQREELAEVVLQALVMRAGTSRCYFHSPTITTSLVFTVSMWKSPGCHGPSVAMLHRTLTLTLQMKPLQVHHGEAIFTTDYSKLWTSLDHNPSMTELLLSTGFCLLVLILVGALGTLAYQKRAMLQVAPSTT", "length": 699, "header": "sp|A0A286YEC0-1|CIROP_MOUSE Isoform 1 of Ciliated left-right organizer metallopeptidase OS=Mus musculus OX=10090 GN=Cirop PE=2 SV=1 CANONICAL=A0A286YEC0-1" }, "isoforms": [ { "isoform_ac": "A0A286YEC0-1", "url": "", "sequence": { "sequence": "MKMWRLLLLGVATGRCLHEETQKSVRLLRPPFSQMPTHFRSSILPLPGSHEPRPLRIQTYYSRAPVPGEAWDPEGETRALAAVTETTRRIQGILAVLPVQGPLLLSRDPAQYCHAVWGDPDTPNYQRCSILNPGYKGESCLGAKIPDAHLRGYSLWPEHGLPQLIQPDGPGVQNADFLLYVQVAHTSKCHKEPSVIAYAACCQLDSEDRPLAGTIVYCGQHLRSPTLSHDDIVMATLHELLHALGFSGQLFKMWRDCPSGLSARENCSTRKQVTRRDERGQLLLTTPAVSHSLAKHLGVPGTLQGAPLEEKQGSLSSHWESRLLQGSIMTATFHGAQHTRLDPVTLAAFEDSGWYQVNHSAAEELLWGQGSGPDFGLVSTCRTGSSDFFCTGSGLGCHYLHLDKGSCDSDSTLEGCRIYKPLAKGSECWKEENGLHTRAENPHGEIYHRHSRCFLANLTSQVLSKHTSQPSTAPDLEDPTGCCYLHQCTHKGAYEVQVEGSPWIPCLPGKAVQIPGYDGLLYCPQGRLCLRDEGARAATSQPMSFTTQDLLSQLSLRLTGTPGHSLGKGQREELAEVVLQALVMRAGTSRCYFHSPTITTSLVFTVSMWKSPGCHGPSVAMLHRTLTLTLQMKPLQVHHGEAIFTTDYSKLWTSLDHNPSMTELLLSTGFCLLVLILVGALGTLAYQKRAMLQVAPSTT", "length": 699, "header": "sp|A0A286YEC0-1|CIROP_MOUSE Isoform 1 of Ciliated left-right organizer metallopeptidase OS=Mus musculus OX=10090 GN=Cirop PE=2 SV=1 CANONICAL=A0A286YEC0-1" }, "locus": { "chromosome": "14", "start_pos": 54936268, "end_pos": 54930278, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000224691", "url": "https://www.ensembl.org/id/ENSMUST00000224691" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000153646", "url": "https://www.ensembl.org/id/ENSMUSP00000153646" } ] } }, { "isoform_ac": "A0A2I3BPF0-1", "url": "", "sequence": { "sequence": "XRLLLLGVATGRCLHEETQKSVRLLRPPFSQMPTHFRSSILPLPGSHEPRPLRIQTYYSRAPVPGEAWDPEGETRALAAVTETTRRIQGILAVLPVQGPLLLSRDPAQYCHAVWGDPDTPNYQRCSILNPGYKGESCLGAKIPDAHLRGYSLWPEHGLPQLIQPDGPGVQNADFLLYVQVAHTSKCHKEATLHELLHALGFSGQLFKMWRDCPSGLSARENCSTRKQVTRRDERGQLLLTTPAVSHSLAKHLGVPGTLQGAPLEEKQGSLSSHWESRLLQGSIMTATFHGAQHTRLDPVTLAAFEDSGWYQVNHSAAEELLWGQGSGPDFGLVSTCRTGSSDFFCTGSGLGCHYLHLDKGSCDSDSTLEGCRIYKPLAKGV", "length": 381, "header": "tr|A0A2I3BPF0-1|A0A2I3BPF0_MOUSE Computationally mapped isoform of Leishmanolysin-like peptidase OS=Mus musculus OX=10090 GN=Cirop PE=3 SV=1 CANONICAL=A0A286YEC0-1" }, "locus": { "chromosome": "14", "start_pos": 54936257, "end_pos": 54932503, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000227947.2", "url": "https://www.ensembl.org/id/ENSMUST00000227947.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000153756.2", "url": "https://www.ensembl.org/id/ENSMUSP00000153756.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates.", "journal": "Nat. Genet.", "date": "2022", "authors": "Szenker-Ravi E, Ott T, Khatoo M, de Bellaing AM, Goh WX, Chong YL, Beckers A, Kannesan D, Louvel G, Anujan P, Ravi V, Bonnard C, Moutton S, Schoen P, Fradin M, Colin E, Megarbane A, Daou L, Chehab G, Di Filippo S, Rooryck C, Deleuze JF, Boland A, Arribard N, Eker R, Tohari S, Ng AY, Rio M, Lim CT, Eisenhaber B, Eisenhaber F, Venkatesh B, Amiel J, Crollius HR, Gordon CT, Gossler A, Roy S, Attie-Bitach T, Blum M, Bouvagnet P, Reversade B", "evidence": [ { "database": "UniProtKB", "id": "A0A286YEC0", "url": "https://www.uniprot.org/uniprot/A0A286YEC0" } ], "reference": [ { "type": "PubMed", "id": "34903892", "url": "https://glygen.org/publication/PubMed/34903892" } ] } ], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1B0GTW7-1", "protein_name": "Ciliated left-right organizer metallopeptidase", "gene_name": "CIROP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLLLLLLLLLPPLVLRVAASRCLHDETQKSVSLLRPPFSQLPSKSRSSSLTLPSSRDPQPLRIQSCYLGDHISDGAWDPEGEGMRGGSRALAAVREATQRIQAVLAVQGPLLLSRDPAQYCHAVWGDPDSPNYHRCSLLNPGYKGESCLGAKIPDTHLRGYALWPEQGPPQLVQPDGPGVQNTDFLLYVRVAHTSKCHQETVSLCCPGWSTAAQSQLTAALTSWAQRRGFVMLPRLCLKLLGSSNLPTLASQSIRITGPSVIAYAACCQLDSEDRPLAGTIVYCAQHLTSPSLSHSDIVMATLHELLHALGFSGQLFKKWRDCPSGFSVRENCSTRQLVTRQDEWGQLLLTTPAVSLSLAKHLGVSGASLGVPLEEEEGLLSSHWEARLLQGSLMTATFDGAQRTRLDPITLAAFKDSGWYQVNHSAAEELLWGQGSGPEFGLVTTCGTGSSDFFCTGSGLGCHYLHLDKGSCSSDPMLEGCRMYKPLANGSECWKKENGFPAGVDNPHGEIYHPQSRCFFANLTSQLLPGDKPRHPSLTPHLKEAELMGRCYLHQCTGRGAYKVQVEGSPWVPCLPGKVIQIPGYYGLLFCPRGRLCQTNEDINAVTSPPVSLSTPDPLFQLSLELAGPPGHSLGKEQQEGLAEAVLEALASKGGTGRCYFHGPSITTSLVFTVHMWKSPGCQGPSVATLHKALTLTLQKKPLEVYHGGANFTTQPSKLLVTSDHNPSMTHLRLSMGLCLMLLILVGVMGTTAYQKRATLPVRPSASYHSPELHSTRVPVRGIREV", "length": 788 }, "evidence": [ { "id": "A0A286YEC0", "url": "https://omabrowser.org/oma/group/A0A286YEC0/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "A0A286YEC0", "url": "https://www.uniprot.org/uniprot/A0A286YEC0" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A286YEC0", "url": "https://www.uniprot.org/uniprot/A0A286YEC0" } ], "pmid": "" }, { "name": "peptidase activity", "id": "GO:0008233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008233", "evidence": [ { "database": "UniProtKB", "id": "A0A286YEC0", "url": "https://www.uniprot.org/uniprot/A0A286YEC0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0A286YEC0", "url": "https://www.uniprot.org/uniprot/A0A286YEC0" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0A286YEC0", "url": "https://www.uniprot.org/uniprot/A0A286YEC0" } ], "pmid": "" }, { "name": "establishment of left/right asymmetry", "id": "GO:0061966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061966", "evidence": [ { "database": "UniProtKB", "id": "A0A286YEC0", "url": "https://www.uniprot.org/uniprot/A0A286YEC0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A286YEC0", "url": "https://www.uniprot.org/uniprot/A0A286YEC0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A286YEC0", "url": "https://www.uniprot.org/uniprot/A0A286YEC0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 358, "end_pos": 360, "annotation": "n_glycosylation_sequon" }, { "start_pos": 457, "end_pos": 459, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", 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