{ "uniprot_canonical_ac": "A0A286YCV9-1", "uniprot_ac": "A0A286YCV9", "uniprot_id": "A0A286YCV9_MOUSE", "mass": { "chemical_mass": 204942.0, "monoisotopic_mass": 204942.0 }, "refseq": { "ac": "XP_006518682", "name": "kinesin-like protein KIF13B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006518682" }, "gene_names": [ { "name": "Kif13b", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A286YCV9", "id": "A0A286YCV9" }, { "name": "5330429L19Rik; 6030414C01; C130021D12Rik; GAKIN", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006518682", "id": "XP_006518682" }, { "name": "Kif13b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006518682", "id": "XP_006518682" } ], "protein_names": [ { "name": "Kinesin family member 13B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A286YCV9" }, { "name": "kinesin 13B; N-3 kinesin", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074646", "id": "NP_001074646" }, { "name": "kinesin-like protein KIF13B isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006518682", "id": "XP_006518682" }, { "name": "kinesin-like protein KIF13B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074646", "id": "NP_001074646" } ], "function": [ { "annotation": "KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivo. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001074646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074646" }, { "database": "PubMed", "id": "34670814", "url": "https://glygen.org/publication/PubMed/34670814" } ] }, { "annotation": "Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development.", "evidence": [ { "database": "RefSeq", "id": "NP_001074646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074646" }, { "database": "PubMed", "id": "33097641", "url": "https://glygen.org/publication/PubMed/33097641" } ] }, { "annotation": "The carboxyl-terminal region of KIF13B containing the CAP-Gly domain is important for the LRP1-DLG1-KIF13B complex formation with implications in the regulation of metabolism, cell polarity, and development.", "evidence": [ { "database": "RefSeq", "id": "NP_001074646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074646" }, { "database": "PubMed", "id": "31487503", "url": "https://glygen.org/publication/PubMed/31487503" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A286YCV9", "url": "https://www.uniprot.org/uniprot/A0A286YCV9" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Kif13b", "url": "https://www.uniprot.org/uniprot/A0A286YCV9", "locus": { "chromosome": "14", "start_pos": 65047066, "end_pos": 64884714, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000060012", "url": "https://www.ensembl.org/id/ENSMUSG00000060012" } ] } } ], "crossref": [ { "id": "ENSMUSG00000060012", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000060012", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01365", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01365", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22730", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22730", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "16554", "url": "https://www.ncbi.nlm.nih.gov/gene/16554", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "E9Q4K7", "url": "https://www.ebi.ac.uk/intact/interactors/id:E9Q4K7*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032405", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032405", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:16554", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16554", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1098265", "url": "http://www.informatics.jax.org/marker/MGI:1098265", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "A0A286YCV9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A286YCV9", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "CKEVAVS", "url": "https://omabrowser.org/oma/group/CKEVAVS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "126886at2759", "url": "http://www.orthodb.org/?query=126886at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10398", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10398", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10398:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10398:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24115", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24115", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24115:SF978", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24115:SF978", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "5B64", "url": "https://www.rcsb.org/structure/5B64", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00225", "url": "http://pfam.xfam.org/family/PF00225", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00498", "url": "http://pfam.xfam.org/family/PF00498", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01302", "url": "http://pfam.xfam.org/family/PF01302", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12423", "url": "http://pfam.xfam.org/family/PF12423", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12473", "url": "http://pfam.xfam.org/family/PF12473", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16183", "url": "http://pfam.xfam.org/family/PF16183", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-6811434", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6811434", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-983189", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983189", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_006518682", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006518682", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A286YCV9", "url": "https://www.uniprot.org/uniprot/A0A286YCV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A286YCV9-1", "url": "https://www.uniprot.org/uniprot/A0A286YCV9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A286YD28", "url": "https://www.uniprot.org/uniprot/A0A286YD28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A286YD28-1", "url": "https://www.uniprot.org/uniprot/A0A286YD28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9Q4K7", "url": "https://www.uniprot.org/uniprot/E9Q4K7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9Q4K7-1", "url": "https://www.uniprot.org/uniprot/E9Q4K7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDSKVKVAVRVRPMNRREIDLHTKCVVDVEANKVILNPVNTNLSKGDARGQPKIFAYDHCFWSMDESVREKYAGQEDVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDLAGSERATKTGAAGDRLKEGSNINKSLTTLGLVISALADQGAGKNKNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVNEDPNARIIRDLREEVEKLREQLTKAEAMKSPELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQTSGIKVGDDKCFLVNLNADPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHGIIDITPEGQVVLTPQKNTRTFVNGSSVSSPIQLHHGDRILWGNNHFFRLNLPKKKKKAEREDEDREASLKNDSSSEQLDADGDSSSEVSSEINFNFEYAQMEVTMKALGSNDPMQSILSSLEQQHEEEKRSALERQRLMYEHELEQLRRRLSPERQNCRGVDRLSFHSPSAQQRLKQWAEEREATLNNSLMRLREQIVKANLLVREASYIAEELDKRTEYKVTLQIPTSSLDANRKRGSLLSEPAIQVRRKGKGKQIWSLEKLENRLLDMRDLYQEWKECEEDSPVSRSYFKRADPFYDEQENHSLIGVANVFLETLFYDVKLQYAVPIINQKGEVAGRLHVEVMRLSGAIGERIAGGDDPTEVSSEKEAQENRLVCMVKILQATGLPQHLCHFVFCKYDFWDQQEPVTVAPEVDTSSSPTSKQPQCMVVFDHCSEFSVNITEDFIEYLSEGALAIEVYGHKMNDPRKNPALWDLGIIQAKTRSLRDRWSEVTRKLEFWVQILEQNENGDYCPVEVIAAKDVPTGGIFQLRQGQSRRVQVEVKSVQESGTLPLMEECILSVGIGCVKVRPLRSPKIHENVHEEEEDMDSYQDRDLERLRRKWLNALTKRQEYLDQQLQKLVSKHDKTEDDADREAQLLEMRLTLTEERNAVMVPSAGSGIPGAPAEWTPVPGMETHIPVIFLDLNADDFSSQDNLDDPEAGWDATLTGEEEEEFFELQIVKQHDGEVKAEASWDSAVHSCPQLSKGTPADERVFLILRVTVQLSHPADMQLVLRKRICVHVHGRQGFAQSLLKKMSHRSSIPGCGVTFEIVSNIPEDAQGVEEREALARMAANVENPASADSEAYIEKYLRSVLAVENLLTLDRLRQEVAVKEQLTGKGKLSRRSISSPSMNRLSGSRQELSPSHSLGSNKGRWESQQDVSQTLVSRGIAPGPPALSVSPQNNQSPDPGLGGVAASYLNPVKSLVPQMPKLLKSLFPVRDDRRGRHSSPLAHQPVPRILVQPTFSDTWATRTEEAQQGSPGPSGALESMVKMAAPAVKICDKPVKVSSPPSPMVVTQPPEGQDGPPSPLSEASSGYFSHSVSSATLSETLTLGLDTTGLGSQTPGSPPALCQVTPEPELAFLSCTQSHPPAPEEAHVPAAPTQSTELEVPRAPLLSEPASAVPTSPFRIRKVRTSELKSFTGMLGGASSGAEEDPLASEDPSNARGQTLGRLEVTSDSEDASEVPEWLREGEYVVVGTNKTGIVRYIGPTDFQEGTWIGVELDLPAGKNDGSIGGKQYFRCNPGYGLLVRPSRVRRAVGTGRRRSSGLQPQGAPEVRRSATISGSATNLASLTAALAKGDRSYKNPENRKSWAS", "length": 1847, "header": "tr|A0A286YCV9-1|A0A286YCV9_MOUSE Isoform 1 of Kinesin family member 13B OS=Mus musculus OX=10090 GN=Kif13b PE=1 SV=1 CANONICAL=A0A286YCV9-1" }, "isoforms": [ { "isoform_ac": "A0A286YCV9-1", "url": "", "sequence": { "sequence": "MGDSKVKVAVRVRPMNRREIDLHTKCVVDVEANKVILNPVNTNLSKGDARGQPKIFAYDHCFWSMDESVREKYAGQEDVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDLAGSERATKTGAAGDRLKEGSNINKSLTTLGLVISALADQGAGKNKNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVNEDPNARIIRDLREEVEKLREQLTKAEAMKSPELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQTSGIKVGDDKCFLVNLNADPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHGIIDITPEGQVVLTPQKNTRTFVNGSSVSSPIQLHHGDRILWGNNHFFRLNLPKKKKKAEREDEDREASLKNDSSSEQLDADGDSSSEVSSEINFNFEYAQMEVTMKALGSNDPMQSILSSLEQQHEEEKRSALERQRLMYEHELEQLRRRLSPERQNCRGVDRLSFHSPSAQQRLKQWAEEREATLNNSLMRLREQIVKANLLVREASYIAEELDKRTEYKVTLQIPTSSLDANRKRGSLLSEPAIQVRRKGKGKQIWSLEKLENRLLDMRDLYQEWKECEEDSPVSRSYFKRADPFYDEQENHSLIGVANVFLETLFYDVKLQYAVPIINQKGEVAGRLHVEVMRLSGAIGERIAGGDDPTEVSSEKEAQENRLVCMVKILQATGLPQHLCHFVFCKYDFWDQQEPVTVAPEVDTSSSPTSKQPQCMVVFDHCSEFSVNITEDFIEYLSEGALAIEVYGHKMNDPRKNPALWDLGIIQAKTRSLRDRWSEVTRKLEFWVQILEQNENGDYCPVEVIAAKDVPTGGIFQLRQGQSRRVQVEVKSVQESGTLPLMEECILSVGIGCVKVRPLRSPKIHENVHEEEEDMDSYQDRDLERLRRKWLNALTKRQEYLDQQLQKLVSKHDKTEDDADREAQLLEMRLTLTEERNAVMVPSAGSGIPGAPAEWTPVPGMETHIPVIFLDLNADDFSSQDNLDDPEAGWDATLTGEEEEEFFELQIVKQHDGEVKAEASWDSAVHSCPQLSKGTPADERVFLILRVTVQLSHPADMQLVLRKRICVHVHGRQGFAQSLLKKMSHRSSIPGCGVTFEIVSNIPEDAQGVEEREALARMAANVENPASADSEAYIEKYLRSVLAVENLLTLDRLRQEVAVKEQLTGKGKLSRRSISSPSMNRLSGSRQELSPSHSLGSNKGRWESQQDVSQTLVSRGIAPGPPALSVSPQNNQSPDPGLGGVAASYLNPVKSLVPQMPKLLKSLFPVRDDRRGRHSSPLAHQPVPRILVQPTFSDTWATRTEEAQQGSPGPSGALESMVKMAAPAVKICDKPVKVSSPPSPMVVTQPPEGQDGPPSPLSEASSGYFSHSVSSATLSETLTLGLDTTGLGSQTPGSPPALCQVTPEPELAFLSCTQSHPPAPEEAHVPAAPTQSTELEVPRAPLLSEPASAVPTSPFRIRKVRTSELKSFTGMLGGASSGAEEDPLASEDPSNARGQTLGRLEVTSDSEDASEVPEWLREGEYVVVGTNKTGIVRYIGPTDFQEGTWIGVELDLPAGKNDGSIGGKQYFRCNPGYGLLVRPSRVRRAVGTGRRRSSGLQPQGAPEVRRSATISGSATNLASLTAALAKGDRSYKNPENRKSWAS", "length": 1847, "header": "tr|A0A286YCV9-1|A0A286YCV9_MOUSE Isoform 1 of Kinesin family member 13B OS=Mus musculus OX=10090 GN=Kif13b PE=1 SV=1 CANONICAL=A0A286YCV9-1" }, "locus": { "chromosome": "14", "start_pos": 65043742, "end_pos": 64890051, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000224503.2", "url": "https://www.ensembl.org/id/ENSMUST00000224503.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000153168.2", "url": "https://www.ensembl.org/id/ENSMUSP00000153168.2" } ] } }, { "isoform_ac": "A0A286YD28-1", "url": "", "sequence": { "sequence": "MDESVREKYAGQEDVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNM", "length": 151, "header": "tr|A0A286YD28-1|A0A286YD28_MOUSE Computationally mapped isoform of Kinesin family member 13B OS=Mus musculus OX=10090 GN=Kif13b PE=1 SV=1 CANONICAL=A0A286YCV9-1" }, "locus": { "chromosome": "14", "start_pos": 64962208, "end_pos": 64951553, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000224126.2", "url": "https://www.ensembl.org/id/ENSMUST00000224126.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000153252.2", "url": "https://www.ensembl.org/id/ENSMUSP00000153252.2" } ] } }, { "isoform_ac": "E9Q4K7-1", "url": "", "sequence": { "sequence": "MGDSKVKVAVRVRPMNRREIDLHTKCVVDVEANKVILNPVNTNLSKGDARGQPKIFAYDHCFWSMDESVREKYAGQEDVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDLAGSERATKTGAAGDRLKEGSNINKSLTTLGLVISALADQGAGKNKNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVNEDPNARIIRDLREEVEKLREQLTKAEAMKSPELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQTSGIKVGDDKCFLVNLNADPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHGIIDITPEGQVVLTPQKNTRTFVNGSSVSSPIQLHHGDRILWGNNHFFRLNLPKKKKKAEREDEDREASLKNDSSSEQLDADGDSSSEVSSEINFNFEYAQMEVTMKALGSNDPMQSILSSLEQQHEEEKRSALERQRLMYEHELEQLRRRLSPERQNCRGVDRLSFHSPSAQQRLKQWAEEREATLNNSLMRLREQIVKANLLVREASYIAEELDKRTEYKVTLQIPTSSLDANRKRGSLLSEPAIQVRRKGKGKQIWSLEKLENRLLDMRDLYQEWKECEEDSPVSRSYFKRADPFYDEQENHSLIGVANVFLETLFYDVKLQYAVPIINQKGEVAGRLHVEVMRLSGAIGERIAGGDDPTEVSSEKEAQENRLVCMVKILQATGLPQHLCHFVFCKYDFWDQQEPVTVAPEVDTSSSPTSKQPQCMVVFDHCSEFSVNITEDFIEYLSEGALAIEVYGHKMNDPRKNPALWDLGIIQAKTRSLRDRWSEVTRKLEFWVQILEQNENGDYCPVEVIAAKDVPTGGIFQLRQGQSRRVQVEVKSVQESGTLPLMEECILSVGIGCVKVRPLRSPKIHENVHEEEEDMDSYQDRDLERLRRKWLNALTKRQEYLDQQLQKLVSKHDKTEDDADREAQLLEMRLTLTEERNAVMVPSAGSGIPGAPAEWTPVPGMETHIPVIFLDLNADDFSSQDNLDDPEAGWDATLTGEEEEEFFELQIVKQHDGEVKAEASWDSAVHSCPQLSKGTPADERVFLILRVTVQLSHPADMQLVLRKRICVHVHGRQGFAQSLLKKMSHRSSIPGCGVTFEIVSNIPEDAQGVEEREALARMAANVENPASADSEAYIEKYLRSVLAVENLLTLDRLRQEVAVKEQLTGKGKLSRRSISSPSMNRLSGSRQELSPSHSLGSNKGRWESQQDVSQTLVSRGIAPGPPALSVSPQNNQSPDPGLGGVAASYLNPVKSLVPQMPKLLKSLFPVRDDRRGRHSSPLAHQPVPRILVQPTFSDTWATRTEEVSHQVGAAPLAEVMAAPAVKICDKPVKVSSPPSPMVVTQPPEGQDGPPSPLSEASSGYFSHSVSSATLSETLTLGLDTTGLGSQTPGSPPALCQVTPEPELAFLSCTQSHPPAPEEAHVPAAPTQSTELEVPRAPLLSEPASAVPTSPFRIRKVRTSELKSFTGMLGGASSGAEEDPLASEDPSNARGQTLGRLEVTSDSEDASEVPEWLREGEYVVVGTNKTGIVRYIGPTDFQEGTWIGVELDLPAGKNDGSIGGKQYFRCNPGYGLLVRPSRVRRAVGTGRRRSSGLQPQGAPEVRRSATISGSATNLASLTAALAKGDRSYKNPENRKSWAS", "length": 1843, "header": "tr|E9Q4K7-1|A0A286YCV9_MOUSE Computationally mapped isoform of Kinesin family member 13B OS=Mus musculus OX=10090 GN=Kif13b PE=1 SV=1 CANONICAL=A0A286YCV9-1" }, "locus": { "chromosome": "14", "start_pos": 65043742, "end_pos": 64890051, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000100473.5", "url": "https://www.ensembl.org/id/ENSMUST00000100473.5" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000098041.5", "url": "https://www.ensembl.org/id/ENSMUSP00000098041.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "A0A286YCV9", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A286YCV9" }, { "id": "28528544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28528544" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B.", "journal": "Structure", "date": "2016", "authors": "Zhu J, Shang Y, Xia Y, Zhang R, Zhang M", "evidence": [ { "database": "UniProtKB", "id": "E9Q4K7", "url": "https://www.uniprot.org/uniprot/E9Q4K7" } ], "reference": [ { "type": "PubMed", "id": "27642159", "url": "https://glygen.org/publication/PubMed/27642159" } ] }, { "title": "The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8.", "journal": "Journal of the American Chemical Society", "date": "2017", "authors": "Chuh KN, Batt AR, Zaro BW, Darabedian N, Marotta NP, Brennan CK, Amirhekmat A, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "A0A286YCV9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A286YCV9" } ], "reference": [ { "type": "PubMed", "id": "28528544", "url": "https://glygen.org/publication/PubMed/28528544" } ] }, { "title": "LDL receptor related protein 1 requires the I3 domain of discs-large homolog 1/DLG1 for interaction with the kinesin motor protein KIF13B.", "journal": "Biochimica et biophysica acta. Molecular cell research", "date": "2019", "authors": "Mills J, Hanada T, Hase Y, Liscum L, Chishti AH", "evidence": [ { "database": "RefSeq", "id": "NP_001074646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074646" } ], "reference": [ { "type": "PubMed", "id": "31487503", "url": "https://glygen.org/publication/PubMed/31487503" } ] }, { "title": "Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2020", "authors": "Yu HL, Peng Y, Zhao Y, Lan YS, Wang B, Zhao L, Sun D, Pan JX, Dong ZQ, Mei L, Ding YQ, Zhu XJ, Xiong WC", "evidence": [ { "database": "RefSeq", "id": "NP_001074646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074646" } ], "reference": [ { "type": "PubMed", "id": "33097641", "url": "https://glygen.org/publication/PubMed/33097641" } ] }, { "title": "KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivo.", "journal": "Life science alliance", "date": "2022", "authors": "Waters SB, Dominguez JR, Cho HD, Sarich NA, Malik AB, Yamada KH", "evidence": [ { "database": "RefSeq", "id": "NP_001074646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074646" } ], "reference": [ { "type": "PubMed", "id": "34670814", "url": "https://glygen.org/publication/PubMed/34670814" } ] } ], "pathway": [ { "id": "mmu:16554", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16554", "resource": "KEGG Pathway" }, { "id": "R-MMU-6811434", "name": "COPI-dependent Golgi-to-ER retrograde traffic", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6811434", "resource": "Reactome", "description": "COPI-dependent Golgi-to-ER retrograde traffic" }, { "id": "R-MMU-983189", "name": "Kinesins", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983189", "resource": "Reactome", "description": "Kinesins" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9NQT8-1", "protein_name": "Kinesin-like protein KIF13B", "gene_name": "KIF13B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 1826 }, "evidence": [ { "id": "45229028", "url": "http://www.informatics.jax.org/homology/45229028", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of axonogenesis", "id": "GO:0050770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050770", "evidence": [ { "database": "UniProtKB", "id": "A0A286YCV9", "url": "https://www.uniprot.org/uniprot/A0A286YCV9" } ], "pmid": "" }, { "name": "microtubule-based movement", "id": "GO:0007018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018", "evidence": [ { "database": "UniProtKB", "id": "A0A286YCV9", "url": "https://www.uniprot.org/uniprot/A0A286YCV9" } ], "pmid": "" }, { "name": "cytoskeleton-dependent intracellular transport", "id": "GO:0030705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030705", "evidence": [ { "database": "UniProtKB", "id": "A0A286YCV9", "url": "https://www.uniprot.org/uniprot/A0A286YCV9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A286YCV9", "url": "https://www.uniprot.org/uniprot/A0A286YCV9" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0A286YCV9", "url": "https://www.uniprot.org/uniprot/A0A286YCV9" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0A286YCV9", "url": "https://www.uniprot.org/uniprot/A0A286YCV9" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0A286YCV9", "url": 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