{ "uniprot_canonical_ac": "A0A1W2Q693-1", "uniprot_ac": "A0A1W2Q693", "uniprot_id": "A0A1W2Q693_RAT", "mass": { "chemical_mass": 94600.0, "monoisotopic_mass": 94600.0 }, "refseq": {}, "gene_names": [ { "name": "Mocos", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1W2Q693", "id": "A0A1W2Q693" }, { "name": "MOCOS", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1W2Q693", "id": "A0A1W2Q693" } ], "protein_names": [ { "name": "Molybdenum cofactor sulfurase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A1W2Q693" }, { "name": "2.8.1.9", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A1W2Q693" }, { "name": "MCS", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A1W2Q693" }, { "name": "MOS", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A1W2Q693" }, { "name": "MoCo sulfurase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A1W2Q693" }, { "name": "Molybdenum cofactor sulfurtransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A1W2Q693" } ], "function": [ { "annotation": "Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.", "evidence": [ { "database": "UniProtKB", "id": "A0A1W2Q693", "url": "https://www.uniprot.org/uniprot/A0A1W2Q693#function" }, { "database": "UniProtKB", "id": "MF_03050", "url": "https://www.uniprot.org/uniprot/MF_03050#function" } ] } ], "disease": [ { "disease_id": "DOID:0060041", "recommended_name": { "id": "DOID:0060041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060041", "name": "autism spectrum disorder", "description": "A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior." }, "synonyms": [], "evidence": [ { "id": "0060041", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060041" } ] }, { "disease_id": "DOID:0070314", "recommended_name": { "id": "DOID:0070314", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070314", "name": "obstructive nephropathy", "description": "A kidney disease characterized by kidney damage and dysfunction resulting from urinary tract obstruction." }, "synonyms": [ { "id": "DOID:0070314", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070314", "name": "CON", "description": "" }, { "id": "DOID:0070314", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070314", "name": "congenital obstructive nephropathy", "description": "" } ], "evidence": [ { "id": "0070314", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070314" } ] }, { "disease_id": "DOID:0070453", "recommended_name": { "id": "DOID:0070453", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070453", "name": "xanthinuria type II", "description": "A xanthinuria characterized by deficiency of xanthine dehydrogenase and aldehyde oxidase that has_material_basis_in homozygous or compound heterozygous mutation in the MOCOS gene on chromosome 18q12." }, "synonyms": [ { "id": "DOID:0070453", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070453", "name": "XAN2", "description": "" }, { "id": "MONDO:0011346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011346", "name": "xanthinuria type II", "description": "Type II xanthinuria, a type of classical xanthinuria, is a rare autosomal recessive disorder of purine metabolism characterized by the deficiency of both xanthine dehydrogenase and aldehyde oxidase, leading to the formation of urinary xanthine urolithiasis and leading, in some patients, to kidney failure. Other less common manifestations include arthropathy, myopathy and duodenal ulcer, while some patients remain asymptomatic." }, { "id": "MONDO:0011346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011346", "name": "XAN2", "description": "" }, { "id": "MONDO:0011346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011346", "name": "XDH and AOX dual deficiency", "description": "" }, { "id": "MONDO:0011346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011346", "name": "xanthine dehydrogenase and aldehyde oxidase, combined deficiency of", "description": "" }, { "id": "MONDO:0011346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011346", "name": "xanthine dehydrogenase and xanthine aldehyde oxidase dual deficiency", "description": "" }, { "id": "MONDO:0011346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011346", "name": "type 2 xanthinuria", "description": "" }, { "id": "MONDO:0011346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011346", "name": "type II xanthinuria", "description": "" }, { "id": "MONDO:0011346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011346", "name": "xanthine dehydrogenase and aldehyde oxidase combined deficiency of", "description": "" }, { "id": "MONDO:0011346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011346", "name": "xanthinuria type 2", "description": "" }, { "id": "MONDO:0011346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011346", "name": "xanthinuria, type 2", "description": "" }, { "id": "MONDO:0011346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011346", "name": "xanthinuria, type II", "description": "" }, { "id": "MIM:603592", "resource": "MIM", "url": "https://www.omim.org/entry/603592", "name": "Xanthinuria 2", "description": "Xanthinuria 2" } ], "evidence": [ { "id": "0070453", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070453" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A1W2Q693", "url": "https://www.uniprot.org/uniprot/A0A1W2Q693" } ], "common_name": "Rat" } ], "gene": [ { "name": "Mocos", "url": "https://www.uniprot.org/uniprot/A0A1W2Q693", "locus": { "chromosome": "18", "start_pos": 15977187, "end_pos": 15931654, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000015113", "url": "https://www.ensembl.org/id/ENSRNOG00000015113" } ] } } ], "crossref": [ { "id": "ENSRNOG00000015113", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015113", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "361300", "url": "https://www.ncbi.nlm.nih.gov/gene/361300", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005303", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011037", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011037", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028886", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028886", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:361300", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:361300", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PCTRCQM", "url": "https://omabrowser.org/oma/group/PCTRCQM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "448292at2759", "url": "http://www.orthodb.org/?query=448292at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14237", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14237", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14237:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14237:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14237:SF80", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14237:SF80", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00266", "url": "http://pfam.xfam.org/family/PF00266", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03473", "url": "http://pfam.xfam.org/family/PF03473", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03476", "url": "http://pfam.xfam.org/family/PF03476", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-947581", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-947581", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_006254528", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006254528", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1308496", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308496", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "42636", "url": "https://www.rhea-db.org/rhea/42636", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "61644", "url": "https://www.rhea-db.org/rhea/61644", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A1W2Q693", "url": "https://www.uniprot.org/uniprot/A0A1W2Q693", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2Q693-1", "url": "https://www.uniprot.org/uniprot/A0A1W2Q693-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4A1G3", "url": "https://www.uniprot.org/uniprot/D4A1G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4A1G3-1", "url": "https://www.uniprot.org/uniprot/D4A1G3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACGATERGPEPPAFQRHPEASAPRLAHGYGLRSMSELRDQEFGRLAGTVYLDHAGATLFPQSQLTNFTKDLMENVYGNPHSQNITSKLTHDTVEQVRYRVLTHFHTTPEDYSVIFTAGSTAALRLVAETFPWVSRSPENSGSHFCYLTDNHTSVVGMRTVAATMNVTSTPVKPEDMWSAEGKGAGACDPDCQLPHLFCYPAQSNFSGTRYPLSWIDEVKSGQRSPVRAPGKWFVLLDAASYVSTSPLDLSAHQADFIPISFYKIFGLPTGLGALLVNKRVAPLLRKGYFGGGTAAVYLAGEDFYIPRSSVAERFEDGTISFLDVIALKHGFDVLERLTGGMVNIQQHTFALLHFTHSALSSLRYPNGAPVVRIYGDSGFSSPDVQGPIINFNVLDDAGKIIGYSQVDKMASLYNIHLRTGCFCNLGACQRHLGLSEEMVKKHFQAGHVCGDDVDIIDGRPTGSVRISFGYMSTLEDAQAFLRFISTIYLRSPGGQPVPQASTSDTGVLSSKSDCQSPQEGPCADPAVSSGSYPDINTVDLDLSQSKASSIQPIPQEKVAGILNGDLGSHIVTNIYLYPIKSCAAFEVTKWPVGSQGLLYDRSWMVVNHNGVCLSQKQEPRLCLIQPCIDLQQKVMVIKAEGMEPIQVPLEEDGERTQICQSRVCADRVNTYDCGENVSRWLSKFCGRPCHLIKQSPHFQRNAKKTPKQGHPPGTAVALSLVNEAQYLLVNTSSVLELQQQLNASDERGKEESFSVKDLISRFRANIITKGARAFEEEQWDEISIGSLHFQVLGPCHRCQMICIDQKTGQRNQDVFQKLSESRGRKVNFGVYLMHSSLDLSSPCFLSVGSEVLPVLKDCGVS", "length": 862, "header": "tr|A0A1W2Q693-1|A0A1W2Q693_RAT Isoform 1 of Molybdenum cofactor sulfurase OS=Rattus norvegicus OX=10116 GN=Mocos PE=1 SV=1 CANONICAL=A0A1W2Q693-1" }, "isoforms": [ { "isoform_ac": "A0A1W2Q693-1", "url": "", "sequence": { "sequence": "MACGATERGPEPPAFQRHPEASAPRLAHGYGLRSMSELRDQEFGRLAGTVYLDHAGATLFPQSQLTNFTKDLMENVYGNPHSQNITSKLTHDTVEQVRYRVLTHFHTTPEDYSVIFTAGSTAALRLVAETFPWVSRSPENSGSHFCYLTDNHTSVVGMRTVAATMNVTSTPVKPEDMWSAEGKGAGACDPDCQLPHLFCYPAQSNFSGTRYPLSWIDEVKSGQRSPVRAPGKWFVLLDAASYVSTSPLDLSAHQADFIPISFYKIFGLPTGLGALLVNKRVAPLLRKGYFGGGTAAVYLAGEDFYIPRSSVAERFEDGTISFLDVIALKHGFDVLERLTGGMVNIQQHTFALLHFTHSALSSLRYPNGAPVVRIYGDSGFSSPDVQGPIINFNVLDDAGKIIGYSQVDKMASLYNIHLRTGCFCNLGACQRHLGLSEEMVKKHFQAGHVCGDDVDIIDGRPTGSVRISFGYMSTLEDAQAFLRFISTIYLRSPGGQPVPQASTSDTGVLSSKSDCQSPQEGPCADPAVSSGSYPDINTVDLDLSQSKASSIQPIPQEKVAGILNGDLGSHIVTNIYLYPIKSCAAFEVTKWPVGSQGLLYDRSWMVVNHNGVCLSQKQEPRLCLIQPCIDLQQKVMVIKAEGMEPIQVPLEEDGERTQICQSRVCADRVNTYDCGENVSRWLSKFCGRPCHLIKQSPHFQRNAKKTPKQGHPPGTAVALSLVNEAQYLLVNTSSVLELQQQLNASDERGKEESFSVKDLISRFRANIITKGARAFEEEQWDEISIGSLHFQVLGPCHRCQMICIDQKTGQRNQDVFQKLSESRGRKVNFGVYLMHSSLDLSSPCFLSVGSEVLPVLKDCGVS", "length": 862, "header": "tr|A0A1W2Q693-1|A0A1W2Q693_RAT Isoform 1 of Molybdenum cofactor sulfurase OS=Rattus norvegicus OX=10116 GN=Mocos PE=1 SV=1 CANONICAL=A0A1W2Q693-1" }, "locus": { "chromosome": "18", "start_pos": 15977107, "end_pos": 15932095, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000093715.2", "url": "https://www.ensembl.org/id/ENSRNOT00000093715.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000076171.1", "url": "https://www.ensembl.org/id/ENSRNOP00000076171.1" } ] } }, { "isoform_ac": "D4A1G3-1", "url": "", "sequence": { "sequence": "MACGATERGPEPPAFQRHPEASAPRLAHGYGLRSMSELRDQEFGRLAGTVYLDHAGATLFPQSQLTNFTKDLMENVYGNPHSQNITSKLTHDTVEQVRYRFEDGTISFLDVIALKHGFDVLERLTGGMVNIQQHTFALLHFTHSALSSLRYPNGAPVVRIYGDSGFSSPDV", "length": 171, "header": "tr|D4A1G3-1|D4A1G3_RAT Computationally mapped isoform of Molybdenum cofactor sulfurase OS=Rattus norvegicus OX=10116 GN=Mocos PE=4 SV=2 CANONICAL=A0A1W2Q693-1" }, "locus": { "chromosome": "18", "start_pos": 15951015, "end_pos": 15932095, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000066583.2", "url": "https://www.ensembl.org/id/ENSRNOT00000066583.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000061024.2", "url": "https://www.ensembl.org/id/ENSRNOP00000061024.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "rno:361300", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:361300", "resource": "KEGG Pathway" }, { "id": "R-RNO-947581", "name": "Molybdenum cofactor biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-947581", "resource": "Reactome", "description": "Molybdenum cofactor biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "Q14CH1-1", "protein_name": "Molybdenum cofactor sulfurase", "gene_name": "Mocos", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MACGAAERGPEPPAFQRHLEASTQRLAHGYGLRSMSELRDQEFGRLAGTVYLDHAGATLFPQSQLTNFTKDLMENVYGNPHSQNITSKLTHDTVEQVRYRILTHFHTTPEDYIVIFTAGSTAALRLVAEAFPWVSRSPENSGSHFCYLTDNHTSVVGMRKVAAAMSVTSIPVKPEDMWSAEGKDAGACDPDCQLPHLFCYPAQSNFSGTRYPLSWVEEVKSGRRSPVNAPGKWFVLLDAASYVSTSPLDLSAHQADFIPISFYKIFGLPTGLGALLVNKHVAPLLRKGYFGGGTAAAYLAGEDFYVPRSSVAERFEDGTISFLDVIALKHGFDALEHLTGGMVNIQQHTFALVQYTHSALSSLRYLNGAPVVRIYSDSEFSSPDVQGPIINFNVLDDGGKIIGYSQVDKMASLYNIHLRTGCFCNLGACQRHLGLSDEMVKKHFQAGHVCGDDVDIIDGRPTGSVRISFGYMSTLEDAQAFLRFISTIYLRSPSDQPVPQASISDAGALTSKSDCHSPQEGSCTDPSVCNGSYPDTNIMDLHPSLSKASSAQQTPQDKAAGILNGDPGSHIVTNIYLYPIKSCAAFEVTKWPVGSQGLLYDRSWMVVNHNGICMSQKQEPRLCLIQPFIDLQQRIMVIKAEGMEPIQVPLEEDGEQTQICQSRVCADRVNTYDCGENVSRWLSKFLGRLCHLIKQSPHFQRNARKTPKKGQPPGTTVALSLVNEAQYLLVNTSSILELQRQLNASDEHGKEESFSMKDLISRFRANIITKGARAFEEEKWDEISIGSLHFQVLGPCHRCQMICINQQTGQRNQDVFQTLSESRGRKVNFGVYLMHSYLDLSSPCFLSVGSEVLPVLKDCGVS", "length": 862 }, "evidence": [ { "id": "45239651", "url": "http://www.informatics.jax.org/homology/45239651", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96EN8-1", "protein_name": "Molybdenum cofactor sulfurase", "gene_name": "MOCOS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGAAAESGRELWTFAGSRDPSAPRLAYGYGPGSLRELRAREFSRLAGTVYLDHAGATLFSQSQLESFTSDLMENTYGNPHSQNISSKLTHDTVEQVRYRILAHFHTTAEDYTVIFTAGSTAALKLVAEAFPWVSQGPESSGSRFCYLTDSHTSVVGMRNVTMAINVISTPVRPEDLWSAEERSASASNPDCQLPHLFCYPAQSNFSGVRYPLSWIEEVKSGRLHPVSTPGKWFVLLDAASYVSTSPLDLSAHQADFVPISFYKIFGFPTGLGALLVHNRAAPLLRKTYFGGGTASAYLAGEDFYIPRQSVAQRFEDGTISFLDVIALKHGFDTLERLTGGMENIKQHTFTLAQYTYVALSSLQYPNGAPVVRIYSDSEFSSPEVQGPIINFNVLDDKGNIIGYSQVDKMASLYNIHLRTGCFCNTGACQRHLGISNEMVRKHFQAGHVCGDNMDLIDGQPTGSVRISFGYMSTLDDVQAFLRFIIDTRLHSSGDWPVPQAHADTGETGAPSADSQADVIPAVMGRRSLSPQEDALTGSRVWNNSSTVNAVPVAPPVCDVARTQPTPSEKAAGVLEGALGPHVVTNLYLYPIKSCAAFEVTRWPVGNQGLLYDRSWMVVNHNGVCLSQKQEPRLCLIQPFIDLRQRIMVIKAKGMEPIEVPLEENSERTQIRQSRVCADRVSTYDCGEKISSWLSTFFGRPCHLIKQSSNSQRNAKKKHGKDQLPGTMATLSLVNEAQYLLINTSSILELHRQLNTSDENGKEELFSLKDLSLRFRANIIINGKRAFEEEKWDEISIGSLRFQVLGPCHRCQMICIDQQTGQRNQHVFQKLSESRETKVNFGMYLMHASLDLSSPCFLSVGSQVLPVLKENVEGHDLPASEKHQDVTS", "length": 888 }, "evidence": [ { "id": "45239651", "url": "http://www.informatics.jax.org/homology/45239651", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "molybdenum ion binding", "id": "GO:0030151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030151", "evidence": [ { "database": "UniProtKB", "id": "A0A1W2Q693", "url": "https://www.uniprot.org/uniprot/A0A1W2Q693" } ], "pmid": "" }, { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "A0A1W2Q693", "url": "https://www.uniprot.org/uniprot/A0A1W2Q693" } ], "pmid": "" }, { "name": "lyase activity", "id": "GO:0016829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016829", "evidence": [ { "database": "UniProtKB", "id": "A0A1W2Q693", "url": "https://www.uniprot.org/uniprot/A0A1W2Q693" } ], "pmid": "" }, { "name": "Mo-molybdopterin cofactor sulfurase activity", "id": "GO:0008265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008265", "evidence": [ { "database": "UniProtKB", "id": "A0A1W2Q693", "url": "https://www.uniprot.org/uniprot/A0A1W2Q693" } ], "pmid": "" }, { "name": "molybdenum cofactor sulfurtransferase activity", "id": "GO:0102867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102867", "evidence": [ { "database": "UniProtKB", "id": "A0A1W2Q693", "url": "https://www.uniprot.org/uniprot/A0A1W2Q693" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "Mo-molybdopterin cofactor biosynthetic process", "id": "GO:0006777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006777", "evidence": [ { "database": "UniProtKB", "id": "A0A1W2Q693", "url": "https://www.uniprot.org/uniprot/A0A1W2Q693" } ], "pmid": "" }, { "name": "molybdopterin cofactor metabolic process", "id": "GO:0043545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043545", "evidence": [ { "database": "UniProtKB", "id": "A0A1W2Q693", "url": 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"output_participant_list": [], "enzyme_list": [ "A0A1W2Q693-1", "Q96EN8-1", "Q14CH1-1", "Q559G8-1", "Q9VRA2-1" ], "evidence": [ { "id": "42636", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42636" } ] }, { "id": "61644", "name": "", "equation": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine = 2 Fe(III)-[cytochrome b5] + H2O + L-arginine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O88994-1", "A0A1W2Q693-1", "Q969Z3-1", "Q5VT66-1", "Q922Q1-1", "Q9CW42-1" ], "evidence": [ { "id": "61644", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/61644" } ] }, { "id": "R-RNO-947499", "name": "Exchange of oxygen with sulfur in MoCo", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-111707" ], "output_participant_list": [ "R-ALL-29432", "R-ALL-947575" ], "enzyme_list": [ "A0A1W2Q693-1" ], "evidence": [ { "id": "R-RNO-947499", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-947499" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-111707", "participant_name": "L-Cys [cytosol]", "crossref": [ { "id": "C00097", "database": "COMPOUND", "url": "" }, { "id": "35235", "database": "ChEBI", "url": "" }, { "id": "000000895042", "database": "ZINC", "url": "" }, { "id": "C00097", "database": "COMPOUND", "url": "" }, { "id": "000000895042", "database": "ZINC", "url": "" }, { "id": "35235", "database": "ChEBI", "url": "" }, { "id": "000000895042", "database": "ZINC", "url": "" }, { "id": "C00097", "database": "COMPOUND", "url": "" }, { "id": "35235", "database": "ChEBI", "url": "" }, { "id": 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