{
    "uniprot_canonical_ac": "A0A1W2Q641-1",
    "uniprot_ac": "A0A1W2Q641",
    "uniprot_id": "A0A1W2Q641_RAT",
    "mass": {
        "chemical_mass": 68117.0,
        "monoisotopic_mass": 68117.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Atp6v1a",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1W2Q641",
            "id": "A0A1W2Q641"
        }
    ],
    "protein_names": [
        {
            "name": "H(+)-transporting two-sector ATPase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A0A1W2Q641"
        },
        {
            "name": "7.1.2.2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A1W2Q641"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0070129",
            "recommended_name": {
                "id": "DOID:0070129",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0070129",
                "name": "autosomal recessive cutis laxa type IID",
                "description": "An autosomal recessive cutis laxa type II classic type that is characterized by generalized skin wrinkling with sparse subcutaneous fat and dysmorphic progeroid facial featuret and that has_material_basis_in homozygous mutation in the ATP6V1A gene on chromosome 3q13."
            },
            "synonyms": [
                {
                    "id": "DOID:0070129",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070129",
                    "name": "ARCL2D",
                    "description": ""
                },
                {
                    "id": "MONDO:0027451",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0027451",
                    "name": "autosomal recessive cutis laxa type 2D",
                    "description": "An autosomal recessive cutis laxa type II classic type characterized by cardiovascular and neurologic involvement and that has material basis in homozygous mutation in the ATP6V1A gene on chromosome 3q13."
                },
                {
                    "id": "MONDO:0027451",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0027451",
                    "name": "ARCL2D",
                    "description": ""
                },
                {
                    "id": "MONDO:0027451",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0027451",
                    "name": "autosomal recessive cutis laxa type IID",
                    "description": ""
                },
                {
                    "id": "MONDO:0027451",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0027451",
                    "name": "cutis laxa, autosomal recessive, type 2D",
                    "description": ""
                },
                {
                    "id": "MONDO:0027451",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0027451",
                    "name": "cutis laxa, autosomal recessive, type IID",
                    "description": ""
                },
                {
                    "id": "MIM:617403",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/617403",
                    "name": "Cutis laxa, autosomal recessive, 2D",
                    "description": "Cutis laxa, autosomal recessive, 2D"
                }
            ],
            "evidence": [
                {
                    "id": "0070129",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070129"
                }
            ]
        },
        {
            "disease_id": "DOID:0112275",
            "recommended_name": {
                "id": "DOID:0112275",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0112275",
                "name": "developmental and epileptic encephalopathy 93",
                "description": "A developmental and epileptic encephalopathy characterized by delayed psychomotor development, early-onset refractory seizures, and impaired intellectual development that has_material_basis_in heterozygous mutation in the ATP6V1A gene on chromosome 3q13.31."
            },
            "synonyms": [
                {
                    "id": "DOID:0112275",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112275",
                    "name": "IECEE3",
                    "description": ""
                },
                {
                    "id": "DOID:0112275",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112275",
                    "name": "DEE93",
                    "description": ""
                },
                {
                    "id": "DOID:0112275",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112275",
                    "name": "infantile or early childhood epileptic encephalopathy 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0020632",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0020632",
                    "name": "epileptic encephalopathy, infantile or early childhood, 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0020632",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0020632",
                    "name": "IECEE3",
                    "description": ""
                },
                {
                    "id": "MONDO:0020632",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0020632",
                    "name": "developmental and epileptic encephalopathy 93",
                    "description": ""
                },
                {
                    "id": "MONDO:0020632",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0020632",
                    "name": "epileptic encephalopathy, infantile or early childhood, 3",
                    "description": ""
                },
                {
                    "id": "MIM:618012",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/618012",
                    "name": "Epileptic encephalopathy, infantile or early childhood, 3",
                    "description": "Epileptic encephalopathy, infantile or early childhood, 3"
                }
            ],
            "evidence": [
                {
                    "id": "0112275",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112275"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1W2Q641",
                    "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                }
            ],
            "common_name": "Rat"
        }
    ],
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        {
            "name": "Atp6v1a",
            "url": "https://www.uniprot.org/uniprot/A0A1W2Q641",
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                "start_pos": 56614694,
                "end_pos": 56560974,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000001992",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000001992"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000001992",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000001992",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd01134",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01134",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd18111",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18111",
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            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd18119",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18119",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "D4A133",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:D4A133*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000194",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000194",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR004100",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004100",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR005725",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005725",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR020003",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020003",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR022878",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR022878",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR023366",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023366",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR024034",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024034",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027417",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR031686",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR031686",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036121",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036121",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:685232",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:685232",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A1W2Q641",
            "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A1W2Q641",
            "database": "O-GlcNAc Database",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "RIVKTFW",
            "url": "https://omabrowser.org/oma/group/RIVKTFW/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5473187at2759",
            "url": "http://www.orthodb.org/?query=5473187at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR43607",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43607",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR43607:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43607:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "6VQ6",
            "url": "https://www.rcsb.org/structure/6VQ6",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "6VQ7",
            "url": "https://www.rcsb.org/structure/6VQ7",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "6VQ8",
            "url": "https://www.rcsb.org/structure/6VQ8",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "6VQ9",
            "url": "https://www.rcsb.org/structure/6VQ9",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "6VQA",
            "url": "https://www.rcsb.org/structure/6VQA",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "6VQB",
            "url": "https://www.rcsb.org/structure/6VQB",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PF00006",
            "url": "http://pfam.xfam.org/family/PF00006",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02874",
            "url": "http://pfam.xfam.org/family/PF02874",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF16886",
            "url": "http://pfam.xfam.org/family/PF16886",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-1222556",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1222556",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-77387",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77387",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-917977",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-917977",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9639288",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9639288",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-983712",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983712",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1596464",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1596464",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "57720",
            "url": "https://www.rhea-db.org/rhea/57720",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A1W2Q641",
            "url": "https://www.uniprot.org/uniprot/A0A1W2Q641",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1W2Q641-1",
            "url": "https://www.uniprot.org/uniprot/A0A1W2Q641-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D4A133",
            "url": "https://www.uniprot.org/uniprot/D4A133",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D4A133-1",
            "url": "https://www.uniprot.org/uniprot/D4A133-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MLLDVLDADTSCTYSWTLGQWSSVLSVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKWEFIPSKNLRVGSHITGGDIYGIVNENSLIKHKIMLPPRSRGSVTYIAPPGNYDASDVVLELEFEGVKEKLSMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMISFYDMARRAVETTAQSDNKITWSIIREHMGEILYKLSSMKFKDPVKDGEAKIKADYAQLLEDMQNAFRSLED",
        "length": 616,
        "header": "tr|A0A1W2Q641-1|A0A1W2Q641_RAT Isoform 1 of H(+)-transporting two-sector ATPase  OS=Rattus norvegicus OX=10116 GN=Atp6v1a PE=1 SV=1 CANONICAL=A0A1W2Q641-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1W2Q641-1",
            "url": "",
            "sequence": {
                "sequence": "MLLDVLDADTSCTYSWTLGQWSSVLSVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKWEFIPSKNLRVGSHITGGDIYGIVNENSLIKHKIMLPPRSRGSVTYIAPPGNYDASDVVLELEFEGVKEKLSMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMISFYDMARRAVETTAQSDNKITWSIIREHMGEILYKLSSMKFKDPVKDGEAKIKADYAQLLEDMQNAFRSLED",
                "length": 616,
                "header": "tr|A0A1W2Q641-1|A0A1W2Q641_RAT Isoform 1 of H(+)-transporting two-sector ATPase  OS=Rattus norvegicus OX=10116 GN=Atp6v1a PE=1 SV=1 CANONICAL=A0A1W2Q641-1"
            },
            "locus": {
                "chromosome": "11",
                "start_pos": 56612581,
                "end_pos": 56584924,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000093467.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000093467.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000076121.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000076121.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D4A133-1",
            "url": "",
            "sequence": {
                "sequence": "MCFKFKSDRASGSGLGTDSALRARAGKFSTMDFSKLPKIRDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKWEFIPSKNLRVGSHITGGDIYGIVNENSLIKHKIMLPPRSRGSVTYIAPPGNYDASDVVLELEFEGVKEKLSMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMISFYDMARRAVETTAQSDNKITWSIIREHMGEILYKLSSMKFKDPVKDGEAKIKADYAQLLEDMQNAFRSLED",
                "length": 647,
                "header": "tr|D4A133-1|A0A1W2Q641_RAT Computationally mapped isoform of H(+)-transporting two-sector ATPase  OS=Rattus norvegicus OX=10116 GN=Atp6v1a PE=1 SV=2 CANONICAL=A0A1W2Q641-1"
            },
            "locus": {
                "chromosome": "11",
                "start_pos": 56612581,
                "end_pos": 56561185,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000002727.6",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000002727.6"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000002727.6",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000002727.6"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "G49108TO",
            "type": "O-linked",
            "subtype": "O-GlcNAcylation",
            "site_category": "reported_with_glycan",
            "site_seq": "",
            "relation": "attached",
            "comment": "O-GlcNAcylation",
            "evidence": [
                {
                    "id": "A0A1W2Q641",
                    "database": "O-GlcNAc Database",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A1W2Q641"
                },
                {
                    "id": "18683930",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/18683930"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme",
        "glycoprotein",
        "glycoprotein_reported_with_glycan"
    ],
    "publication": [
        {
            "title": "Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins.",
            "journal": "Journal of the American Chemical Society",
            "date": "2008",
            "authors": "Clark PM, Dweck JF, Mason DE, Hart CR, Buck SB, Peters EC, Agnew BJ, Hsieh-Wilson LC",
            "evidence": [
                {
                    "database": "O-GlcNAc Database",
                    "id": "A0A1W2Q641",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A1W2Q641"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18683930",
                    "url": "https://glygen.org/publication/PubMed/18683930"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:685232",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:685232",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-1222556",
            "name": "ROS and RNS production in phagocytes",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1222556",
            "resource": "Reactome",
            "description": "ROS and RNS production in phagocytes"
        },
        {
            "id": "R-RNO-77387",
            "name": "Insulin receptor recycling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77387",
            "resource": "Reactome",
            "description": "Insulin receptor recycling"
        },
        {
            "id": "R-RNO-917977",
            "name": "Transferrin endocytosis and recycling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-917977",
            "resource": "Reactome",
            "description": "Transferrin endocytosis and recycling"
        },
        {
            "id": "R-RNO-9639288",
            "name": "Amino acids regulate mTORC1",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9639288",
            "resource": "Reactome",
            "description": "Amino acids regulate mTORC1"
        },
        {
            "id": "R-RNO-983712",
            "name": "Ion channel transport",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983712",
            "resource": "Reactome",
            "description": "Ion channel transport"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 15,
                "go_terms": [
                    {
                        "name": "proton-transporting V-type ATPase, V1 domain",
                        "id": "GO:0033180",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033180",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "proton-transporting V-type ATPase complex",
                        "id": "GO:0033176",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033176",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "extrinsic component of synaptic vesicle membrane",
                        "id": "GO:0098850",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098850",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "secretory granule",
                        "id": "GO:0030141",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030141",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "apical plasma membrane",
                        "id": "GO:0016324",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "clathrin-coated vesicle membrane",
                        "id": "GO:0030665",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030665",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "microvillus",
                        "id": "GO:0005902",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transmembrane transporter complex",
                        "id": "GO:1902495",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902495",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "vacuolar proton-transporting V-type ATPase, V1 domain",
                        "id": "GO:0000221",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000221",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATPase complex",
                        "id": "GO:1904949",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904949",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "ATP binding",
                        "id": "GO:0005524",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "proton-transporting ATP synthase activity, rotational mechanism",
                        "id": "GO:0046933",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046933",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "proton-transporting ATPase activity, rotational mechanism",
                        "id": "GO:0046961",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046961",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "intracellular iron ion homeostasis",
                        "id": "GO:0006879",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006879",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to increased oxygen levels",
                        "id": "GO:0036295",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036295",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synaptic vesicle lumen acidification",
                        "id": "GO:0097401",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097401",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "proton transmembrane transport",
                        "id": "GO:1902600",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902600",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATP metabolic process",
                        "id": "GO:0046034",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046034",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q641",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 122,
            "end_pos": 124,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 313,
            "end_pos": 315,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "57720",
            "name": "",
            "equation": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P10719-1",
                "A0A1W2Q641-1",
                "P06576-1",
                "P38606-1",
                "P56480-1",
                "P50516-1",
                "P17255-1",
                "P00830-1",
                "P54647-1",
                "Q55CS9-1",
                "Q27331-1",
                "P48602-1",
                "Q05825-1",
                "Q9VK47-1",
                "Q8T4C4-1"
            ],
            "evidence": [
                {
                    "id": "57720",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/57720"
                }
            ]
        },
        {
            "id": "R-RNO-1222516",
            "name": "Intraphagosomal pH is lowered to 5 by V-ATPase",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, phagocytic vesicle membrane, phagocytic vesicle lumen",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A1W2Q641-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-1222516",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1222516"
                }
            ]
        },
        {
            "id": "R-RNO-5252133",
            "name": "ATP6AP1 binds V-ATPase",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, early endosome membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A1W2Q641-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-5252133",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5252133"
                }
            ]
        },
        {
            "id": "R-RNO-74723",
            "name": "Endosome acidification",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "endosome",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A1W2Q641-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-74723",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-74723"
                }
            ]
        },
        {
            "id": "R-RNO-917841",
            "name": "Acidification of Tf:TfR1 containing endosome",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "endosome membrane",
            "input_participant_list": [],
            "output_participant_list": [
                "R-ALL-74722"
            ],
            "enzyme_list": [
                "A0A1W2Q641-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-917841",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-917841"
                }
            ]
        },
        {
            "id": "R-RNO-9639286",
            "name": "RRAGC,D exchanges GTP for GDP",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "lysosomal membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q63486-1",
                "Q63487-1",
                "A0A1W2Q641-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9639286",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9639286"
                }
            ]
        },
        {
            "id": "R-RNO-9640167",
            "name": "RRAGA,B exchanges GDP for GTP",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "lysosomal membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q63486-1",
                "Q63487-1",
                "A0A1W2Q641-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9640167",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9640167"
                }
            ]
        },
        {
            "id": "R-RNO-9640168",
            "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "lysosomal membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q63486-1",
                "Q63487-1",
                "A0A1W2Q641-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9640168",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9640168"
                }
            ]
        },
        {
            "id": "R-RNO-9640175",
            "name": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "lysosomal membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q63486-1",
                "Q63487-1",
                "A0A1W2Q641-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9640175",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9640175"
                }
            ]
        },
        {
            "id": "R-RNO-9640195",
            "name": "RRAGA,B hydrolyzes GTP",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "lysosomal membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P42346-1",
                "Q63486-1",
                "Q63487-1",
                "D3ZV22-1",
                "A0A1W2Q641-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9640195",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9640195"
                }
            ]
        },
        {
            "id": "R-RNO-9645598",
            "name": "RRAGC,D hydrolyzes GTP",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "lysosomal membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q63486-1",
                "Q63487-1",
                "A0A1W2Q641-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9645598",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9645598"
                }
            ]
        },
        {
            "id": "R-RNO-9645608",
            "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "lysosomal membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P42346-1",
                "Q63486-1",
                "Q63487-1",
                "A0A1W2Q641-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9645608",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9645608"
                }
            ]
        },
        {
            "id": "R-RNO-9646468",
            "name": "mTORC1 binds RHEB:GTP",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "lysosomal membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P42346-1",
                "Q63486-1",
                "Q63487-1",
                "A0A1W2Q641-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9646468",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9646468"
                }
            ]
        }
    ],
    "reaction_participants": [
        {
            "participant_id": "R-ALL-74722",
            "participant_name": "H+ [endosome lumen]",
            "crossref": [
                {
                    "id": "C00080",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "15378",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "HMDB0059597",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "8145820",
                    "database": "PubChem Substance",
                    "url": ""
                },
                {
                    "id": "C00080",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "15378",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "HMDB0059597",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "8145820",
                    "database": "PubChem Substance",
                    "url": ""
                },
                {
                    "id": "C00080",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "15378",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "HMDB0059597",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "8145820",
                    "database": "PubChem Substance",
                    "url": ""
                },
                {
                    "id": "C00080",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "15378",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "HMDB0059597",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "8145820",
                    "database": "PubChem Substance",
                    "url": ""
                },
                {
                    "id": "HMDB0059597",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "C00080",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "8145820",
                    "database": "PubChem Substance",
                    "url": ""
                },
                {
                    "id": "15378",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "C00080",
                    "database": "COMPOUND",
                    "url": ""
                },
                {
                    "id": "15378",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "HMDB0059597",
                    "database": "HMDB Metabolite",
                    "url": ""
                },
                {
                    "id": "8145820",
                    "database": "PubChem Substance",
                    "url": ""
                }
            ]
        }
    ],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A0A1W2Q641",
            "gene_name": "Atp6v1a",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "A0A1W2Q641",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A0A1W2Q641",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A1W2Q641"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "D3ZV22",
            "gene_name": "Bmt2",
            "activity": [
                {
                    "ec_number": "2.1.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "D3ZV22",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/D3ZV22"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P00830",
            "gene_name": "ATP2",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "P00830",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P00830"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P00830",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P00830"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P06576",
            "gene_name": "ATP5F1B",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "P06576",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P06576"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P06576",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P06576"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P10719",
            "gene_name": "Atp5f1b",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "P10719",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P10719"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P10719",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P10719"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P17255",
            "gene_name": "VMA1",
            "activity": [
                {
                    "ec_number": "3.1.-.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P17255",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P17255"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "P17255",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P17255"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P17255",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P17255"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P38606",
            "gene_name": "ATP6V1A",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "P38606",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P38606"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P38606",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P38606"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P42346",
            "gene_name": "Mtor",
            "activity": [
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
                    "evidence": [
                        {
                            "id": "P42346",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P42346"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.1",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P42346",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P42346"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P48602",
            "gene_name": "Vha68-1",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "P48602",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P48602"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P48602",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P48602"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P50516",
            "gene_name": "Atp6v1a",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "P50516",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P50516"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P50516",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P50516"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P54647",
            "gene_name": "vatA",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "P54647",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P54647"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P54647",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P54647"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P56480",
            "gene_name": "Atp5f1b",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "P56480",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P56480"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P56480",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P56480"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q05825",
            "gene_name": "ATPsynbeta",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q05825",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q05825"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q05825",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q05825"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q27331",
            "gene_name": "Vha68-2",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q27331",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q27331"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q27331",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q27331"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q55CS9",
            "gene_name": "atp5f1b",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q55CS9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CS9"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q55CS9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CS9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q63486",
            "gene_name": "Rraga",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q63486",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q63486"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q63487",
            "gene_name": "RragB",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q63487",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q63487"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8T4C4",
            "gene_name": "ATPsynbetaL",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q8T4C4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8T4C4"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8T4C4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8T4C4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9VK47",
            "gene_name": "Vha68-3",
            "activity": [
                {
                    "ec_number": "7.1.2.2",
                    "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q9VK47",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9VK47"
                        }
                    ]
                },
                {
                    "ec_number": "7.1.2.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9VK47",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9VK47"
                        }
                    ]
                }
            ]
        }
    ],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                },
                {
                    "field": "total_sites",
                    "count": 1
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 1
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 1
                }
            ],
            "sort_fields": [
                "glytoucan_ac",
                "type",
                "subtype",
                "site_category",
                "site_seq",
                "relation",
                "comment"
            ]
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
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