{
    "uniprot_canonical_ac": "A0A1W2Q625-1",
    "uniprot_ac": "A0A1W2Q625",
    "uniprot_id": "A0A1W2Q625_RAT",
    "mass": {
        "chemical_mass": 71872.0,
        "monoisotopic_mass": 71872.0
    },
    "refseq": {
        "ac": "NP_001100108",
        "name": "anion exchange transporter",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100108"
    },
    "gene_names": [
        {
            "name": "Slc26a7",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1W2Q625",
            "id": "A0A1W2Q625"
        },
        {
            "name": "Slc26a7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006237973",
            "id": "XP_006237973"
        }
    ],
    "protein_names": [
        {
            "name": "Anion exchange transporter",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A0A1W2Q625"
        },
        {
            "name": "Solute carrier family 26 member 7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A1W2Q625"
        },
        {
            "name": "anion exchange transporter isoform X2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006237973",
            "id": "XP_006237973"
        },
        {
            "name": "anion exchange transporter",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100108",
            "id": "NP_001100108"
        },
        {
            "name": "solute carrier family 26 (anion exchanger), member 7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100108",
            "id": "NP_001100108"
        }
    ],
    "function": [
        {
            "annotation": "SLC26A7 is a Cl(-) uptake system under histamine stimulation",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001100108",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100108"
                },
                {
                    "database": "PubMed",
                    "id": "17404755",
                    "url": "https://glygen.org/publication/PubMed/17404755"
                }
            ]
        },
        {
            "annotation": "Slc26a1, Slc26a6 and Slc26a7 are novel participants in the extracellular transport of bicarbonate during enamel maturation. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001100108",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100108"
                },
                {
                    "database": "PubMed",
                    "id": "26671068",
                    "url": "https://glygen.org/publication/PubMed/26671068"
                }
            ]
        },
        {
            "annotation": "Suggest that the increase in Slc26a7 expression caused by acid challenge represents an adaptive response, indicating that Slc26a7 contributes to the regulation of acid-base balance by the kidney.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001100108",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100108"
                },
                {
                    "database": "PubMed",
                    "id": "18663336",
                    "url": "https://glygen.org/publication/PubMed/18663336"
                }
            ]
        },
        {
            "annotation": "Thyroglobulin regulates the expression and localization of the novel iodide transporter solute carrier family 26 member 7 (SLC26A7) in thyrocytes.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001100108",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100108"
                },
                {
                    "database": "PubMed",
                    "id": "35644541",
                    "url": "https://glygen.org/publication/PubMed/35644541"
                }
            ]
        },
        {
            "annotation": "Vasopressin increases the expression of SLC26A7 protein through posttranscriptional mechanisms in the outer medullary collecting duct",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001100108",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100108"
                },
                {
                    "database": "PubMed",
                    "id": "16352747",
                    "url": "https://glygen.org/publication/PubMed/16352747"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050328",
            "recommended_name": {
                "id": "DOID:0050328",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050328",
                "name": "congenital hypothyroidism",
                "description": "A hypothyroidism that is present at birth."
            },
            "synonyms": [
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "hypothyroidism due to TSH receptor mutations",
                    "description": "Hypothyroidism due to thyroid-stimulating hormone (TSH) receptor mutations is a type of primary congenital hypothyroidism, a permanent thyroid hormone deficiency that is present from birth due to thyroid resistance to TSH."
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "CHNG1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "TSH resistance",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "hypothyroidism, congenital, nongoitrous, type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "congenital nongoitrous hypothryoidism 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "congenital nongoitrous hypothyroidism 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "hypothyroidism due to unresponsiveness to thyrotropin",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "hypothyroidism, Nonautoimmune",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "hypothyroidism, congenital, due to TSH resistance",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "hypothyroidism, congenital, nongoitrous, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "thyroid-stimulating hormone, resistance to",
                    "description": ""
                },
                {
                    "id": "MONDO:0010142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010142",
                    "name": "thyrotropin resistance",
                    "description": ""
                },
                {
                    "id": "MIM:275200",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/275200",
                    "name": "Hypothyroidism, congenital, non-goitrous, 1",
                    "description": "Hypothyroidism, congenital, non-goitrous, 1"
                }
            ],
            "evidence": [
                {
                    "id": "0050328",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050328"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1W2Q625",
                    "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Slc26a7",
            "url": "https://www.uniprot.org/uniprot/A0A1W2Q625",
            "locus": {
                "chromosome": "5",
                "start_pos": 27887042,
                "end_pos": 28021658,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000006096",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000006096"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000006096",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000006096",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd07042",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07042",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "297910",
            "url": "https://www.ncbi.nlm.nih.gov/gene/297910",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001902",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001902",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002645",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002645",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011547",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011547",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036513",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036513",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:297910",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:297910",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "FVDHTVM",
            "url": "https://omabrowser.org/oma/group/FVDHTVM/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1067648at2759",
            "url": "http://www.orthodb.org/?query=1067648at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11814",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11814:SF75",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814:SF75",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00916",
            "url": "http://pfam.xfam.org/family/PF00916",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01740",
            "url": "http://pfam.xfam.org/family/PF01740",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-427601",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-427601",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_006237973",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006237973",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1310846",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310846",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A1W2Q610",
            "url": "https://www.uniprot.org/uniprot/A0A1W2Q610",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1W2Q610-1",
            "url": "https://www.uniprot.org/uniprot/A0A1W2Q610-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1W2Q625",
            "url": "https://www.uniprot.org/uniprot/A0A1W2Q625",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1W2Q625-1",
            "url": "https://www.uniprot.org/uniprot/A0A1W2Q625-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6AL80",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AL80",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6AL80-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AL80-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3Z8P6",
            "url": "https://www.uniprot.org/uniprot/D3Z8P6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3Z8P6-1",
            "url": "https://www.uniprot.org/uniprot/D3Z8P6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MTGAKRKKRSVLWGKMHTPHREDIKQWCKRRLPILEWAPQYNLKENLLPDTVSGVLLAVQQVTQGLSFAILSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISANAVERLVPQSNRNLTTQSNSSVLGLSEFELQRIGVAAAVSFLGGVIQLVMFVLQLGNATFLLTEPVISAMTTGAATHVVTSQVKYLLGIKMPYISGPLGFFYIYAYVFENIKSVQLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGRIPKGIPPPRAPPMNILSAVLTEAFGVALVGYVASLALAQGSAKKFKYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWISTYIFTICFAANVGLLFGVVCTIAIVLGRFPRAKTLSITDMKEMELKVKTETYDENSQQIKIISINNPLVFLNAKKFSADLMKIILKETDGSQALDDVSKCEQNTLLSPLPNGSCTEEASQPCPSEKYSLVLNCSGLTFFDYTGVSTLVELYLDCKSRSVDVFLANCTASLIKAMTYYGDLDTEKPIFFDSVATAISVIQSNKNLSKDTDHSEV",
        "length": 656,
        "header": "tr|A0A1W2Q625-1|A0A1W2Q625_RAT Isoform 1 of Anion exchange transporter  OS=Rattus norvegicus OX=10116 GN=Slc26a7 PE=3 SV=2 CANONICAL=A0A1W2Q625-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1W2Q610-1",
            "url": "",
            "sequence": {
                "sequence": "MTGAKRKKRSVLWGKMHTPHREDIKQWCKRRLPILEWAPQYNLKENLLPDTVSGVLLAVQQVTQGLSFAILSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISANAVERLVPQSNRNLTTQSNSSVLGLSEFELQRIGVAAAVSFLGGVIQLVMFVLQLGNATFLLTEPVISAMTTGAATHVVTSQVKYLLGIKMPYISGPLGFFYIYAYVFENIKSVQLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGRIPKGIPPPRAPPMNILSAVLTEAFGVALVGYVASLALAQGSAKKFKYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWISTYIFTICFAANVGLLFGVVCTIAIVLGRFPRAKTLSITDMKEMELKVKTETYDNTENWPPSKSTNVKVFPGSLKTGSNVRSLSVTPRRMENSQQIKIISINNPLVFLNAKKFSADLMKIILKETDGSQALDDVSKCEQNTLLSPLPNGSCTEEASQPCPSEKYSLVLNCSGLTFFDYTGVSTLVELYLDCKSRSVDVFLANCTASLIKAMTYYGDLDTEKPIFFDSVATAISVIQSNKNLSKDTDHSEV",
                "length": 692,
                "header": "tr|A0A1W2Q610-1|A0A1W2Q610_RAT Computationally mapped isoform of Anion exchange transporter  OS=Rattus norvegicus OX=10116 GN=Slc26a7 PE=1 SV=2 CANONICAL=A0A1W2Q625-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 28021300,
                "end_pos": 27887409,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000093186.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000093186.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000076092.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000076092.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A1W2Q625-1",
            "url": "",
            "sequence": {
                "sequence": "MTGAKRKKRSVLWGKMHTPHREDIKQWCKRRLPILEWAPQYNLKENLLPDTVSGVLLAVQQVTQGLSFAILSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISANAVERLVPQSNRNLTTQSNSSVLGLSEFELQRIGVAAAVSFLGGVIQLVMFVLQLGNATFLLTEPVISAMTTGAATHVVTSQVKYLLGIKMPYISGPLGFFYIYAYVFENIKSVQLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGRIPKGIPPPRAPPMNILSAVLTEAFGVALVGYVASLALAQGSAKKFKYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWISTYIFTICFAANVGLLFGVVCTIAIVLGRFPRAKTLSITDMKEMELKVKTETYDENSQQIKIISINNPLVFLNAKKFSADLMKIILKETDGSQALDDVSKCEQNTLLSPLPNGSCTEEASQPCPSEKYSLVLNCSGLTFFDYTGVSTLVELYLDCKSRSVDVFLANCTASLIKAMTYYGDLDTEKPIFFDSVATAISVIQSNKNLSKDTDHSEV",
                "length": 656,
                "header": "tr|A0A1W2Q625-1|A0A1W2Q625_RAT Isoform 1 of Anion exchange transporter  OS=Rattus norvegicus OX=10116 GN=Slc26a7 PE=3 SV=2 CANONICAL=A0A1W2Q625-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 28021300,
                "end_pos": 27887409,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000093409.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000093409.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000076107.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000076107.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6AL80-1",
            "url": "",
            "sequence": {
                "sequence": "MTGAKRKKRSVLWGKMHTPHREDIKQWCKRRLPILEWAPQYNLKENLLPDTVSGVLLAVQQVTQGLSFAILSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISANAVERLVPQSNRNLTTQSNSSVLGLSEFELQRIGVAAAVSFLGGVIQLVMFVLQLGNATFLLTEPVISAMTTGAATHVVTSQVKYLLGIKMPYISGPLGFFYIYAYVFENIKSVQLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLDPSAPCSPNEHPLRSAHGSFRSCTCRLRGLAGSRTRICQEVQIFS",
                "length": 310,
                "header": "tr|A0A8I6AL80-1|A0A8I6AL80_RAT Computationally mapped isoform of Solute carrier family 26 member 7  OS=Rattus norvegicus OX=10116 GN=Slc26a7 PE=4 SV=1 CANONICAL=A0A1W2Q625-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 28021300,
                "end_pos": 27935359,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000106456.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000106456.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000094547.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000094547.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3Z8P6-1",
            "url": "",
            "sequence": {
                "sequence": "MTGAKRKKRSVLWGKMHTPHREDIKQWCKRRLPILEWAPQYNLKENLLPDTVSGVLLAVQQVTQGLSFAILSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISANAVERLVPQSNRNLTTQSNSSVLGLSEFELQRIGVAAAVSFLGGVIQIYAYVFENIKSVQLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGRIPKGIPPPRAPPMNILSAVLTEAFGVALVGYVASLALAQGSAKKFKYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWISTYIFTICFAANVGLLFGVVCTIAIVLGRFPRAKTLSITDMKEMELKVKTETYDENSQQIKIISINNPLVFLNAKKFSADLMKIILKETDGSQALDDVSKCEQNTLLSPLPNGSCTEEASQPCPSEKYSLVLNCSGLTFFDYTGVSTLVELYLDCKSRSVDVFLANCTASLIKAMTYYGDLDTEKPIFFDSVATAISVIQSNKNLSKDTDHSEV",
                "length": 601,
                "header": "tr|D3Z8P6-1|D3Z8P6_RAT Computationally mapped isoform of Anion exchange transporter  OS=Rattus norvegicus OX=10116 GN=Slc26a7 PE=1 SV=1 CANONICAL=A0A1W2Q625-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 28021300,
                "end_pos": 27887409,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000067331.4",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000067331.4"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000058989.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000058989.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats.",
            "journal": "American journal of physiology. Renal physiology",
            "date": "2006",
            "authors": "Petrovic S, Amlal H, Sun X, Karet F, Barone S, Soleimani M",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001100108",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100108"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16352747",
                    "url": "https://glygen.org/publication/PubMed/16352747"
                }
            ]
        },
        {
            "title": "SLC26A7 can function as a chloride-loading mechanism in parietal cells.",
            "journal": "Pflugers Archiv : European journal of physiology",
            "date": "2007",
            "authors": "Kosiek O, Busque SM, Foller M, Shcheynikov N, Kirchhoff P, Bleich M, Muallem S, Geibel JP",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001100108",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100108"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17404755",
                    "url": "https://glygen.org/publication/PubMed/17404755"
                }
            ]
        },
        {
            "title": "Increased acid load and deletion of AE1 increase Slc26a7 expression.",
            "journal": "Nephron. Physiology",
            "date": "2008",
            "authors": "Sun X, Petrovic S",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001100108",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100108"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18663336",
                    "url": "https://glygen.org/publication/PubMed/18663336"
                }
            ]
        },
        {
            "title": "SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.",
            "journal": "PloS one",
            "date": "2015",
            "authors": "Yin K, Lei Y, Wen X, Lacruz RS, Soleimani M, Kurtz I, Snead ML, White SN, Paine ML",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001100108",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100108"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26671068",
                    "url": "https://glygen.org/publication/PubMed/26671068"
                }
            ]
        },
        {
            "title": "Thyroglobulin regulates the expression and localization of the novel iodide transporter solute carrier family 26 member 7 (SLC26A7) in thyrocytes.",
            "journal": "Endocrine journal",
            "date": "2022-10-28",
            "authors": "Kiriya Mitsuo, Kawashima Akira, Fujiwara Yoko, Tanimura Yuta, Yoshihara Aya, Nakamura Yasuhiro, Tanigawa Kazunari, Kondo Tetsuo, Suzuki Koichi",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001100108",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100108"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "35644541",
                    "url": "https://glygen.org/publication/PubMed/35644541"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:297910",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:297910",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-427601",
            "name": "Multifunctional anion exchangers",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-427601",
            "resource": "Reactome",
            "description": "Multifunctional anion exchangers"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8R2Z3-1",
            "protein_name": "Anion exchange transporter",
            "gene_name": "Slc26a7",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MTGAKRKKRSVLWGKMHTPHREDIKQWCKRRLPILEWAPQYNLKENLLPDTVSGIMLAVQQVAQGLSFAMLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISANAVERLVPQSSRNLTTQSNSSVLGLSEFELQRIGVAAAVSFLGGVIQLVMFVLQLGSATFLLTEPVISAMTTGAATHVVTSQVKYLLGIKMPYISGPLGFFYIYAYVFENIKSVQLEALLFSLLSIIVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPNGIPPPRAPPMNILSAVLTEAFGVALVGYVASLALAQGSAKKFKYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWISTYIFTICFAANVGLLFGVICTIAIVLGRFPRAKTLSITDMKEMELKVKTEMHDETSQQIKIISINNPLVFLNAKKFSADLMKIILKESDSNQPLDDVSKCEQNTLLSSLSNGNCNEEASQPCSSEKCSLVLNCSGLTFFDYTGVSTLVELYLDCKSRSVDVFLANCTASLIKAMTYYGDLDTEKPIFFDSVPAAISIIQSNKNLSKASDHSEV",
                "length": 656
            },
            "evidence": [
                {
                    "id": "45243675",
                    "url": "http://www.informatics.jax.org/homology/45243675",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q8TE54-1",
            "protein_name": "Anion exchange transporter",
            "gene_name": "SLC26A7",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDISKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKNLSKLSDHSEV",
                "length": 656
            },
            "evidence": [
                {
                    "id": "45243675",
                    "url": "http://www.informatics.jax.org/homology/45243675",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 11,
                "go_terms": [
                    {
                        "name": "monoatomic anion transmembrane transport",
                        "id": "GO:0098656",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098656",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "oxalate transport",
                        "id": "GO:0019532",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019532",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "gastric acid secretion",
                        "id": "GO:0001696",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001696",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chloride transport",
                        "id": "GO:0006821",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006821",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "bicarbonate transport",
                        "id": "GO:0015701",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015701",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "monoatomic anion transport",
                        "id": "GO:0006820",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006820",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sulfate transport",
                        "id": "GO:0008272",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008272",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "iodide transport",
                        "id": "GO:0015705",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015705",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "thyroid hormone generation",
                        "id": "GO:0006590",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006590",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nitrate transmembrane transport",
                        "id": "GO:0015706",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015706",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "gluconate transmembrane transport",
                        "id": "GO:0035429",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035429",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 5,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endosome",
                        "id": "GO:0005768",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "basolateral plasma membrane",
                        "id": "GO:0016323",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "apical plasma membrane",
                        "id": "GO:0016324",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "lateral plasma membrane",
                        "id": "GO:0016328",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016328",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 7,
                "go_terms": [
                    {
                        "name": "chloride channel activity",
                        "id": "GO:0005254",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005254",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "monoatomic anion channel activity",
                        "id": "GO:0005253",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005253",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "bicarbonate transmembrane transporter activity",
                        "id": "GO:0015106",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015106",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chloride transmembrane transporter activity",
                        "id": "GO:0015108",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015108",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "oxalate transmembrane transporter activity",
                        "id": "GO:0019531",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019531",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sulfate transmembrane transporter activity",
                        "id": "GO:0015116",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015116",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chloride:bicarbonate antiporter activity",
                        "id": "GO:0140900",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140900",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2Q625",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2Q625"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 125,
            "end_pos": 127,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 131,
            "end_pos": 133,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 169,
            "end_pos": 171,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 554,
            "end_pos": 556,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 575,
            "end_pos": 577,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 608,
            "end_pos": 610,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 646,
            "end_pos": 648,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
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                },
                {
                    "field": "n_linked_glycan_sites",
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                },
                {
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                },
                {
                    "field": "o_linked_glycan_sites",
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            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
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                    "field": "total",
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                {
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                {
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                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
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                    "field": "total",
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                {
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                {
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                {
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                {
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        {
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                {
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