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"malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "A0A1W2PPD8", "url": "https://www.uniprot.org/uniprot/A0A1W2PPD8" } ], "common_name": "Human" } ], "gene": [ { "name": "KDM4F", "url": "https://www.uniprot.org/uniprot/A0A1W2PPD8", "locus": { "chromosome": "11", "start_pos": 95051338, "end_pos": 95049422, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000255855", "url": "https://www.ensembl.org/id/ENSG00000255855" } ] } } ], "crossref": [ { "id": "KDM4F", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=KDM4F", "database": "GeneCards", "categories": [ "Organism-specific", "Gene Annotation" ] }, { "id": "52413", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=52413", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "IPR003347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003349", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NHITSCP", "url": "https://omabrowser.org/oma/group/NHITSCP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10694", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10694", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10694:SF90", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10694:SF90", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02373", "url": "http://pfam.xfam.org/family/PF02373", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02375", "url": "http://pfam.xfam.org/family/PF02375", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "60200", "url": "https://www.rhea-db.org/rhea/60200", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A1W2PPD8", "url": "https://www.uniprot.org/uniprot/A0A1W2PPD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PPD8-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PPD8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHRAGLAKVIPPKEWKARQMYDDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRHLANSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQRLECLARELFPGNSRGCEGFLRHKVALISPTVLKKNGIPFNRMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKVASQCSCGEARVTFSMDAFVRILQPESYELWKHRQDLTVVDYMEPRVAESQEPSNWREDIALRRAALGLRHLRNHITSCPTRTVAPRLCYNPKGGGTDAVPGSAIQALETSAWVLPPSTGRWGPCRGCGRGRGRGRGRGRRPRELGTEETTVQSAAKRRLSVGTGSRAPGRKPQLQFADEALTDKPAPLSGGLPHFAKASGCCCAPDLQPLGPPLDPDEPMHPGPCLLSLDSTASSLPLVVPMTPPSVTVPLITLSRDTGGDWKSPVNLAKVVAMDHSYASRVPVPTKFSRISWAPDSSAGAKARQRYATEFGDIFLQCMINPLDPWPLNMVSNVK", "length": 638, "header": "sp|A0A1W2PPD8-1|KDM4F_HUMAN Isoform 1 of Probable lysine-specific demethylase 4F OS=Homo sapiens OX=9606 GN=KDM4F PE=3 SV=1 CANONICAL=A0A1W2PPD8-1" }, "isoforms": [ { "isoform_ac": "A0A1W2PPD8-1", "url": "", "sequence": { "sequence": "MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHRAGLAKVIPPKEWKARQMYDDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRHLANSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQRLECLARELFPGNSRGCEGFLRHKVALISPTVLKKNGIPFNRMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKVASQCSCGEARVTFSMDAFVRILQPESYELWKHRQDLTVVDYMEPRVAESQEPSNWREDIALRRAALGLRHLRNHITSCPTRTVAPRLCYNPKGGGTDAVPGSAIQALETSAWVLPPSTGRWGPCRGCGRGRGRGRGRGRRPRELGTEETTVQSAAKRRLSVGTGSRAPGRKPQLQFADEALTDKPAPLSGGLPHFAKASGCCCAPDLQPLGPPLDPDEPMHPGPCLLSLDSTASSLPLVVPMTPPSVTVPLITLSRDTGGDWKSPVNLAKVVAMDHSYASRVPVPTKFSRISWAPDSSAGAKARQRYATEFGDIFLQCMINPLDPWPLNMVSNVK", "length": 638, "header": "sp|A0A1W2PPD8-1|KDM4F_HUMAN Isoform 1 of Probable lysine-specific demethylase 4F OS=Homo sapiens OX=9606 GN=KDM4F PE=3 SV=1 CANONICAL=A0A1W2PPD8-1" }, "locus": { "chromosome": "11", "start_pos": 95051335, "end_pos": 95049422, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000545950.2", "url": "https://www.ensembl.org/id/ENST00000545950.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000491279.1", "url": "https://www.ensembl.org/id/ENSP00000491279.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A1W2PPD8", "url": "https://www.uniprot.org/uniprot/A0A1W2PPD8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "A0A1W2PPD8", "url": "https://www.uniprot.org/uniprot/A0A1W2PPD8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A1W2PPD8", "url": "https://www.uniprot.org/uniprot/A0A1W2PPD8" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A0A1W2PPD8", "url": "https://www.uniprot.org/uniprot/A0A1W2PPD8" } ], "pmid": "" }, { "name": "histone H3K9 demethylase activity", "id": "GO:0032454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032454", "evidence": [ { "database": "UniProtKB", "id": "A0A1W2PPD8", "url": "https://www.uniprot.org/uniprot/A0A1W2PPD8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "60200", "name": "", "equation": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A5Q5-1", "A0A0G2K5I7-1", "M0RB75-1", "F1LS62-1", "A0A1W2PPD8-1", "O94953-1", "B2RXH2-1", "Q6B0I6-1", "Q9H3R0-1", "O75164-1", "Q8VCD7-1", "Q91VY5-1", "Q8BW72-1", "Q3U2K5-1", "Q9V6L0-1", "Q9V333-1" ], "evidence": [ { "id": "60200", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60200" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K5I7", "gene_name": "Kdm4a", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "A0A0G2K5I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K5I7" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "A0A0G2K5I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K5I7" } ] } ] }, { "uniprot_ac": "A0A1W2PPD8", "gene_name": "KDM4F", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "A0A1W2PPD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1W2PPD8" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "A0A1W2PPD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1W2PPD8" } ] } ] }, { "uniprot_ac": "A1A5Q5", "gene_name": "Kdm4d", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "A1A5Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1A5Q5" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "A1A5Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1A5Q5" } ] } ] }, { "uniprot_ac": "B2RXH2", "gene_name": "KDM4E", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "B2RXH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXH2" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "B2RXH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXH2" } ] } ] }, { "uniprot_ac": "F1LS62", "gene_name": "Kdm4c", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "F1LS62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LS62" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "F1LS62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LS62" } ] } ] }, { "uniprot_ac": "M0RB75", "gene_name": "Kdm4b", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "M0RB75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RB75" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "M0RB75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RB75" } ] } ] }, { "uniprot_ac": "O75164", "gene_name": "KDM4A", "activity": [ { "ec_number": "1.14.11.69", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate.", "evidence": [ { "id": "O75164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75164" } ] }, { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "O75164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75164" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "O75164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75164" } ] }, { "ec_number": "1.14.11.69", "activity": "", "evidence": [ { "id": "O75164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75164" } ] } ] }, { "uniprot_ac": "O94953", "gene_name": "KDM4B", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "O94953", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94953" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "O94953", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94953" } ] } ] }, { "uniprot_ac": "Q3U2K5", "gene_name": "Kdm4d", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "Q3U2K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U2K5" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "Q3U2K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U2K5" } ] } ] }, { "uniprot_ac": "Q6B0I6", "gene_name": "KDM4D", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "Q6B0I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6B0I6" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "Q6B0I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6B0I6" } ] } ] }, { "uniprot_ac": "Q8BW72", "gene_name": "Kdm4a", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "Q8BW72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BW72" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "Q8BW72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BW72" } ] }, { "ec_number": "1.14.11.69", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate.", "evidence": [ { "id": "Q8BW72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BW72" } ] }, { "ec_number": "1.14.11.69", "activity": "", "evidence": [ { "id": "Q8BW72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BW72" } ] } ] }, { "uniprot_ac": "Q8VCD7", "gene_name": "Kdm4c", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "Q8VCD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCD7" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "Q8VCD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCD7" } ] } ] }, { "uniprot_ac": "Q91VY5", "gene_name": "Kdm4b", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "Q91VY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VY5" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "Q91VY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VY5" } ] } ] }, { "uniprot_ac": "Q9H3R0", "gene_name": "KDM4C", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "Q9H3R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H3R0" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "Q9H3R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H3R0" } ] } ] }, { "uniprot_ac": "Q9V333", "gene_name": "Kdm4A", "activity": [ { "ec_number": "1.14.11.27", "activity": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate.", "evidence": [ { "id": "Q9V333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V333" } ] }, { "ec_number": "1.14.11.69", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate.", "evidence": [ { "id": "Q9V333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V333" } ] }, { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "Q9V333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V333" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "Q9V333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V333" } ] }, { "ec_number": "1.14.11.69", "activity": "", "evidence": [ { "id": "Q9V333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V333" } ] } ] }, { "uniprot_ac": "Q9V6L0", "gene_name": "Kdm4B", "activity": [ { "ec_number": "1.14.11.27", "activity": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate.", "evidence": [ { "id": "Q9V6L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V6L0" } ] }, { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "Q9V6L0", "database": "UniProtKB", "url": 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