{
    "uniprot_canonical_ac": "A0A1L4AAC2-1",
    "uniprot_ac": "A0A1L4AAC2",
    "uniprot_id": "A0A1L4AAC2_DROME",
    "mass": {
        "chemical_mass": 100249.0,
        "monoisotopic_mass": 100249.0
    },
    "refseq": {
        "ac": "NP_001334707",
        "name": "uncharacterized protein",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334707"
    },
    "gene_names": [
        {
            "name": "Dmel\\CG45067",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1L4AAC2",
            "id": "A0A1L4AAC2"
        },
        {
            "name": "CG14955; Dmel\\CG45067",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334707",
            "id": "NP_001334707"
        },
        {
            "name": "CG14955",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1L4AAC2",
            "id": "A0A1L4AAC2"
        },
        {
            "name": "CG45067",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334707",
            "id": "NP_001334707"
        },
        {
            "name": "CG45067",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1L4AAC2",
            "id": "A0A1L4AAC2"
        },
        {
            "name": "Dmel_CG45067",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1L4AAC2",
            "id": "A0A1L4AAC2"
        }
    ],
    "protein_names": [
        {
            "name": "Prominin-like protein",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A0A1L4AAC2"
        },
        {
            "name": "CG45067-PB",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334707",
            "id": "NP_001334707"
        },
        {
            "name": "uncharacterized protein",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334707",
            "id": "NP_001334707"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0070438",
            "recommended_name": {
                "id": "DOID:0070438",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0070438",
                "name": "retinal macular dystrophy",
                "description": "A macular degeneration characterized by non-progression or slow progression and drusen-like deposits in varying degrees."
            },
            "synonyms": [
                {
                    "id": "DOID:0070438",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070438",
                    "name": "MCDR",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "North Carolina macular dystrophy",
                    "description": "North Carolina macular dystrophy (NCMD) is a non-progressive autosomal dominant macular disorder of congenital or infantile onset characterized by loss of central vision, the accumulation of drusen in the macula and atrophy of photoreceptor cells with a variable phenotype at macular examination."
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "CAPE dystrophy",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "MCDR1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "NCMD",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "North Carolina macular dystrophy",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "North Carolina macular dystrophy, retinal 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "caped",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "central areolar pigment epithelial dystrophy",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "central retinal pigment epithelial dystrophy",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "macular dystrophy 1, North Carolina type",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "progressive foveal dystrophy",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "foveal dystrophy progressive",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "foveal dystrophy, progressive",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "foveal dystrophy, progressive, formerly",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "macular dystrophy retinal 1 North Carolina type",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "macular dystrophy, retinal, 1, NORTH Carolina type",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "retinal pigment epithelial dystrophy central",
                    "description": ""
                },
                {
                    "id": "MONDO:0007630",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007630",
                    "name": "retinal pigment epithelial dystrophy, central",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "0070438",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070438"
                }
            ]
        },
        {
            "disease_id": "DOID:0110376",
            "recommended_name": {
                "id": "DOID:0110376",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0110376",
                "name": "retinitis pigmentosa 41",
                "description": "A retinitis pigmentosa that has_material_basis_in mutation in the PROM1 gene on chromosome 4p15."
            },
            "synonyms": [
                {
                    "id": "DOID:0110376",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110376",
                    "name": "RP41",
                    "description": ""
                },
                {
                    "id": "MONDO:0012796",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012796",
                    "name": "retinitis pigmentosa 41",
                    "description": "Any retinitis pigmentosa in which the cause of the disease is a mutation in the PROM1 gene."
                },
                {
                    "id": "MONDO:0012796",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012796",
                    "name": "PROM1 retinitis pigmentosa",
                    "description": ""
                },
                {
                    "id": "MONDO:0012796",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012796",
                    "name": "RP41",
                    "description": ""
                },
                {
                    "id": "MONDO:0012796",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012796",
                    "name": "retinitis pigmentosa 41",
                    "description": ""
                },
                {
                    "id": "MONDO:0012796",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012796",
                    "name": "retinitis pigmentosa caused by mutation in PROM1",
                    "description": ""
                },
                {
                    "id": "MONDO:0012796",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012796",
                    "name": "retinitis pigmentosa type 41",
                    "description": ""
                },
                {
                    "id": "MONDO:0012796",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012796",
                    "name": "RP 41",
                    "description": ""
                },
                {
                    "id": "MONDO:0012796",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012796",
                    "name": "retinal Degeneration, autosomal recessive, prominin-related",
                    "description": ""
                },
                {
                    "id": "MIM:612095",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/612095",
                    "name": "Retinitis pigmentosa 41",
                    "description": "Retinitis pigmentosa 41"
                }
            ],
            "evidence": [
                {
                    "id": "0110376",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110376"
                }
            ]
        },
        {
            "disease_id": "DOID:0111019",
            "recommended_name": {
                "id": "DOID:0111019",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111019",
                "name": "cone-rod dystrophy 12",
                "description": "A cone-rod dystrophy that has_material_basis_in homozygous or heterozygous mutation in the PROM1 gene on chromosome 4p15."
            },
            "synonyms": [
                {
                    "id": "DOID:0111019",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111019",
                    "name": "CORD12",
                    "description": ""
                },
                {
                    "id": "MONDO:0012983",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012983",
                    "name": "cone-rod dystrophy 12",
                    "description": "Any cone-rod dystrophy in which the cause of the disease is a mutation in the PROM1 gene."
                },
                {
                    "id": "MONDO:0012983",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012983",
                    "name": "CORD12",
                    "description": ""
                },
                {
                    "id": "MONDO:0012983",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012983",
                    "name": "PROM1 cone-rod dystrophy",
                    "description": ""
                },
                {
                    "id": "MONDO:0012983",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012983",
                    "name": "cone-rod dystrophy 12",
                    "description": ""
                },
                {
                    "id": "MONDO:0012983",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012983",
                    "name": "cone-rod dystrophy caused by mutation in PROM1",
                    "description": ""
                },
                {
                    "id": "MONDO:0012983",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012983",
                    "name": "cone-rod dystrophy type 12",
                    "description": ""
                },
                {
                    "id": "MIM:612657",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/612657",
                    "name": "Cone-rod dystrophy 12",
                    "description": "Cone-rod dystrophy 12"
                }
            ],
            "evidence": [
                {
                    "id": "0111019",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111019"
                }
            ]
        },
        {
            "disease_id": "DOID:9351",
            "recommended_name": {
                "id": "DOID:9351",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9351",
                "name": "diabetes mellitus",
                "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both."
            },
            "synonyms": [
                {
                    "id": "DOID:9351",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9351",
                    "name": "diabetes",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "9351",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:9351"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1L4AAC2",
                    "url": "https://www.uniprot.org/uniprot/A0A1L4AAC2"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "gene": [
        {
            "name": "Dmel\\CG45067",
            "url": "https://www.uniprot.org/uniprot/A0A1L4AAC2",
            "locus": {
                "chromosome": "3L",
                "start_pos": 3111233,
                "end_pos": 3114467,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "FBgn0266437",
                        "url": "https://www.ensembl.org/id/FBgn0266437"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "FBgn0266437",
            "url": "https://bgee.org/?page=gene&gene_id=FBgn0266437",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "FBgn0266437",
            "url": "https://flybase.org/reports/FBgn0266437",
            "database": "FlyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "38371",
            "url": "https://www.ncbi.nlm.nih.gov/gene/38371",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR008795",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008795",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "dme:Dmel_CG45067",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG45067",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "FYRANEI",
            "url": "https://omabrowser.org/oma/group/FYRANEI/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3572915at2759",
            "url": "http://www.orthodb.org/?query=3572915at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR22730",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22730",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR22730:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22730:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF05478",
            "url": "http://pfam.xfam.org/family/PF05478",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001334707",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334707",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1L4AAC2",
            "url": "https://www.uniprot.org/uniprot/A0A1L4AAC2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1L4AAC2-1",
            "url": "https://www.uniprot.org/uniprot/A0A1L4AAC2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MELKVTMWIWVIAFRLHVVKSQTNQPLHSSSKLIDQGSLVRFRRLSPQNRYAEPESRSNNGDADSMCPITYLSHVFTGSVVSYAKEVPKGYISKDGNDIGSKVQEDDWEAYLASQKGLKILVLLLVLLFLLILILGLLYACCCVAWEKNERSSRGCRYCCGILLAILALLMLLFLILAIMAATQLNINLKNLKASGCYPSNSSQSSADYIFQKASERLRHLYVINYDQKVKRIKSALNQDPSIKYPNRELEVHAKAIERLIEVLRNMRRIKPVMLRIKNRLLDARRLATQFRDALRGVKRDLMVILIADCTHSECQDFYRANEIKMLDMGCLHYDSLPEFEPLLESVQEVIDSKFIDYPLQAVGQLRRMSSAIKNRMSDILDSVNKDLNKGAKKLQERYEASLKVLRQVVEEMKKDMPLVVKTNPRSRSTPAADLRRKLGSSWFGTTLCLIVLLMLVPLLLLFGLLIALFSPKVASWLLCAVLVALFILFSVGVILVLFYLVHGALIYQAFCSRKFPQPVDNKSINPNKFLPENVTTFRSMPMVRTSEILQSCVRNESLYNVLGIKEIYDPYGFRDDVMIDVVKSLEKMGNTSMPGAPKEIHPDAEESAKKLLTGNLSTYDIKDYTKYICPQLVPEPNPGPLDGLTRKLESLANKVEPGVTLKNQAIHLRAYQKHLCVPLAAIVQRLIKRLKQMDWLLSGGYGSFVKYLHHLLDKIKQGDDLLRQDSKKEADEVARNISKLVKSGLDDYVRVVEEATKEDMESCEPLIREDDEAMVEYADLCNRIAKPMNAIWFWLLLFSSLLLPTICCTHFLRSRLNSLKHSVATPVSYGESNFMAPGILPLGLPQCQCYRYLPVSAETNVDYLEGMEDYYVDQVKRKRE",
        "length": 881,
        "header": "tr|A0A1L4AAC2-1|A0A1L4AAC2_DROME Isoform 1 of Prominin-like protein  OS=Drosophila melanogaster OX=7227 GN=Dmel\\CG45067 PE=3 SV=1 CANONICAL=A0A1L4AAC2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1L4AAC2-1",
            "url": "",
            "sequence": {
                "sequence": "MELKVTMWIWVIAFRLHVVKSQTNQPLHSSSKLIDQGSLVRFRRLSPQNRYAEPESRSNNGDADSMCPITYLSHVFTGSVVSYAKEVPKGYISKDGNDIGSKVQEDDWEAYLASQKGLKILVLLLVLLFLLILILGLLYACCCVAWEKNERSSRGCRYCCGILLAILALLMLLFLILAIMAATQLNINLKNLKASGCYPSNSSQSSADYIFQKASERLRHLYVINYDQKVKRIKSALNQDPSIKYPNRELEVHAKAIERLIEVLRNMRRIKPVMLRIKNRLLDARRLATQFRDALRGVKRDLMVILIADCTHSECQDFYRANEIKMLDMGCLHYDSLPEFEPLLESVQEVIDSKFIDYPLQAVGQLRRMSSAIKNRMSDILDSVNKDLNKGAKKLQERYEASLKVLRQVVEEMKKDMPLVVKTNPRSRSTPAADLRRKLGSSWFGTTLCLIVLLMLVPLLLLFGLLIALFSPKVASWLLCAVLVALFILFSVGVILVLFYLVHGALIYQAFCSRKFPQPVDNKSINPNKFLPENVTTFRSMPMVRTSEILQSCVRNESLYNVLGIKEIYDPYGFRDDVMIDVVKSLEKMGNTSMPGAPKEIHPDAEESAKKLLTGNLSTYDIKDYTKYICPQLVPEPNPGPLDGLTRKLESLANKVEPGVTLKNQAIHLRAYQKHLCVPLAAIVQRLIKRLKQMDWLLSGGYGSFVKYLHHLLDKIKQGDDLLRQDSKKEADEVARNISKLVKSGLDDYVRVVEEATKEDMESCEPLIREDDEAMVEYADLCNRIAKPMNAIWFWLLLFSSLLLPTICCTHFLRSRLNSLKHSVATPVSYGESNFMAPGILPLGLPQCQCYRYLPVSAETNVDYLEGMEDYYVDQVKRKRE",
                "length": 881,
                "header": "tr|A0A1L4AAC2-1|A0A1L4AAC2_DROME Isoform 1 of Prominin-like protein  OS=Drosophila melanogaster OX=7227 GN=Dmel\\CG45067 PE=3 SV=1 CANONICAL=A0A1L4AAC2-1"
            },
            "locus": {
                "chromosome": "3L",
                "start_pos": 3114443,
                "end_pos": 3111302,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0445828",
                        "url": "https://www.ensembl.org/id/FBtr0445828"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0402781",
                        "url": "https://www.ensembl.org/id/FBpp0402781"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "dme:Dmel_CG45067",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG45067",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1L4AAC2",
                                "url": "https://www.uniprot.org/uniprot/A0A1L4AAC2"
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