{ "uniprot_canonical_ac": "A0A1L1STQ7-1", "uniprot_ac": "A0A1L1STQ7", "uniprot_id": "A0A1L1STQ7_MOUSE", "mass": { "chemical_mass": 72122.0, "monoisotopic_mass": 72122.0 }, "refseq": { "ac": "NP_035539", "name": "schlafen 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035539" }, "gene_names": [ { "name": "Slfn3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1L1STQ7", "id": "A0A1L1STQ7" }, { "name": "Slfn3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035539", "id": "NP_035539" } ], "protein_names": [ { "name": "Schlafen 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A1L1STQ7" }, { "name": "schlafen 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035539", "id": "NP_035539" } ], "function": [ { "annotation": "Study characterized the role of Slfn3 in the intestinal homeostasis. Slfn3KO mice have a phenotype of decreased weight gain that is unlikely caused by a single gene but instead multiple genes/pathways. This includes the metabolic pathways of glycerolipid, linoleic and arachidonic acid metabolism, sex-dependent disregulation of glucose transporters, Glut2 and SGLT1, and intestinal differentiation genes, Notch2 and Cdx2. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_035539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035539" }, { "database": "PubMed", "id": "31260507", "url": "https://glygen.org/publication/PubMed/31260507" } ] }, { "annotation": "Vil-Cre specific Schlafen 3 knockout mice exhibit sex-specific differences in intestinal differentiation markers and Schlafen family members expression levels. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_035539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035539" }, { "database": "PubMed", "id": "34710177", "url": "https://glygen.org/publication/PubMed/34710177" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A1L1STQ7", "url": "https://www.uniprot.org/uniprot/A0A1L1STQ7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Slfn3", "url": "https://www.uniprot.org/uniprot/A0A1L1STQ7", "locus": { "chromosome": "11", "start_pos": 83105980, "end_pos": 83082156, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000018986", "url": "https://www.ensembl.org/id/ENSMUSG00000018986" } ] } } ], "crossref": [ { "id": "ENSMUSG00000018986", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000018986", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "20557", "url": "https://www.ncbi.nlm.nih.gov/gene/20557", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029684", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029684", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:20557", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:20557", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1329005", "url": "http://www.informatics.jax.org/marker/MGI:1329005", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "VKMGGYT", "url": "https://omabrowser.org/oma/group/VKMGGYT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5398472at2759", "url": "http://www.orthodb.org/?query=5398472at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12155", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12155", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12155:SF40", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12155:SF40", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04326", "url": "http://pfam.xfam.org/family/PF04326", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "A0A1L1STQ7", "url": "https://www.uniprot.org/uniprot/A0A1L1STQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L1STQ7-1", "url": "https://www.uniprot.org/uniprot/A0A1L1STQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Z0I5", "url": "https://www.uniprot.org/uniprot/Q9Z0I5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9Z0I5-1", "url": "https://www.uniprot.org/uniprot/Q9Z0I5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGASEMKDGPEQEQRHRAGHTWKHGIRASSWLAVGNSQEKSPSVDCRSSHRTLGFSRTGVCLHTAILPTEDNGLNLWKQKGLHLGNRGSDWKTNIIVDQDTDYAELVLFIGEITLGEKNRNSMKDIQLRRKEAKSILQAVCTLLNSGGGVVKAHIKNQNYSFTRDGMGLDLVNSLPGIMHLPHDYLDFMQHKDYFFVFVKPLKPNQKGPGITTLKTNLYRRINSISDEVKVANAVQLLKSRTDPEEKAESRPSSPGKIVCNETLNECLSLFNRDWLAYEETFCFTKSIHAEVKLTPKEKIFPKEKILELLPQTVSAFANTDGGFLFIGLDGKTQQIIGFEAEKSNLVLLESEIEKCIQQLPVTHFCGEKEKIKYTCKFIEVRKSGAVCAYVCALRVERFCCAVFAAEPESWHVEGGCVKRFTTEEWVKRQMDATAVMPGKVICCPEALYMKPFSQHEGYEHLVRTELGSLLKGTLVISKSWALDLGLQEKQEVIWDVLHISQGSLLTLYVFVQGDENLEGNSSLLGELGAELKGYYKQIALTLKQMLLNHCGYTAEIGIIVKITYLGHKTMCLYDTSTKIRYPQKYYLSAKAVKDLEKALVEILGSYESFYSLPRRNWDSFMSAFLNVGSYIVPVLRNV", "length": 640, "header": "tr|A0A1L1STQ7-1|A0A1L1STQ7_MOUSE Isoform 1 of Schlafen 3 OS=Mus musculus OX=10090 GN=Slfn3 PE=1 SV=1 CANONICAL=A0A1L1STQ7-1" }, "isoforms": [ { "isoform_ac": "A0A1L1STQ7-1", "url": "", "sequence": { "sequence": "MPGASEMKDGPEQEQRHRAGHTWKHGIRASSWLAVGNSQEKSPSVDCRSSHRTLGFSRTGVCLHTAILPTEDNGLNLWKQKGLHLGNRGSDWKTNIIVDQDTDYAELVLFIGEITLGEKNRNSMKDIQLRRKEAKSILQAVCTLLNSGGGVVKAHIKNQNYSFTRDGMGLDLVNSLPGIMHLPHDYLDFMQHKDYFFVFVKPLKPNQKGPGITTLKTNLYRRINSISDEVKVANAVQLLKSRTDPEEKAESRPSSPGKIVCNETLNECLSLFNRDWLAYEETFCFTKSIHAEVKLTPKEKIFPKEKILELLPQTVSAFANTDGGFLFIGLDGKTQQIIGFEAEKSNLVLLESEIEKCIQQLPVTHFCGEKEKIKYTCKFIEVRKSGAVCAYVCALRVERFCCAVFAAEPESWHVEGGCVKRFTTEEWVKRQMDATAVMPGKVICCPEALYMKPFSQHEGYEHLVRTELGSLLKGTLVISKSWALDLGLQEKQEVIWDVLHISQGSLLTLYVFVQGDENLEGNSSLLGELGAELKGYYKQIALTLKQMLLNHCGYTAEIGIIVKITYLGHKTMCLYDTSTKIRYPQKYYLSAKAVKDLEKALVEILGSYESFYSLPRRNWDSFMSAFLNVGSYIVPVLRNV", "length": 640, "header": "tr|A0A1L1STQ7-1|A0A1L1STQ7_MOUSE Isoform 1 of Schlafen 3 OS=Mus musculus OX=10090 GN=Slfn3 PE=1 SV=1 CANONICAL=A0A1L1STQ7-1" }, "locus": { "chromosome": "11", "start_pos": 83105924, "end_pos": 83082163, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000214041.2", "url": "https://www.ensembl.org/id/ENSMUST00000214041.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000150425.2", "url": "https://www.ensembl.org/id/ENSMUSP00000150425.2" } ] } }, { "isoform_ac": "Q9Z0I5-1", "url": "", "sequence": { "sequence": "MKDIQLRRKEAKSILQAVCTLLNSGGGVVKAHIKNQNYSFTRDGMGLDLVNSLPGIMHLPHDYLDFMQHKDYFFVFVKPLKPNQKGPGITTLKTNLYRRINSISDEVKVANAVQLLKSRTDPEEKAESRPSSPGKIVCNETLNECLSLFNRDWLAYEETFCFTKSIHAEVKLTPKEKIFPKEKILELLPQTVSAFANTDGGFLFIGLDGKTQQIIGFEAEKSNLVLLESEIEKCIQQLPVTHFCGEKEKIKYTCKFIEVRKSGAVCAYVCALRVERFCCAVFAAEPESWHVEGGCVKRFTTEEWVKRQMDATAVMPGKVICCPEALYMKPFSQHEGYEHLVRTELGSLLKGTLVISKSWALDLGLQEKQEVIWDVLHISQGSLLTLYVFVQGDENLEGNSSLLGELGAELKGYYKQIALTLKQMLLNHCGYTAEIGIIVKITYLGHKTMCLYDTSTKIRYPQKYYLSAKAVKDLEKALVEILGSYESFYSLPRRNWDSFMSAFLNVGSYIVPVLRNV", "length": 517, "header": "tr|Q9Z0I5-1|A0A1L1STQ7_MOUSE Computationally mapped isoform of Schlafen 3 OS=Mus musculus OX=10090 GN=Slfn3 PE=1 SV=1 CANONICAL=A0A1L1STQ7-1" }, "locus": { "chromosome": "11", "start_pos": 83105924, "end_pos": 83103500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000019130.8", "url": "https://www.ensembl.org/id/ENSMUST00000019130.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000019130.8", "url": "https://www.ensembl.org/id/ENSMUSP00000019130.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Schlafen 3 knockout mice display gender-specific differences in weight gain, food efficiency, and expression of markers of intestinal epithelial differentiation, metabolism, and immune cell function.", "journal": "PloS one", "date": "2019", "authors": "Vomhof-DeKrey EE, Lee J, Lansing J, Brown C, Darland D, Basson MD", "evidence": [ { "database": "RefSeq", "id": "NP_035539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035539" } ], "reference": [ { "type": "PubMed", "id": "31260507", "url": "https://glygen.org/publication/PubMed/31260507" } ] }, { "title": "Vil-Cre specific Schlafen 3 knockout mice exhibit sex-specific differences in intestinal differentiation markers and Schlafen family members expression levels.", "journal": "PloS one", "date": "2021", "authors": "Vomhof-DeKrey EE, Stover AD, Labuhn M, Osman MR, Basson MD", "evidence": [ { "database": "RefSeq", "id": "NP_035539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035539" } ], "reference": [ { "type": "PubMed", "id": "34710177", "url": "https://glygen.org/publication/PubMed/34710177" } ] } ], "pathway": [ { "id": "mmu:20557", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:20557", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6IEE8-1", "protein_name": "Schlafen family member 12-like", "gene_name": "SLFN12L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDLARKEFLRGNGLAAGKMNISIDLDTNYAELVLNVGRVTLGENNRKKMKDCQLRKQQNENVSRAVCALLNSGGGVIKAEVENKGYSYKKDGIGLDLENSFSNMLPFVPNFLDFMQNGNYFHIFVKSWSLETSGPQIATLSSSLYKRDVTSAKVMNASAALEFLKDMEKTGGRAYLRPEFPAKRACVDVQEESNMEALAADFFNRTELGYKEKLTFTESTHVEIKNFSTEKLLQRITEILPQYVSAFANTDGGYLFVGLNEDKEVIGFKAEKSYLTKLEEVTKNSIGKLPVHHFCVEKGTINYLCKFLGVYDKGRLCGYVYALRVERFCCAVFAKKPDSWHVKDNRVKQLTEKEWIQFMVDSEPVCEELPSPASTSSPVSQSYPLREYINFKIQPLRYHLPGLSEKITCAPKTFCRNLFSQHEGLKQLICEEMGSVNKGSLIFSRSWSLDLGLQENHKVLCDALLISQDKPPVLYTFHMVQDEEFKDYSTQTAQTLKQKLAKIGGYTKKVCVMTKIFYLSPEGKTSCQYDLNSQVIYPESYYWTTAQTMKDLEKALSNILPKENQIFLFVCLFRFCLFVCWFVCFFLR", "length": 588 }, "evidence": [ { "id": "45243713", "url": "http://www.informatics.jax.org/homology/45243713", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8IYM2-1", "protein_name": "Ribonuclease SLFN12", "gene_name": "SLFN12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNISVDLETNYAELVLDVGRVTLGENSRKKMKDCKLRKKQNESVSRAMCALLNSGGGVIKAEIENEDYSYTKDGIGLDLENSFSNILLFVPEYLDFMQNGNYFLIFVKSWSLNTSGLRITTLSSNLYKRDITSAKVMNATAALEFLKDMKKTRGRLYLRPELLAKRPCVDIQEENNMKALAGVFFDRTELDRKEKLTFTESTHVEIKNFSTEKLLQRIKEILPQYVSAFANTDGGYLFIGLNEDKEIIGFKAEMSDLDDLEREIEKSIRKMPVHHFCMEKKKINYSCKFLGVYDKGSLCGYVCALRVERFCCAVFAKEPDSWHVKDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQINTSLPAPHSWPLLEWQRQRHHCPGLSGRITYTPENLCRKLFLQHEGLKQLICEEMDSVRKGSLIFSRSWSVDLGLQENHKVLCDALLISQDSPPVLYTFHMVQDEEFKGYSTQTALTLKQKLAKIGGYTKKVCVMTKIFYLSPEGMTSCQYDLRSQVIYPESYYFTRRKYLLKALFKALKRLKSLRDQFSFAENLYQIIGIDCFQKNDKKMFKSCRRLT", "length": 578 }, "evidence": [ { "id": "45243713", "url": "http://www.informatics.jax.org/homology/45243713", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9TPX1-1", "protein_name": "Schlafen family member 4", "gene_name": "Slfn4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSITVDQDTDYAELVLSIGEITLGEKTRKSMKDSQRRKREAKTFQQAVCTLLNSGGGVAKARIKNQNYDFSRDGVGQDLENFLPHILDFPHEYLDFKQVKDYFLMFVKAWKLKQKGPGITTLKTNLYIRSISSSIELKAVNAVKFLKSRKCSKGRSDSRLSSPGTIVCNEVLNECLNLFNRDCFTCKEKFCFTKATHAEVKLTPKENILEILPQTVSSFANADGGYLFIGLDGKTQEIIGFEAEKSDLVHLESEIEKCIRQLPVTHFCEEREKIKYTCKFMEVHKPGAACSFVCALRVERFCCAVFAAEPESWHVEDSCVKRFTAEDWVKRQMDGPACFSKQDKGPLQSSRLPHSPRSCCPDNPDALQQSAGLPVISGKVISSPEALCGKLFSTQEAHEQLLWAQLDSLPKGTLVVTKRWALDLPLQDKHGVILDTLHIPQDSLLTLHGFVLGGEDLEDDSTLLRELGAELKGYYKQTAVTLKQTLANHGSYTEKIGIAIKITYLGHNKAVSLYDSSSKIHYPTKYYLTTETAKNLEKALAEILGSRESFYSLPRQNCSDHFIFAFFLSFSFLLVFLFWSWGLNPEP", "length": 587 }, "evidence": [ { "id": "45243713", "url": "http://www.informatics.jax.org/homology/45243713", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1STQ7", "url": "https://www.uniprot.org/uniprot/A0A1L1STQ7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1STQ7", "url": "https://www.uniprot.org/uniprot/A0A1L1STQ7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1STQ7", "url": "https://www.uniprot.org/uniprot/A0A1L1STQ7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA nuclease activity", "id": "GO:0004540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004540", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1STQ7", "url": "https://www.uniprot.org/uniprot/A0A1L1STQ7" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1STQ7", "url": "https://www.uniprot.org/uniprot/A0A1L1STQ7" } ], "pmid": "" }, { "name": "catalytic activity, acting on a rRNA", "id": "GO:0140102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140102", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1STQ7", "url": "https://www.uniprot.org/uniprot/A0A1L1STQ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" }, { "start_pos": 262, "end_pos": 264, "annotation": "n_glycosylation_sequon" }, { "start_pos": 522, "end_pos": 524, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { 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