{
    "uniprot_canonical_ac": "A0A1F4-1",
    "uniprot_ac": "A0A1F4",
    "uniprot_id": "EYS_DROME",
    "mass": {
        "chemical_mass": 234104.0,
        "monoisotopic_mass": 234104.0
    },
    "refseq": {
        "ac": "NP_001027571",
        "name": "eyes shut, isoform F",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027571"
    },
    "gene_names": [
        {
            "name": "eys",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "21A6; CG15388; CG15389; CG33955; CG7245; CT35437; Dmel\\CG33955; Eyes Shut; Eys; EYS; mAb 21A6; mAb21A6; MAb21A6; spacemaker; spam; Spam; SPAM",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027571",
            "id": "NP_001027571"
        },
        {
            "name": "21A6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "CG15388",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "CG15389",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "CG33955",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "CG7245",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "CT35437",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "Dmel\\CG33955",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "Dmel_CG33955",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "EYS",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "Eyes Shut",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "Eys",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "MAb21A6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "SPAM",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "Spam",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "eys",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027571",
            "id": "NP_001027571"
        },
        {
            "name": "mAb 21A6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "mAb21A6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "spacemaker",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        },
        {
            "name": "spam",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "id": "A0A1F4"
        }
    ],
    "protein_names": [
        {
            "name": "Protein eyes shut",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A0A1F4"
        },
        {
            "name": "CG33955-PF; eys-PF; agrin-like; eyes shut; fibropellin; spacemaker; spam; eyeshut; Eye shut",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027571",
            "id": "NP_001027571"
        },
        {
            "name": "Protein spacemaker",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A1F4"
        },
        {
            "name": "eyes shut, isoform F",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027571",
            "id": "NP_001027571"
        }
    ],
    "function": [
        {
            "annotation": "Essential for the formation of matrix-filled interrhabdomeral space: critical for the formation of epithelial lumina in the retina. Acts together with prominin (prom) and the cell adhesion molecule chaoptin (chp) to choreograph the partitioning of rhabdomeres into an open system.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1F4",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#function"
                },
                {
                    "database": "PubMed",
                    "id": "17036004",
                    "url": "https://glygen.org/publication/PubMed/17036004"
                },
                {
                    "database": "PubMed",
                    "id": "17011488",
                    "url": "https://glygen.org/publication/PubMed/17011488"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050572",
            "recommended_name": {
                "id": "DOID:0050572",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050572",
                "name": "cone-rod dystrophy",
                "description": "A retinal degeneration that characterized by progressive deterioration of the cone and rod photoreceptor cells."
            },
            "synonyms": [
                {
                    "id": "DOID:0050572",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050572",
                    "name": "cone-rod retinal dystrophy",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "0050572",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050572"
                }
            ]
        },
        {
            "disease_id": "DOID:0110384",
            "recommended_name": {
                "id": "DOID:0110384",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0110384",
                "name": "retinitis pigmentosa 25",
                "description": "A retinitis pigmentosa that has_material_basis_in mutation in the EYS gene on chromosome 6q12."
            },
            "synonyms": [
                {
                    "id": "DOID:0110384",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110384",
                    "name": "RP25",
                    "description": ""
                },
                {
                    "id": "MONDO:0011272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011272",
                    "name": "retinitis pigmentosa 25",
                    "description": "Any retinitis pigmentosa in which the cause of the disease is a mutation in the EYS gene."
                },
                {
                    "id": "MONDO:0011272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011272",
                    "name": "EYS retinitis pigmentosa",
                    "description": ""
                },
                {
                    "id": "MONDO:0011272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011272",
                    "name": "RP25",
                    "description": ""
                },
                {
                    "id": "MONDO:0011272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011272",
                    "name": "retinitis pigmentosa 25",
                    "description": ""
                },
                {
                    "id": "MONDO:0011272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011272",
                    "name": "retinitis pigmentosa caused by mutation in EYS",
                    "description": ""
                },
                {
                    "id": "MONDO:0011272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011272",
                    "name": "retinitis pigmentosa type 25",
                    "description": ""
                },
                {
                    "id": "MONDO:0011272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011272",
                    "name": "RP 25",
                    "description": ""
                },
                {
                    "id": "MIM:602772",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/602772",
                    "name": "Retinitis pigmentosa 25",
                    "description": "Retinitis pigmentosa 25"
                }
            ],
            "evidence": [
                {
                    "id": "0110384",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110384"
                }
            ]
        },
        {
            "disease_id": "DOID:10584",
            "recommended_name": {
                "id": "DOID:10584",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:10584",
                "name": "retinitis pigmentosa",
                "description": "A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss."
            },
            "synonyms": [
                {
                    "id": "DOID:10584",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10584",
                    "name": "pericentral pigmentary retinopathy",
                    "description": ""
                },
                {
                    "id": "MONDO:0019200",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019200",
                    "name": "retinitis pigmentosa",
                    "description": "Retinitis pigmentosa (RP) is an inherited retinal dystrophy leading to progressive loss of the photoreceptors and retinal pigment epithelium and resulting in blindness usually after several decades."
                },
                {
                    "id": "MONDO:0019200",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019200",
                    "name": "retinitis pigmentosa",
                    "description": ""
                },
                {
                    "id": "MONDO:0019200",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019200",
                    "name": "pericentral pigmentary retinopathy",
                    "description": ""
                },
                {
                    "id": "MONDO:0019200",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019200",
                    "name": "Rod-cone dystrophy",
                    "description": ""
                },
                {
                    "id": "MIM:268000",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/268000",
                    "name": "Retinitis pigmentosa",
                    "description": "Retinitis pigmentosa"
                }
            ],
            "evidence": [
                {
                    "id": "10584",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:10584"
                }
            ]
        },
        {
            "disease_id": "DOID:8466",
            "recommended_name": {
                "id": "DOID:8466",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:8466",
                "name": "retinal degeneration",
                "description": "A retinal disease that is characterized by deterioration of the retina caused by the progressive and eventual death of the cells of the retina."
            },
            "synonyms": [
                {
                    "id": "DOID:8466",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:8466",
                    "name": "degeneration of retina",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "8466",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:8466"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 521,
            "end_pos": 521,
            "sequence_org": "E",
            "sequence_mut": "K",
            "comment": "In eys(734); fails to form an interrhabdomeral space.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1F4",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4"
                },
                {
                    "database": "PubMed",
                    "id": "17011488",
                    "url": "https://glygen.org/publication/PubMed/17011488"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1F4",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "gene": [
        {
            "name": "eys",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "locus": {
                "chromosome": "2L",
                "start_pos": 2358944,
                "end_pos": 2311680,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "FBgn0031414",
                        "url": "https://www.ensembl.org/id/FBgn0031414"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "FBgn0031414",
            "url": "https://bgee.org/?page=gene&gene_id=FBgn0031414",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00054",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd00110",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00110",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "FBgn0031414",
            "url": "https://flybase.org/reports/FBgn0031414",
            "database": "FlyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "3771890",
            "url": "https://www.ncbi.nlm.nih.gov/gene/3771890",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000152",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR000742",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001791",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001791",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001881",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013320",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR018097",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "dme:Dmel_CG33955",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG33955",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "FYCEIAL",
            "url": "https://omabrowser.org/oma/group/FYCEIAL/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "101939at2759",
            "url": "http://www.orthodb.org/?query=101939at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24049",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24049",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24049:SF22",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24049:SF22",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00008",
            "url": "http://pfam.xfam.org/family/PF00008",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00054",
            "url": "http://pfam.xfam.org/family/PF00054",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02210",
            "url": "http://pfam.xfam.org/family/PF02210",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_A0A1F4",
            "url": "http://purl.obolibrary.org/obo/PR_A0A1F4",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001027571",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027571",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1F4",
            "url": "https://www.uniprot.org/uniprot/A0A1F4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1F4-1",
            "url": "https://www.uniprot.org/uniprot/A0A1F4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "M9PBU9",
            "url": "https://www.uniprot.org/uniprot/M9PBU9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "M9PBU9-1",
            "url": "https://www.uniprot.org/uniprot/M9PBU9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSNVHQFDTQTMAESPQIRRDMGRLCATWPSKDSEDGAGTALRAATPLTANGATTTGLSVTLAPKDMQRNHLLKMPTATIEKPTITATIASSSSTSTSTTRKSVTATRSLKLNPNILLPTLRILARGLLLPALILAILVGSSQAGFACLSNPCVFGVCIDGLNSSYSCYCIDGYTGIQCQTNWDECWSSPCQNGGTCVDGVAYYNCTCPEGFSGSNCEENVDECMSNPCQNGGLCRDRTNGYICTCQPGYLGSHCELDVAVCETGTGARCQHGGECIEGPGLEFTCDCPAGWHGRICQEEINECASSPCQNGGVCVDKLAAYACACPMGYTGINCEEEILICADNPCQNNALCLMEEGVPTCYCVPDYHGEKCEFQYDECQLGPRCMNGGVCIDGVDTFSCSCPPLLTGMLCECLMVGEESLDCNYTAPATQSPPRRTTTTSTMAPPTVRPVTPPETTVSPSRASEEVEIIVVTTSAPAEVVTSVLSPSSSSSSSEEGVSVEIKTPTVAPPESGSHSISVEQTTAVPAQPEPESEQEPESKPHPESESASESETETEEEIIPGTTARPPTSRSSSSSEESPSIFTTLPPLPGKPQTSASSESSGEVVTSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTTPAPVFVQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWTEVPTTAAPFFTEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNEVIPSLITTTGSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHDEFTTPQPVEITTGHPLQTEDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGTAAPPATPAPVPPATTTPPPSPPSLATETPTLPPTLPPVTLPPVTQPPPTIPPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVTESSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKLGCYNGGTCVTTSEGSRCVCRFDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIMLAAAQGTKGGHYMALFLQKGLMQFQFSCGLQTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQAREIFGDALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTCEISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGSVNGLSSFVAYTVPIPLEYSLELSFKILPQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNTLPHDLPLHSGFQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACLQHGATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPLVNGYECDCPVGRTGKNCEEVIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQDKKIGFVSLSLQGGVVEFRISGPSNHVTVVRSVRMLAIGEWHKIKMAQRGRWLTLWVEGSASSALAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGFPIPFRGCVRGLVVSGTRIVLNETNIVESRNIRDCDGTACGGDSCESGGHCWLDEKLQPHCICPEYAKGDRCEYSETCKLIPCKNNGRCLRSGRCSCPNGWGGFYCEIAMSKPTTPSFRGNSYLILPPPRIPMKDKRRGPSLYVRPREAIQVSLNFSTIEPDGLLLWSEHERSKFLGLGLEAGHLKLASNLLGSTNDTVRAPASGFIADGAWHWTSVLLDRSRLELQLDGEVIFTERLPEGGRSLGSTTPRSTLAGRRKNSSKEPTISYEDVFYLGGFPNSDSVSRRTKGRFFDPFKGCLQDIQFGAEPTAIISDFSTYQGENIGSCDLHGDEPLTV",
        "length": 2176,
        "header": "sp|A0A1F4-1|EYS_DROME Isoform 1 of Protein eyes shut  OS=Drosophila melanogaster OX=7227 GN=eys PE=1 SV=1 CANONICAL=A0A1F4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1F4-1",
            "url": "",
            "sequence": {
                "sequence": "MSNVHQFDTQTMAESPQIRRDMGRLCATWPSKDSEDGAGTALRAATPLTANGATTTGLSVTLAPKDMQRNHLLKMPTATIEKPTITATIASSSSTSTSTTRKSVTATRSLKLNPNILLPTLRILARGLLLPALILAILVGSSQAGFACLSNPCVFGVCIDGLNSSYSCYCIDGYTGIQCQTNWDECWSSPCQNGGTCVDGVAYYNCTCPEGFSGSNCEENVDECMSNPCQNGGLCRDRTNGYICTCQPGYLGSHCELDVAVCETGTGARCQHGGECIEGPGLEFTCDCPAGWHGRICQEEINECASSPCQNGGVCVDKLAAYACACPMGYTGINCEEEILICADNPCQNNALCLMEEGVPTCYCVPDYHGEKCEFQYDECQLGPRCMNGGVCIDGVDTFSCSCPPLLTGMLCECLMVGEESLDCNYTAPATQSPPRRTTTTSTMAPPTVRPVTPPETTVSPSRASEEVEIIVVTTSAPAEVVTSVLSPSSSSSSSEEGVSVEIKTPTVAPPESGSHSISVEQTTAVPAQPEPESEQEPESKPHPESESASESETETEEEIIPGTTARPPTSRSSSSSEESPSIFTTLPPLPGKPQTSASSESSGEVVTSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTTPAPVFVQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWTEVPTTAAPFFTEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNEVIPSLITTTGSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHDEFTTPQPVEITTGHPLQTEDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGTAAPPATPAPVPPATTTPPPSPPSLATETPTLPPTLPPVTLPPVTQPPPTIPPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVTESSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKLGCYNGGTCVTTSEGSRCVCRFDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIMLAAAQGTKGGHYMALFLQKGLMQFQFSCGLQTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQAREIFGDALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTCEISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGSVNGLSSFVAYTVPIPLEYSLELSFKILPQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNTLPHDLPLHSGFQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACLQHGATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPLVNGYECDCPVGRTGKNCEEVIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQDKKIGFVSLSLQGGVVEFRISGPSNHVTVVRSVRMLAIGEWHKIKMAQRGRWLTLWVEGSASSALAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGFPIPFRGCVRGLVVSGTRIVLNETNIVESRNIRDCDGTACGGDSCESGGHCWLDEKLQPHCICPEYAKGDRCEYSETCKLIPCKNNGRCLRSGRCSCPNGWGGFYCEIAMSKPTTPSFRGNSYLILPPPRIPMKDKRRGPSLYVRPREAIQVSLNFSTIEPDGLLLWSEHERSKFLGLGLEAGHLKLASNLLGSTNDTVRAPASGFIADGAWHWTSVLLDRSRLELQLDGEVIFTERLPEGGRSLGSTTPRSTLAGRRKNSSKEPTISYEDVFYLGGFPNSDSVSRRTKGRFFDPFKGCLQDIQFGAEPTAIISDFSTYQGENIGSCDLHGDEPLTV",
                "length": 2176,
                "header": "sp|A0A1F4-1|EYS_DROME Isoform 1 of Protein eyes shut  OS=Drosophila melanogaster OX=7227 GN=eys PE=1 SV=1 CANONICAL=A0A1F4-1"
            },
            "locus": {
                "chromosome": "2L",
                "start_pos": 2357874,
                "end_pos": 2323766,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0344662",
                        "url": "https://www.ensembl.org/id/FBtr0344662"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0311004",
                        "url": "https://www.ensembl.org/id/FBpp0311004"
                    }
                ]
            }
        },
        {
            "isoform_ac": "M9PBU9-1",
            "url": "",
            "sequence": {
                "sequence": "MSNVHQFDTQTMAESPQIRRDMGRLCATWPSKDSEDGAGTALRAATPLTANGATTTGLSVTLAPKDMQRNHLLKMPTATIEKPTITATIASSSSTSTSTTRKSVTATRSLKLNPNILLPTLRILARGLLLPALILAILVGSSQAGFACLSNPCVFGVCIDGLNSSYSCYCIDGYTGIQCQTNWDECWSSPCQNGGTCVDGVAYYNCTCPEGFSGSNCEENVDECMSNPCQNGGLCRDRTNGYICTCQPGYLGSHCELDVAVCETGTGARCQHGGECIEGPGLEFTCDCPAGWHGRICQEEINECASSPCQNGGVCVDKLAAYACACPMGYTGINCEEEILICADNPCQNNALCLMEEGVPTCYCVPDYHGEKCEFQYDECQLGPRCMNGGVCIDGVDTFSCSCPPLLTGMLCECLMVGEESLDCNYTAPATQSPPRRTTTTSTMAPPTVRPVTPPETTVSPSRASEEVEIIVVTTSAPAEVVTSVLSPSSSSSSSEEGVSVEIKTPTVAPPESGSHSISVEQTTAVPAQPEPESEQEPESKPHPESESASESETETEEEIIPGTTARPPTSRSSSSSEESPSIFTTLPPLPGKPQTSASSESSGEVVTSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTTPAPVFVQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWTEVPTTAAPFFTEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNEVIPSLITTTGSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHDEFTTPQPVEITTGHPLQTEDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGTAAPPATPAPVPPATTTPPPSPPSLATETPTLPPTLPPVTLPPVTQPPPTIPPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVTESSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKLGCYNGGTCVTTSEGSRCVCRFDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIMLAAAQGTKGGHYMALFLQKGLMQFQFSCGLQTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQAREIFGDALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTCEISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGSVNGLSSFVAYTVPIPLEYSLELSFKILPQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNTLPHDLPLHSGFQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACLQHGATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPLVNGYECDCPVGRTGKNCEEVIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQDKKIGFVSLSLQGGVVEFRISGPSNHVTVVRSVRMLAIGEWHKIKMAQRGRWLTLWVEGSASSALAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGFPIPFRGCVRGLVVSGTRIVLNETNIVESRNIRDCDGTACGGDSCESGGHCWLDEKLQPHCICPEYAKGDRCEYSETCKLIPCKNNGRCLRSGRCSCPNGWGGFYCEIAMSKPTTPSFRGNSYLILPPPRIPMKDKRRGPSLYVRPREAIQVSLNFSTIEPDGLLLWSEHERSKFLGLGLEAGHLKLASNLLGSTNDTVRAPASGFIADGAWHWTSVLLDRSRLELQLDGEVIFTERLPEGGRSLGSTTPRSTLAGRRKNSSKEPTISYEDVFYLGGFPNSDSVSRRTKGRFFDPFKGCLQDIQFGAEPTAIISDFSTYQGENIGSCDLHGDEPLTV",
                "length": 2176,
                "header": "tr|M9PBU9-1|EYS_DROME Computationally mapped isoform of Protein eyes shut  OS=Drosophila melanogaster OX=7227 GN=eys PE=1 SV=2 CANONICAL=A0A1F4-1"
            },
            "locus": {
                "chromosome": "2L",
                "start_pos": 2357874,
                "end_pos": 2323766,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0344662",
                        "url": "https://www.ensembl.org/id/FBtr0344662"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0311004",
                        "url": "https://www.ensembl.org/id/FBpp0311004"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 1165,
            "start_aa": "Asn",
            "end_pos": 1165,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn1165",
            "evidence": [
                {
                    "id": "A0A1F4",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 1170,
            "start_aa": "Asn",
            "end_pos": 1170,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn1170",
            "evidence": [
                {
                    "id": "A0A1F4",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 1176,
            "start_aa": "Asn",
            "end_pos": 1176,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn1176",
            "evidence": [
                {
                    "id": "A0A1F4",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "reported",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 1471,
            "start_aa": "Asn",
            "end_pos": 1471,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn1471",
            "evidence": [
                {
                    "id": "A0A1F4",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing"
                },
                {
                    "id": "17893096",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/17893096"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 163,
            "start_aa": "Asn",
            "end_pos": 163,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn163",
            "evidence": [
                {
                    "id": "A0A1F4",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 1665,
            "start_aa": "Asn",
            "end_pos": 1665,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn1665",
            "evidence": [
                {
                    "id": "A0A1F4",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 1861,
            "start_aa": "Asn",
            "end_pos": 1861,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn1861",
            "evidence": [
                {
                    "id": "A0A1F4",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 1994,
            "start_aa": "Asn",
            "end_pos": 1994,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn1994",
            "evidence": [
                {
                    "id": "A0A1F4",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 2035,
            "start_aa": "Asn",
            "end_pos": 2035,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn2035",
            "evidence": [
                {
                    "id": "A0A1F4",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 205,
            "start_aa": "Asn",
            "end_pos": 205,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn205",
            "evidence": [
                {
                    "id": "A0A1F4",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 2099,
            "start_aa": "Asn",
            "end_pos": 2099,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn2099",
            "evidence": [
                {
                    "id": "A0A1F4",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 425,
            "start_aa": "Asn",
            "end_pos": 425,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn425",
            "evidence": [
                {
                    "id": "A0A1F4",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_predicted",
        "glycoprotein_reported"
    ],
    "publication": [
        {
            "title": "The agrin/perlecan-related protein eyes shut is essential for epithelial lumen formation in the Drosophila retina.",
            "journal": "Developmental cell",
            "date": "2006",
            "authors": "Husain N, Pellikka M, Hong H, Klimentova T, Choe KM, Clandinin TR, Tepass U",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1F4",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17011488",
                    "url": "https://glygen.org/publication/PubMed/17011488"
                }
            ]
        },
        {
            "title": "Transforming the architecture of compound eyes.",
            "journal": "Nature",
            "date": "2006-10-12",
            "authors": "Zelhof Andrew C, Hardy Robert W, Becker Ann, Zuker Charles S",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1F4",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17036004",
                    "url": "https://glygen.org/publication/PubMed/17036004"
                }
            ]
        },
        {
            "title": "Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster.",
            "journal": "Glycobiology",
            "date": "2007",
            "authors": "Koles K, Lim JM, Aoki K, Porterfield M, Tiemeyer M, Wells L, Panin V",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1F4",
                    "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17893096",
                    "url": "https://glygen.org/publication/PubMed/17893096"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "dme:Dmel_CG33955",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG33955",
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