{ "uniprot_canonical_ac": "A0A1D9BZF0-1", "uniprot_ac": "A0A1D9BZF0", "uniprot_id": "GCNA_MOUSE", "mass": { "chemical_mass": 53394.0, "monoisotopic_mass": 53394.0 }, "refseq": {}, "gene_names": [ { "name": "Gcna", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0", "id": "A0A1D9BZF0" } ], "protein_names": [ { "name": "Germ cell nuclear acidic protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A1D9BZF0" }, { "name": "Acidic repeat-containing protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A1D9BZF0" }, { "name": "Germ cell nuclear antigen", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A1D9BZF0" } ], "function": [ { "annotation": "May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage (PubMed:31839538). Can resolve the topoisomerase II (TOP2A) DPCs (PubMed:31839538).", "evidence": [ { "database": "UniProtKB", "id": "A0A1D9BZF0", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0#function" }, { "database": "PubMed", "id": "31839538", "url": "https://glygen.org/publication/PubMed/31839538" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A1D9BZF0", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Gcna", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0", "locus": {} } ], "crossref": [ { "id": "105113", "url": "http://www.informatics.jax.org/marker/MGI:105113", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "4852011at2759", "url": "http://www.orthodb.org/?query=4852011at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34403", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34403", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34403:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34403:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A1D9BZF0", "url": "http://purl.obolibrary.org/obo/PR_A0A1D9BZF0", "database": "PRO", "categories": [ "Protein" ] }, { "id": "A0A1D9BZF0", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D9BZF0-1", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSGSSSSSSSSGSSSGSCSTSGSGSTSGSSTTSSSSSSSSSSSSSSSSSSKEYMPELPKQRKASCVVIDSESDSDNTSDEKNTTVCEISSGDETSDIDRPGGQKLPLIVIDDDDDGSPDLKNTKQKSDEPQMSVLEKEGVECIGSDSTSPHDVCEIWDVCGSSNQTSSELEPEGEPESEAKGEPESEAKGEPESEAKGEPESEAKGESESEAKGEMETEAKGESESEAKGEMETEAKGESESEAKGEMETEAKGEPESEAKGEMETEAKGEPESEAKGEMETEAKGESESEAKGEMETEAKGESESEAKGEMETEAKGEPESEAKGEMETEAKGEPESEAKGEPEPEAAKGEMETEAAMGEVETEAAMGEPEQEITAEEAKKKRAAYLLAQQRKRKRKNRFICMSSSKPRRKRRRADPQDGADPQDGADPQDRADPQDLADPQDRGDSQDMPSLPGTSDEPIPSGQPVCPRKGMASSRGRGRGRGRGRGRGRGRGRGRGRGAKAGK", "length": 507, "header": "sp|A0A1D9BZF0-1|GCNA_MOUSE Isoform 1 of Germ cell nuclear acidic protein OS=Mus musculus OX=10090 GN=Gcna PE=1 SV=1 CANONICAL=A0A1D9BZF0-1" }, "isoforms": [ { "isoform_ac": "A0A1D9BZF0-1", "url": "", "sequence": { "sequence": "MDSGSSSSSSSSGSSSGSCSTSGSGSTSGSSTTSSSSSSSSSSSSSSSSSSKEYMPELPKQRKASCVVIDSESDSDNTSDEKNTTVCEISSGDETSDIDRPGGQKLPLIVIDDDDDGSPDLKNTKQKSDEPQMSVLEKEGVECIGSDSTSPHDVCEIWDVCGSSNQTSSELEPEGEPESEAKGEPESEAKGEPESEAKGEPESEAKGESESEAKGEMETEAKGESESEAKGEMETEAKGESESEAKGEMETEAKGEPESEAKGEMETEAKGEPESEAKGEMETEAKGESESEAKGEMETEAKGESESEAKGEMETEAKGEPESEAKGEMETEAKGEPESEAKGEPEPEAAKGEMETEAAMGEVETEAAMGEPEQEITAEEAKKKRAAYLLAQQRKRKRKNRFICMSSSKPRRKRRRADPQDGADPQDGADPQDRADPQDLADPQDRGDSQDMPSLPGTSDEPIPSGQPVCPRKGMASSRGRGRGRGRGRGRGRGRGRGRGRGAKAGK", "length": 507, "header": "sp|A0A1D9BZF0-1|GCNA_MOUSE Isoform 1 of Germ cell nuclear acidic protein OS=Mus musculus OX=10090 GN=Gcna PE=1 SV=1 CANONICAL=A0A1D9BZF0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability.", "journal": "Developmental cell", "date": "2020-01-06", "authors": "Dokshin Gregoriy A, Davis Gregory M, Sawle Ashley D, Eldridge Matthew D, Nicholls Peter K, Gourley Taylin E, Romer Katherine A, Molesworth Luke W, Tatnell Hannah R, Ozturk Ahmet R, de Rooij Dirk G, Hannon Gregory J, Page David C, Mello Craig C, Carmell Michelle A", "evidence": [ { "database": "UniProtKB", "id": "A0A1D9BZF0", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0" } ], "reference": [ { "type": "PubMed", "id": "31839538", "url": "https://glygen.org/publication/PubMed/31839538" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "A0A1D9BZF0", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0" } ], "pmid": "" }, { "name": "homologous chromosome pairing at meiosis", "id": "GO:0007129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007129", "evidence": [ { "database": "UniProtKB", "id": "A0A1D9BZF0", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0" } ], "pmid": "" }, { "name": "meiotic chromosome condensation", "id": "GO:0010032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010032", "evidence": [ { "database": "UniProtKB", "id": "A0A1D9BZF0", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0" } ], "pmid": "" }, { "name": "homologous recombination", "id": "GO:0035825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035825", "evidence": [ { "database": "UniProtKB", "id": "A0A1D9BZF0", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0" } ], "pmid": "" }, { "name": "protein-DNA covalent cross-linking repair", "id": "GO:0106300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106300", "evidence": [ { "database": "UniProtKB", "id": "A0A1D9BZF0", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0" } ], "pmid": "" }, { "name": "protein-DNA covalent cross-linking", "id": "GO:0018142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018142", "evidence": [ { "database": "UniProtKB", "id": "A0A1D9BZF0", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0" } ], "pmid": "" }, { "name": "DNA integrity checkpoint signaling", "id": "GO:0031570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031570", "evidence": [ { "database": "UniProtKB", "id": "A0A1D9BZF0", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "condensed chromosome", "id": "GO:0000793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000793", "evidence": [ { "database": "UniProtKB", "id": "A0A1D9BZF0", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0" } ], "pmid": "" }, { "name": "PML body", "id": "GO:0016605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "database": "UniProtKB", "id": "A0A1D9BZF0", "url": "https://www.uniprot.org/uniprot/A0A1D9BZF0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }