{ "uniprot_canonical_ac": "A0A0G2KB96-1", "uniprot_ac": "A0A0G2KB96", "uniprot_id": "A0A0G2KB96_RAT", "mass": { "chemical_mass": 138563.0, "monoisotopic_mass": 138563.0 }, "refseq": {}, "gene_names": [ { "name": "Stil", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96", "id": "A0A0G2KB96" } ], "protein_names": [ { "name": "STIL, centriolar assembly protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2KB96" } ], "function": [], "disease": [ { "disease_id": "DOID:0070278", "recommended_name": { "id": "DOID:0070278", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070278", "name": "primary autosomal recessive microcephaly 7", "description": "A primary autosomal recessive microcephaly that has_material_basis_in homozygous or compound heterozygous mutation in the STIL gene on chromosome 1p33." }, "synonyms": [ { "id": "DOID:0070278", "resource": "Disease Ontology", "url": 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012989", "name": "MCPH7", "description": "" }, { "id": "MIM:612703", "resource": "MIM", "url": "https://www.omim.org/entry/612703", "name": "Microcephaly 7, primary, autosomal recessive", "description": "Microcephaly 7, primary, autosomal recessive" } ], "evidence": [ { "id": "0070278", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070278" } ] }, { "disease_id": "DOID:10907", "recommended_name": { "id": "DOID:10907", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10907", "name": "microcephaly", "description": "A congenital nervous system abnormality that is characterized by a significantly smaller than normal head in infants." }, "synonyms": [ { "id": "DOID:10907", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10907", "name": "Microcephalus", "description": "" }, { "id": "DOID:10907", "resource": "Disease 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"length": 1264, "header": "tr|A0A0G2KB96-1|A0A0G2KB96_RAT Isoform 1 of STIL, centriolar assembly protein OS=Rattus norvegicus OX=10116 GN=Stil PE=4 SV=2 CANONICAL=A0A0G2KB96-1" }, "locus": { "chromosome": "5", "start_pos": 128572549, "end_pos": 128523725, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000081075.2", "url": "https://www.ensembl.org/id/ENSRNOT00000081075.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075706.2", "url": "https://www.ensembl.org/id/ENSRNOP00000075706.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 21, "go_terms": [ { "name": "positive regulation of centriole replication", "id": "GO:0046601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046601", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "embryonic axis specification", "id": "GO:0000578", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000578", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "in utero embryonic development", "id": "GO:0001701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "forebrain development", "id": "GO:0030900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030900", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "multicellular organism growth", "id": "GO:0035264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035264", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "neural tube closure", "id": "GO:0001843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "neural tube development", "id": "GO:0021915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021915", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "determination of left/right symmetry", "id": "GO:0007368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007368", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "positive regulation of G1/S transition of mitotic cell cycle", "id": "GO:1900087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900087", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "heart looping", "id": "GO:0001947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001947", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "smoothened signaling pathway", "id": "GO:0007224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007224", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "non-motile cilium assembly", "id": "GO:1905515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "centrosome duplication", "id": "GO:0051298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051298", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "floor plate development", "id": "GO:0033504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033504", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "regulation of centriole replication", "id": "GO:0046599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046599", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "notochord development", "id": "GO:0030903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030903", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "mitotic spindle organization", "id": "GO:0007052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007052", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "protein localization to centrosome", "id": "GO:0071539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071539", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "positive regulation of cyclin-dependent protein serine/threonine kinase activity", "id": "GO:0045737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB96", "url": "https://www.uniprot.org/uniprot/A0A0G2KB96" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": 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