{
    "uniprot_canonical_ac": "A0A0G2KAU4-1",
    "uniprot_ac": "A0A0G2KAU4",
    "uniprot_id": "A0A0G2KAU4_RAT",
    "mass": {
        "chemical_mass": 78529.0,
        "monoisotopic_mass": 78529.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Rasgrp3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4",
            "id": "A0A0G2KAU4"
        }
    ],
    "protein_names": [
        {
            "name": "RAS guanyl releasing protein 3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A0G2KAU4"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:10763",
            "recommended_name": {
                "id": "DOID:10763",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:10763",
                "name": "hypertension",
                "description": "An artery disease characterized by chronic elevated blood pressure in the arteries."
            },
            "synonyms": [
                {
                    "id": "DOID:10763",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10763",
                    "name": "HTN",
                    "description": ""
                },
                {
                    "id": "DOID:10763",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10763",
                    "name": "hyperpiesia",
                    "description": ""
                },
                {
                    "id": "DOID:10763",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10763",
                    "name": "vascular hypertensive disorder",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "10763",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:10763"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2KAU4",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Rasgrp3",
            "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4",
            "locus": {
                "chromosome": "6",
                "start_pos": 19895390,
                "end_pos": 19958578,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000032703",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000032703"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000032703",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000032703",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00051",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd00155",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00155",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd06224",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06224",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd20862",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20862",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "313874",
            "url": "https://www.ncbi.nlm.nih.gov/gene/313874",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000651",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000651",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001895",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001895",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002048",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002219",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002219",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR008937",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008937",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011992",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR018247",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR020454",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020454",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR023578",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023578",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036964",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036964",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR046349",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR046349",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:313874",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:313874",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "MYRDASG",
            "url": "https://omabrowser.org/oma/group/MYRDASG/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "4260488at2759",
            "url": "http://www.orthodb.org/?query=4260488at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23113",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23113:SF178",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113:SF178",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00130",
            "url": "http://pfam.xfam.org/family/PF00130",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00617",
            "url": "http://pfam.xfam.org/family/PF00617",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13202",
            "url": "http://pfam.xfam.org/family/PF13202",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-1169092",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169092",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-5673001",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5673001",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_006239819",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006239819",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1304612",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1304612",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2KAU4",
            "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2KAU4-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZZN2",
            "url": "https://www.uniprot.org/uniprot/D3ZZN2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZZN2-1",
            "url": "https://www.uniprot.org/uniprot/D3ZZN2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGELNDSYLPRIMLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWITKFPAEFNLDLGLIRMTEEFREVASQLGYEKHSNLMDISSIPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPESLPGSPALPPVQDEVFEFPGVTARHRDLDSRDITLVTGSSRKISVRVQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKLHDKAAKDKGFAKWENEKPTLHAGVDVVDRGTAFEPDQDDEQDEAQQGVEDG",
        "length": 691,
        "header": "tr|A0A0G2KAU4-1|A0A0G2KAU4_RAT Isoform 1 of RAS guanyl releasing protein 3  OS=Rattus norvegicus OX=10116 GN=Rasgrp3 PE=3 SV=1 CANONICAL=A0A0G2KAU4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2KAU4-1",
            "url": "",
            "sequence": {
                "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGELNDSYLPRIMLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWITKFPAEFNLDLGLIRMTEEFREVASQLGYEKHSNLMDISSIPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPESLPGSPALPPVQDEVFEFPGVTARHRDLDSRDITLVTGSSRKISVRVQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKLHDKAAKDKGFAKWENEKPTLHAGVDVVDRGTAFEPDQDDEQDEAQQGVEDG",
                "length": 691,
                "header": "tr|A0A0G2KAU4-1|A0A0G2KAU4_RAT Isoform 1 of RAS guanyl releasing protein 3  OS=Rattus norvegicus OX=10116 GN=Rasgrp3 PE=3 SV=1 CANONICAL=A0A0G2KAU4-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 19932248,
                "end_pos": 19897562,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000079819.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000079819.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000075529.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000075529.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3ZZN2-1",
            "url": "",
            "sequence": {
                "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGELNDSYLPRIMLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWITKFPAEFNLDLGLIRMTEEFREVASQLGYEKHSNLMDISSIPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVELWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPESLPGSPALPPVQDEVFEFPGVTARHRDLDSRDITLVTGSSRKISVRVQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKLHDKAAKDKGFAKWENEKPTLHAGVDVVDRGTAFEPDQDDEQDEAQQGVEDG",
                "length": 603,
                "header": "tr|D3ZZN2-1|A0A0G2KAU4_RAT Computationally mapped isoform of RAS guanyl releasing protein 3  OS=Rattus norvegicus OX=10116 GN=Rasgrp3 PE=3 SV=1 CANONICAL=A0A0G2KAU4-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 19932248,
                "end_pos": 19897562,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000051239.5",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000051239.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000051116.3",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000051116.3"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:313874",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:313874",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-1169092",
            "name": "Activation of RAS in B cells",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169092",
            "resource": "Reactome",
            "description": "Activation of RAS in B cells"
        },
        {
            "id": "R-RNO-5673001",
            "name": "RAF/MAP kinase cascade",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5673001",
            "resource": "Reactome",
            "description": "RAF/MAP kinase cascade"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6NZH9-1",
            "protein_name": "RAS, guanyl releasing protein 3",
            "gene_name": "Rasgrp3",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGDLNDSYLPRIVLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGHEKHISLMDISSVPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPGSLPGSPALPPVQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPTVQAGVDVVDRGTAFEPDQDDGQDEAKQGGEDG",
                "length": 691
            },
            "evidence": [
                {
                    "id": "45236582",
                    "url": "http://www.informatics.jax.org/homology/45236582",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q8IV61-1",
            "protein_name": "Ras guanyl-releasing protein 3",
            "gene_name": "RASGRP3",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVHAGVDVVDRGTEFELDQDEGEETRQDGEDG",
                "length": 690
            },
            "evidence": [
                {
                    "id": "45236582",
                    "url": "http://www.informatics.jax.org/homology/45236582",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "GTPase activator activity",
                        "id": "GO:0005096",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KAU4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "kinase binding",
                        "id": "GO:0019900",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KAU4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "guanyl-nucleotide exchange factor activity",
                        "id": "GO:0005085",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KAU4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "small GTPase binding",
                        "id": "GO:0031267",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KAU4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "calcium ion binding",
                        "id": "GO:0005509",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KAU4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 5,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KAU4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4"
                            }
                        ],
                        "pmid": ""
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