{ "uniprot_canonical_ac": "A0A0G2KAE6-1", "uniprot_ac": "A0A0G2KAE6", "uniprot_id": "A0A0G2KAE6_RAT", "mass": { "chemical_mass": 65660.0, "monoisotopic_mass": 65660.0 }, "refseq": { "ac": "NP_001100036", "name": "mitoguardin 2 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100036" }, "gene_names": [ { "name": "Miga2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "id": "A0A0G2KAE6" } ], "protein_names": [ { "name": "Mitoguardin 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2KAE6" }, { "name": "family with sequence similarity 73, member B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100036", "id": "NP_001100036" }, { "name": "mitoguardin 2 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100036", "id": "NP_001100036" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAE6", "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6" } ], "common_name": "Rat" } ], "gene": [ { "name": "Miga2", "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "locus": { "chromosome": "3", "start_pos": 13658896, "end_pos": 13636238, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000017513", "url": "https://www.ensembl.org/id/ENSRNOG00000017513" } ] } } ], "crossref": [ { "id": "ENSRNOG00000017513", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017513", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "296623", "url": "https://www.ncbi.nlm.nih.gov/gene/296623", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:296623", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:296623", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SNWPCIQ", "url": "https://omabrowser.org/oma/group/SNWPCIQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2883389at2759", "url": "http://www.orthodb.org/?query=2883389at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21508", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21508", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21508:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21508:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10265", "url": "http://pfam.xfam.org/family/PF10265", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-1483166", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1483166", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_006233843", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006233843", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1310887", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310887", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2KAE6", "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2KAE6-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z899", "url": "https://www.uniprot.org/uniprot/D3Z899", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z899-1", "url": "https://www.uniprot.org/uniprot/D3Z899-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFRRTEGMSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRKKKQVGPEMGSEQLGTFPMPILMARKVPSVKKGCSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSLASMVMVNSSSPTAACSGSWETRGMEESVPTMDGSAESLYVQGMELFEEALQKWEQALSVGQRGDGGSTPTPGDSLQNPDTSSEALSEPESQRREFAEKLESLLHRAYHLQEEFGSTLPSDNMLLDLERTLMLPLTEGSLCLRADDEDSLTSEDSFFSATELFESLQIGEYPLPLSRPAAAYEEALQLVKEGKVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEERNNQVFFGEVGRQMVTGLMTKAEKSPKGFLESYEEMLNYALRPETWATTRLELEGRGVACMSFFDIVLDFILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLSEVCAFFKHQIVQYLRDMFDLDNVRYTSVPALAEDILQLSRRRSEILLGYLGAPVASSTGLNGPLPRENGPLDELQ", "length": 593, "header": "tr|A0A0G2KAE6-1|A0A0G2KAE6_RAT Isoform 1 of Mitoguardin 2 OS=Rattus norvegicus OX=10116 GN=Miga2 PE=1 SV=1 CANONICAL=A0A0G2KAE6-1" }, "isoforms": [ { "isoform_ac": "A0A0G2KAE6-1", "url": "", "sequence": { "sequence": "MAFRRTEGMSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRKKKQVGPEMGSEQLGTFPMPILMARKVPSVKKGCSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSLASMVMVNSSSPTAACSGSWETRGMEESVPTMDGSAESLYVQGMELFEEALQKWEQALSVGQRGDGGSTPTPGDSLQNPDTSSEALSEPESQRREFAEKLESLLHRAYHLQEEFGSTLPSDNMLLDLERTLMLPLTEGSLCLRADDEDSLTSEDSFFSATELFESLQIGEYPLPLSRPAAAYEEALQLVKEGKVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEERNNQVFFGEVGRQMVTGLMTKAEKSPKGFLESYEEMLNYALRPETWATTRLELEGRGVACMSFFDIVLDFILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLSEVCAFFKHQIVQYLRDMFDLDNVRYTSVPALAEDILQLSRRRSEILLGYLGAPVASSTGLNGPLPRENGPLDELQ", "length": 593, "header": "tr|A0A0G2KAE6-1|A0A0G2KAE6_RAT Isoform 1 of Mitoguardin 2 OS=Rattus norvegicus OX=10116 GN=Miga2 PE=1 SV=1 CANONICAL=A0A0G2KAE6-1" }, "locus": { "chromosome": "3", "start_pos": 13657453, "end_pos": 13640777, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000088509.2", "url": "https://www.ensembl.org/id/ENSRNOT00000088509.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075370.1", "url": "https://www.ensembl.org/id/ENSRNOP00000075370.1" } ] } }, { "isoform_ac": "D3Z899-1", "url": "", "sequence": { "sequence": "MAFRRTEGMSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRKKKQVGPEMGSEQLGTFPMPILMARKVPSVKKGCSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSLASMVMVNSSSPTAACSGSWETRGMEESVPTMDGSAESLYVQGMELFEEALQKWEQALSVGQRGDGGSTPTPGDSLQNPDTSSEALSEPESQRREFAEKLESLLHRAYHLQEEFGSTLPSDNMLLDLERTLMLPLTEGSLCLRADDEDSLTSEDSFFSATELFESLQIGEYPLPLSRPAAAYEEALQLVKEGKVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEERNNQVFFGEVGRQMVTGLMTKAEKSPKGFLESYEEMLNYALRPETWATTRLELEGRGVACMSFFDIVLDFILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMHQIVQYLRDMFDLDNVRYTSVPALAEDILQLSRRRSEILLGYLGAPVASSTGLNGPLPRENGPLDELQ", "length": 554, "header": "tr|D3Z899-1|D3Z899_RAT Computationally mapped isoform of Mitoguardin 2 OS=Rattus norvegicus OX=10116 GN=Miga2 PE=1 SV=1 CANONICAL=A0A0G2KAE6-1" }, "locus": { "chromosome": "3", "start_pos": 13657453, "end_pos": 13640777, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000065300.4", "url": "https://www.ensembl.org/id/ENSRNOT00000065300.4" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000062428.1", "url": "https://www.ensembl.org/id/ENSRNOP00000062428.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:296623", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:296623", "resource": "KEGG Pathway" }, { "id": "R-RNO-1483166", "name": "Synthesis of PA", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1483166", "resource": "Reactome", "description": "Synthesis of PA" } ], "orthologs": [ { "uniprot_canonical_ac": "Q7L4E1-1", "protein_name": "Mitoguardin 2", "gene_name": "MIGA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFRRAEGTSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRRKKQVGPEMGGEQLGTVPLPILLARKVPSVKKGYSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSVASMMAVNSSSPTAACSGLWDARGMEESLTTSDGNAESLYMQGMELFEEALQKWEQALSVGQRGDSGSTPMPRDGLRNPETASEPLSEPESQRKEFAEKLESLLHRAYHLQEEFGSTFPADSMLLDLERTLMLPLTEGSLRLRADDEDSLTSEDSFFSATELFESLQTGDYPIPLSRPAAAYEEALQLVKEGRVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEDKSNQLFFGKVGRQMVTGLMTKAEKSPKGFLESYEEMLSYALRPETWATTRLELEGRGVVCMSFFDIVLDFILMDAFEDLENPPASVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLAEVCAFFKHQIVQYLRDMFDLDNVRYTSLPALADDILQLSRRRSEILLGYLGVPAASSAGVNGALPRENGPLGELQ", "length": 593 }, "evidence": [ { "id": "45233476", "url": "http://www.informatics.jax.org/homology/45233476", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BK03-1", "protein_name": "Mitoguardin 2", "gene_name": "Miga2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFRRTEGMSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRKKKQVGPEMGGEQLGTVPMPILMARKVPSVKKGCSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSLASMVVVNSSSPTAACSGSWEARGMEESVPTTDGSAESLYVQGMELFEEALQKWEQALSVGQRGDGGSTPTPGDSLQNPDTASEALSEPESQRREFAEKLESLLHRAYHLQEEFGSTFPSDSMLLDLERTLMLPLTEGSLRLRADDEDSLTSEDSFFSATEIFESLQIGEYPLPLSRPAAAYEEALQLVKEGRVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEERSNQIFFGEVGRQMVTGLMTKAEKSPKGFLESYEEMLSYALRPETWATTRLELEGRGVACMSFFDIVLDFILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLSEVCAFFKHQIVQYLRDMFDLDNVRYTSVPALAEDILQLSRRRSEILLGYLGAPVASSIGLNGPLPRENGPLEELQ", "length": 593 }, "evidence": [ { "id": "45233476", "url": "http://www.informatics.jax.org/homology/45233476", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAE6", "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAE6", "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAE6", "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAE6", "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "bone development", "id": "GO:0060348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAE6", "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6" } ], "pmid": "" }, { "name": "mitochondrial fusion", "id": "GO:0008053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008053", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAE6", "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }