{
    "uniprot_canonical_ac": "A0A0G2KAE3-1",
    "uniprot_ac": "A0A0G2KAE3",
    "uniprot_id": "A0A0G2KAE3_RAT",
    "mass": {
        "chemical_mass": 46695.0,
        "monoisotopic_mass": 46695.0
    },
    "refseq": {
        "ac": "XP_006240232",
        "name": "kelch domain-containing protein 1 isoform X2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006240232"
    },
    "gene_names": [
        {
            "name": "Klhdc1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2KAE3",
            "id": "A0A0G2KAE3"
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    ],
    "protein_names": [
        {
            "name": "Kelch domain containing 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A0G2KAE3"
        },
        {
            "name": "kelch domain-containing protein 1 isoform X2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006240232",
            "id": "XP_006240232"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
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                    "database": "UniProtKB",
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            ],
            "common_name": "Rat"
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        {
            "name": "Klhdc1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2KAE3",
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                "start_pos": 87765424,
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                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000004425",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000004425"
                    }
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    ],
    "crossref": [
        {
            "id": "ENSRNOG00000004425",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004425",
            "database": "Bgee",
            "categories": [
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            ]
        },
        {
            "id": "314190",
            "url": "https://www.ncbi.nlm.nih.gov/gene/314190",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR011043",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011043",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011498",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011498",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015915",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "GYMSVAD",
            "url": "https://omabrowser.org/oma/group/GYMSVAD/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR46228",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46228",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR46228:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46228:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF07646",
            "url": "http://pfam.xfam.org/family/PF07646",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13418",
            "url": "http://pfam.xfam.org/family/PF13418",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13854",
            "url": "http://pfam.xfam.org/family/PF13854",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13964",
            "url": "http://pfam.xfam.org/family/PF13964",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
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            "id": "XP_006240231",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006240231",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1308211",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308211",
            "database": "RGD",
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            ]
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            "url": "https://www.uniprot.org/uniprot/A0A0G2KAE3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
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            "id": "A0A0G2KAE3-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2KAE3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6GDD5",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GDD5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6GDD5-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GDD5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B0K005",
            "url": "https://www.uniprot.org/uniprot/B0K005",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B0K005-1",
            "url": "https://www.uniprot.org/uniprot/B0K005-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
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        "sequence": "MADSQAFCVAEERSGHCAVVDGHFLYVWGGYVSIEDNEVYLPNDEIWTYDVDSGLWKMHLMEGELPPSMSGSCGACINGRLYVFGGYDDKGYSNRLYFVDLRTRDGTYIWEKITKFEGQPPTPRDKLSCWVYKDRLIYFGGYGYRRHSELQECFDVHDASWEEQIFWGWHNDVHVFDTKTRTWSQPEIKGGVPPQPRAAHSCAVLGNKGYVFGGRVLQTRMNDLHYLNLDTWVWSGRISVNGESPKHRSWHTLTAIADDKLFLFGGLSADNIPLSDGWIHNIITNCWKQLRHLPYTRPRLWHTACLGKENEIMVFGGSKDNLLFLDTGHCNDLLIFQTQPYSLLRSCLDCIGKNAIILKSQISLLPPKLLQQVFQKITFWTAANYRKEQRIQKGETENKQPRVSSC",
        "length": 406,
        "header": "tr|A0A0G2KAE3-1|A0A0G2KAE3_RAT Isoform 1 of Kelch domain containing 1  OS=Rattus norvegicus OX=10116 GN=Klhdc1 PE=4 SV=1 CANONICAL=A0A0G2KAE3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2KAE3-1",
            "url": "",
            "sequence": {
                "sequence": "MADSQAFCVAEERSGHCAVVDGHFLYVWGGYVSIEDNEVYLPNDEIWTYDVDSGLWKMHLMEGELPPSMSGSCGACINGRLYVFGGYDDKGYSNRLYFVDLRTRDGTYIWEKITKFEGQPPTPRDKLSCWVYKDRLIYFGGYGYRRHSELQECFDVHDASWEEQIFWGWHNDVHVFDTKTRTWSQPEIKGGVPPQPRAAHSCAVLGNKGYVFGGRVLQTRMNDLHYLNLDTWVWSGRISVNGESPKHRSWHTLTAIADDKLFLFGGLSADNIPLSDGWIHNIITNCWKQLRHLPYTRPRLWHTACLGKENEIMVFGGSKDNLLFLDTGHCNDLLIFQTQPYSLLRSCLDCIGKNAIILKSQISLLPPKLLQQVFQKITFWTAANYRKEQRIQKGETENKQPRVSSC",
                "length": 406,
                "header": "tr|A0A0G2KAE3-1|A0A0G2KAE3_RAT Isoform 1 of Kelch domain containing 1  OS=Rattus norvegicus OX=10116 GN=Klhdc1 PE=4 SV=1 CANONICAL=A0A0G2KAE3-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 87764393,
                "end_pos": 87712802,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000082500.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000082500.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000075367.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000075367.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6GDD5-1",
            "url": "",
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                "length": 378,
                "header": "tr|A0A8I6GDD5-1|A0A0G2KAE3_RAT Computationally mapped isoform of Kelch domain containing 1  OS=Rattus norvegicus OX=10116 GN=Klhdc1 PE=4 SV=1 CANONICAL=A0A0G2KAE3-1"
            },
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                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000115995.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000115995.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000085804.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000085804.1"
                    }
                ]
            }
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            "url": "",
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                "length": 303,
                "header": "tr|B0K005-1|A0A0G2KAE3_RAT Computationally mapped isoform of Kelch domain containing 1  OS=Rattus norvegicus OX=10116 GN=Klhdc1 PE=4 SV=1 CANONICAL=A0A0G2KAE3-1"
            },
            "locus": {
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                "start_pos": 87743334,
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                "evidence": [
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                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000064668.3",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000064668.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000059485.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000059485.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q80YG3-1",
            "protein_name": "Kelch domain-containing protein 1",
            "gene_name": "Klhdc1",
            "tax_id": 10090,
            "organism": "Mus musculus",
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                "sequence": "MADPQAFCVAEERSGHCAVVDGHFLYVWGGYVSIEDNEVYLPNDEMWTYDIDSGLWKMHLMEGELPPSMSGSCGACIHGRLYVFGGYDDKGYSNRLYFVNLRTRDGTYTWEKITKFDGQPPTPRDKLSCWVYKDRLIYFGGYGYRRHSELQECFDVHDASWEEQIFWGWHNDVHVFDTKTRTWSQPEIKGGVPPQPRAAHSCAVLGNKGYVFGGRVLQTRMNDLHYLNLDTWVWSGRISVNGESPKHRSWHTLTAITDDKLFLFGGLNADNIPLSDGWIHNITTNCWKQLRHLPYTRPRLWHTACLGKENEIMVFGGSKDNLLFLDTGHCNDLLIFQTQPYSLLRSCLDCIGKNAIILKSQISLLPPKLLQQVLKKITFWTAANYRKEQRIRKEETENNQPRVSSC",
                "length": 406
            },
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                {
                    "id": "45241711",
                    "url": "http://www.informatics.jax.org/homology/45241711",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q8N7A1-1",
            "protein_name": "Kelch domain-containing protein 1",
            "gene_name": "KLHDC1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MADSQLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKTRPRLWHTACLGKENEIMVFGGSKDDLLALDTGHCNDLLIFQTQPYSLLRSCLDCIGKNSIMLESQISLLPPKLLQQVLKKITFWAAANHREEQRVQKEETENKYQWISSN",
                "length": 406
            },
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                {
                    "id": "45241711",
                    "url": "http://www.informatics.jax.org/homology/45241711",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
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        "categories": [
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
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                                "database": "UniProtKB",
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                                "url": "https://www.uniprot.org/uniprot/A0A0G2KAE3"
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                    {
                        "name": "cytosol",
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                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
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                                "database": "UniProtKB",
                                "id": "A0A0G2KAE3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KAE3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Cul5-RING ubiquitin ligase complex",
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                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031466",
                        "evidence": [
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                            }
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                        "pmid": ""
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                "name": "Molecular Function",
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                        "name": "ubiquitin ligase-substrate adaptor activity",
                        "id": "GO:1990756",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KAE3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KAE3"
                            }
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                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "ubiquitin-dependent protein catabolic process via the C-end degron rule pathway",
                        "id": "GO:0140627",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140627",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KAE3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KAE3"
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    "reaction_participants": [],
    "reaction_enzymes": [],
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    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
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        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
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}