{ "uniprot_canonical_ac": "A0A0G2K8S8-1", "uniprot_ac": "A0A0G2K8S8", "uniprot_id": "A0A0G2K8S8_RAT", "mass": { "chemical_mass": 29605.0, "monoisotopic_mass": 29605.0 }, "refseq": {}, "gene_names": [ { "name": "Tigar", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8", "id": "A0A0G2K8S8" } ], "protein_names": [ { "name": "TP53 induced glycolysis regulatory phosphatase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K8S8" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "common_name": "Rat" } ], "gene": [ { "name": "Tigar", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8", "locus": { "chromosome": "4", "start_pos": 159927139, "end_pos": 159946029, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000051816", "url": "https://www.ensembl.org/id/ENSRNOG00000051816" } ] } } ], "crossref": [ { "id": "cd07067", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07067", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "502894", "url": "https://www.ncbi.nlm.nih.gov/gene/502894", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CLNQDSH", "url": "https://omabrowser.org/oma/group/CLNQDSH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46517", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46517", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46517:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46517:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00300", "url": "http://pfam.xfam.org/family/PF00300", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "1560038", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1560038", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K8S8-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A9E3", "url": "https://www.uniprot.org/uniprot/A0A8I6A9E3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A9E3-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A9E3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AIY8", "url": "https://www.uniprot.org/uniprot/A0A8I6AIY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AIY8-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AIY8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRFALTIIRHGETRLNKEKIIQGQGVDAPLSETGFRQAAATGQFLSNVHFTHAFSSDLTRTKQTIHGILEKSRFCKDIAVKYDSRLRERMYGVAEGKPLSELRAMAKAAGEECPMFTPPGGETVEQQVKMRGKDFFDFICQLILGKAGQRENFLPGAPDNCLESSLAEVFPVGKHGSLGTDPKHGALGLTASILVVSHGAYMRSLFGYFLSDLRCSLPATIDKFELSSITPNTGISVFIIDCEEARKPTVQCVCMNLQEHLNKGVEKH", "length": 269, "header": "tr|A0A0G2K8S8-1|A0A0G2K8S8_RAT Isoform 1 of TP53 induced glycolysis regulatory phosphatase OS=Rattus norvegicus OX=10116 GN=Tigar PE=4 SV=1 CANONICAL=A0A0G2K8S8-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K8S8-1", "url": "", "sequence": { "sequence": "MPRFALTIIRHGETRLNKEKIIQGQGVDAPLSETGFRQAAATGQFLSNVHFTHAFSSDLTRTKQTIHGILEKSRFCKDIAVKYDSRLRERMYGVAEGKPLSELRAMAKAAGEECPMFTPPGGETVEQQVKMRGKDFFDFICQLILGKAGQRENFLPGAPDNCLESSLAEVFPVGKHGSLGTDPKHGALGLTASILVVSHGAYMRSLFGYFLSDLRCSLPATIDKFELSSITPNTGISVFIIDCEEARKPTVQCVCMNLQEHLNKGVEKH", "length": 269, "header": "tr|A0A0G2K8S8-1|A0A0G2K8S8_RAT Isoform 1 of TP53 induced glycolysis regulatory phosphatase OS=Rattus norvegicus OX=10116 GN=Tigar PE=4 SV=1 CANONICAL=A0A0G2K8S8-1" }, "locus": { "chromosome": "4", "start_pos": 159945971, "end_pos": 159929001, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000091662.2", "url": "https://www.ensembl.org/id/ENSRNOT00000091662.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074722.2", "url": "https://www.ensembl.org/id/ENSRNOP00000074722.2" } ] } }, { "isoform_ac": "A0A8I6A9E3-1", "url": "", "sequence": { "sequence": "MPRFALTIIRHGETRLNKEKIIQGQGVDAPLSETGFRQAAATGQFLSNVHFTHAFSSDLTRTKQFDFICQLILGKAGQRENFLPGAPDNCLESSLAEVFPVGKHGSLGTDPKHGALGLTASILVVSHGAYMRSLFGYFLSDLRCSLPATIDKFELSSITPNTGISVFIIDCEEARKPTVQCVCMNLQEHLNKGVEKH", "length": 197, "header": "tr|A0A8I6A9E3-1|A0A8I6A9E3_RAT Computationally mapped isoform of TP53 induced glycolysis regulatory phosphatase OS=Rattus norvegicus OX=10116 GN=Tigar PE=4 SV=1 CANONICAL=A0A0G2K8S8-1" }, "locus": { "chromosome": "4", "start_pos": 159945971, "end_pos": 159929001, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000098356.1", "url": "https://www.ensembl.org/id/ENSRNOT00000098356.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000088153.1", "url": "https://www.ensembl.org/id/ENSRNOP00000088153.1" } ] } }, { "isoform_ac": "A0A8I6AIY8-1", "url": "", "sequence": { "sequence": "MPRFALTIIRHGETRLNKEKIIQGQGVDAPLSETGFRQAAATGQFLSNVHFTHAFSSDLTRTKQTIHGILEKSRFCKDIAVKYDSRLRERMYGVAEGKPLSELRAMAKAAGEECPMFTPPGGETVEQVKMRGKDFFDFICQLILGKAGQRENFLPGAPDNCLESSLAEVFPVGKHGSLGTDPKHGALGLTASILVVSHGAYMRSLFGYFLSDLRCSLPATIDKFELSSITPNTGISVFIIDCEEARKPTVQCVCMNLQEHLNKGVEKH", "length": 268, "header": "tr|A0A8I6AIY8-1|A0A8I6AIY8_RAT Computationally mapped isoform of TP53 induced glycolysis regulatory phosphatase OS=Rattus norvegicus OX=10116 GN=Tigar PE=4 SV=1 CANONICAL=A0A0G2K8S8-1" }, "locus": { "chromosome": "4", "start_pos": 159945971, "end_pos": 159929001, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000111057.1", "url": "https://www.ensembl.org/id/ENSRNOT00000111057.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000092807.1", "url": "https://www.ensembl.org/id/ENSRNOP00000092807.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q8BZA9-1", "protein_name": "Fructose-2,6-bisphosphatase TIGAR", "gene_name": "Tigar", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRFALTVIRHGETRLNKEKIIQGQGVDAPLSETGFRQAAAAGQFLSNVQFTHAFSSDLTRTKQTIHGILEKSRFCKDMAVKYDSRLRERMYGVAEGKPLSELRAMAKAAGEECPMFTPPGGETVEQVKMRGKDFFDFICQLILGKAGQRESVLPGAPGSGLESSLAEVFPVGKHGSLGANPKGGTLGLAASILVVSHGAYMRSLFGYFLSDLRCSLPGARDKLELSSITPNTGISVFIIDCEEARQPSIQCVCMNLQEHLNGVTEKQH", "length": 269 }, "evidence": [ { "id": "45238929", "url": "http://www.informatics.jax.org/homology/45238929", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NQ88-1", "protein_name": "Fructose-2,6-bisphosphatase TIGAR", "gene_name": "TIGAR", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQAAAAGIFLNNVKFTHAFSSDLMRTKQTMHGILERSKFCKDMTVKYDSRLRERKYGVVEGKALSELRAMAKAAREECPVFTPPGGETLDQVKMRGIDFFEFLCQLILKEADQKEQFSQGSPSNCLETSLAEIFPLGKNHSSKVNSDSGIPGLAASVLVVSHGAYMRSLFDYFLTDLKCSLPATLSRSELMSVTPNTGMSLFIINFEEGREVKPTVQCICMNLQDHLNGLTETR", "length": 270 }, "evidence": [ { "id": "45238929", "url": "http://www.informatics.jax.org/homology/45238929", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 24, "go_terms": [ { "name": "negative regulation of mitophagy", "id": "GO:1901525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901525", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "regulation of pentose-phosphate shunt", "id": "GO:0043456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043456", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "response to ischemia", "id": "GO:0002931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002931", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "response to gamma radiation", "id": "GO:0010332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010332", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "negative regulation of neuron death", "id": "GO:1901215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901215", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "cellular response to hypoxia", "id": "GO:0071456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "negative regulation of reactive oxygen species metabolic process", "id": "GO:2000378", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000378", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "positive regulation of DNA repair", "id": "GO:0045739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045739", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "negative regulation of glycolytic process", "id": "GO:0045820", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045820", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "negative regulation of programmed cell death", "id": "GO:0043069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043069", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "glycolytic process", "id": "GO:0006096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006096", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "reactive oxygen species metabolic process", "id": "GO:0072593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072593", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "mitophagy", "id": "GO:0000423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000423", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "positive regulation of cardiac muscle cell apoptotic process", "id": "GO:0010666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010666", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "cardiac muscle cell apoptotic process", "id": "GO:0010659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010659", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "cellular response to cobalt ion", "id": "GO:0071279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071279", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "fructose 2,6-bisphosphate metabolic process", "id": "GO:0006003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006003", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "intestinal epithelial cell development", "id": "GO:0060576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060576", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "glucose catabolic process to lactate via pyruvate", "id": "GO:0019661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019661", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "regulation of response to DNA damage checkpoint signaling", "id": "GO:1902153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902153", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "positive regulation of hexokinase activity", "id": "GO:1903301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903301", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "negative regulation of glucose catabolic process to lactate via pyruvate", "id": "GO:1904024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904024", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "fructose-2,6-bisphosphate 2-phosphatase activity", "id": "GO:0004331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004331", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8S8", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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