{ "uniprot_canonical_ac": "A0A0G2K849-1", "uniprot_ac": "A0A0G2K849", "uniprot_id": "A0A0G2K849_RAT", "mass": { "chemical_mass": 104924.0, "monoisotopic_mass": 104924.0 }, "refseq": {}, "gene_names": [ { "name": "Taf4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K849", "id": "A0A0G2K849" } ], "protein_names": [ { "name": "TATA-box binding protein associated factor 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K849" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "common_name": "Rat" } ], "gene": [ { "name": "Taf4", "url": "https://www.uniprot.org/uniprot/A0A0G2K849", "locus": { "chromosome": "3", "start_pos": 167017993, "end_pos": 167083356, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000054497", "url": "https://www.ensembl.org/id/ENSRNOG00000054497" } ] } } ], "crossref": [ { "id": "ENSRNOG00000054497", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000054497", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08045", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08045", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GQTMQGG", "url": "https://omabrowser.org/oma/group/GQTMQGG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR15138", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15138", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15138:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15138:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05236", "url": "http://pfam.xfam.org/family/PF05236", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07531", "url": "http://pfam.xfam.org/family/PF07531", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-674695", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-674695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804756", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-73776", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73776", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-73779", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73779", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-75953", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75953", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-76042", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-76042", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1588072", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1588072", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K849-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K849-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPELRAAAAGALGNHVVSGSPAGAAGAGPAASAEGAPAAAPEPPPAGRARPAGGGPRRPGSSSPRRLLVPAGPAPAPAKLRPPPEASAGPCPVAAAAATAAAAAGPDPAAAAPPAGPGASKPGPPGPPGPGAAQTLNGSAAPPTAPHAAPAVSPVNNGPAPPPAAGSVIQAAPAPAAPSPPAAPAPAAPPPPAPPAPVAPARPPGHPAAPAPPVSPAAAAAAAAAAAQNGAAPAPAAASGGAAGLGQPGAGAQGAKAEAPKPGPGPGPGPAAAAAAAGVAGGGAAGGVLLGPAMPGALPGPAPGTPAGLAKGAAAATPSLPRTPAATTGAIRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAHAQAQPQSTMAPRPATPTGAAPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPTTTLQRSPGVQPQLVLGGSAQPASLGTATAVQTGTPQRTVTGASTTSTAATETMENVKKCKSFLSTLIKLASSGKQSTETAANVKDLVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSAAFIQQSQQQQPPASQATTALTAVVLSSSVQRTAGKTAASVTSALQPPVISLTQPTQVGVGKQAPPTPLVIQQPPKPGALIRPPQVTLTQTPMVALRQPHNRIMLTTPQQIQLNQLQPVPVVKPTVLPGTKALSTVSAQAAAAQKNKLKEPGGGSFRDDDDINDVASMAGVNLSEESARILATNSELVGTLTRSCKDDTFLLPAPLQRRILEIGKKHGITELHPDVVSYVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQELAQMRQRDANLTALAAIGPRKKRKVDCAGPGSGAEGSGPGAAVPGGSGVGTPRQFTRQRITRVNLRDLIFCLENERETSHSLLLYKAFLK", "length": 1038, "header": "tr|A0A0G2K849-1|A0A0G2K849_RAT Isoform 1 of TATA-box binding protein associated factor 4 OS=Rattus norvegicus OX=10116 GN=Taf4 PE=1 SV=2 CANONICAL=A0A0G2K849-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K849-1", "url": "", "sequence": { "sequence": "MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPELRAAAAGALGNHVVSGSPAGAAGAGPAASAEGAPAAAPEPPPAGRARPAGGGPRRPGSSSPRRLLVPAGPAPAPAKLRPPPEASAGPCPVAAAAATAAAAAGPDPAAAAPPAGPGASKPGPPGPPGPGAAQTLNGSAAPPTAPHAAPAVSPVNNGPAPPPAAGSVIQAAPAPAAPSPPAAPAPAAPPPPAPPAPVAPARPPGHPAAPAPPVSPAAAAAAAAAAAQNGAAPAPAAASGGAAGLGQPGAGAQGAKAEAPKPGPGPGPGPAAAAAAAGVAGGGAAGGVLLGPAMPGALPGPAPGTPAGLAKGAAAATPSLPRTPAATTGAIRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAHAQAQPQSTMAPRPATPTGAAPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPTTTLQRSPGVQPQLVLGGSAQPASLGTATAVQTGTPQRTVTGASTTSTAATETMENVKKCKSFLSTLIKLASSGKQSTETAANVKDLVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSAAFIQQSQQQQPPASQATTALTAVVLSSSVQRTAGKTAASVTSALQPPVISLTQPTQVGVGKQAPPTPLVIQQPPKPGALIRPPQVTLTQTPMVALRQPHNRIMLTTPQQIQLNQLQPVPVVKPTVLPGTKALSTVSAQAAAAQKNKLKEPGGGSFRDDDDINDVASMAGVNLSEESARILATNSELVGTLTRSCKDDTFLLPAPLQRRILEIGKKHGITELHPDVVSYVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQELAQMRQRDANLTALAAIGPRKKRKVDCAGPGSGAEGSGPGAAVPGGSGVGTPRQFTRQRITRVNLRDLIFCLENERETSHSLLLYKAFLK", "length": 1038, "header": "tr|A0A0G2K849-1|A0A0G2K849_RAT Isoform 1 of TATA-box binding protein associated factor 4 OS=Rattus norvegicus OX=10116 GN=Taf4 PE=1 SV=2 CANONICAL=A0A0G2K849-1" }, "locus": { "chromosome": "3", "start_pos": 167083356, "end_pos": 167019253, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000082981.2", "url": "https://www.ensembl.org/id/ENSRNOT00000082981.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074471.2", "url": "https://www.ensembl.org/id/ENSRNOP00000074471.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-RNO-674695", "name": "RNA Polymerase II Pre-transcription Events", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-674695", "resource": "Reactome", "description": "RNA Polymerase II Pre-transcription Events" }, { "id": "R-RNO-6804756", "name": "Regulation of TP53 Activity through Phosphorylation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804756", "resource": "Reactome", "description": "Regulation of TP53 Activity through Phosphorylation" }, { "id": "R-RNO-73776", "name": "RNA Polymerase II Promoter Escape", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73776", "resource": "Reactome", "description": "RNA Polymerase II Promoter Escape" }, { "id": "R-RNO-73779", "name": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73779", "resource": "Reactome", "description": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" }, { "id": "R-RNO-75953", "name": "RNA Polymerase II Transcription Initiation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75953", "resource": "Reactome", "description": "RNA Polymerase II Transcription Initiation" }, { "id": "R-RNO-76042", "name": "RNA Polymerase II Transcription Initiation And Promoter Clearance", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-76042", "resource": "Reactome", "description": "RNA Polymerase II Transcription Initiation And Promoter Clearance" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "positive regulation of transcription initiation by RNA polymerase II", "id": "GO:0060261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060261", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "protein phosphorylation", "id": "GO:0006468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "ovarian follicle development", "id": "GO:0001541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001541", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "transcription initiation at RNA polymerase II promoter", "id": "GO:0006367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006367", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "mRNA transcription by RNA polymerase II", "id": "GO:0042789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042789", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "DNA-templated transcription initiation", "id": "GO:0006352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006352", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "monoubiquitinated histone H2A deubiquitination", "id": "GO:0035522", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035522", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "histone H3 acetylation", "id": "GO:0043966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043966", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "RNA polymerase II preinitiation complex assembly", "id": "GO:0051123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051123", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "monoubiquitinated histone deubiquitination", "id": "GO:0035521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035521", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "transcription factor TFTC complex", "id": "GO:0033276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033276", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "male germ cell nucleus", "id": "GO:0001673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001673", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "MLL1 complex", "id": "GO:0071339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071339", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "transcription factor TFIID complex", "id": "GO:0005669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005669", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "aryl hydrocarbon receptor binding", "id": "GO:0017162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017162", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "core promoter sequence-specific DNA binding", "id": "GO:0001046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001046", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" }, { "name": "RNA polymerase II general transcription initiation factor activity", "id": "GO:0016251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016251", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K849", "url": "https://www.uniprot.org/uniprot/A0A0G2K849" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 600, "end_pos": 602, "annotation": "n_glycosylation_sequon" }, { "start_pos": 797, "end_pos": 799, "annotation": "n_glycosylation_sequon" }, { "start_pos": 878, "end_pos": 880, "annotation": "n_glycosylation_sequon" }, { "start_pos": 958, "end_pos": 960, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }