The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-166245", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-166245" } ] }, { "id": "R-RNO-166271", "name": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P41499-2", "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-166271", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-166271" } ] }, { "id": "R-RNO-5668414", "name": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZTD1-1", "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-5668414", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5668414" } ] }, { "id": "R-RNO-5668417", "name": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZTD1-1", "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-5668417", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5668417" } ] }, { "id": "R-RNO-5668454", "name": "K63polyUb-cIAP1,2 ubiquitinates TRAF3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZTD1-1", "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-5668454", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5668454" } ] }, { "id": "R-RNO-5668481", "name": "Protesomal degradation of K48polyUb-TRAF3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZTD1-1", "P28064-1", "P28073-1", "P28075-1", "P28077-1", "Q4KM35-1", "Q9JHW0-1", "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-5668481", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5668481" } ] }, { "id": "R-RNO-5668534", "name": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZTD1-1", "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-5668534", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5668534" } ] }, { "id": "R-RNO-5668543", "name": "TRAF3:NIK binds TRAF2:cIAP1/2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZTD1-1", "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-5668543", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5668543" } ] }, { "id": "R-RNO-5676593", "name": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZTD1-1", "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-5676593", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5676593" } ] }, { "id": "R-RNO-5676595", "name": "TRAFs bind RANK:RANKL", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZTD1-1", "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-5676595", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5676595" } ] }, { "id": "R-RNO-5676596", "name": "TRAF3 binds BAFFR:BAFF", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZTD1-1", "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-5676596", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5676596" } ] }, { "id": "R-RNO-5676597", "name": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZTD1-1", "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-5676597", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5676597" } ] }, { "id": "R-RNO-5676598", "name": "TRAF2:cIAP1/2 complex binds FN14:TWEAK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZTD1-1", "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-5676598", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5676598" } ] }, { "id": "R-RNO-5690843", "name": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61589-1", "D3ZAR8-1", "B5DF45-1", "B2RYG6-1", "A0A0G2K7X2-1" ], "evidence": [ { "id": "R-RNO-5690843", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5690843" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K7X2", "gene_name": "Traf3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2K7X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A0G2K7X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K7X2" } ] } ] }, { "uniprot_ac": "B2RYG6", "gene_name": "Otub1", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "B2RYG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYG6" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "B2RYG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYG6" } ] } ] }, { "uniprot_ac": "B5DF45", "gene_name": "Traf6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "B5DF45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DF45" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "B5DF45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DF45" } ] } ] }, { "uniprot_ac": "D3ZAR8", "gene_name": "Otub2", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "D3ZAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZAR8" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "D3ZAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZAR8" } ] } ] }, { "uniprot_ac": "D3ZTD1", "gene_name": "Map3k14", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZTD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZTD1" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "D3ZTD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZTD1" } ] } ] }, { "uniprot_ac": "P28064", "gene_name": "Psmb8", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28064" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28064" } ] } ] }, { "uniprot_ac": "P28073", "gene_name": "Psmb6", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28073" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28073" } ] } ] }, { "uniprot_ac": "P28075", "gene_name": "Psmb5", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28075", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28075" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28075", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28075" } ] } ] }, { "uniprot_ac": "P28077", "gene_name": "Psmb9", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28077" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28077" } ] } ] }, { "uniprot_ac": "P41499", "gene_name": "Ptpn11", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P41499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41499" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P41499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41499" } ] } ] }, { "uniprot_ac": "P61589", "gene_name": "Rhoa", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61589" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61589" } ] } ] }, { "uniprot_ac": "Q4KM35", "gene_name": "Psmb10", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q4KM35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM35" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q4KM35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM35" } ] } ] }, { "uniprot_ac": "Q9JHW0", "gene_name": "Psmb7", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q9JHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHW0" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q9JHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHW0" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }