{ "uniprot_canonical_ac": "A0A0G2K7M1-1", "uniprot_ac": "A0A0G2K7M1", "uniprot_id": "A0A0G2K7M1_RAT", "mass": { "chemical_mass": 35692.0, "monoisotopic_mass": 35692.0 }, "refseq": {}, "gene_names": [ { "name": "AABR07030729.1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1", "id": "A0A0G2K7M1" } ], "protein_names": [ { "name": "Glyceraldehyde-3-phosphate dehydrogenase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A0G2K7M1" }, { "name": "1.2.1.12", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K7M1" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7M1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1" } ], "common_name": "Rat" } ], "gene": [ { "name": "AABR07030729.1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1", "locus": { "chromosome": "10", "start_pos": 98813794, "end_pos": 98814795, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000030224", "url": "https://www.ensembl.org/id/ENSRNOG00000030224" } ] } } ], "crossref": [ { "id": "ENSRNOG00000030224", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000030224", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020830", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020830", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020831", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020831", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VFGMRNP", "url": "https://omabrowser.org/oma/group/VFGMRNP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10836", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10836", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10836:SF111", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10836:SF111", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00044", "url": "http://pfam.xfam.org/family/PF00044", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02800", "url": "http://pfam.xfam.org/family/PF02800", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "15003802", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=15003802", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "10300", "url": "https://www.rhea-db.org/rhea/10300", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66684", "url": "https://www.rhea-db.org/rhea/66684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2K7M1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K7M1-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKVGVNGFGHIGRLVTRAAFSSGKVEIVAINDPFIDLNYIVYMFQYGSTHGKFNGTVKAENGKLVIKGKPITIFQERDPANIKWGDAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSVDAPMFVMGVNHEKYDNSLKIVSNASCTTNCLAPLAKVIHDNFGIVEGLMTTVLAITATQKAMDGPSGKLWCDGRGATQNIIPASNGAAKAVGKVIPELNGNLTGTAFCVPTPNVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEDQVVSCDFNSNSYSSTFDAGASIALNDNFVKFISWYDNEYGYSNRVVDLMAYMASKE", "length": 333, "header": "tr|A0A0G2K7M1-1|A0A0G2K7M1_RAT Isoform 1 of Glyceraldehyde-3-phosphate dehydrogenase OS=Rattus norvegicus OX=10116 GN=AABR07030729.1 PE=1 SV=1 CANONICAL=A0A0G2K7M1-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K7M1-1", "url": "", "sequence": { "sequence": "MVKVGVNGFGHIGRLVTRAAFSSGKVEIVAINDPFIDLNYIVYMFQYGSTHGKFNGTVKAENGKLVIKGKPITIFQERDPANIKWGDAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSVDAPMFVMGVNHEKYDNSLKIVSNASCTTNCLAPLAKVIHDNFGIVEGLMTTVLAITATQKAMDGPSGKLWCDGRGATQNIIPASNGAAKAVGKVIPELNGNLTGTAFCVPTPNVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEDQVVSCDFNSNSYSSTFDAGASIALNDNFVKFISWYDNEYGYSNRVVDLMAYMASKE", "length": 333, "header": "tr|A0A0G2K7M1-1|A0A0G2K7M1_RAT Isoform 1 of Glyceraldehyde-3-phosphate dehydrogenase OS=Rattus norvegicus OX=10116 GN=AABR07030729.1 PE=1 SV=1 CANONICAL=A0A0G2K7M1-1" }, "locus": { "chromosome": "10", "start_pos": 98814795, "end_pos": 98813797, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000044922.2", "url": "https://www.ensembl.org/id/ENSRNOT00000044922.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074263.1", "url": "https://www.ensembl.org/id/ENSRNOP00000074263.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7M1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "NAD binding", "id": "GO:0051287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051287", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7M1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1" } ], "pmid": "" }, { "name": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity", "id": "GO:0004365", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004365", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7M1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1" } ], "pmid": "" }, { "name": "peptidyl-cysteine S-nitrosylase activity", "id": "GO:0035605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035605", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7M1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1" } ], "pmid": "" }, { "name": "NADP binding", "id": "GO:0050661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050661", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7M1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "glucose metabolic process", "id": "GO:0006006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006006", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7M1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1" } ], "pmid": "" }, { "name": "glycolytic process", "id": "GO:0006096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006096", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7M1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" }, { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10300", "name": "", "equation": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04797-1", "F1LUV3-1", "Q9ESV6-1", "A0A0G2K7M1-1", "E9PTV9-1", "E9PTN6-1", "M0R660-1", "O14556-1", "P04406-1", "P16858-1", "Q64467-1", "A0A1D5RLD8-1", "S4R1W1-1", "P00358-1", "P00359-1", "P00360-1", "Q94469-1", "P07486-1", "P07487-1", "Q7JY07-1" ], "evidence": [ { "id": "10300", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10300" } ] }, { "id": "66684", "name": "", "equation": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] = L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7M1-1", "E9PTV9-1", "F1LUV3-1", "E9PTN6-1", "M0R660-1", "Q9ESV6-1", "P04797-1", "P04406-1", "P16858-1", "A0A1D5RLD8-1", "S4R1W1-1", "Q64467-1" ], "evidence": [ { "id": "66684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66684" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K7M1", "gene_name": "AABR07030729.1", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "A0A0G2K7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "A0A0G2K7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K7M1" } ] } ] }, { "uniprot_ac": "A0A1D5RLD8", "gene_name": "Gm10358", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "A0A1D5RLD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1D5RLD8" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "A0A1D5RLD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1D5RLD8" } ] } ] }, { "uniprot_ac": "E9PTN6", "gene_name": "LOC108352348", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "E9PTN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PTN6" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "E9PTN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PTN6" } ] } ] }, { "uniprot_ac": "E9PTV9", "gene_name": "AABR07032392.1", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "E9PTV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PTV9" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "E9PTV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PTV9" } ] } ] }, { "uniprot_ac": "F1LUV3", "gene_name": "ENSRNOG00000066746", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "F1LUV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LUV3" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "F1LUV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LUV3" } ] } ] }, { "uniprot_ac": "M0R660", "gene_name": "AABR07070043.1", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "M0R660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R660" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "M0R660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R660" } ] } ] }, { "uniprot_ac": "O14556", "gene_name": "GAPDHS", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "O14556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14556" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "O14556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14556" } ] } ] }, { "uniprot_ac": "P00358", "gene_name": "TDH2", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "P00358", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00358" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "P00358", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00358" } ] } ] }, { "uniprot_ac": "P00359", "gene_name": "TDH3", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "P00359", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00359" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "P00359", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00359" } ] } ] }, { "uniprot_ac": "P00360", "gene_name": "TDH1", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "P00360", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00360" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "P00360", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00360" } ] } ] }, { "uniprot_ac": "P04406", "gene_name": "GAPDH", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "P04406", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04406" } ] }, { "ec_number": "2.6.99.-", "activity": "", "evidence": [ { "id": "P04406", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04406" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "P04406", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04406" } ] } ] }, { "uniprot_ac": "P04797", "gene_name": "Gapdh", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "P04797", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04797" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "P04797", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04797" } ] }, { "ec_number": "2.6.99.-", "activity": "", "evidence": [ { "id": "P04797", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04797" } ] } ] }, { "uniprot_ac": "P07486", "gene_name": "Gapdh1", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "P07486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07486" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "P07486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07486" } ] } ] }, { "uniprot_ac": "P07487", "gene_name": "Gapdh2", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "P07487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07487" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "P07487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07487" } ] } ] }, { "uniprot_ac": "P16858", "gene_name": "Gapdh", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH.", "evidence": [ { "id": "P16858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16858" } ] }, { "ec_number": "2.6.99.-", "activity": "", "evidence": [ { "id": "P16858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16858" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "P16858", "database": "UniProtKB", "url": 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