{ "uniprot_canonical_ac": "A0A0G2K7L4-1", "uniprot_ac": "A0A0G2K7L4", "uniprot_id": "A0A0G2K7L4_RAT", "mass": { "chemical_mass": 50290.0, "monoisotopic_mass": 50290.0 }, "refseq": { "ac": "NP_001178914", "name": "inositol-tetrakisphosphate 1-kinase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178914" }, "gene_names": [ { "name": "Itpk1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "id": "A0A0G2K7L4" }, { "name": "Itpk1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017449793", "id": "XP_017449793" } ], "protein_names": [ { "name": "Inositol-tetrakisphosphate 1-kinase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K7L4" }, { "name": "inositol 1,3,4-triphosphate 5/6 kinase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178914", "id": "NP_001178914" }, { "name": "inositol-tetrakisphosphate 1-kinase isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017449793", "id": "XP_017449793" }, { "name": "inositol-tetrakisphosphate 1-kinase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178914", "id": "NP_001178914" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L4", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ], "common_name": "Rat" } ], "gene": [ { "name": "Itpk1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "locus": { "chromosome": "6", "start_pos": 121710755, "end_pos": 121844107, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000008051", "url": "https://www.ensembl.org/id/ENSRNOG00000008051" } ] } } ], "crossref": [ { "id": "ENSRNOG00000008051", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000008051", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "500709", "url": "https://www.ncbi.nlm.nih.gov/gene/500709", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008656", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008656", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041429", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041429", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:500709", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:500709", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VGERTCC", "url": "https://omabrowser.org/oma/group/VGERTCC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "180652at2759", "url": "http://www.orthodb.org/?query=180652at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14217", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14217", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14217:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14217:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05770", "url": "http://pfam.xfam.org/family/PF05770", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17927", "url": "http://pfam.xfam.org/family/PF17927", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-1855167", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855167", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-1855204", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855204", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983231", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_017449793", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017449793", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1595691", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1595691", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "12452", "url": "https://www.rhea-db.org/rhea/12452", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "13253", "url": "https://www.rhea-db.org/rhea/13253", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "20940", "url": "https://www.rhea-db.org/rhea/20940", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "70263", "url": "https://www.rhea-db.org/rhea/70263", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "70271", "url": "https://www.rhea-db.org/rhea/70271", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "70287", "url": "https://www.rhea-db.org/rhea/70287", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2K7L4", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K7L4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AFB6", "url": "https://www.uniprot.org/uniprot/A0A8I6AFB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AFB6-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AFB6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AUQ3", "url": "https://www.uniprot.org/uniprot/A0A8I6AUQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AUQ3-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AUQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AUY6", "url": "https://www.uniprot.org/uniprot/A0A8I6AUY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AUY6-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AUY6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZQM7", "url": "https://www.uniprot.org/uniprot/D3ZQM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZQM7-1", "url": "https://www.uniprot.org/uniprot/D3ZQM7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGDDTMRLLEQNGLAFPFICKTRVAHGTNSHEMAIVFNQEGLSAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSGSSPGPSLMPPVWTGSGRSSGRTVGHTGVARGLCAPLAGRMPDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVAPLRHNRLLAEPAGSLAGERTCSASPGCCSSMKGQDTPWKTEAEAGNMGAGGGGSAKLPHQRLGCTTGVSPSFQQHCVASLATKASSQ", "length": 463, "header": "tr|A0A0G2K7L4-1|A0A0G2K7L4_RAT Isoform 1 of Inositol-tetrakisphosphate 1-kinase OS=Rattus norvegicus OX=10116 GN=Itpk1 PE=1 SV=1 CANONICAL=A0A0G2K7L4-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K7L4-1", "url": "", "sequence": { "sequence": "MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGDDTMRLLEQNGLAFPFICKTRVAHGTNSHEMAIVFNQEGLSAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSGSSPGPSLMPPVWTGSGRSSGRTVGHTGVARGLCAPLAGRMPDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVAPLRHNRLLAEPAGSLAGERTCSASPGCCSSMKGQDTPWKTEAEAGNMGAGGGGSAKLPHQRLGCTTGVSPSFQQHCVASLATKASSQ", "length": 463, "header": "tr|A0A0G2K7L4-1|A0A0G2K7L4_RAT Isoform 1 of Inositol-tetrakisphosphate 1-kinase OS=Rattus norvegicus OX=10116 GN=Itpk1 PE=1 SV=1 CANONICAL=A0A0G2K7L4-1" }, "locus": { "chromosome": "6", "start_pos": 121844038, "end_pos": 121712341, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000080829.2", "url": "https://www.ensembl.org/id/ENSRNOT00000080829.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074255.1", "url": "https://www.ensembl.org/id/ENSRNOP00000074255.1" } ] } }, { "isoform_ac": "A0A8I6AFB6-1", "url": "", "sequence": { "sequence": "MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGDDTMRLLEQNGLAFPFICKTRVAHGTNSHEMAIVFNQEGLSAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSGVYRIWFLSHKSLTRVCMCSQLDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVAPLRHNRLLAEPAGSLAGERTCSASPGCCSSMKGQDTPWKTEAEAGNMGAGGGGSAKLPHQRLGCTTGVSPSFQQHCVASLATKASSQ", "length": 419, "header": "tr|A0A8I6AFB6-1|A0A8I6AFB6_RAT Computationally mapped isoform of Inositol-tetrakisphosphate 1-kinase OS=Rattus norvegicus OX=10116 GN=Itpk1 PE=3 SV=1 CANONICAL=A0A0G2K7L4-1" }, "locus": { "chromosome": "6", "start_pos": 121844038, "end_pos": 121712341, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000119725.1", "url": "https://www.ensembl.org/id/ENSRNOT00000119725.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000091296.1", "url": "https://www.ensembl.org/id/ENSRNOP00000091296.1" } ] } }, { "isoform_ac": "A0A8I6AUQ3-1", "url": "", "sequence": { "sequence": "MLKPERQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGDDTMRLLEQNGLAFPFICKTRVAHGTNSHEMAIVFNQEGLSAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVAPLRHNRLLAEPAGSLAGERTCSASPGCCSSMKGQDTPWKTEAEAGNMGAGGGGSAKLPHQRLGCTTGVSPSFQQHCVASLATKASSQ", "length": 388, "header": "tr|A0A8I6AUQ3-1|A0A8I6AUQ3_RAT Computationally mapped isoform of Inositol-tetrakisphosphate 1-kinase OS=Rattus norvegicus OX=10116 GN=Itpk1 PE=1 SV=1 CANONICAL=A0A0G2K7L4-1" }, "locus": { "chromosome": "6", "start_pos": 121785189, "end_pos": 121712341, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000095173.1", "url": "https://www.ensembl.org/id/ENSRNOT00000095173.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000097242.1", "url": "https://www.ensembl.org/id/ENSRNOP00000097242.1" } ] } }, { "isoform_ac": "A0A8I6AUY6-1", "url": "", "sequence": { "sequence": "MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGDDTMRLLEQNGLAFPFICKTRVAHGTNSHEMAIVFNQEGLSAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSAPKNPGLNRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVAPLRHNRLLAEPAGSLAGERTCSASPGCCSSMKGQDTPWKTEAEAGNMGAGGGGSAKLPHQRLGCTTGVSPSFQQHCVASLATKASSQ", "length": 428, "header": "tr|A0A8I6AUY6-1|A0A8I6AUY6_RAT Computationally mapped isoform of Inositol-tetrakisphosphate 1-kinase OS=Rattus norvegicus OX=10116 GN=Itpk1 PE=1 SV=1 CANONICAL=A0A0G2K7L4-1" }, "locus": { "chromosome": "6", "start_pos": 121844038, "end_pos": 121712341, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000095210.1", "url": "https://www.ensembl.org/id/ENSRNOT00000095210.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000097430.1", "url": "https://www.ensembl.org/id/ENSRNOP00000097430.1" } ] } }, { "isoform_ac": "D3ZQM7-1", "url": "", "sequence": { "sequence": "MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGDDTMRLLEQNGLAFPFICKTRVAHGTNSHEMAIVFNQEGLSAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVAPLRHNRLLAEPAGSLAGERTCSASPGCCSSMKGQDTPWKTEAEAGNMGAGGGGSAKLPHQRLGCTTGVSPSFQQHCVASLATKASSQ", "length": 421, "header": "tr|D3ZQM7-1|D3ZQM7_RAT Computationally mapped isoform of Inositol-tetrakisphosphate 1-kinase OS=Rattus norvegicus OX=10116 GN=Itpk1 PE=1 SV=3 CANONICAL=A0A0G2K7L4-1" }, "locus": { "chromosome": "6", "start_pos": 121844038, "end_pos": 121712341, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000010656.8", "url": "https://www.ensembl.org/id/ENSRNOT00000010656.8" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000010656.7", "url": "https://www.ensembl.org/id/ENSRNOP00000010656.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "rno:500709", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:500709", "resource": "KEGG Pathway" }, { "id": "R-RNO-1855167", "name": "Synthesis of pyrophosphates in the cytosol", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855167", "resource": "Reactome", "description": "Synthesis of pyrophosphates in the cytosol" }, { "id": "R-RNO-1855204", "name": "Synthesis of IP3 and IP4 in the cytosol", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855204", "resource": "Reactome", "description": "Synthesis of IP3 and IP4 in the cytosol" }, { "id": "R-RNO-983231", "name": "Factors involved in megakaryocyte development and platelet production", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983231", "resource": "Reactome", "description": "Factors involved in megakaryocyte development and platelet production" } ], "orthologs": [ { "uniprot_canonical_ac": "Q13572-1", "protein_name": "Inositol-tetrakisphosphate 1-kinase", "gene_name": "ITPK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQTFLKGKRVGYWLSEKKIKKLNFQAFAELCRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLATKASSQ", "length": 414 }, "evidence": [ { "id": "45226745", "url": "http://www.informatics.jax.org/homology/45226745", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BYN3-1", "protein_name": "Inositol-tetrakisphosphate 1-kinase", "gene_name": "Itpk1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGEDTMRLLEQNGLAFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVAPLRHNRLLAEPAGSLAGERTCSASPGCCGSMKGQDTPWKTETEAGNMGAGASAKLPHQRLGCTTGVSPSFQQHCVASLATKASSQ", "length": 419 }, "evidence": [ { "id": "45226745", "url": "http://www.informatics.jax.org/homology/45226745", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "inositol tetrakisphosphate 1-kinase activity", "id": "GO:0047325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047325", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L4", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ], "pmid": "" }, { "name": "inositol-1,3,4-trisphosphate 6-kinase activity", "id": "GO:0052725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052725", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L4", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ], "pmid": "" }, { "name": "inositol-1,3,4-trisphosphate 5-kinase activity", "id": "GO:0052726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052726", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L4", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L4", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L4", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ], "pmid": "" }, { "name": "inositol tetrakisphosphate 6-kinase activity", "id": "GO:0000825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000825", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L4", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L4", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "phosphorylation", "id": "GO:0016310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L4", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ], "pmid": "" }, { "name": "neural tube development", "id": "GO:0021915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021915", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L4", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ], "pmid": "" }, { "name": "necroptotic process", "id": "GO:0070266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070266", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L4", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ], "pmid": "" }, { "name": "inositol trisphosphate metabolic process", "id": "GO:0032957", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032957", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L4", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 328, "end_pos": 330, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12452", "name": "", "equation": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7L4-1", "Q13572-1", "Q8BYN3-1", "Q55D87-1" ], "evidence": [ { "id": "12452", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12452" } ] }, { "id": "13253", "name": "", "equation": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7L4-1", "Q13572-1", "Q8BYN3-1" ], "evidence": [ { "id": "13253", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13253" } ] }, { "id": "20940", "name": "", "equation": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7L4-1", "Q13572-1", "Q8BYN3-1" ], "evidence": [ { "id": "20940", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20940" } ] }, { "id": "70263", "name": "", "equation": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7L4-1", "Q13572-1", "Q8BYN3-1" ], "evidence": [ { "id": "70263", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70263" } ] }, { "id": "70271", "name": "", "equation": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7L4-1", "Q13572-1", "Q8BYN3-1" ], "evidence": [ { "id": "70271", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70271" } ] }, { "id": "70287", "name": "", "equation": "1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7L4-1", "Q13572-1", "Q8BYN3-1" ], "evidence": [ { "id": "70287", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70287" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K7L4", "gene_name": "Itpk1", "activity": [ { "ec_number": "2.7.1.134", "activity": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+).", "evidence": [ { "id": "A0A0G2K7L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ] }, { "ec_number": "2.7.1.159", "activity": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+).", "evidence": [ { "id": "A0A0G2K7L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ] }, { "ec_number": "2.7.1.134", "activity": "", "evidence": [ { "id": "A0A0G2K7L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ] }, { "ec_number": "2.7.1.159", "activity": "", "evidence": [ { "id": "A0A0G2K7L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ] } ] }, { "uniprot_ac": "Q13572", "gene_name": "ITPK1", "activity": [ { "ec_number": "2.7.1.134", "activity": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+).", "evidence": [ { "id": "Q13572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13572" } ] }, { "ec_number": "2.7.1.159", "activity": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+).", "evidence": [ { "id": "Q13572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13572" } ] }, { "ec_number": "2.7.1.134", "activity": "", "evidence": [ { "id": "Q13572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13572" } ] }, { "ec_number": "2.7.1.159", "activity": "", "evidence": [ { "id": "Q13572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13572" } ] } ] }, { "uniprot_ac": "Q55D87", "gene_name": "ITPK1", "activity": [ { "ec_number": "2.7.1.134", "activity": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+).", "evidence": [ { "id": "Q55D87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55D87" } ] }, { "ec_number": "2.7.1.134", "activity": "", "evidence": [ { "id": "Q55D87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55D87" } ] } ] }, { "uniprot_ac": "Q8BYN3", "gene_name": "Itpk1", "activity": [ { "ec_number": "2.7.1.134", "activity": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+).", "evidence": [ { "id": "Q8BYN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYN3" } ] }, { "ec_number": "2.7.1.159", "activity": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+).", "evidence": [ { "id": "Q8BYN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYN3" } ] }, { "ec_number": "2.7.1.134", "activity": "", "evidence": [ { "id": "Q8BYN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYN3" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }