{ "uniprot_canonical_ac": "A0A0G2K735-1", "uniprot_ac": "A0A0G2K735", "uniprot_id": "A0A0G2K735_RAT", "mass": { "chemical_mass": 110043.0, "monoisotopic_mass": 110043.0 }, "refseq": {}, "gene_names": [ { "name": "Uba7", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K735", "id": "A0A0G2K735" } ], "protein_names": [ { "name": "E1 ubiquitin-activating enzyme", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A0G2K735" }, { "name": "6.2.1.45", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K735" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ], "common_name": "Rat" } ], "gene": [ { "name": "Uba7", "url": "https://www.uniprot.org/uniprot/A0A0G2K735", "locus": { "chromosome": "8", "start_pos": 108674099, "end_pos": 108665292, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000029195", "url": "https://www.ensembl.org/id/ENSRNOG00000029195" } ] } } ], "crossref": [ { "id": "ENSRNOG00000029195", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000029195", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01491", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01491", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "301000", "url": "https://www.ncbi.nlm.nih.gov/gene/301000", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019572", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019572", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023318", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023318", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032420", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032420", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035985", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035985", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042449", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042449", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045886", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045886", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:301000", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301000", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FWSGHRK", "url": "https://omabrowser.org/oma/group/FWSGHRK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "20494at2759", "url": "http://www.orthodb.org/?query=20494at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10953", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10953", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10953:SF162", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10953:SF162", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00899", "url": "http://pfam.xfam.org/family/PF00899", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF09358", "url": "http://pfam.xfam.org/family/PF09358", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF10585", "url": "http://pfam.xfam.org/family/PF10585", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16190", "url": "http://pfam.xfam.org/family/PF16190", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16191", "url": "http://pfam.xfam.org/family/PF16191", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169408", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5656169", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5656169", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1308323", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308323", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K735-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K735-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6G652", "url": "https://www.uniprot.org/uniprot/A0A8I6G652", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6G652-1", "url": "https://www.uniprot.org/uniprot/A0A8I6G652-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZEU5", "url": "https://www.uniprot.org/uniprot/D3ZEU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZEU5-1", "url": "https://www.uniprot.org/uniprot/D3ZEU5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEELYSRQLYVLGLPAMQRIREAKVLLCGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWADLAAQFFLSEESLGRSRAEASQPQLAQLNEAVQISVHRGDITEDLVRGFQVVVLTDSKLEDQLNMGALCHKNRVYFLMAETRGLVGRLFCDFGEDFTVVDPTEVEPTSAAIQDISQGSPGIVTLRGGSKRPSFYDGDLVMFSDIEGMVELNSHSPQPVRVQKDGSLEIGDTTTFSRYLRGGVVTEVKRPKTVKHKPLDIALLQPCMVVQNTQEIQRAHCLHQTFHALHKFQQLHGRLPKPWDPDDAETVVWLAQDLEPLKGAKEESLDEALLRTIALSSAGSLSPMAAILGGVAAQEVLKAVSGKFMPLDQWLYFDALECLPEDETLLPSPEDCHPRNCRYDGQIAVFGTGFQEKLSYKHYLLQVGAGAIGCEMLKGFALVGLGVRDNGGVTIADMDHVERSNLSRQFLFRPKDTGRPKAEVAAEAAHRLNPDLQVTSHTCPLDPTTEDIYDDDFFSRVDGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTRGSASVFVPYVTEVYKGPTSAEEAPYPVCTLRHFPSTVEHSLQWAQDEFEGLFRLSAETINDYQQTCTSSLLGTDGTGILALLQQVMGVLRTRPQTWQDCVVWALGHWQLCFRDNIVELLRKFPSDKVLEDGTLFWSGSKKCPHPLQFDPNQDTHFLYVLAAANLYARMHGLPGSQSQTALRELLTLTLLQEPDSMPQNLFSAEFGQEQLKELQETLDDWNKGPPLKPVLFGKDDSSNFHEDFVVAATDLRCQNYGILPVNRARIKQTIGRIIPAIATSTAVVAGLLGLELYKVVSGPRPLGTFRHSYLHLAENHFIRSAPSAPAMQSFHHLEWTCWHRLTVPAGQPERTLESLLAHLQEEHGLTVRMLLHDQALLYSSGWPFEKQAQHLGLRVTELVQQVTGQKPKPGLRVLVFELSCEGEDDEMAFPPLHYEL", "length": 990, "header": "tr|A0A0G2K735-1|A0A0G2K735_RAT Isoform 1 of E1 ubiquitin-activating enzyme OS=Rattus norvegicus OX=10116 GN=Uba7 PE=1 SV=2 CANONICAL=A0A0G2K735-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K735-1", "url": "", "sequence": { "sequence": "MDEELYSRQLYVLGLPAMQRIREAKVLLCGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWADLAAQFFLSEESLGRSRAEASQPQLAQLNEAVQISVHRGDITEDLVRGFQVVVLTDSKLEDQLNMGALCHKNRVYFLMAETRGLVGRLFCDFGEDFTVVDPTEVEPTSAAIQDISQGSPGIVTLRGGSKRPSFYDGDLVMFSDIEGMVELNSHSPQPVRVQKDGSLEIGDTTTFSRYLRGGVVTEVKRPKTVKHKPLDIALLQPCMVVQNTQEIQRAHCLHQTFHALHKFQQLHGRLPKPWDPDDAETVVWLAQDLEPLKGAKEESLDEALLRTIALSSAGSLSPMAAILGGVAAQEVLKAVSGKFMPLDQWLYFDALECLPEDETLLPSPEDCHPRNCRYDGQIAVFGTGFQEKLSYKHYLLQVGAGAIGCEMLKGFALVGLGVRDNGGVTIADMDHVERSNLSRQFLFRPKDTGRPKAEVAAEAAHRLNPDLQVTSHTCPLDPTTEDIYDDDFFSRVDGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTRGSASVFVPYVTEVYKGPTSAEEAPYPVCTLRHFPSTVEHSLQWAQDEFEGLFRLSAETINDYQQTCTSSLLGTDGTGILALLQQVMGVLRTRPQTWQDCVVWALGHWQLCFRDNIVELLRKFPSDKVLEDGTLFWSGSKKCPHPLQFDPNQDTHFLYVLAAANLYARMHGLPGSQSQTALRELLTLTLLQEPDSMPQNLFSAEFGQEQLKELQETLDDWNKGPPLKPVLFGKDDSSNFHEDFVVAATDLRCQNYGILPVNRARIKQTIGRIIPAIATSTAVVAGLLGLELYKVVSGPRPLGTFRHSYLHLAENHFIRSAPSAPAMQSFHHLEWTCWHRLTVPAGQPERTLESLLAHLQEEHGLTVRMLLHDQALLYSSGWPFEKQAQHLGLRVTELVQQVTGQKPKPGLRVLVFELSCEGEDDEMAFPPLHYEL", "length": 990, "header": "tr|A0A0G2K735-1|A0A0G2K735_RAT Isoform 1 of E1 ubiquitin-activating enzyme OS=Rattus norvegicus OX=10116 GN=Uba7 PE=1 SV=2 CANONICAL=A0A0G2K735-1" }, "locus": { "chromosome": "8", "start_pos": 108673985, "end_pos": 108665461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000084429.2", "url": "https://www.ensembl.org/id/ENSRNOT00000084429.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074046.2", "url": "https://www.ensembl.org/id/ENSRNOP00000074046.2" } ] } }, { "isoform_ac": "A0A8I6G652-1", "url": "", "sequence": { "sequence": "MDEELYSRQLYVLGLPAMQRIREAKVLLCGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWADLAAQFFLSEESLGRSRAEASQPQLAQLNEAVQISVHRGDITEDLVRGFQVVVLTDSKLEDQLNMGALCHKNRVYFLMAETRGLVGRLFCDFGEDFTVVDPTEVEPTSAAIQDISQGSPGIVTLRGGSKRPSFYDGDLVMFSDIEGMVELNSHSPQPVRVQKDGSLEIGDTTTFSRYLRGGVVTEVKRPKTVKHKPLDIALLQPCMVVQNTQEIQRAHCLHQTFHALHKFQQLHGRLPKPWDPDDAETVVWLAQDLEPLKGAKEESLDEALLRTIALSSAGSLSPMAAILGGVAAQEVLKAVSGKFMPLDQWLYFDALECLPEDETLLPSPEDCHPRNCRYDGQIAVFGTGFQEKLSYKHYLLVGAGAIGCEMLKGFALVGLGVRDNGGVTIADMDHVERSNLSRQFLFRPKDTGRPKAEVAAEAAHRLNPDLQVTSHTCPLDPTTEDIYDDDFFSRVDGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTRGSASVFVPYVTEVYKGPTSAEEAPYPVCTLRHFPSTVEHSLQTRQPNGLYFLRCLRTELCSGQDPKSAHIPCNLIPTKTRISSMYWQLPTCMHGCMGCRAHKVRLHSGNC", "length": 665, "header": "tr|A0A8I6G652-1|A0A8I6G652_RAT Computationally mapped isoform of Ubiquitin-like modifier activating enzyme 7 OS=Rattus norvegicus OX=10116 GN=Uba7 PE=1 SV=1 CANONICAL=A0A0G2K735-1" }, "locus": { "chromosome": "8", "start_pos": 108669918, "end_pos": 108665461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000097917.1", "url": "https://www.ensembl.org/id/ENSRNOT00000097917.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000081578.1", "url": "https://www.ensembl.org/id/ENSRNOP00000081578.1" } ] } }, { "isoform_ac": "D3ZEU5-1", "url": "", "sequence": { "sequence": "MDEELYSRQLYVLGLPAMQRIREAKVLLCGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWADLAAQFFLSEESLGRSRAEASQPQLAQLNEAVQISVHRGDITEDLVRGFQVVVLTDSKLEDQLNMGALCHKNRVYFLMAETRGLVGRLFCDFGEDFTVVDPTEVEPTSAAIQDISQGSPGIVTLRGGSKRPSFYDGDLVMFSDIEGMVELNSHSPQPVRVQKDGSLEIGDTTTFSRYLRGGVVTEVKRPKTVKHKPLDIALLQPCMVVQNTQEIQRAHCLHQTFHALHKFQQLHGRLPKPWDPDDAETVVWLAQDLEPLKGAKEESLDEALLRTIALSSAGSLSPMAAILGGVAAQEVLKAVSGKFMPLDQWLYFDALECLPEDETLLPSPEDCHPRNCRYDGQIAVFGTGFQEKLSYKHYLLVGAGAIGCEMLKGFALVGLGVRDNGGVTIADMDHVERSNLSRQFLFRPKDTGRPKAEVAAEAAHRLNPDLQVTSHTCPLDPTTEDIYDDDFFSRVDGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTRGSASVFVPYVTEVYKGPTSAEEAPYPVCTLRHFPSTVEHSLQWAQDEFEGLFRLSAETINDYQQCLRTELCSGQDPKSAHIPCNLIPTKTRISSMYWQLPTCMHGCMGCRAHKVRLHSGNC", "length": 676, "header": "tr|D3ZEU5-1|D3ZEU5_RAT Computationally mapped isoform of Ubiquitin-like modifier activating enzyme 7 OS=Rattus norvegicus OX=10116 GN=Uba7 PE=3 SV=1 CANONICAL=A0A0G2K735-1" }, "locus": { "chromosome": "8", "start_pos": 108669918, "end_pos": 108665461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000068295.3", "url": "https://www.ensembl.org/id/ENSRNOT00000068295.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000062984.1", "url": "https://www.ensembl.org/id/ENSRNOP00000062984.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "rno:301000", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301000", "resource": "KEGG Pathway" }, { "id": "R-RNO-1169408", "name": "ISG15 antiviral mechanism", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169408", "resource": "Reactome", "description": "ISG15 antiviral mechanism" }, { "id": "R-RNO-5656169", "name": "Termination of translesion DNA synthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5656169", "resource": "Reactome", "description": "Termination of translesion DNA synthesis" }, { "id": "R-RNO-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "P41226-1", "protein_name": "Ubiquitin-like modifier-activating enzyme 7", "gene_name": "UBA7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDALDASKLLDEELYSRQLYVLGSPAMQRIQGARVLVSGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWSDLAAQFLLSEQDLERSRAEASQELLAQLNRAVQVVVHTGDITEDLLLDFQVVVLTAAKLEEQLKVGTLCHKHGVCFLAADTRGLVGQLFCDFGEDFTVQDPTEAEPLTAAIQHISQGSPGILTLRKGANTHYFRDGDLVTFSGIEGMVELNDCDPRSIHVREDGSLEIGDTTTFSRYLRGGAITEVKRPKTVRHKSLDTALLQPHVVAQSSQEVHHAHCLHQAFCALHKFQHLHGRPPQPWDPVDAETVVGLARDLEPLKRTEEEPLEEPLDEALVRTVALSSAGVLSPMVAMLGAVAAQEVLKAISRKFMPLDQWLYFDALDCLPEDGELLPSPEDCALRGSRYDGQIAVFGAGFQEKLRRQHYLLVGAGAIGCELLKVFALVGLGAGNSGGLTVVDMDHIERSNLSRQFLFRSQDVGRPKAEVAAAAARGLNPDLQVIPLTYPLDPTTEHIYGDNFFSRVDGVAAALDSFQARRYVAARCTHYLKPLLEAGTSGTWGSATVFMPHVTEAYRAPASAAASEDAPYPVCTVRYFPSTAEHTLQWARHEFEELFRLSAETINHHQQAHTSLADMDEPQTLTLLKPVLGVLRVRPQNWQDCVAWALGHWKLCFHYGIKQLLRHFPPNKVLEDGTPFWSGPKQCPQPLEFDTNQDTHLLYVLAAANLYAQMHGLPGSQDWTALRELLKLLPQPDPQQMAPIFASNLELASASAEFGPEQQKELNKALEVWSVGPPLKPLMFEKDDDSNFHVDFVVAAASLRCQNYGIPPVNRAQSKRIVGQIIPAIATTTAAVAGLLGLELYKVVSGPRPRSAFRHSYLHLAENYLIRYMPFAPAIQTFHHLKWTSWDRLKVPAGQPERTLESLLAHLQEQHGLRVRILLHGSALLYAAGWSPEKQAQHLPLRVTELVQQLTGQAPAPGQRVLVLELSCEGDDEDTAFPPLHYEL", "length": 1012 }, "evidence": [ { "id": "45235090", "url": "http://www.informatics.jax.org/homology/45235090", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DBK7-1", "protein_name": "E1 ubiquitin-activating enzyme", "gene_name": "Uba7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDEELYSRQLYVLGLPAMQRIQEAKVLLCGLQGLGAEVAKNLVLTGVGSLTLHDPHPTCWADLAAQCFLSEESLGRNRAEASQAQLAQLNEAVQISVHSGDITEDLLQGFQVVVLTDSKLEDQLKVGPLCHKHGVRFLMAETRGLVGRLFCDFGEDFTVLDPTEVEPMTAAIQDISQGFPGIVTLRGDTKRHSFHDGDLVIFSDIEGMVELNSCSPQSVRVQKDGSLEIGDTTTFSRYLRGGVVTEVKRPKTVRHKPLDIALLQPHVVAQNTQEVQRAHCLHQAFHVLHKFQQLHGRLPKPWDPDDAETVVELAQDLEPLKGTEEESLDEALLRTIALSSAGTLSPMAAIMGGVAAQEVLKAISRKFMPLDQWLYFDALECLPEDETLLPSPEDCQPRNCRYDGQIAVFGTDLQEKLSDQHYLLVGAGAIGCEMLKVFALVGLGVRANGGVTVADMDYIERSNLSRQFLFRPKDVRRPKAEVAAAAAHRLNPDLRATPYTCPLDPTTEDIYDDSFFSRVNGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTWGSASVFVPYVTEAYRGPASDAASEDAPYPVCTLRHIPSSMEHSVQWAQDQFEGLFRLSTETINCYQQTCTSLSATDRTETLALLQQVMGVLRTRPQTWQDCVVWALGHWQLCFHDKVLEGGTQFSSGSNKCPHPLQFDPNHDMHFLYVLAAANLYARMHGLPGSQSQPALRELLTRLLESDSRPQNLFSAEHGQEQLKELQETLDDWRKGPPLKPVLFVKDDDSNFHVDFVVAATDLRCQNYGILPVNHARIKQIVGRIIPAIATSTAVVAGLLGLELYKVVSGLRSHGTFRHSYLHLAENHFIRSAPSAPAVQSFRDLKWTCWDRLKVPAVQPERTLKSLLAHLQEEHGLKVEMLLHHQALLYSSGWSSEKQAQHLCLRVTELVQHVTGWKPKPGLKVLVFELSCEGEEEEMAFPPLHYEL", "length": 977 }, "evidence": [ { "id": "45235090", "url": "http://www.informatics.jax.org/homology/45235090", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "protein modification process", "id": "GO:0036211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036211", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ], "pmid": "" }, { "name": "modification-dependent protein catabolic process", "id": "GO:0019941", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019941", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ], "pmid": "" }, { "name": "ISG15-protein conjugation", "id": "GO:0032020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032020", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ], "pmid": "" }, { "name": "protein sumoylation", "id": "GO:0016925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016925", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ], "pmid": "" }, { "name": "ubiquitin activating enzyme activity", "id": "GO:0004839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004839", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ], "pmid": "" }, { "name": "ISG15 activating enzyme activity", "id": "GO:0019782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019782", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K735", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-RNO-1169397", "name": "Activation of ISG15 by UBA7 E1 ligase", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-RNO-936550", "R-RNO-936552" ], "output_participant_list": [], "enzyme_list": [ "A0A0G2K735-1" ], "evidence": [ { "id": "R-RNO-1169397", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169397" } ] }, { "id": "R-RNO-1169404", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q4V8J2-1", "A0A0G2K735-1" ], "evidence": [ { "id": "R-RNO-1169404", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169404" } ] }, { "id": "R-RNO-5653754", "name": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q4V8J2-1", "A0A0G2K735-1", "A0A8I5ZJ91-1" ], "evidence": [ { "id": "R-RNO-5653754", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5653754" } ] }, { "id": "R-RNO-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYH3-1", "F1LP64-1", "Q5BK82-1", "Q91ZY8-1", "O88846-1", "Q9JK66-1", "Q62921-1", "D3ZXK7-1", "Q2TL32-1", "Q8K4S7-1", "Q62940-1", "P63149-1", "B2GV24-1", "P61078-1", "Q3T1H6-1", "Q6P7A2-1", "Q71F54-1", "Q8R4T2-1", "A0A0G2JUC9-1", "A0A0G2K612-1", "D3ZHB7-1", "A0A8I5YBG5-1", "G3V930-1", "D3ZJB8-1", "D3ZLS5-1", "D3ZXM0-1", "D4ABK2-1", "D4ADD3-1", "D3ZDI6-1", "Q5PQN1-1", "D3Z8X6-1", "D4ACF2-1", "A0A0G2K9T1-1", "D4A1V8-1", "F1M9Q3-1", "Q66H79-1", "Q920M9-1", "B1H278-1", "B5DFI8-1", "P62839-1", "Q4V8J2-1", "Q63364-1", "Q6MFZ5-1", "Q810I1-1", "Q91Z63-1", "D3ZBM4-1", "D3ZDK2-1", "P62255-1", "Q3B7D1-1", "Q5U203-1", "Q6J2U6-1", "Q99PD2-1", "Q9EQX9-1", "D3ZVM4-1", "D3ZBM7-1", "Q5XIQ4-1", "Q68LP1-1", "Q6Y290-1", "F1M3F2-1", "A0A0G2K0E7-1", "A0A0G2QC40-1", "D3ZFK0-1", "A0A0G2K6H9-1", "A0A0G2K735-1", "A0A8I5ZZN6-1", "D3ZS02-1", "F1M7B8-1" ], "evidence": [ { "id": "R-RNO-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983140" } ] }, { "id": "R-RNO-983152", "name": "Transfer of ubiquitin from E1 to E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63149-1", "P61078-1", "B5DFI8-1", "P62839-1", "Q4V8J2-1", "Q99MI7-1", "D3ZDK2-1", "P62255-1", "Q3B7D1-1", "Q5U203-1", "Q5U300-1", "Q9EQX9-1", "D4A8H3-1", "A0A0G2K735-1" ], "evidence": [ { "id": "R-RNO-983152", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983152" } ] }, { "id": "R-RNO-983153", "name": "E1 mediated ubiquitin activation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MI7-1", "Q5U300-1", "D4A8H3-1", "A0A0G2K735-1" ], "evidence": [ { "id": "R-RNO-983153", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983153" } ] }, { "id": "R-RNO-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYH3-1", "F1LP64-1", "Q5BK82-1", "Q91ZY8-1", "O88846-1", "Q9JK66-1", "Q62921-1", "D3ZXK7-1", "Q2TL32-1", "Q8K4S7-1", "Q62940-1", "P63149-1", "B2GV24-1", "P61078-1", "Q3T1H6-1", "Q6P7A2-1", "Q71F54-1", "Q8R4T2-1", "A0A0G2JUC9-1", "A0A0G2K612-1", "D3ZHB7-1", "A0A8I5YBG5-1", "G3V930-1", "D3ZJB8-1", "D3ZLS5-1", "D3ZXM0-1", "D4ABK2-1", "D4ADD3-1", "D3ZDI6-1", "Q5PQN1-1", "D3Z8X6-1", "D4ACF2-1", "A0A0G2K9T1-1", "D4A1V8-1", "F1M9Q3-1", "Q66H79-1", "Q920M9-1", "B1H278-1", "B5DFI8-1", "P62839-1", "Q4V8J2-1", "Q63364-1", "Q6MFZ5-1", "Q810I1-1", "Q91Z63-1", "D3ZBM4-1", "D3ZDK2-1", "P62255-1", "Q3B7D1-1", "Q5U203-1", "Q6J2U6-1", "Q99PD2-1", "Q9EQX9-1", "D3ZVM4-1", "D3ZBM7-1", "Q5XIQ4-1", "Q68LP1-1", "Q6Y290-1", "F1M3F2-1", "A0A0G2K0E7-1", "A0A0G2QC40-1", "D3ZFK0-1", "A0A0G2K6H9-1", "A0A0G2K735-1", "A0A8I5ZZN6-1", "D3ZS02-1", "F1M7B8-1" ], "evidence": [ { "id": "R-RNO-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983156" } ] }, { "id": "R-RNO-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYH3-1", "F1LP64-1", "Q5BK82-1", "Q91ZY8-1", "O88846-1", "Q9JK66-1", "Q62921-1", "D3ZXK7-1", "Q2TL32-1", "Q8K4S7-1", "Q62940-1", "P63149-1", "B2GV24-1", "P61078-1", "Q3T1H6-1", "Q6P7A2-1", "Q71F54-1", "Q8R4T2-1", "A0A0G2JUC9-1", "A0A0G2K612-1", "D3ZHB7-1", "A0A8I5YBG5-1", "G3V930-1", "D3ZJB8-1", "D3ZLS5-1", "D3ZXM0-1", "D4ABK2-1", "D4ADD3-1", "D3ZDI6-1", "Q5PQN1-1", "D3Z8X6-1", "D4ACF2-1", "A0A0G2K9T1-1", "D4A1V8-1", "F1M9Q3-1", "Q66H79-1", "Q920M9-1", "B1H278-1", "B5DFI8-1", "P62839-1", "Q4V8J2-1", "Q63364-1", "Q6MFZ5-1", "Q810I1-1", "Q91Z63-1", "D3ZBM4-1", "D3ZDK2-1", "P62255-1", "Q3B7D1-1", "Q5U203-1", "Q6J2U6-1", "Q99PD2-1", "Q9EQX9-1", "D3ZVM4-1", "D3ZBM7-1", "Q5XIQ4-1", "Q68LP1-1", "Q6Y290-1", "F1M3F2-1", "A0A0G2K0E7-1", "A0A0G2QC40-1", "D3ZFK0-1", "A0A0G2K6H9-1", "A0A0G2K735-1", "A0A8I5ZZN6-1", "D3ZS02-1", "F1M7B8-1" ], "evidence": [ { "id": "R-RNO-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983157" } ] } ], "reaction_participants": [ { "participant_id": "R-RNO-936550", "participant_name": "Uba7 [cytosol]", "crossref": [ { "id": "1308323", "database": "RGD", "url": "" }, { "id": "XP_006243803.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOG00000029195", "database": "Ensembl", "url": "" }, { "id": "A0A0G2K735", "database": "UniProt", "url": "" }, { "id": "ENSRNOT00000084429", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000074046", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-RNO-936552", "participant_name": "Isg15 [cytosol]", "crossref": [ { "id": "ENSRNOG00000069527", "database": "Ensembl", "url": "" }, { "id": "XP_006239625.1", "database": "RefSeq", "url": "" }, { "id": "D4A3X3", "database": "UniProt", "url": "" }, { "id": "ENSRNOT00000096620", "database": "Ensembl", "url": "" }, { "id": "1310312", "database": "RGD", "url": "" }, { "id": "NP_001100170.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOP00000090709", "database": "Ensembl", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JUC9", "gene_name": "Herc2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2JUC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JUC9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A0G2JUC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JUC9" } ] } ] }, { "uniprot_ac": "A0A0G2K0E7", "gene_name": "Ube3b", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2K0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0E7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A0G2K0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0E7" } ] } ] }, { "uniprot_ac": "A0A0G2K612", "gene_name": "Smurf1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2K612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K612" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A0G2K612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K612" } ] } ] }, { "uniprot_ac": "A0A0G2K6H9", "gene_name": "Rnf19b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A0G2K6H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6H9" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A0G2K6H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6H9" } ] } ] }, { "uniprot_ac": "A0A0G2K735", "gene_name": "Uba7", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A0G2K735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "A0A0G2K735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ] } ] }, { "uniprot_ac": "A0A0G2K9T1", "gene_name": "Itch", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2K9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9T1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A0G2K9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9T1" } ] } ] }, { "uniprot_ac": "A0A0G2QC40", "gene_name": "Mkrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2QC40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2QC40" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A0G2QC40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2QC40" } ] } ] }, { "uniprot_ac": "A0A8I5YBG5", "gene_name": "Ubr2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A8I5YBG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5YBG5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A8I5YBG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5YBG5" } ] } ] }, { "uniprot_ac": "A0A8I5ZJ91", "gene_name": "Rev1", "activity": [ { "ec_number": "2.7.7.-", "activity": "", "evidence": [ { "id": "A0A8I5ZJ91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZJ91" } ] } ] }, { "uniprot_ac": "A0A8I5ZZN6", "gene_name": "Ubr1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A8I5ZZN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZN6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A8I5ZZN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZN6" } ] } ] }, { "uniprot_ac": "B1H278", "gene_name": "Trim11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "B1H278", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1H278" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "B1H278", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1H278" } ] } ] }, { "uniprot_ac": "B2GV24", "gene_name": "Ufl1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "B2GV24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV24" } ] } ] }, { "uniprot_ac": "B5DFI8", "gene_name": "Ube2s", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "B5DFI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFI8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "B5DFI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFI8" } ] } ] }, { "uniprot_ac": "D3Z8X6", "gene_name": "Dtx3l", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3Z8X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8X6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3Z8X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8X6" } ] } ] }, { "uniprot_ac": "D3ZBM4", "gene_name": "Rnf182", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZBM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZBM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM4" } ] } ] }, { "uniprot_ac": "D3ZBM7", "gene_name": "Hace1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZBM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "D3ZBM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM7" } ] } ] }, { "uniprot_ac": "D3ZDI6", "gene_name": "Mylip", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZDI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDI6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZDI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDI6" } ] } ] }, { "uniprot_ac": "D3ZDK2", "gene_name": "Ube2d1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZDK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "D3ZDK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "D3ZDK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK2" } ] } ] }, { "uniprot_ac": "D3ZFK0", "gene_name": "Rnf144b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3ZFK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFK0" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3ZFK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFK0" } ] } ] }, { "uniprot_ac": "D3ZHB7", "gene_name": "Ube3c", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHB7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "D3ZHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHB7" } ] } ] }, { "uniprot_ac": "D3ZJB8", "gene_name": "Arih2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3ZJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJB8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3ZJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJB8" } ] } ] }, { "uniprot_ac": "D3ZLS5", "gene_name": "Hectd1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "D3ZLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLS5" } ] } ] }, { "uniprot_ac": "D3ZS02", "gene_name": "Cbll1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZS02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZS02" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZS02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZS02" } ] } ] }, { "uniprot_ac": "D3ZVM4", "gene_name": "Trim71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZVM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZVM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ] } ] }, { "uniprot_ac": "D3ZXK7", "gene_name": "Rnf123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZXK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXK7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZXK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXK7" } ] } ] }, { "uniprot_ac": "D3ZXM0", "gene_name": "Rnf19a", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3ZXM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXM0" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3ZXM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXM0" } ] } ] }, { "uniprot_ac": "D4A1V8", "gene_name": "Dzip3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D4A1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1V8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D4A1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1V8" } ] } ] }, { "uniprot_ac": "D4A8H3", "gene_name": "Uba6", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "D4A8H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A8H3" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "D4A8H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A8H3" } ] } ] }, { "uniprot_ac": "D4ABK2", "gene_name": "Rnf217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D4ABK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ABK2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D4ABK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ABK2" } ] } ] }, { "uniprot_ac": "D4ACF2", "gene_name": "Trim21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D4ACF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACF2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D4ACF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACF2" } ] } ] }, { "uniprot_ac": "D4ADD3", "gene_name": "Hecw2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D4ADD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADD3" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "D4ADD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADD3" } ] } ] }, { "uniprot_ac": "F1LP64", "gene_name": "Trip12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1LP64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LP64" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1LP64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LP64" } ] } ] }, { "uniprot_ac": "F1M3F2", "gene_name": "Smurf2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1M3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3F2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1M3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3F2" } ] } ] }, { "uniprot_ac": "F1M7B8", "gene_name": "Ube3a", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1M7B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M7B8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1M7B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M7B8" } ] } ] }, { "uniprot_ac": "F1M9Q3", "gene_name": "Ltn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1M9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M9Q3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1M9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M9Q3" } ] } ] }, { "uniprot_ac": "G3V930", "gene_name": "Rnf41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "G3V930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V930" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "G3V930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V930" } ] } ] }, { "uniprot_ac": "O88846", "gene_name": "Rnf4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O88846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88846" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O88846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88846" } ] } ] }, { "uniprot_ac": "P61078", "gene_name": "Ube2d3", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61078" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61078" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61078" } ] } ] }, { "uniprot_ac": "P62255", "gene_name": "Ube2g1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62255" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62255" } ] } ] }, { "uniprot_ac": "P62839", "gene_name": "Ube2d2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62839" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62839" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62839" } ] } ] }, { "uniprot_ac": "P63149", "gene_name": "Ube2b", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P63149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63149" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P63149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63149" } ] } ] }, { "uniprot_ac": "Q2TL32", "gene_name": "Ubr4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TL32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TL32" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q2TL32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TL32" } ] } ] }, { "uniprot_ac": "Q3B7D1", "gene_name": "Ube2z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3B7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3B7D1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3B7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3B7D1" } ] } ] }, { "uniprot_ac": "Q3T1H6", "gene_name": "Ube3d", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3T1H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3T1H6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q3T1H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3T1H6" } ] } ] }, { "uniprot_ac": "Q4V8J2", "gene_name": "Ube2l6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q4V8J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8J2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q4V8J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8J2" } ] } ] }, { "uniprot_ac": "Q5BK82", "gene_name": "Trim69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5BK82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK82" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5BK82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK82" } ] } ] }, { "uniprot_ac": "Q5PQN1", "gene_name": "Herc4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5PQN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQN1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5PQN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQN1" } ] } ] }, { "uniprot_ac": "Q5U203", "gene_name": "Ube2f", "activity": [ { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "Q5U203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U203" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "Q5U203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U203" } ] } ] }, { "uniprot_ac": "Q5U300", "gene_name": "Uba1", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "Q5U300", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U300" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "Q5U300", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U300" } ] } ] }, { "uniprot_ac": "Q5XIQ4", "gene_name": "Mgrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5XIQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIQ4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5XIQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIQ4" } ] } ] }, { "uniprot_ac": "Q62921", "gene_name": "Rbck1", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q62921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62921" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q62921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62921" } ] } ] }, { "uniprot_ac": "Q62940", "gene_name": "Nedd4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q62940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62940" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q62940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62940" } ] } ] }, { "uniprot_ac": "Q63364", "gene_name": "Pja2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q63364", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63364" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q63364", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63364" } ] } ] }, { "uniprot_ac": "Q66H79", "gene_name": "Trim32", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q66H79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66H79" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q66H79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66H79" } ] } ] }, { "uniprot_ac": "Q68LP1", "gene_name": "Mib2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q68LP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68LP1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q68LP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68LP1" } ] } ] }, { "uniprot_ac": "Q6AYH3", "gene_name": "Rnf34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6AYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYH3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6AYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYH3" } ] } ] }, { "uniprot_ac": "Q6J2U6", "gene_name": "Rnf114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6J2U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J2U6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6J2U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J2U6" } ] } ] }, { "uniprot_ac": "Q6MFZ5", "gene_name": "Trim39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6MFZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MFZ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6MFZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MFZ5" } ] } ] }, { "uniprot_ac": "Q6P7A2", "gene_name": "Ube4a", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6P7A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6P7A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A2" } ] } ] }, { "uniprot_ac": "Q6Y290", "gene_name": "Rnf130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6Y290", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Y290" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6Y290", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Y290" } ] } ] }, { "uniprot_ac": "Q71F54", "gene_name": "Sh3rf1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q71F54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71F54" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q71F54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71F54" } ] } ] }, { "uniprot_ac": "Q810I1", "gene_name": "Trim50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q810I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q810I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I1" } ] } ] }, { "uniprot_ac": "Q8K4S7", "gene_name": "Cblb", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8K4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4S7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8K4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4S7" } ] } ] }, { "uniprot_ac": "Q8R4T2", "gene_name": "Siah2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8R4T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4T2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8R4T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4T2" } ] } ] }, { "uniprot_ac": "Q91Z63", "gene_name": "Trim63", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q91Z63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Z63" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q91Z63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Z63" } ] } ] }, { "uniprot_ac": "Q91ZY8", "gene_name": "Trim9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q91ZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZY8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q91ZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZY8" } ] } ] }, { "uniprot_ac": "Q920M9", "gene_name": "Siah1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q920M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q920M9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q920M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q920M9" } ] } ] }, { "uniprot_ac": "Q99MI7", "gene_name": "Uba3", "activity": [ { "ec_number": "6.2.1.64", "activity": "ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 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