{ "uniprot_canonical_ac": "A0A0G2K6V2-1", "uniprot_ac": "A0A0G2K6V2", "uniprot_id": "A0A0G2K6V2_RAT", "mass": { "chemical_mass": 178330.0, "monoisotopic_mass": 178330.0 }, "refseq": { "ac": "XP_008771910", "name": "lysine demethylase 5D isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008771910" }, "gene_names": [ { "name": "Kdm5d", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2", "id": "A0A0G2K6V2" }, { "name": "Jarid1d", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008771910", "id": "XP_008771910" }, { "name": "Kdm5d", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008771910", "id": "XP_008771910" } ], "protein_names": [ { "name": "[histone H3]-trimethyl-L-lysine(4) demethylase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A0G2K6V2" }, { "name": "1.14.11.67", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K6V2" }, { "name": "lysine demethylase 5D isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008771910", "id": "XP_008771910" } ], "function": [], "disease": [ { "disease_id": "DOID:0050888", "recommended_name": { "id": "DOID:0050888", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050888", "name": "syndromic intellectual disability", "description": "An intellectual disability that is characterized by the presence of associated medical and behavioral sign and symptoms." }, "synonyms": [], "evidence": [ { "id": "0050888", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050888" } ] }, { "disease_id": "DOID:0060041", "recommended_name": { "id": "DOID:0060041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060041", "name": "autism spectrum disorder", "description": "A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior." }, "synonyms": [], "evidence": [ { "id": "0060041", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060041" } ] }, { "disease_id": "DOID:0060809", "recommended_name": { "id": "DOID:0060809", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060809", "name": "syndromic X-linked intellectual disability Claes-Jensen type", "description": "A syndromic X-linked intellectual disability characterized by severe intellectual deficit associated with variable clinical manifestations including spasticity, cryptorchidism, maxillary hypoplasia, alopecia areata, epilepsy, short stature, impaired speech and behavioral problems that has_material_basis_in mutation in the KDM5C gene on chromosome Xp11." }, "synonyms": [ { "id": "DOID:0060809", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060809", "name": "MRXSCJ", "description": "" }, { "id": "DOID:0060809", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060809", "name": "MRXSJ", "description": "" }, { "id": "DOID:0060809", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060809", "name": "syndromic X-linked intellectual disability due to JARID1C mutation", "description": "" }, { "id": "DOID:0060809", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060809", "name": "syndromic X-linked mental retardation JARID1C-related", "description": "" }, { "id": "DOID:0060809", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060809", "name": "mental retardation, X-linked, syndromic, Claes-Jensen type", "description": "" }, { "id": "MONDO:0010355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010355", "name": "syndromic X-linked intellectual disability Claes-Jensen type", "description": "" }, { "id": "MONDO:0010355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010355", "name": "MRXSCJ", "description": "" }, { "id": "MONDO:0010355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010355", "name": "MRXSJ", "description": "" }, { "id": "MONDO:0010355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010355", "name": "intellectual developmental disorder, X-linked syndromic, Claes-Jensen type, X-linked recessive", "description": "" }, { "id": "MONDO:0010355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010355", "name": "intellectual disability, X-linked, syndromic, Claes-Jensen type", "description": "" }, { "id": "MONDO:0010355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010355", "name": "mental retardation, X-linked, syndromic, Claes-Jensen type", "description": "" }, { "id": "MONDO:0010355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010355", "name": "syndromic X-linked intellectual disability Claes-Jensen type", "description": "" }, { "id": "MONDO:0010355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010355", "name": "syndromic X-linked intellectual disability JARID1C-related", "description": "" }, { "id": "MONDO:0010355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010355", "name": "syndromic X-linked intellectual disability due to JARID1C mutation", "description": "" }, { "id": "MONDO:0010355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010355", "name": "syndromic X-linked mental retardation JARID1C-related", "description": "" }, { "id": "MONDO:0010355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010355", "name": "intellectual disability, X-linked, syndromic, 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communicating, taking care of him or herself, and social skills." }, "synonyms": [], "evidence": [ { "id": "1059", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1059" } ] }, { "disease_id": "DOID:1574", "recommended_name": { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences." }, "synonyms": [ { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "Ethanol abuse", "description": "" }, { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "alcohol abuse", "description": "" } ], "evidence": [ { "id": "1574", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K6V2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2" } ], "common_name": "Rat" } ], "gene": [ { "name": "Kdm5d", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2", "locus": { "chromosome": "Y", "start_pos": 624018, "end_pos": 530401, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000060496", "url": "https://www.ensembl.org/id/ENSRNOG00000060496" } ] } } ], "crossref": [ { "id": "cd15604", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15604", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16875", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16875", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100312983", "url": "https://www.ncbi.nlm.nih.gov/gene/100312983", 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"https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013637", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013637", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036431", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036431", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:100312983", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:100312983", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SAVNCKC", "url": "https://omabrowser.org/oma/group/SAVNCKC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10694", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10694", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10694:SF137", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10694:SF137", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "http://pfam.xfam.org/family/PF00628", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01388", "url": "http://pfam.xfam.org/family/PF01388", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02373", "url": "http://pfam.xfam.org/family/PF02373", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02375", "url": "http://pfam.xfam.org/family/PF02375", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02928", "url": "http://pfam.xfam.org/family/PF02928", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08429", "url": "http://pfam.xfam.org/family/PF08429", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_008771910", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008771910", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "2314436", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=2314436", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "60208", "url": "https://www.rhea-db.org/rhea/60208", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2K6V2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K6V2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZLH9", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZLH9-1", "url": 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"length": 1560, "header": "tr|A0A0G2K6V2-1|A0A0G2K6V2_RAT Isoform 1 of [histone H3]-trimethyl-L-lysine(4) demethylase OS=Rattus norvegicus OX=10116 GN=Kdm5d PE=3 SV=1 CANONICAL=A0A0G2K6V2-1" }, "locus": { "chromosome": "Y", "start_pos": 623360, "end_pos": 540936, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000086056.3", "url": "https://www.ensembl.org/id/ENSRNOT00000086056.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073953.2", "url": "https://www.ensembl.org/id/ENSRNOP00000073953.2" } ] } }, { "isoform_ac": "A0A8I5ZLH9-1", "url": "", "sequence": { "sequence": "MHICGVYVCLYYFFSKAVAGLLNNLFSYRLETPQLTLTELQILLKQMCTLPCTIHQIDEVKDVLQQVETYQIETREALTSLPYSLEILQSLMEKGQQLRVEVPEAHQLEELLEQAQWLDQVKQALAPSGQKHSLVIMKKLLVMGTKLASSPSVNKARAELQELLTIAERWEEKALFCLDARMVITTP", "length": 187, "header": "tr|A0A8I5ZLH9-1|A0A0G2K6V2_RAT Computationally mapped isoform of [histone H3]-trimethyl-L-lysine(4) demethylase OS=Rattus norvegicus OX=10116 GN=Kdm5d PE=3 SV=1 CANONICAL=A0A0G2K6V2-1" }, "locus": { "chromosome": "Y", "start_pos": 620874, "end_pos": 616988, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000093053.2", "url": "https://www.ensembl.org/id/ENSRNOT00000093053.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000078705.1", "url": "https://www.ensembl.org/id/ENSRNOP00000078705.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "rno:100312983", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:100312983", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q62240-1", "protein_name": "Lysine-specific demethylase 5D", "gene_name": "Kdm5d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLNKIVMEEGGYEAICKDRRWARVAQRLNYPSGKNIGSLLRSHYERIIYPYEIFQSGANLVQCNTDPFDSEERDKEYKPHSIPLRQSVQPSKFSCYSRRGKRLQPEPEPTEEDIEKNPELKKLQIYGAGPKMIGLGLKAKEKTLRKKDSKQPDKEEVTCPATIVVKGEASEFGKVTSAFSDKNLNHSFEPCMKMTMQLRNNHSSTQFMNSYVCRICSRGDEVDKFLLCDGCSDNYHIFCLLPPLSEVPKGVWRCPKCILAECKSPPEAFGFEQATQEYTLQSFGEMADSFKADYFNMPVHMVPTEVVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVNNSKWDLSPEEKEYAACGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEDVMKRLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPVGRQCIEHYRRLRRYCVFSHEELICKMAAFPEKLDLNLAVAVHKEMFIMVQEERRLRKTLLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDSLVCLSHINDLCKCSRNRQYLRYRYTLDELPAMLQKLKIRAESFDNWANKVQAALEVEDGRKRSFEELRALESEARDRRFPNSELLQRLKKCLTEAEACISQVLGLISNSEDRLQTPQITLTELQLLLKQMGTLPCTMHQIDEVKDVLQQVESYQIETREALTSLPYSLEILQSLMEKGQQLRVEVPEAHQLEELLEQAQWLDQVKQALAPSGQRHSLVIMKKLLVMGTKVASSPSVNKARAELQELLTIAECWEEKAHFCLKASQKHSPATLEVIIREAENIPVYLPNIQSLKEALTKAQAWIADVNEIQNGDHYPCLDDLEGLVAVGRDLPVELEELRQLENQVLTAHSWKEKASKTFLKKNSCYTLLEVLCPCADAGSVSTKRSRWIEKEMGLYKYDTELLGLSAQDLRDPGSVIMAFKEGEEKEKEGILHLRHINSAKPSPMSSSMNASATSICICGQVCAGVESLQCDLCHDWFHGQCVTVPHLLSSVRASHTSSQLLAWWEWDTKFLCPLCMRSRRPRLETILSLLVGLQRLSVRLPEGEALQCLTERAIGWQGRARQALASEDVTALLKQLEKSRQQLQDELRHKKPPTLPSGFAFDCLTENSGKDILKEEEELVLNEERIKSSEKIVPKESSCKGDKELLPSLLSQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENYSIWQLLQAGQNPNLERIHTLLELEKPENPGNWSEEQTPERRRQRRQKVVLSRKGEDFTQKELESKRVKSSRIKPKEEKFQKPILGDNVLYTHHTEHTNILKEHINSVQGKDPSPSSSFPSLTPLLHLSYFHQQKL", "length": 1548 }, "evidence": [ { "id": "45234132", "url": "http://www.informatics.jax.org/homology/45234132", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BY66-1", "protein_name": "Lysine-specific demethylase 5D", "gene_name": "KDM5D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVIEEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHPFDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLELPEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDHSPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL", "length": 1539 }, "evidence": [ { "id": "45234132", "url": "http://www.informatics.jax.org/homology/45234132", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "histone H3K4me/H3K4me2/H3K4me3 demethylase activity", "id": "GO:0034647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034647", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K6V2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2" } ], "pmid": "" }, { "name": "histone H3K4 demethylase activity", "id": "GO:0032453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032453", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K6V2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2" } ], "pmid": "" }, { "name": "nuclear androgen receptor binding", "id": "GO:0050681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050681", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K6V2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K6V2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K6V2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "T cell antigen processing and presentation", "id": "GO:0002457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002457", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K6V2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K6V2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K6V2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2" } ], "pmid": "" }, { "name": "regulation of androgen receptor signaling pathway", "id": "GO:0060765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060765", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K6V2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K6V2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1174, "end_pos": 1176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1186, "end_pos": 1188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1305, "end_pos": 1307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1422, "end_pos": 1424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1454, "end_pos": 1456, "annotation": "n_glycosylation_sequon" }, { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" }, { "start_pos": 843, "end_pos": 845, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "60208", "name": "", "equation": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8I5ZPK6-1", "A0A0G2K1H0-1", "A0A0G2K3N6-1", "A0A0G2K6V2-1", "Q9UGL1-1", "Q9BY66-1", "P29375-1", "P41229-1", "Q62240-1", "Q3UXZ9-1", "Q80Y84-1", "P41230-1", "P47156-1", "Q9VMJ7-1" ], "evidence": [ { "id": "60208", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60208" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K1H0", "gene_name": "Kdm5c", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "A0A0G2K1H0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K1H0" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "A0A0G2K1H0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K1H0" } ] } ] }, { "uniprot_ac": "A0A0G2K3N6", "gene_name": "Kdm5b", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "A0A0G2K3N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K3N6" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "A0A0G2K3N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K3N6" } ] } ] }, { "uniprot_ac": "A0A0G2K6V2", "gene_name": "Kdm5d", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "A0A0G2K6V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "A0A0G2K6V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V2" } ] } ] }, { "uniprot_ac": "A0A8I5ZPK6", "gene_name": "Kdm5a", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "A0A8I5ZPK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZPK6" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "A0A8I5ZPK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZPK6" } ] } ] }, { "uniprot_ac": "P29375", "gene_name": "KDM5A", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "P29375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29375" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "P29375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29375" } ] } ] }, { "uniprot_ac": "P41229", "gene_name": "KDM5C", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "P41229", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41229" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "P41229", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41229" } ] } ] }, { "uniprot_ac": "P41230", "gene_name": "Kdm5c", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "P41230", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41230" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "P41230", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41230" } ] } ] }, { "uniprot_ac": "P47156", "gene_name": "JHD2", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "P47156", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47156" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "P47156", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47156" } ] } ] }, { "uniprot_ac": "Q3UXZ9", "gene_name": "Kdm5a", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "Q3UXZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UXZ9" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "Q3UXZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UXZ9" } ] } ] }, { "uniprot_ac": "Q62240", "gene_name": "Kdm5d", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "Q62240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62240" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "Q62240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62240" } ] } ] }, { "uniprot_ac": "Q80Y84", "gene_name": "Kdm5b", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "Q80Y84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80Y84" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "Q80Y84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80Y84" } ] } ] }, { "uniprot_ac": "Q9BY66", "gene_name": "KDM5D", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "Q9BY66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY66" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "Q9BY66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY66" } ] } ] }, { "uniprot_ac": "Q9UGL1", "gene_name": "KDM5B", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "Q9UGL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UGL1" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "Q9UGL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UGL1" } ] } ] }, { "uniprot_ac": "Q9VMJ7", "gene_name": "Kdm5", "activity": [ { "ec_number": "1.14.11.67", "activity": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate.", "evidence": [ { "id": "Q9VMJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMJ7" } ] }, { "ec_number": "1.14.11.67", "activity": "", "evidence": [ { "id": "Q9VMJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMJ7" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", 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