{ "uniprot_canonical_ac": "A0A0G2K615-1", "uniprot_ac": "A0A0G2K615", "uniprot_id": "A0A0G2K615_RAT", "mass": { "chemical_mass": 25936.0, "monoisotopic_mass": 25936.0 }, "refseq": { "ac": "NP_001333352", "name": "protein Mis18-beta", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333352" }, "gene_names": [ { "name": "Oip5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K615", "id": "A0A0G2K615" }, { "name": "Oip5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333352", "id": "NP_001333352" }, { "name": "RGD1564263", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333352", "id": "NP_001333352" } ], "protein_names": [ { "name": "Opa interacting protein 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K615" }, { "name": "protein Mis18-beta", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333352", "id": "NP_001333352" } ], "function": [ { "annotation": "Raf1 interacts with OIP5 to participate in oxaliplatin-induced neuropathic pain.", "evidence": [ { "database": "RefSeq", "id": "NP_001333352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333352" }, { "database": "PubMed", "id": "34229010", "url": "https://glygen.org/publication/PubMed/34229010" } ] }, { "annotation": "Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K615", "url": "https://www.uniprot.org/uniprot/A0A0G2K615#function" }, { "database": "UniProtKB", "id": "ARBA00003694", "url": "https://www.uniprot.org/uniprot/ARBA00003694#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K615", "url": "https://www.uniprot.org/uniprot/A0A0G2K615" } ], "common_name": "Rat" } ], "gene": [ { "name": "Oip5", "url": "https://www.uniprot.org/uniprot/A0A0G2K615", "locus": { "chromosome": "3", "start_pos": 106593760, "end_pos": 106603250, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000057458", "url": "https://www.ensembl.org/id/ENSRNOG00000057458" } ] } } ], "crossref": [ { "id": "ENSRNOG00000057458", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000057458", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "499873", "url": "https://www.ncbi.nlm.nih.gov/gene/499873", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:499873", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:499873", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MDIHNVP", "url": "https://omabrowser.org/oma/group/MDIHNVP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR16431", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16431", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16431:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16431:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03226", "url": "http://pfam.xfam.org/family/PF03226", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-606279", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-606279", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001333352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333352", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1564263", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1564263", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K615", "url": "https://www.uniprot.org/uniprot/A0A0G2K615", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K615-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K615-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATLSPRGLPVVETQSCSGSCDTPFSSSMEWDTQVVEGFSPLGSSGSEVKASPVDLRLPAWLKPERCAVFHCASCYAVLGDTVHLAWDLSKFLGALAFSRVTNNVVLLEPLLVGIEGSLKSSTYNLLFCNSCGTPVGFHLYSTRAALAALRGHFCLSCDKMLCYLLKTKAIVNTSEMDIYNVPLPEKIAELKEKIMLMHSRLNSLLRVLKEKTPPQSDQENRTSNKQGNNTILGFIE", "length": 237, "header": "tr|A0A0G2K615-1|A0A0G2K615_RAT Isoform 1 of Opa interacting protein 5 OS=Rattus norvegicus OX=10116 GN=Oip5 PE=4 SV=2 CANONICAL=A0A0G2K615-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K615-1", "url": "", "sequence": { "sequence": "MATLSPRGLPVVETQSCSGSCDTPFSSSMEWDTQVVEGFSPLGSSGSEVKASPVDLRLPAWLKPERCAVFHCASCYAVLGDTVHLAWDLSKFLGALAFSRVTNNVVLLEPLLVGIEGSLKSSTYNLLFCNSCGTPVGFHLYSTRAALAALRGHFCLSCDKMLCYLLKTKAIVNTSEMDIYNVPLPEKIAELKEKIMLMHSRLNSLLRVLKEKTPPQSDQENRTSNKQGNNTILGFIE", "length": 237, "header": "tr|A0A0G2K615-1|A0A0G2K615_RAT Isoform 1 of Opa interacting protein 5 OS=Rattus norvegicus OX=10116 GN=Oip5 PE=4 SV=2 CANONICAL=A0A0G2K615-1" }, "locus": { "chromosome": "3", "start_pos": 106603225, "end_pos": 106595664, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000084290.2", "url": "https://www.ensembl.org/id/ENSRNOT00000084290.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073638.2", "url": "https://www.ensembl.org/id/ENSRNOP00000073638.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Raf1 interacts with OIP5 to participate in oxaliplatin-induced neuropathic pain.", "journal": "Life sciences", "date": "2021", "authors": "Yu W, Zheng Z, Wei W, Li L, Zhang Y, Sun Y, Cao J, Zang W, Shao J", "evidence": [ { "database": "RefSeq", "id": "NP_001333352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333352" } ], "reference": [ { "type": "PubMed", "id": "34229010", "url": "https://glygen.org/publication/PubMed/34229010" } ] } ], "pathway": [ { "id": "rno:499873", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:499873", "resource": "KEGG Pathway" }, { "id": "R-RNO-606279", "name": "Deposition of new CENPA-containing nucleosomes at the centromere", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-606279", "resource": "Reactome", "description": "Deposition of new CENPA-containing nucleosomes at the centromere" } ], "orthologs": [ { "uniprot_canonical_ac": "A2AQ14-1", "protein_name": "Protein Mis18-beta", "gene_name": "Oip5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATLSRRSLRFLETQSRRDSCDTPFSLTSSMEWDTQVVEGFSPLGSSESKVKASPVDLRLPAWLEPERCAVFHCARCYAVLGDTLHLAWDLSRSLGALAFSKVTNNVVLLEPFLVGIEGFLKSSTYNLLFCNSCGTPVGFHLYSTHAAMAALRGHFCLSSDKMLCYLLKTNAIVNTSEMDFHNVPLPEKIAELKEKIMLMHTRLNSLTGLLKGKSPHQFKQENQQARKQHILGLTASPKIL", "length": 241 }, "evidence": [ { "id": "45234846", "url": "http://www.informatics.jax.org/homology/45234846", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "O43482-1", "protein_name": "Protein Mis18-beta", "gene_name": "OIP5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAQPLRHRSRCATPPRGDFCGGTERAIDQASFTTSMEWDTQVVKGSSPLGPAGLGAEEPAAGPQLPSWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCGSCGIPVGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIVNASEMDIQNVPLSEKIAELKEKIVLTHNRLKSLMKILSEVTPDQSKPEN", "length": 229 }, "evidence": [ { "id": "45234846", "url": "http://www.informatics.jax.org/homology/45234846", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K615", "url": "https://www.uniprot.org/uniprot/A0A0G2K615" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K615", "url": "https://www.uniprot.org/uniprot/A0A0G2K615" } ], "pmid": "" }, { "name": "chromosome, centromeric region", "id": "GO:0000775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000775", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K615", "url": "https://www.uniprot.org/uniprot/A0A0G2K615" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K615", "url": "https://www.uniprot.org/uniprot/A0A0G2K615" } ], "pmid": 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