{
    "uniprot_canonical_ac": "A0A0G2K606-1",
    "uniprot_ac": "A0A0G2K606",
    "uniprot_id": "A0A0G2K606_RAT",
    "mass": {
        "chemical_mass": 7934.0,
        "monoisotopic_mass": 7934.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "LOC120103497",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K606",
            "id": "A0A0G2K606"
        }
    ],
    "protein_names": [
        {
            "name": "General transcription and DNA repair factor IIH subunit TFB5",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A0A0G2K606"
        }
    ],
    "function": [
        {
            "annotation": "In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2K606",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K606#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "RU368032",
                    "url": "https://www.uniprot.org/uniprot/RU368032#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0111866",
            "recommended_name": {
                "id": "DOID:0111866",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111866",
                "name": "trichothiodystrophy",
                "description": "A syndrome characterized by sparse, brittle, sulfur-deficient hair that is easily broken and in more severe cases delayed development, significant intellectual disability, and recurrent infections."
            },
            "synonyms": [
                {
                    "id": "DOID:0111866",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111866",
                    "name": "TTD",
                    "description": ""
                },
                {
                    "id": "MONDO:0011125",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011125",
                    "name": "trichothiodystrophy 1, photosensitive",
                    "description": ""
                },
                {
                    "id": "MONDO:0011125",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011125",
                    "name": "PIBIDS syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0011125",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011125",
                    "name": "trichothiodystrophy 1, photosensitive",
                    "description": ""
                },
                {
                    "id": "MONDO:0011125",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011125",
                    "name": "TTD1",
                    "description": ""
                },
                {
                    "id": "MONDO:0011125",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011125",
                    "name": "Tay syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0011125",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011125",
                    "name": "ichthyosiform erythroderma with hair Abnormality and mental and Growth retardation",
                    "description": ""
                },
                {
                    "id": "MONDO:0011125",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011125",
                    "name": "trichothiodystrophy with congenital ichthyosis",
                    "description": ""
                },
                {
                    "id": "MONDO:0011125",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011125",
                    "name": "trichothiodystrophy, photosensitive",
                    "description": ""
                },
                {
                    "id": "MIM:601675",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/601675",
                    "name": "Trichothiodystrophy 1, photosensitive",
                    "description": "Trichothiodystrophy 1, photosensitive"
                }
            ],
            "evidence": [
                {
                    "id": "0111866",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111866"
                }
            ]
        },
        {
            "disease_id": "DOID:0111871",
            "recommended_name": {
                "id": "DOID:0111871",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111871",
                "name": "photosensitive trichothiodystrophy 3",
                "description": "A photosensitive trichothiodystrophy that has_material_basis_in homozygous or compound heterozygous mutation in the GTF2H5 gene on chromosome 6q25.3."
            },
            "synonyms": [
                {
                    "id": "DOID:0111871",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111871",
                    "name": "TTD3",
                    "description": ""
                },
                {
                    "id": "DOID:0111871",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111871",
                    "name": "trichothiodystrophy complementation group A",
                    "description": ""
                },
                {
                    "id": "MONDO:0014619",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014619",
                    "name": "trichothiodystrophy 3, photosensitive",
                    "description": ""
                },
                {
                    "id": "MONDO:0014619",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014619",
                    "name": "trichothiodystrophy 3, photosensitive",
                    "description": ""
                },
                {
                    "id": "MONDO:0014619",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014619",
                    "name": "TTD3",
                    "description": ""
                },
                {
                    "id": "MONDO:0014619",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014619",
                    "name": "trichothiodystrophy, complementation group A",
                    "description": ""
                },
                {
                    "id": "MIM:616395",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/616395",
                    "name": "Trichothiodystrophy 3, photosensitive",
                    "description": "Trichothiodystrophy 3, photosensitive"
                }
            ],
            "evidence": [
                {
                    "id": "0111871",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111871"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2K606",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K606"
                }
            ],
            "common_name": "Rat"
        }
    ],
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        {
            "name": "LOC120103497",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K606",
            "locus": {
                "chromosome": "6",
                "start_pos": 27111546,
                "end_pos": 27111331,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000052193",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000052193"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000052193",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000052193",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "IPR009400",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009400",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035935",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035935",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "TIKERRM",
            "url": "https://omabrowser.org/oma/group/TIKERRM/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR28580",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28580",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR28580:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28580:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF06331",
            "url": "http://pfam.xfam.org/family/PF06331",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "41355253",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=41355253",
            "database": "RGD",
            "categories": [
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            ]
        },
        {
            "id": "A0A0G2K606",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K606",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2K606-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K606-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
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        "sequence": "MANTLKGVLIECDSATKQFFLYLNESNALGKKFVIQDIDDTHAFVIVELVNVLQEQVGELMDQNASCLTQK",
        "length": 71,
        "header": "tr|A0A0G2K606-1|A0A0G2K606_RAT Isoform 1 of General transcription and DNA repair factor IIH subunit TFB5  OS=Rattus norvegicus OX=10116 GN=LOC120103497 PE=3 SV=1 CANONICAL=A0A0G2K606-1"
    },
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        {
            "isoform_ac": "A0A0G2K606-1",
            "url": "",
            "sequence": {
                "sequence": "MANTLKGVLIECDSATKQFFLYLNESNALGKKFVIQDIDDTHAFVIVELVNVLQEQVGELMDQNASCLTQK",
                "length": 71,
                "header": "tr|A0A0G2K606-1|A0A0G2K606_RAT Isoform 1 of General transcription and DNA repair factor IIH subunit TFB5  OS=Rattus norvegicus OX=10116 GN=LOC120103497 PE=3 SV=1 CANONICAL=A0A0G2K606-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 27111543,
                "end_pos": 27111331,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000087058.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000087058.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000073629.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000073629.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "transcription by RNA polymerase II",
                        "id": "GO:0006366",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366",
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                            }
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                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006367",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "A0A0G2K606",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K606"
                            }
                        ],
                        "pmid": ""
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                        "id": "GO:0006294",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006294",
                        "evidence": [
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                                "id": "A0A0G2K606",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K606"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "transcription factor TFIIH holo complex",
                        "id": "GO:0005675",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005675",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K606",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K606"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription factor TFIIH core complex",
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                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000439",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "A0A0G2K606",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K606"
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                    }
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            "annotation": "n_glycosylation_sequon"
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        {
            "start_pos": 64,
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    "interactions": [],
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    "reaction_enzymes": [],
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    "cluster_types": [],
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}
