{
    "uniprot_canonical_ac": "A0A0G2K5W4-1",
    "uniprot_ac": "A0A0G2K5W4",
    "uniprot_id": "A0A0G2K5W4_RAT",
    "mass": {
        "chemical_mass": 72460.0,
        "monoisotopic_mass": 72460.0
    },
    "refseq": {
        "ac": "NP_001264086",
        "name": "CREB3 regulatory factor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264086"
    },
    "gene_names": [
        {
            "name": "Crebrf",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4",
            "id": "A0A0G2K5W4"
        },
        {
            "name": "Crebrf",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264086",
            "id": "NP_001264086"
        },
        {
            "name": "RGD1310862",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264086",
            "id": "NP_001264086"
        }
    ],
    "protein_names": [
        {
            "name": "CREB3 regulatory factor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264086",
            "id": "NP_001264086"
        },
        {
            "name": "CREB3 regulatory factor",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A0G2K5W4"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2K5W4",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Crebrf",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4",
            "locus": {
                "chromosome": "10",
                "start_pos": 16404596,
                "end_pos": 16461999,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000020769",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000020769"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000020769",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020769",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd14809",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14809",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "303016",
            "url": "https://www.ncbi.nlm.nih.gov/gene/303016",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR004827",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004827",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR039165",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039165",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR046347",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR046347",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:303016",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:303016",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "MYQKNGP",
            "url": "https://omabrowser.org/oma/group/MYQKNGP/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "4258465at2759",
            "url": "http://www.orthodb.org/?query=4258465at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21552",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21552",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21552:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21552:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-8874211",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8874211",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001264086",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264086",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1310862",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310862",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2K5W4",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2K5W4-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D4A811",
            "url": "https://www.uniprot.org/uniprot/D4A811",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D4A811-1",
            "url": "https://www.uniprot.org/uniprot/D4A811-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MPQPSVSGMDPPFGDAFRSHTFSEQTLMSTDLLANSSDPDFMYELDREMNYQQNPRDNFLSLEDCKDIENLETFTDVLDNEDALTSNWEQWDTYCEDLTKYTKLTSCDIWGTKEVDYLGLDDFSSPYQDEEVISKTPTLAQLNSEDSQSVSDSLYYPDSLFSVKQNPLPPSSFPSKKITSRAAAPVCSSKILQAEVPSSDCVQKASKPTSSTQIMVKTNMYHNEKVNFHVECKDYVKKAKVKINPVQQGRPLLSQVHIDAAKENTCYCGAVVKRQEKRGVEPHQGHGTPALPFRETQELLLSPLPQHGPGLVATAESGSLSASTSVSDSSQKKEEHNYSLFVSDNMREQPTKYSPEDDEDDEDDIDDEDHDEGFGSEHELSENEEEEEEEEDYEDDRDDDISDTFSEPGYENDSVEDLKEMTSISSRKRGKRRYFWEYSEQLTPSQQERILRPSEWNRDTLPSNMYQKNGLHHGKYAVKKSRRTDVEDLTPNPKKLLQIGNELRKLNKVISDLTPVSELPLTARPRSRKEKNKLASRACRLKKKAQYEANKVKLWGLNTEYDNLLFVINSIKQDIVNRVQNPREERGPSMGQKLEILIKDTLGLPVAGQTSEFVNQVLGKTAEGNPTGGLVGLRIPASKV",
        "length": 640,
        "header": "tr|A0A0G2K5W4-1|A0A0G2K5W4_RAT Isoform 1 of CREB3 regulatory factor  OS=Rattus norvegicus OX=10116 GN=Crebrf PE=4 SV=1 CANONICAL=A0A0G2K5W4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2K5W4-1",
            "url": "",
            "sequence": {
                "sequence": "MPQPSVSGMDPPFGDAFRSHTFSEQTLMSTDLLANSSDPDFMYELDREMNYQQNPRDNFLSLEDCKDIENLETFTDVLDNEDALTSNWEQWDTYCEDLTKYTKLTSCDIWGTKEVDYLGLDDFSSPYQDEEVISKTPTLAQLNSEDSQSVSDSLYYPDSLFSVKQNPLPPSSFPSKKITSRAAAPVCSSKILQAEVPSSDCVQKASKPTSSTQIMVKTNMYHNEKVNFHVECKDYVKKAKVKINPVQQGRPLLSQVHIDAAKENTCYCGAVVKRQEKRGVEPHQGHGTPALPFRETQELLLSPLPQHGPGLVATAESGSLSASTSVSDSSQKKEEHNYSLFVSDNMREQPTKYSPEDDEDDEDDIDDEDHDEGFGSEHELSENEEEEEEEEDYEDDRDDDISDTFSEPGYENDSVEDLKEMTSISSRKRGKRRYFWEYSEQLTPSQQERILRPSEWNRDTLPSNMYQKNGLHHGKYAVKKSRRTDVEDLTPNPKKLLQIGNELRKLNKVISDLTPVSELPLTARPRSRKEKNKLASRACRLKKKAQYEANKVKLWGLNTEYDNLLFVINSIKQDIVNRVQNPREERGPSMGQKLEILIKDTLGLPVAGQTSEFVNQVLGKTAEGNPTGGLVGLRIPASKV",
                "length": 640,
                "header": "tr|A0A0G2K5W4-1|A0A0G2K5W4_RAT Isoform 1 of CREB3 regulatory factor  OS=Rattus norvegicus OX=10116 GN=Crebrf PE=4 SV=1 CANONICAL=A0A0G2K5W4-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 16439766,
                "end_pos": 16408898,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000079462.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000079462.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000073583.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000073583.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D4A811-1",
            "url": "",
            "sequence": {
                "sequence": "MDPPFGDAFRSHTFSEQTLMSTDLLANSSDPDFMYELDREMNYQQNPRDNFLSLEDCKDIENLETFTDVLDNEDALTSNWEQWDTYCEDLTKYTKLTSCDIWGTKEVDYLGLDDFSSPYQDEEVISKTPTLAQLNSEDSQSVSDSLYYPDSLFSVKQNPLPPSSFPSKKITSRAAAPVCSSKILQAEVPSSDCVQKASKPTSSTQIMVKTNMYHNEKVNFHVECKDYVKKAKVKINPVQQGRPLLSQVHIDAAKENTCYCGAVVKRQEKRGVEPHQGHGTPALPFRETQELLLSPLPQHGPGLVATAESGSLSASTSVSDSSQKKEEHNYSLFVSDNMREQPTKYSPEDDEDDEDDIDDEDHDEGFGSEHELSENEEEEEEEEDYEDDRDDDISDTFSEPGYENDSVEDLKEMTSISSRKRGKRRYFWEYSEQLTPSQQERILRPSEWNRDTLPSNMYQKNGLHHGKYAVKKSRRTDVEDLTPNPKKLLQIGNELRKLNKVISDLTPVSELPLTARPRSRKEKNKLASRACRLKKKAQYEANKVKLWGLNTEYDNLLFVINSIKQDIVNRVQNPREERGPSMGQKLEILIKDTLGKENIVRHQLMIYSARVKEEFFPPPFLPHLLPPLGRDLSSLVYSHLTYLTFHP",
                "length": 647,
                "header": "tr|D4A811-1|D4A811_RAT Computationally mapped isoform of CREB3 regulatory factor  OS=Rattus norvegicus OX=10116 GN=Crebrf PE=4 SV=2 CANONICAL=A0A0G2K5W4-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 16437658,
                "end_pos": 16416021,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000028186.8",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000028186.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000028186.6",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000028186.6"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:303016",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:303016",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-8874211",
            "name": "CREB3 factors activate genes",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8874211",
            "resource": "Reactome",
            "description": "CREB3 factors activate genes"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8CDG5-1",
            "protein_name": "CREB3 regulatory factor",
            "gene_name": "Crebrf",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MPQPSVSGMDPPFGDAFRSHTFSEQTLMSTDLLANSSDPDFMYELDREMNYQQNPRDNFLSLEDCKDIENLETFTDVLDNEDALTSNWEQWDTYCEDLTKYTKLTSCDIWGTKEVDYLGLDDFSSPYQDEEVISKTPTLAQLNSEDSQSVSDSLYYPDSLFSVKQNPLPPSSFPSKKITNRAAAPVCSSKTLQAEVPSSDCVQKASKPTSSTQIMVKTNMYHNEKVNFHVECKDYVKKAKVKINPVQQGRPLLSQVHIDAAKENTCYCGAVAKRQERRGVEPHQGRGTPALPFKETQELLLSPLTQDSPGLVATAESGSLSASTSVSDSSQKKEEHNYSLFVSDNMREQPTKYSPEDDEDDEDEFDDEDHDEGFGSEHELSENEEEEEEEEDYEDDRDDDISDTFSEPGYENDSVEDLKEMTSISSRKRGKRRYFWEYSEQLTPSQQERILRPSEWNRDTLPSNMYQKNGLHHGKYAVKKSRRTDVEDLTPNPKKLLQIGNELRKLNKVISDLTPVSELPLTARPRSRKEKNKLASRACRLKKKAQYEANKVKLWGLNTEYDNLLFVINSIKQDIVNRVQNPREEREPSMGQKLEILIKDTLGLPVAGQTSEFVNQVLGKTAEGNPTGGLVGLRIPASKV",
                "length": 640
            },
            "evidence": [
                {
                    "id": "45231440",
                    "url": "http://www.informatics.jax.org/homology/45231440",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q8IUR6-1",
            "protein_name": "CREB3 regulatory factor",
            "gene_name": "CREBRF",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MPQPSVSGMDPPFGDAFRSHTFSEQTLMSTDLLANSSDPDFMYELDREMNYQQNPRDNFLSLEDCKDIENLESFTDVLDNEGALTSNWEQWDTYCEDLTKYTKLTSCDIWGTKEVDYLGLDDFSSPYQDEEVISKTPTLAQLNSEDSQSVSDSLYYPDSLFSVKQNPLPSSFPGKKITSRAAAPVCSSKTLQAEVPLSDCVQKASKPTSSTQIMVKTNMYHNEKVNFHVECKDYVKKAKVKINPVQQSRPLLSQIHTDAAKENTCYCGAVAKRQEKKGMEPLQGHATPALPFKETQELLLSPLPQEGPGSLAAGESSSLSASTSVSDSSQKKEEHNYSLFVSDNLGEQPTKCSPEEDEEDEEDVDDEDHDEGFGSEHELSENEEEEEEEEDYEDDKDDDISDTFSEPGYENDSVEDLKEVTSISSRKRGKRRYFWEYSEQLTPSQQERMLRPSEWNRDTLPSNMYQKNGLHHGKYAVKKSRRTDVEDLTPNPKKLLQIGNELRKLNKVISDLTPVSELPLTARPRSRKEKNKLASRACRLKKKAQYEANKVKLWGLNTEYDNLLFVINSIKQEIVNRVQNPRDERGPNMGQKLEILIKDTLGLPVAGQTSEFVNQVLEKTAEGNPTGGLVGLRIPTSKV",
                "length": 639
            },
            "evidence": [
                {
                    "id": "45231440",
                    "url": "http://www.informatics.jax.org/homology/45231440",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 6,
                "go_terms": [
                    {
                        "name": "negative regulation of glucocorticoid mediated signaling pathway",
                        "id": "GO:1900170",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900170",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K5W4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of prolactin signaling pathway",
                        "id": "GO:1902213",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902213",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K5W4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K5W4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K5W4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to unfolded protein",
                        "id": "GO:0006986",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006986",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K5W4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "maternal behavior",
                        "id": "GO:0042711",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042711",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K5W4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K5W4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear body",
                        "id": "GO:0016604",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K5W4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding",
                        "id": "GO:0000977",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K5W4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription factor activity, RNA polymerase II-specific",
                        "id": "GO:0000981",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K5W4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription activator activity, RNA polymerase II-specific",
                        "id": "GO:0001228",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K5W4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K5W4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 337,
            "end_pos": 339,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 35,
            "end_pos": 37,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 412,
            "end_pos": 414,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
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